Testosterone regulates cardiac contractile activation by modulating SERCA but not NCX activity

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 304, Issue 3, 2013, Pages

  Witayavanitkul, Namthip ^a   Woranush, Warunya ^a   Bupha Intr, Tepmanas ^a   Wattanapermpool, Jonggonnee ^a  

^a Mahidol University ^*  (Thailand)

Author keywords

Gender; Na+ Ca2+ exchanger; Orchidectomized rat; Sarco(endo)plasmic reticulum Ca2+ ATPase; Sex difference

Indexed keywords

HEAT SHOCK PROTEIN 20; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM CALCIUM EXCHANGE PROTEIN; TESTOSTERONE; TESTOSTERONE PROPIONATE; THAPSIGARGIN;

ANIMAL EXPERIMENT; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; HEART CONTRACTION; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE RELAXATION; HORMONE DEFICIENCY; MALE; MYOFILAMENT; NONHUMAN; ORCHIECTOMY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; BLOTTING, WESTERN; BODY WEIGHT; HEART; MALE; MUSCLE CONTRACTION; MUSCLE PROTEINS; MUSCLE, SKELETAL; MYOCARDIAL CONTRACTION; ORCHIECTOMY; ORGAN SIZE; PROTEOLIPIDS; RATS; RATS, SPRAGUE-DAWLEY; SARCOMERES; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SEMINAL VESICLES; SODIUM-CALCIUM EXCHANGER; TESTOSTERONE; TRABECULAR MESHWORK;

EID: 84873293059     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00555.2012     Document Type: Article

References (36)

1. Babu GJ, Bhupathy P, Petrashevskaya NN, Wang H, Raman S, Wheeler D, Jagatheesan G, Wieczorek D, Schwartz A, Janssen PM, Ziolo MT, Periasamy M. Targeted overexpression of sarcolipin in the mouse heart decreases sarcoplasmic reticulum calcium transport and cardiac contractility. J Biol Chem 281: 3972-3979, 2006.
2. Babu GJ, Zheng Z, Natarajan P, Wheeler D, Janssen PM, Periasamy M. Overexpression of sarcolipin decreases myocyte contractility and calcium transient. Cardiovasc Res 65: 177-186, 2005.
3. Basaria S, Nguyen T, Rosenson RS, Dobs AS. Effect of methyl testosterone administration on plasma viscosity in postmenopausal women. Clin Endocrinol (Oxf) 57: 209-214, 2002.
4. Bers DM. Cardiac excitation-contraction coupling. Nature 415: 198-205, 2002.
5. Bilezikjian LM, Kranias EG, Potter JD, Schwartz A. Studies on phosphorylation of canine cardiac sarcoplasmic reticulum by calmodulin-dependent protein kinase. Circ Res 49: 1356-1362, 1981.
6. Bupha-Intr T, Wattanapermpool J. Regulatory role of ovarian sex hormones in calcium uptake activity of cardiac sarcoplasmic reticulum. Am J Physiol Heart Circ Physiol 291: H1101-H1108, 2006.
7. + exchanger activity in sex hormone-related protection of cardiac myocytes from deactivation in hypercapnic acidosis. Am J Physiol Regul Integr Comp Physiol 292: R837-R843, 2007.
8. Callies F, Stromer H, Schwinger RH, Bolck B, Hu K, Frantz S, Leupold A, Beer S, Allolio B, Bonz AW. Administration of testosterone is associated with a reduced susceptibility to myocardial ischemia. Endocrinology 144: 4478-4483, 2003.
9. Chu A, Dixon MC, Saito A, Seiler S, Fleischer S. Isolation of sarcoplasmic reticulum fractions referable to longitudinal tubules and junctional terminal cisternae from rabbit skeletal muscle. Methods Enzymol 157: 36-46, 1988.
10. 2+ handling and contractile function. Physiol Res 58: 293-297, 2009.
11. 2+-handling in failing human myocardium. J Mol Cell Cardiol 33: 1345-1353, 2001.
12. Er F, Gassanov N, Brandt MC, Madershahian N, Hoppe UC. Impact of dihydrotestosterone on L-type calcium channels in human ventricular cardiomyocytes. Endocr Res 34: 59-67, 2009.
13. Farrell SR, Ross JL, Howlett SE. Sex differences in mechanisms of cardiac excitation-contraction coupling in rat ventricular myocytes. Am J Physiol Heart Circ Physiol 299: H36-H45, 2010.
14. Golden KL, Marsh JD, Jiang Y, Brown T, Moulden J. Gonadectomy of adult male rats reduces contractility of isolated cardiac myocytes. Am J Physiol Endocrinol Metab 285: E449-E453, 2003.
15. Haisenleder DJ, Burger LL, Aylor KW, Dalkin AC, Walsh HE, Shupnik MA, Marshall JC. Testosterone stimulates follicle-stimulating hormone beta transcription via activation of extracellular signal-regulated kinase: evidence in rat pituitary cells. Biol Reprod 72: 523-529, 2005.
16. Hatanaka Y, Mukai H, Mitsuhashi K, Hojo Y, Murakami G, Kom-atsuzaki Y, Sato R, Kawato S. Androgen rapidly increases dendritic thorns of CA3 neurons in male rat hippocampus. Biochem Biophys Res Commun 381: 728-732, 2009.
17. Iellamo F, Volterrani M, Caminiti G, Karam R, Massaro R, Fini M, Collins P, Rosano GM. Testosterone therapy in women with chronic heart failure: a pilot double-blind, randomized, placebo-controlled study. J Am Coll Cardiol 56: 1310-1316, 2010.
18. Janssen PM, de Tombe PP. Protein kinase A does not alter unloaded velocity of sarcomere shortening in skinned rat cardiac trabeculae. Am J Physiol Heart Circ Physiol 273: H2415-H2422, 1997.
19. Kennedy RH, Liu SJ. Sex differences in L-type calcium current after chronic ethanol consumption in rats. Toxicol Appl Pharmacol 189: 196-203, 2003.
20. Kranias EG, Hajjar RJ. Modulation of cardiac contractility by the phopholamban/SERCA2a regulatome. Circ Res 110: 1646-1660, 2012.
21. Linke WA, Popov VI, Pollack GH. Passive and active tension in single cardiac myofibrils. Biophys J 67: 782-792, 1994.
22. 2+/calmodulin-dependent protein kinase II. Br J Pharmacol 157: 705-715, 2009.
23. Marsh JD, Lehmann MH, Ritchie RH, Gwathmey JK, Green GE, Schiebinger RJ. Androgen receptors mediate hypertrophy in cardiac myocytes. Circulation 98: 256-261, 1998.
24. Mason SA, MacLeod KT. Cardiac action potential duration and calcium regulation in males and females. Biochem Biophys Res Commun 388: 565-570, 2009.
25. 2+ exchanger expression in left ventricle myocardium of dogs with progression of heart failure. Heart Vessels 20: 23-32, 2005.
26. Monasky MM, Varian KD, Janssen PM. Gender comparison of contractile performance and (3-adrenergic response in isolated rat cardiac trabeculae. J Comp Physiol B 178: 307-313, 2008.
27. 2+ transient in rat ventricular myocytes. J Physiol 468: 35-52, 1993.
28. Pham TV, Robinson RB, Danilo P Jr, Rosen MR. Effects of gonadal steroids on gender-related differences in transmural dispersion of L-type calcium current. Cardiovasc Res 53: 752-762, 2002.
29. Regitz-Zagrosek V, Oertelt-Prigione S, Seeland U, Hetzer R. Sex and gender differences in myocardial hypertrophy and heart failure. Circ J 74: 1265-1273, 2010.
30. Ren J, Hintz KK, Roughead ZK, Duan J, Colligan PB, Ren BH, Lee KJ, Zeng H. Impact of estrogen replacement on ventricular myocyte contractile function and protein kinase B/Akt activation. Am J Physiol Heart Circ Physiol 284: H1800-H1807, 2003.
31. Salas MA, Valverde CA, Sanchez G, Said M, Rodriguez JS, Portian-sky EL, Kaetzel MA, Dedman JR, Donoso P, Kranias EG, Mattiazzi A. The signalling pathway of CaMKII-mediated apoptosis and necrosis in the ischemia/reperfusion injury. JMol Cell Cardiol 48: 1298-1306, 2010.
32. Scantlebury DC, Borlaug BA. Why are women more likely than men to develop heart failure with preserved ejection fraction? Curr Opin Cardiol 26: 562-568, 2012.
33. Scheuer J, Malhotra A, Schaible TF, Capasso J. Effects of gonadec-tomy and hormonal replacement on rat hearts. Circ Res 61: 12-19, 1987.
34. Tsang S, Wong SS, Wu S, Kravtsov GM, Wong TM. Testosterone-augmented contractile responses to a1- and p1-adrenoceptor stimulation are associated with increased activities of RyR, SERCA, and NCX in the heart. Am J Physiol Cell Physiol 296: C766-C782, 2009.
35. Vila-Petroff M, Salas MA, Said M, Valverde CA, Sapia L, Portiansky E, Hajjar RJ, Kranias EG, Mundina-Weilenmann C, Mattiazzi A. CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury. Cardiovasc Res 73: 689-698, 2007.
36. 2+ current in rat left ventricular cardiomyocytes. Acta Physiol (Oxf) 202: 629-640, 2011.