Ephexin4-mediated promotion of cell migration and anoikis resistance is regulated by serine 897 phosphorylation of EphA2

FEBS Open Bio

Volumn 3, Issue , 2013, Pages 78-82

  Kawai, Hiromu ^a   Kobayashi, Masakazu ^a   Hiramoto Yamaki, Nao ^a,b   Harada, Kohei ^a   Negishi, Manabu ^a   Katoh, Hironori ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Anoikis resistance; Cell migration; EphA2; Ephexin; RhoG; RhoGEF

Indexed keywords

EPHEXIN 4; EPHRIN A2; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SERINE; UNCLASSIFIED DRUG;

ANOIKIS; ARTICLE; CELL MIGRATION; CELL STRAIN HEK293; CELL STRAIN MCF 7; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TUMOR GROWTH;

EID: 84873259297     PISSN: 22115463     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fob.2013.01.002     Document Type: Article

References (22)

1. Pasquale E.B. Eph-Ephrin bidirectional signaling in physiology and disease. Cell 2008, 133:38-52.
2. Pasquale E.B. Eph receptors and ephrins in cancer: bidirectional signalling and beyond. Nat. Rev. Cancer 2010, 10:165-180.
3. Merlos-Suarez A., Batlle E. Eph-ephrin signalling in adult tissues and cancer. Curr. Opin. Cell Biol. 2008, 20:194-200.
4. Miao H., Li D.Q., Mukherjee A., Guo H., Petty H., Cutter J., Basilion J.P., Sedor J., Wu J., Danielpour D., Sloan A.E., Cohen M.l., Wang B. EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt. Cancer Cell 2009, 16:9-20.
5. Katoh H., Yasui H., Yamaguchi Y., Aoki J., Fujita H., Mori K., Negishi M. Small GTPase RhoG is a key regulator for neurite outgrowth in PC12 cells. Mol. Cell. Biol. 2000, 20:7378-7387.
6. deBakker C.D., Haney L.B., Kinchen J.M., Grimsley C., Lu M., Klingele D., Hsu P.K., Chou B.K., Cheng L.C., Blangy A., Sondek J., Hengartner M.O., Wu Y.C., Ravichandran K.S. Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO. Curr. Biol. 2004, 14:2208-2216.
7. Katoh H., Hiramoto K., Negishi M. Activation of Rac1 by RhoG regulates cell migration. J. Cell Sci. 2006, 119:56-65.
8. Katoh H., Negishi M. RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo. Nature 2003, 424:461-464.
9. Hiramoto K., Negishi M., Katoh H. Dock4 is regulated by RhoG and promotes Rac-dependent cell migration. Exp. Cell Res. 2006, 312:4205-4216.
10. Murga C., Zohar M., Teramoto H., Gutkind J.S. Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kB. Oncogene 2002, 21:207-216.
11. Yamaki N., Negishi M., Katoh H. RhoG regulates anoikis through a phosphatidylinositol 3-kinase-dependent mechanism. Exp. Cell Res. 2007, 313:2821-2832.
12. Fujimoto S., Negishi M., Katoh H. RhoG promotes neural progenitor cell proliferation in mouse cerebral cortex. Mol. Biol. Cell 2009, 20:4941-4950.
13. Simpson C.D., Anyiwe K., Schimmer A.D. Anoikis resistance and tumor metastasis. Cancer Lett. 2008, 272:177-185.
14. Shamah S.M., Lin M.Z., Goldberg J.L., Estrach S., Sahin M., Hu L., Bazalakova M., Neve R.L., Corfas G., Debant A., Greenberg M.E. EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. Cell 2001, 312:233-244.
15. Sahin M., Greer P.L., Lin M.Z., Poucher H., Eberhart J., Schmidt S., Wright T.M., Shamah S.M., O'Connell S., Cowan C.W., Hu L., Goldberg J.L., Debant A., Corfas G., Krull C.E., Greenberg M.E. Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse. Neuron 2005, 46:191-204.
16. Hiramoto-Yamaki N., Takeuchi S., Ueda S., Harada K., Fujimoto S., Negishi M., Katoh H. Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. J. Cell Biol. 2010, 190:461-477.
17. Harada K., Hiramoto-Yamaki N., Negishi M., Katoh H. Ephexin4 and EphA2 mediate resistance to anoikis through RhoG and phosphatidylinositol 3-kinase. Exp. Cell Res. 2011, 317:1701-1713.
18. Takeuchi S., Yamaki N., Negishi M., Katoh H. β2-Chimaerin binds to EphA receptors and regulates cell migration. FEBS Lett. 2007, 583:1237-1242.
19. Ito Y., Oinuma I., Katoh H., Kaibuchi K., Negishi M. Sema4D/plexin-B1 activates GSK-3β through R-Ras GAP activity, inducing growth cone collapse. EMBO Rep. 2006, 7:704-709.
20. Kullander K., Klein R. Mechanisms and functions of Eph and ephrin signalling. Nat. Rev. Mol. Cell Biol. 2002, 3:475-486.
21. Pasquale E.B. Eph receptor signalling casts a wide net on cell behavior. Nat. Rev. Mol. Cell Biol. 2005, 6:462-475.
22. Kitzing T.M., Sahadevan A.S., Brandt D.T., Knieling H., Hannemann S., Fackler O.T., Großhans J., Grosse R. Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion. Genes Dev. 2007, 21:1478-1483.