Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D1, D2 and serotonin 5-HT1A multi-action profile

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 4, 2013, Pages 856-868

  Sun, Haifeng ^a   Zhu, Liyuan ^a   Yang, Huicui ^b   Qian, Wangke ^a   Guo, Lin ^a   Zhou, Shengbin ^a   Gao, Bo ^b   Li, Zeng ^a   Zhou, Yu ^a   Jiang, Hualiang ^a   Chen, Kaixian ^a   Zhen, Xuechu ^a,b   Liu, Hong ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

Author keywords

Asymmetric synthesis; Dopamine receptors; Multi action; New pharmacological profile; Serotonin receptors; Tetrahydroprotoberberines

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; BERBINE DERIVATIVE; CANADINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; HALOPERIDOL; KETANSERIN; PHENCYCLIDINE; RISPERIDONE; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; SPIPERONE; STEPHOLIDINE; TETRAHYDROPALMATINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASYMMETRIC SYNTHESIS; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DOSE RESPONSE; DRUG DESIGN; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; EMBRYO; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; MALE; NERVE CELL STIMULATION; NONHUMAN; PREPULSE INHIBITION; RAT; RECEPTOR AFFINITY; SCHIZOPHRENIA; SINGLE UNIT ACTIVITY;

ANIMALS; ANTIPSYCHOTIC AGENTS; BERBERINE; BERBERINE ALKALOIDS; CHO CELLS; CRICETINAE; CRICETULUS; HEK293 CELLS; HUMANS; MICROWAVES; MOTOR ACTIVITY; PROTEIN BINDING; RATS; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; SCHIZOPHRENIA; SEROTONIN 5-HT1 RECEPTOR AGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 84873285437     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.12.016     Document Type: Article

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