Scientific Opinion on the substantiation of health claims related to alpha linolenic acid (ALA) and brain and neurological development (ID 491), “molecule precursors regulating cell functions” (ID 492, 4671), maintenance of normal cardiac function (ID 509, 579), “nutrient tasks and interactions” (ID 576), maintenance of normal blood pressure (ID 575), and enhancement of mood (ID 578, 601, 3182) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

EFSA Journal

Volumn 9, Issue 4, 2011, Pages

[No Author Info available]

Author keywords

Alpha linolenic acid (ALA); blood pressure; brain development; cardiac function; health claims; mood

Indexed keywords

EID: 84873326103     PISSN: None     EISSN: 18314732     Source Type: Journal    
DOI: 10.2903/j.efsa.2011.2050     Document Type: Article

References (22)

1. Ascherio A, Rimm EB, Giovannucci EL, Spiegelman D, Stampfer M and Willett WC, 1996. Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States. British Medical Journal (Clinical Research Edition), 313, 84–90.
2. Brouwer IA, Katan MB and Zock PL, 2004. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. Journal of Nutrition, 134, 919–922.
3. de Lorgeril M, Renaud S, Mamelle N, Salen P, Martin JL, Monjaud I, Guidollet J, Touboul P and Delaye J, 1994. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet, 343, 1454–1459.
4. Dolecek TA and Granditis G, 1991. Dietary polyunsaturated fatty acids and mortality in the Multiple Risk Factor Intervention Trial (MRFIT). World Review of Nutrition and Dietetics, 66, 205–216.
5. Edwards R, Peet M, Shay J and Horrobin D, 1998. Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients. Journal of Affective Disorders, 48, 149–155.
6. EFSA (European Food Safety Authority), 2009. Scientific Opinion of Panel on Dietetic Products, Nutrition and Allergies on the substantiation of a health claim related to ALA and contribution to brain development pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA Journal 1005, 1–9.
7. EFSA Panel on Dietetic Products Nutrition and Allergies (NDA), 2009. Scientific Opinion on the substantiation of health claims related to alpha-linolenic acid and maintenance of normal blood cholesterol concentrations (ID 493) and maintenance of normal blood pressure (ID 625) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal, 7(9):1252, 17 pp.
8. EFSA Panel on Dietetic Products Nutrition and Allergies (NDA), 2010. Scientific Opinion on Dietary Reference Values for fats, including saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids, and cholesterol. EFSA Journal, 8(3):1461, 107 pp.
9. Folsom AR and Demissie Z, 2004. Fish intake, marine omega-3 fatty acids, and mortality in a cohort of postmenopausal women. American Journal of Epidemiology, 160, 1005–1010.
10. Gezondheidsraad, 2001. Voedingsnormen energie, eiwitten, vetten en verteerbare koolhydraten. Publicatie nr 2001/19.
11. Hu FB, Stampfer MJ, Manson JE, Rimm EB, Wolk A, Colditz GA, Hennekens CH and Willett WC, 1999. Dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease among women. American Journal of Clinical Nutrition, 69, 890–897.
12. Hu FB, Bronner L, Willett WC, Stampfer MJ, Rexrode KM, Albert CM, Hunter D and Manson JE, 2002. Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. Journal of the American Medical Association, 287, 1815–1821.
13. Joshi K, Lad S, Kale M, Patwardhan B, Mahadik SP, Patni B, Chaudhary A, Bhave S and Pandit A, 2006. Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD). Prostaglandins Leukotrienes and Essential Fatty Acids, 74, 17–21.
14. Natvig H, Borchgrevink CF, Dedichen J, Owren PA, Schiotz EH and Westlund K, 1968. A controlled trial of the effect of linolenic acid on incidence of coronary heart disease. The Norwegian vegetable oil experiment of 1965–66. Scandinavian Journal of Clinical and Laboratory Investigation. Supplement, 105, 1–20.
15. Oomen CM, Ocke MC, Feskens EJ, Kok FJ and Kromhout D, 2001. alpha-Linolenic acid intake is not beneficially associated with 10-y risk of coronary artery disease incidence: the Zutphen Elderly Study. American Journal of Clinical Nutrition, 74, 457–463.
16. Pietinen P, Ascherio A, Korhonen P, Hartman AM, Willett WC, Albanes D and Virtamo J, 1997. Intake of fatty acids and risk of coronary heart disease in a cohort of Finnish men. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. American Journal of Epidemiology, 145, 876–887.
17. Ross BM, Seguin J and Sieswerda LE, 2007. Omega-3 fatty acids as treatments for mental illness: which disorder and which fatty acid? Lipids in Health and Disease, 6, 21.
18. Schachter H, Kourad K, Merali Z, Lumb A, Tran K, Miguelez M, Lewin G, Sampson M, Barrowman N, Senechal H, McGahern C, Zhang L, Morrison A, Shlik J, Pan Y, Lowcock EC, Gaboury I, Bradwejn J and Duffy A, 2005. Effects of omega-3 fatty acids on mental health. Evidence Report/Technology Assessment No. 116. (Prepared by the University of Ottawa Evidence-based Practice Center, Under Contract No. 290–02-0021.) AHRQ Publication No. 05-E022-2. Rockville, MD: Agency for Healthcare Research and Quality.
19. Singh RB, Niaz MA, Sharma JP, Kumar R, Rastogi V and Moshiri M, 1997. Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: the Indian experiment of infarct survival-4. Cardiovascular Drugs and Therapy, 11, 485–491.
20. Singh RB, Dubnov G, Niaz MA, Ghosh S, Singh R, Rastogi SS, Manor O, Pella D and Berry EM, 2002. Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean Diet Heart Study): a randomised single-blind trial. Lancet, 360, 1455–1461.
21. Wang C, Harris WS, Chung M, Lichtenstein AH, Balk EM, Kupelnick B, Jordan HS and Lau J, 2006. n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review. American Journal of Clinical Nutrition, 84, 5–17.
22. Yehuda S, Rabinovitz S and Mostofsky DI, 2005. Mixture of essential fatty acids lowers test anxiety. Nutritional Neuroscience, 8, 265–267.