Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini

Journal of Biological Chemistry

Volumn 288, Issue 5, 2013, Pages 3265-3274

  Pal, Kasturi ^a   Mathur, Maneesh ^a   Kumar, Puneet ^b   DeFea, Kathryn ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARRESTINS; G PROTEIN COUPLED RECEPTORS; SIGNALING EVENTS;

BIOCHEMISTRY;

BIOLOGY;

BETA ARRESTIN; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; NEUROKININ 1 RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 2; SERINE; THREONINE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN TRANSPORT; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

ACTIN DEPOLYMERIZING FACTORS; AMINO ACID SEQUENCE; ANIMALS; ARRESTINS; CALCIUM; CELL MOVEMENT; CHO CELLS; CRICETINAE; ENDOCYTOSIS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HEK293 CELLS; HUMANS; INTRACELLULAR SPACE; KINETICS; MICE; MUTANT PROTEINS; PHOSPHORYLATION; RECEPTOR, PAR-2; RECEPTORS, NEUROKININ-1; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBCELLULAR FRACTIONS;

EID: 84873279763     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.400234     Document Type: Article

References (31)

1. De Fea, K. A., Vaughn, Z. D., O'Bryan, E. M., Nishijima, D., Déry, O., and Bunnett, N. W. (2000) The proliferative and antiapoptotic effects of substance P are facilitated by formation of a β-arrestin-dependent scaffolding complex. Proc. Natl. Acad. Sci. U. S. A. 97, 11086-11091
2. De Fea, K. A., Zalevsky, J., Thoma, M. S., Déry, O., Mullins, R. D., and Bunnett, N. W. (2000) β-Arrestin-dependent endocytosis of proteinaseactivated receptor 2 is required for intracellular targeting of activated ERK1/2. J. Cell Biol. 148, 1267-1281
3. Kumar, P., Lau, C. S., Mathur, M., Wang, P., and De Fea, K. A. (2007) Differential effects of β-arrestins on the internalization, desensitization and ERK1/2 activation downstream of protease activated receptor-2. Am. J. Physiol. Cell Physiol. 293, C346-C357
4. Stalheim, L., Ding, Y., Gullapalli, A., Paing, M. M., Wolfe, B. L., Morris, D. R., and Trejo, J. (2005) Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking. Mol. Pharmacol. 67, 78-87
5. Ge, L., Ly, Y., Hollenberg, M., and De Fea, K. (2003) A β-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis. J. Biol. Chem. 278, 34418-34426
6. Al-Ani, B., Hansen, K. K., and Hollenberg, M. D. (2004) Proteinase-activated receptor-2. Key role of amino-terminal dipeptide residues of the tethered ligand for receptor activation. Mol. Pharmacol. 65, 149-156
7. Lovgren, A. K., Kovacs, J. J., Xie, T., Potts, E. N., Li, Y., Foster, W. M., Liang, J., Meltzer, E. B., Jiang, D., Lefkowitz, R. J., and Noble, P. W. (2011) β-Arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix. Sci. Transl. Med. 3, 74ra23
8. Nystedt, S., Emilsson, K., Wahlestedt, C., and Sundelin, J. (1994) Molecular cloning of a potential proteinase activated receptor. Proc. Natl. Acad. Sci. U. S. A. 91, 9208-9212
9. q/11, G-protein receptor kinase-2/3, and β-arrestin-1/2. Mol. Biol. Cell 9, 2305-2324
10. McConalogue, K., Déry, O., Lovett, M., Wong, H., Walsh, J. H., Grady, E. F., and Bunnett, N. W. (1999) Substance P-induced trafficking of β-arrestins. The role of β-arrestins in endocytosis of the neurokinin-1 receptor. J. Biol. Chem. 274, 16257-16268
11. Morris, D. R., Ding, Y., Ricks, T. K., Gullapalli, A., Wolfe, B. L., and Trejo, J. (2006) Protease-activated receptor-2 is essential for factor VIIa and Xainduced signaling, migration, and invasion of breast cancer cells. Cancer Res. 66, 307-314
12. 2+ signalling, proline-rich tyrosine kinase-2 activation, and mitogen-activated protein kinase activity. Cell. Signal. 16, 21-29
13. Ge, L., Shenoy, S. K., Lefkowitz, R. J., and De Fea, K. (2004) Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both β-arrestin-1 and -2. J. Biol. Chem. 279, 55419-55424
14. Zoudilova, M., Kumar, P., Ge, L., Wang, P., Bokoch, G. M., and De Fea, K. A. (2007) β-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2. J. Biol. Chem. 282, 20634-20646
15. Böhm, S. K., Grady, E. F., and Bunnett, N. W. (1997) Regulatory mechanisms that modulate signalling by G-protein-coupled receptors. Biochem. J. 322, 1-18
16. Luttrell, L. M., and Lefkowitz, R. J. (2002) The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals. J. Cell Sci. 115, 455-465
17. Ferguson, S. S., Downey, W. E., 3rd, Colapietro, A. M., Barak, L. S., Ménard, L., and Caron, M. G. (1996) Role of β-arrestin in mediating agonistpromoted G protein-coupled receptor internalization. Science 271, 363-366
18. Böhm, S. K., Khitin, L. M., Grady, E. F., Aponte, G., Payan, D. G., and Bunnett, N. W. (1996) Mechanisms of desensitization and resensitization of proteinase-activated receptor-2. J. Biol. Chem. 271, 22003-22016
19. Déry, O., Defea, K. A., and Bunnett, N. W. (2001) Protein kinase C-mediated desensitization of the neurokinin 1 receptor. Am. J. Physiol. Cell Physiol. 280, C1097-C1106
20. Ramachandran, R., Mihara, K., Mathur, M., Rochdi, M. D., Bouvier, M., Defea, K., and Hollenberg, M. D. (2009) Agonist-biased signaling via proteinase activated receptor-2. Differential activation of calcium and mitogenactivated protein kinase pathways. Mol. Pharmacol. 76, 791-801
21. Exton, J. H. (1994) Phosphoinositide phospholipases and G proteins in hormone action. Annu. Rev. Physiol. 56, 349-369
22. Yu, Y. J., Arttamangkul, S., Evans, C. J., Williams, J. T., and von Zastrow, M. (2009) Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of μ-opioid receptors in CNS neurons. J. Neurosci. 29, 222-233
23. Déry, O., Thoma, M. S., Wong, H., Grady, E. F., and Bunnett, N. W. (1999) Trafficking of proteinase-activated receptor-2 and β-arrestin-1 tagged with green fluorescent protein. β-Arrestin-dependent endocytosis of a proteinase receptor. J. Biol. Chem. 274, 18524-18535
24. Zoudilova, M., Min, J., Richards, H. L., Carter, D., Huang, T., and De Fea, K. A. (2010) β-Arrestins scaffold cofilin with chronophin to direct localized actin filament severing and membrane protrusions downstream of protease-activated receptor-2. J. Biol. Chem. 285, 14318-14329
25. Ricks, T. K., and Trejo, J. (2009) Phosphorylation of protease-activated receptor-2 differentially regulates desensitization and internalization. J. Biol. Chem. 284, 34444-34457
26. Defea, K. (2008) β-Arrestins and heterotrimeric G-proteins. Collaborators and competitors in signal transduction. Br. J. Pharmacol. 153, S298-S309
27. Tohgo, A., Choy, E. W., Gesty-Palmer, D., Pierce, K. L., Laporte, S., Oakley, R. H., Caron, M. G., Lefkowitz, R. J., and Luttrell, L. M. (2003) The stability of the G protein-coupled receptor-β-arrestin interaction determines the mechanism and functional consequence of ERK activation. J. Biol. Chem. 278, 6258-6267
28. Goodman, O. B., Jr., Krupnick, J. G., Santini, F., Gurevich, V. V., Penn, R. B., Gagnon, A. W., Keen, J. H., and Benovic, J. L. (1996) β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor. Nature 383, 447-450
29. Gurevich, V. V., Dion, S. B., Onorato, J. J., Ptasienski, J., Kim, C. M., Sterne-Marr, R., Hosey, M. M., and Benovic, J. L. (1995) Arrestin interactions with G protein-coupled receptors. Direct binding studies of wild type and mutant arrestins with rhodopsin, β2-adrenergic, and m2 muscarinic cholinergic receptors. J. Biol. Chem. 270, 720-731
30. Shukla, A. K., Violin, J. D., Whalen, E. J., Gesty-Palmer, D., Shenoy, S. K., and Lefkowitz, R. J. (2008) Distinct conformational changes in β-arrestin report biased agonism at seven-transmembrane receptors. Proc. Natl. Acad. Sci. U. S. A. 105, 9988-9993
31. 2-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin. Sci. Signal. 4, ra57