A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis

Circulation

Volumn 127, Issue 4, 2013, Pages 486-499

  Le, Nhat Tu ^a   Heo, Kyung Sun ^a   Takei, Yuichiro ^a   Lee, Hakjoo ^a   Woo, Chang Hoon ^a,e   Chang, Eugene ^a   McClain, Carolyn ^a   Hurley, Cheryl ^a   Wang, Xin ^b   Li, Faqian ^c   Xu, Haodong ^a,c   Morrell, Craig ^a   Sullivan, Mark A ^c   Cohen, Michael S ^d   Serafimova, Iana M ^d   Taunton, Jack ^d   Fujiwara, Keigi ^a   Abe, Jun Ichi ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e Yeungnam University College of Medicine   (South Korea)

Author keywords

Diabetes mellitus; Endothelial dysfunction; ERK5; P90RSK; Signal transduction

Indexed keywords

ADENOVIRUS VECTOR; APOLIPOPROTEIN E; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FLUOROMETHYL KETONE METHOXYETHYLAMINE; GLUCOSE; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE 7; MULTIENZYME COMPLEX; P90 RIBOSOMAL S6 KINASE; PROTEIN SERINE THREONINE KINASE INHIBITOR; S6 KINASE; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; LEUKOCYTE; LEUKOCYTE ROLLING; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; ATHEROSCLEROSIS; DIABETIC ANGIOPATHIES; DRUG SYNERGISM; GLUCOSE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROGEN PEROXIDE; LEUKOCYTE ROLLING; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MITOGEN-ACTIVATED PROTEIN KINASE 7; NITRIC OXIDE SYNTHASE TYPE III; OXIDANTS; PHOSPHORYLATION; RATS; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA;

EID: 84873188560     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.112.116988     Document Type: Article

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