A common LRP4 haplotype is associated with bone mineral density and hip geometry in men-Data from the Odense Androgen Study (OAS)

Bone

Volumn 53, Issue 2, 2013, Pages 414-420

  Boudin, Eveline ^a   Steenackers, Ellen ^a   Freitas, Fenna de ^a   Nielsen, Torben Leo ^b   Andersen, Marianne ^b   Brixen, Kim ^b   Hul, Wim Van ^a   Piters, Elke ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Bone mineral density; Hip geometry; LRP4; Osteoporosis; Wnt signaling

Indexed keywords

CELL PROTEIN; LIPOPROTEIN RELATED PROTEIN 4; UNCLASSIFIED DRUG;

ADULT; AGED; ANTHROPOMETRIC PARAMETERS; ARTICLE; BONE DENSITY; BONE STRENGTH; BONE STRUCTURE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA SEQUENCE; FEMUR; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPING TECHNIQUE; GROUPS BY AGE; HAPLOTYPE; HIP GEOMETRY; HUMAN; LIPOPROTEIN RELATED PROTEIN 4 GENE; LUMBAR SPINE; MALE; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN LOCALIZATION; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; BONE DENSITY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HIP; HUMANS; LDL-RECEPTOR RELATED PROTEINS; MALE; MIDDLE AGED; WNT SIGNALING PATHWAY;

EID: 84873276428     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2013.01.014     Document Type: Article

References (37)

1. Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med 1993, 94:646-650.
2. Johnell O., Kanis J.A. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 2006, 17:1726-1733.
3. Leboime A., Confavreux C.B., Mehsen N., Paccou J., David C., Roux C. Osteoporosis and mortality. Joint Bone Spine 2010, 77(Suppl. 2):S107-S112.
4. Chen Y., Shen H., Yang F., Liu P.Y., Tang N., Recker R.R., et al. Choice of study phenotype in osteoporosis genetic research. J Bone Miner Metab 2009, 27:121-126.
5. Ferrari S. Human genetics of osteoporosis. Best Pract Res Clin Endocrinol Metab 2008, 22:723-735.
6. Kiel D.P., Demissie S., Dupuis J., Lunetta K.L., Murabito J.M., Karasik D. Genome-wide association with bone mass and geometry in the Framingham Heart Study. BMC Med Genet 2007, 8(Suppl. 1):S14.
7. Richards J.B., Rivadeneira F., Inouye M., Pastinen T.M., Soranzo N., Wilson S.G., et al. Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet 2008, 371:1505-1512.
8. Richards J.B., Kavvoura F.K., Rivadeneira F., Styrkarsdottir U., Estrada K., Halldorsson B.V., et al. Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture. Ann Intern Med 2009, 151:528-537.
9. Styrkarsdottir U., Halldorsson B.V., Gretarsdottir S., Gudbjartsson D.F., Walters G.B., Ingvarsson T., et al. Multiple genetic loci for bone mineral density and fractures. N Engl J Med 2008, 358:2355-2365.
10. Styrkarsdottir U., Halldorsson B.V., Gretarsdottir S., Gudbjartsson D.F., Walters G.B., Ingvarsson T., et al. New sequence variants associated with bone mineral density. Nat Genet 2009, 41:15-17.
11. Rivadeneira F., Styrkarsdottir U., Estrada K., Halldorsson B.V., Hsu Y.H., Richards J.B., et al. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet 2009, 41:1199-1206.
12. Koller D.L., Ichikawa S., Lai D., Padgett L.R., Doheny K.F., Pugh E., et al. Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women. J Clin Endocrinol Metab 2010, 95:1802-1809.
13. Kung A.W., Xiao S.M., Cherny S., Li G.H., Gao Y., Tso G., et al. Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies. Am J Hum Genet 2010, 86:229-239.
14. Yang T.L., Guo Y., Liu Y.J., Shen H., Liu Y.Z., Lei S.F., et al. Genetic variants in the SOX6 gene are associated with bone mineral density in both Caucasian and Chinese populations. Osteoporos Int 2012, 23:781-787.
15. Duncan E.L., Danoy P., Kemp J.P., Leo P.J., McCloskey E., Nicholson G.C., et al. Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk. PLoS Genet 2011, 7:e1001372.
16. Guo Y., Tan L.J., Lei S.F., Yang T.L., Chen X.D., Zhang F., et al. Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis. PLoS Genet 2010, 6:e1000806.
17. Guo Y., Zhang L.S., Yang T.L., Tian Q., Xiong D.H., Pei Y.F., et al. IL21R and PTH may underlie variation of femoral neck bone mineral density as revealed by a genome-wide association study. J Bone Miner Res 2010, 25:1042-1048.
18. Timpson N.J., Tobias J.H., Richards J.B., Soranzo N., Duncan E.L., Sims A.M., et al. Common variants in the region around Osterix are associated with bone mineral density and growth in childhood. Hum Mol Genet 2009, 18:1510-1517.
19. Xiong D.H., Liu X.G., Guo Y.F., Tan L.J., Wang L., Sha B.Y., et al. Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups. Am J Hum Genet 2009, 84:388-398.
20. Liu J.M., Zhang M.J., Zhao L., Cui B., Li Z.B., Zhao H.Y., et al. Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women. J Clin Endocrinol Metab 2010, 95:E112-E120.
21. Kumar J., Swanberg M., McGuigan F., Callreus M., Gerdhem P., Akesson K. LRP4 association to bone properties and fracture and interaction with genes in the Wnt- and BMP signaling pathways. Bone 2011, 49:343-348.
22. Johnson E.B., Hammer R.E., Herz J. Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice. Hum Mol Genet 2005, 14:3523-3538.
23. Li Y., Pawlik B., Elcioglu N., Aglan M., Kayserili H., Yigit G., et al. LRP4 mutations alter Wnt/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndrome. Am J Hum Genet 2010, 86:696-706.
24. Balemans W., Ebeling M., Patel N., Van Hul E., Olson P., Dioszegi M., et al. Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST). Hum Mol Genet 2001, 10:537-543.
25. Brunkow M.E., Gardner J.C., Van Ness J., Paeper B.W., Kovacevich B.R., Proll S., et al. Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Am J Hum Genet 2001, 68:577-589.
26. Leupin O., Piters E., Halleux C., Hu S., Kramer I., Morvan F., et al. Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function. J Biol Chem 2011, 286:19489-19500.
27. Crabtree N., Lunt M., Holt G., Kroger H., Burger H., Grazio S., et al. Hip geometry, bone mineral distribution, and bone strength in European men and women: the EPOS study. Bone 2000, 27:151-159.
28. Nielsen T.L., Wraae K., Brixen K., Hermann A.P., Andersen M., Hagen C. Prevalence of overweight, obesity and physical inactivity in 20- to 29-year-old, Danish men. Relation to sociodemography, physical dysfunction and low socioeconomic status: the Odense Androgen Study. Int J Obes (Lond) 2006, 30:805-815.
29. Nielsen T.L., Wraae K., Brixen K.T., Andersen M., Hagen C. The Odense Androgen Study. Ugeskr Laeger 2004, 166:1449-1451.
30. Piters E., Balemans W., Nielsen T.L., Andersen M., Boudin E., Brixen K., et al. Common genetic variation in the DKK1 gene is associated with hip axis length but not with bone mineral density and bone turnover markers in young adult men: results from the Odense Androgen Study. Calcif Tissue Int 2010, 86:271-281.
31. Gauderman M.J., WJ QUANTO 1.1: a computer program for power and sample size calculations for genetic-epidemiology studies http://hydra.usc.edu/gxe.
32. Lettre G., Lange C., Hirschhorn J.N. Genetic model testing and statistical power in population-based association studies of quantitative traits. Genet Epidemiol 2007, 31:358-362.
33. Purcell S., Neale B., Todd-Brown K., Thomas L., Ferreira M.A., Bender D., et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007, 81:559-575.
34. Piters E., de Freitas F., Nielsen T.L., Andersen M., Brixen K., Van Hul W. Association study of polymorphisms in the SOST gene region and parameters of bone strength and body composition in both young and elderly men: data from the Odense Androgen Study. Calcif Tissue Int 2012, 90:30-39.
35. Kumar J., Swanberg M., McGuigan F., Callreus M., Gerdhem P., Akesson K. LRP4 association to bone properties and fracture and interaction with genes in the Wnt- and BMP signaling pathways. Bone 2012, 49:343-348.
36. Brixen K., Beckers S., Peeters A., Piters E., Balemans W., Nielsen T.L., et al. Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with peak bone mass in non-sedentary men: results from the Odense androgen study. Calcif Tissue Int 2007, 81:421-429.
37. Balemans W., Piters E., Cleiren E., Ai M., Van Wesenbeeck L., Warman M.L., et al. The binding between sclerostin and LRP5 is altered by DKK1 and by high-bone mass LRP5 mutations. Calcif Tissue Int 2008, 82:445-453.