Alzheimer's disease and retinal neurodegeneration share a consistent stress response of the neurovascular unit

Cellular Physiology and Biochemistry

Volumn 30, Issue 6, 2012, Pages 1436-1443

  Busch, Stephanie ^a   Wu, Liang ^a   Feng, Yuxi ^a   Gretz, Norbert ^a   Hoffmann, Sigrid ^a   Hammes, Hans Peter ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Alzheimer's disease; Neurodegeneration; Neurovascular unit; Polycystic kidney disease; Retinopathy

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; HIGH MOBILITY GROUP B1 PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL ACTIVATION; IMMUNOHISTOCHEMISTRY; MICROGLIA; NEOVASCULARIZATION (PATHOLOGY); NERVE CELL LESION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RETINA NEOVASCULARIZATION;

RATTUS;

EID: 84873193567     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000343331     Document Type: Article

References (26)

1. Hardy J, Selkoe DJ: The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002;297:353-356. (Pubitemid 34790756)
2. Koistinaho M, Kettunen MI, Goldsteins G, Keinanen R, Salminen A: Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation. Proc Natl Acad Sci USA 2002;99:1610-1615. (Pubitemid 34136540)
3. Zlokovic BV: The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008;57:178-201.
4. Heneka MT, O'Banion MK: Inflammatory processes in Alzheimer's disease. J Neuroimmunol 2007;184:69-91. (Pubitemid 46365992)
5. Demos C, Bandyopadhyay M, Rohrer B: Identification of candidate genes for human retinal degeneration loci using differentially expressed genes from mouse photoreceptor dystrophy models. Mol Vis 2008;14:1639-1649.
6. Farkas E, Luiten PG: Cerebral microvascular pathology in aging and Alzheimer's disease. Prog Neurobiol 2001;64:575-611. (Pubitemid 32304447)
7. Gallagher AR, Hoffmann S, Brown N, Cedzich A, Meruvu S: A truncated polycystin-2 protein causes polycystic kidney disease and retinal degeneration in transgenic rats. J Am Soc Nephrol 2006;17:2719-2730. (Pubitemid 44484662)
8. Feng Y, Wang Y, Stock O, Pfister F, Tanimoto N: Vasoregression linked to neuronal damage in the rat with defect of polycystin-2. PLoS One 2009;4:e7328.
9. Feng Y, Wang Y, Li L, Wu L, Hoffmann S: Gene expression profiling of vasoregression in the retina-involvement of microglial cells. PLoS One 2011;6:e16865.
10. Takeda A, Wakai M, Niwa H, Dei R, Yamamoto M: Neuronal and glial advanced glycation end product [Nepsilon-(carboxymethyl) lysine]] in Alzheimer's disease brains. Acta Neuropathol 2001;101:27-35. (Pubitemid 32124497)
11. Takata K, Takada T, Ito A, Asai M, Tawa M: Microglial Amyloid-beta1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer's Disease. Int J Alzheimers Dis 2012:685739.
12. Kawabata H, Setoguchi T, Yone K, Souda M, Yoshida H: High mobility group box 1 is upregulated after spinal cord injury and is associated with neuronal cell apoptosis. Spine (Phila Pa 1976) 2010;35:1109-1115.
13. De Rivero Vaccari JP, Minkiewicz J, Wang X, De Rivero Vaccari JC, German R: Astrogliosis involves activation of retinoic acid-inducible gene-like signaling in the innate immune response after spinal cord injury. Glia 2012;60:414-421.
14. Lewis GP, Erickson PA, Guerin CJ, Anderson DH, Fisher SK: Basic fibroblast growth factor: a potential regulator of proliferation and intermediate filament expression in the retina. J Neurosci 1992;12:3968-3978.
15. Hartig W, Grosche J, Distler C, Grimm D, El-Hifnawi E: Alterations of Muller (glial) cells in dystrophic retinae of RCS rats. J Neurocytol 1995;24:507-517.
16. McGillem GS, Dacheux RF: Rabbit retinal Muller cells undergo antigenic changes in response to experimentally induced proliferative vitreoretinopathy. Exp Eye Res 1999;68:617-627. (Pubitemid 29244149)
17. Dvoriantchikova G, Hernandez E, Grant J, Santos AR, Yang H: The high-mobility group box-1 nuclear factor mediates retinal injury after ischemia reperfusion. Invest Ophthalmol Vis Sci 2011;52:7187-7194.
18. Takata K, Kitamura Y, Kakimura J, Shibagaki K, Tsuchiya D: Role of high mobility group protein-1 (HMG1) in amyloid-beta homeostasis. Biochem Biophys Res Commun 2003;301:699-703. (Pubitemid 36268947)
19. Yan SD, Chen X, Fu J, Chen M, Zhu H: RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease. Nature 1996;382:685-691. (Pubitemid 26282167)
20. Gao HM, Zhou H, Zhang F, Wilson BC, Kam W: HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration. J Neurosci 2011;31:1081-1092.
21. Southern L, Williams J, Esiri MM: Immunohistochemical study of N-epsilon-carboxymethyl lysine (CML) in human brain: relation to vascular dementia. BMC Neurol 2007;7:35.
22. Stitt A, Gardiner TA, Alderson NL, Canning P, Frizzell N: The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes. Diabetes 2002;51:2826-2832. (Pubitemid 34970937)
23. Hammes HP, Alt A, Niwa T, Clausen JT, Bretzel RG: Differential accumulation of advanced glycation end products in the course of diabetic retinopathy. Diabetologia 1999;42:728-736. (Pubitemid 29265591)
24. Hammes HP, Hoerauf H, Alt A, Schleicher E, Clausen JT: N (epsilon) (carboxymethyl) lysin and the AGE receptor RAGE colocalize in age-related macular degeneration. Invest Ophthalmol Vis Sci 1999;40:1855-1859. (Pubitemid 29297167)
25. Nunan J, Small DH: Regulation of APP cleavage by alpha-, beta-and gamma-secretases. FEBS Lett 2000;483:6-10.
26. Chasseigneaux S, Allinquant B: Functions of Abeta, sAPPalpha and sAPPbeta: similarities and differences. J Neurochem 2012;120:S99-108.