Genotoxic effect of Bothrops snake venoms and isolated toxins on human lymphocyte DNA

Toxicon

Volumn 65, Issue , 2013, Pages 9-14

  Marcussi, Silvana ^a,b   Stábeli, Rodrigo G ^c   Santos Filho, Norival A ^a   Menaldo, Danilo L ^a   Silva Pereira, Luciana L ^b   Zuliani, Juliana P ^c   Calderon, Leonardo A ^c   da Silva, Saulo L ^d   Greggi Antunes, Lusânia M ^a   Soares, Andreimar M ^c  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF LAVRAS   (Brazil)

^c UNIVERSIDADE FEDERAL DE RONDÔNIA   (Brazil)

^d Universidade Federal de Sao Joao Del Rey   (Brazil)

Author keywords

Bothrops snake; Comet; Genotoxic potential; Micronucleus; Snake venom toxins

Indexed keywords

BOTHROPS ATROX TOXIN; BOTHROPS JARARACUSSU TOXIN; BOTHROPS TOXIN I; BOTHROPS TOXIN II; CISPLATIN; DOXORUBICIN; MYOTOXIN; SNAKE VENOM; UNCLASSIFIED DRUG;

ADULT; APOPTOSIS; ARTICLE; BOTHROPS; BOTHROPS ALTERNATUS; BOTHROPS ATROX; BOTHROPS BRAZILI; BOTHROPS JARARACUSSU; BOTHROPS MOOJENI; CELL CYCLE; CELL DIFFERENTIATION; CELL ISOLATION; CELL VIABILITY; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; FEMALE; GENOTOXICITY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LYMPHOCYTE; MALE; MICRONUCLEUS; MICRONUCLEUS TEST; NORMAL HUMAN; PRIORITY JOURNAL; TOXICITY TESTING;

ANIMALS; BOTHROPS; COMET ASSAY; CROTALID VENOMS; DNA BREAKS; HUMANS; LYMPHOCYTES; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MUTAGENICITY TESTS; MUTAGENS;

EID: 84873312912     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2012.12.020     Document Type: Article

References (35)

1. Alves R.M., Antonucci G.A., Paiva H.H., Cintra A.C., Franco J.J., Mendonça-Franqueiro E.P., Dorta D.J., Giglio J.R., Rosa J.C., Fuly A.L., Dias-Baruffi M., Soares A.M., Sampaio S.V. Evidence of caspase-mediated apoptosis induced by L-amino acid oxidase isolated from Bothrops atrox snake venom. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 2008, 151:542-550.
2. 2 in Bothrops snake venoms: effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu. Biochimie 2000, 82:755-763.
3. Brugger E.M., Wagner J., Schumacher D.M., Koch K., Podlech J., Metzler M., Lehmann L. Mutagenicity of the mycotoxin alternariol in cultured mammalian cells. Toxicol. Lett. 2006, 164:221-230.
4. Collins A.R. The comet assay for DNA damage and repair: principles, applications, and limitations. Mol. Biotechnol. 2004, 26:249-261.
5. Collins A.R., Duthie S.J., Dobson V.L. Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA. Carcinogenesis 1993, 14:1733-1735.
6. Dönmez-Altuntas H., Dumlupinar G., Imamoglu N., Hamurcu Z., Liman B.C. Effects of the mycotoxin citrinin on micronucleus formation in a cytokinesis-block genotoxicity assay in cultured human lymphocytes. J. Appl. Toxicol. 2007, 27:337-341.
7. Fenech M. The in vitro micronucleus technique. Mutat. Res. 2000, 455:81-95.
8. Fenech M. Cytokinesis-block micronucleus cytome assay. Nat. Protoc. 2007, 2:1084-1104.
9. Fenech M. The micronucleus assay determination of chromosomal level DNA damage. Methods Mol. Biol. 2008, 410:185-216.
10. Fenech M., Morley A. Measurement of micronuclei in lymphocytes. Mutat. Res. 1985, 147:29-36.
11. Fenech M., Morley A. Solutions to the kinetic problem in the micronucleus test. Cytobios 1985, 43:233-246.
12. Iwanaga S., Suzuki T. Enzymes in snake venoms. Handbook of Experimental Pharmacology 1979, vol. 52:61-158. Springer-Verlag, Berlin.
13. Kang T.S., Georgieva D., Genov N., Murakami M.T., Sinha M., Kumar R.P., Kaur P., Kumar S., Dey S., Sharma S., Vrielink A., Betzel C., Takeda S., Arni R.K., Singh T.P., Kini R.M. Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis. FEBS J. 2011, 278:4544-4576.
14. King G.F. Venoms as a platform for human drugs: translating toxins into therapeutics. Expert Opin. Biol. Ther. 2011, 11:1469-1484.
15. Kirsch-Volders M. The CB in vitro micronucleus assay in human lymphocytes, special issue. Mutat. Res. 1997, 392:1-2.
16. Koh C.Y., Kini R.M. From snake venom toxins to therapeutics - cardiovascular examples. Toxicon 2012, 59:497-506.
17. Koh D.C., Armugam A., Jeyaseelan K. Snake venom components and their applications in biomedicine. Cell. Mol. Life Sci. 2006, 63:3030-3041.
18. Lee Y.J., Kang S.J., Kim B.M., Kim Y.J., Woo H.D., Chung H.W. Cytotoxicity of honeybee (Apis mellifera) venom in normal human lymphocytes and HL-60 cells. Chem. Biol. Interact. 2007, 169:189-197.
19. Lerda D., Biaggi Bistoni M., Peralta N., Ychari S., Vazquez M., Bosio G. Fumonisins in foods from Cordoba (Argentina), presence and genotoxicity. Food Chem. Toxicol. 2005, 43:691-698.
20. 2 from Viperidae snake venoms: how do they induce skeletal muscle damage?. Acta Chim. Slov. 2011, 58:647-659.
21. 2 to non-enzymatic membrane disruptors. Toxicon 2012, 60:520-530.
22. 2 homologues from Viperidae snake venoms: biomimetic activities and potential applications. Curr. Pharm. Des. 2010, 16:3224-3230.
23. Marcussi S., Bernardes C.P., Santos-Filho N.A., Mazzi M.V., Oliveira C.Z., Izidoro L.F., Fuly A.L., Magro A.J., Braz A.S., Fontes M.R., Giglio J.R., Soares A.M. Molecular and functional characterization of a new non-hemorrhagic metalloprotease from Bothrops jararacussu snake venom with antiplatelet activity. Peptides 2007, 28:2328-2339.
24. Marcussi S., Santos P.R.S., Menaldo D.L., Silveira L.B., Santos-Filho N.A., Mazzi M.V., Silva S.L., Stábeli R.G., Antunes L.M.G., Soares A.M. Evaluation of the genotoxicity of Crotalus durissus terrificus snake venom and its isolated toxins on human lymphocytes. Mutat. Res. Gen. Toxic. Environ. Mutat. 2011, 724:59-63.
25. Ouanes Z., Abid S., Ayed I., Anane R., Mobio T., Creppy E.E., Bacha H. Induction of micronuclei by Zearalenone in Vero monkey kidney cells and in bone marrow cells of mice: protective effect of Vitamin E. Mutat. Res. 2003, 538:63-70.
26. Singh N.P., McCoy M.T., Tice R.R., Scheider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell. Res. 1988, 175:184-191.
27. 2 myotoxins from Bothrops snake venoms: structure-function relationship. Curr. Org. Chem. 2004, 8:1677-1690.
28. Soares A.M. Use of snake venom for biomedical researches and drug development. Open J. Biochem. Biotechnol. 2012, 1:1-4.
29. Varanda E.A., Monti R., Tavares D.C. Inhibitory effect of propolis and bee venom on the mutagenicity of some direct- and indirect-acting mutagens. Teratog. Carcinog. Mutagen 1999, 19:403-413.
30. Vonk F.J., Jackson K., Doley R., Madaras F., Mirtschin P.J., Vidal N. Snake venom: from fieldwork to the clinic: recent insights into snake biology, together with new technology allowing high-throughput screening of venom, bring new hope for drug discovery. Bioessays 2011, 33:269-279.
31. Wang J.S., Groopman J.D. DNA damage by mycotoxins. Mutat. Res. 1999, 424:167-181.
32. Wang G.L., Li D.L., Fang H.J. Site-directed mutagenesis of melittin gene and its expression in Escherichia coli. Yi Chuan Xue Bao 2000, 27:176-182.
33. Yamasaki S.C., Villarroel J.S., Barone J.M., Zambotti-Villela L., Silveira P.F. Aminopeptidase active ties, oxidative stress and renal function in Crotalus durissus terrificus envenomation in mice. Toxicon 2008, 52:445-454.
34. Zargan J., Sajad M., Umar S., Naime M., Ali S., Khan H.A. Scorpion (Androctonus crassicauda) venom limits growth of transformed cells (SH-SY5Y and MCF-7) by cytotoxicity and cell cycle arrest. Exp. Mol. Pathol. 2011, 91:447-454.
35. Zhang L., Cui L. A cytotoxin isolated from Agkistrodon acutus snake venom induces apoptosis via Fas pathway in A549 cells. Toxicol. In Vitro 2007, 21:1095-1103.