Coupling of functional connectivity and regional cerebral blood flow reveals a physiological basis for network hubs of the human brain

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 5, 2013, Pages 1929-1934

  Liang, Xia ^a,b   Zou, Qihong ^c   He, Yong ^b   Yang, Yihong ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b BEIJING NORMAL UNIVERSITY   (China)

^c PEKING UNIVERSITY   (China)

Author keywords

Connectomics; FMRI; Graph theory; Metabolism; Modularity

Indexed keywords

ADULT; ARTICLE; BLOOD OXYGENATION; BRAIN; BRAIN BLOOD FLOW; BRAIN FUNCTION; BRAIN METABOLISM; FEMALE; FRONTAL CORTEX; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUNCTIONAL NEUROIMAGING; HUMAN; IMAGE ANALYSIS; INSULA; MALE; MENTAL TASK; NEUROPHYSIOLOGY; NORMAL HUMAN; PARIETAL CORTEX; PRIORITY JOURNAL; REST; SPIN LABELING; WORKING MEMORY;

ADULT; BRAIN; BRAIN MAPPING; CEREBROVASCULAR CIRCULATION; EXECUTIVE FUNCTION; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MEMORY, SHORT-TERM; NERVE NET; PHOTIC STIMULATION; REGIONAL BLOOD FLOW; SPACE PERCEPTION; TASK PERFORMANCE AND ANALYSIS; VISUAL PERCEPTION; YOUNG ADULT;

EID: 84873171641     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1214900110     Document Type: Article

References (36)

1. Bullmore E, Sporns O (2009) Complex brain networks: Graph theoretical analysis of structural and functional systems. Nat Rev Neurosci 10(3):186-198.
2. He Y, Evans A (2010) Graph theoretical modeling of brain connectivity. Curr Opin Neurol 23(4):341-350.
3. Achard S, Salvador R, Whitcher B, Suckling J, Bullmore E (2006) A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs. J Neurosci 26(1):63-72. (Pubitemid 43090914)
4. He Y, et al. (2009) Uncovering intrinsic modular organization of spontaneous brain activity in humans. PLoS ONE 4(4):e5226.
5. Gong G, et al. (2009) Mapping anatomical connectivity patterns of human cerebral cortex using in vivo diffusion tensor imaging tractography. Cereb Cortex 19(3):524-536.
6. Hagmann PC, et al. (2008) Mapping the structural core of human cerebral cortex. PLoS Biol 6(7):e159.
7. Buckner RL, et al. (2009) Cortical hubs revealed by intrinsic functional connectivity: Mapping, assessment of stability, and relation to Alzheimer's disease. J Neurosci 29(6):1860-1873.
8. Tomasi D, Volkow ND (2010) Functional connectivity density mapping. Proc Natl Acad Sci USA 107(21):9885-9890.
9. Raichle ME, et al. (2001) A default mode of brain function. Proc Natl Acad Sci USA 98(2):676-682. (Pubitemid 32105102)
10. Vaishnavi SN, et al. (2010) Regional aerobic glycolysis in the human brain. Proc Natl Acad Sci USA 107(41):17757-17762.
11. Paulson OB, Hasselbalch SG, Rostrup E, Knudsen GM, Pelligrino D (2010) Cerebral blood flow response to functional activation. J Cereb Blood Flow Metab 30(1):2-14.
12. Newberg AB, et al. (2005) Concurrent CBF and CMRGlc changes during human brain activation by combined fMRI-PET scanning. Neuroimage 28(2):500-506. (Pubitemid 41443519)
13. Fox PT, Raichle ME (1986) Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc Natl Acad Sci USA 83(4):1140-1144. (Pubitemid 16086428)
14. Fox PT, Raichle ME, Mintun MA, Dence C (1988) Nonoxidative glucose consumption during focal physiologic neural activity. Science 241(4864):462-464.
15. Hoge RD, et al. (1999) Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex. Proc Natl Acad Sci USA 96(16):9403-9408. (Pubitemid 29374767)
16. Bullmore E, Sporns O (2012) The economy of brain network organization. Nat Rev Neurosci 13(5):336-349.
17. Várkuti B, et al. (2011) Quantifying the link between anatomical connectivity, gray matter volume and regional cerebral blood flow: An integrative MRI study. PLoS ONE 6(4):e14801.
18. Sepulcre J, et al. (2010) The organization of local and distant functional connectivity in the human brain. PLOS Comput Biol 6(6):e1000808.
19. Kim J, et al. (2006) Continuous ASL perfusion fMRI investigation of higher cognition: Quantification of tonic CBF changes during sustained attention and working memory tasks. Neuroimage 31(1):376-385. (Pubitemid 43728970)
20. Petrides M, Alivisatos B, Meyer E, Evans AC (1993) Functional activation of the human frontal cortex during the performance of verbal working memory tasks. Proc Natl Acad Sci USA 90(3):878-882. (Pubitemid 23053913)
21. Lerch JP, et al. (2006) Mapping anatomical correlations across cerebral cortex (MACACC) using cortical thickness from MRI. Neuroimage 31(3):993-1003. (Pubitemid 43851317)
22. He Y, et al. (2009) Impaired small-world efficiency in structural cortical networks in multiple sclerosis associated with white matter lesion load. Brain 132(Pt 12):3366-3379.
23. Haatveit BC, et al. (2010) The validity of d prime as a working memory index: Results from the "Bergen n-back task" J Clin Exp Neuropsychol 32(8):871-880.
24. Zuo XN, et al. (2012) Network centrality in the human functional connectome. Cereb Cortex 22(8):1862-1875.
25. Zou Q, Wu CW, Stein EA, Zang Y, Yang Y (2009) Static and dynamic characteristics of cerebral blood flow during the resting state. Neuroimage 48(3):515-524.
26. Drzezga A, et al. (2011) Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden. Brain 134(Pt 6):1635-1646.
27. Walker LC, Jucker M (2011) Amyloid by default. Nat Neurosci 14(6):669-670.
28. Wang J, et al. (2012) Disrupted functional brain connectome in individuals at risk for Alzheimer's disease. Biol Psychiatry, 10.1016/j.biopsych.2012.03.026.
29. Honey CJS, et al. (2009) Predicting human resting-state functional connectivity from structural connectivity. Proc Natl Acad Sci USA 106(6):2035-2040.
30. Honey CJK, Kötter R, Breakspear M, Sporns O (2007) Network structure of cerebral cortex shapes functional connectivity on multiple time scales. Proc Natl Acad Sci USA 104(24):10240-10245. (Pubitemid 47175293)
31. Rubinov M, Sporns O, van Leeuwen C, Breakspear M (2009) Symbiotic relationship between brain structure and dynamics. BMC Neurosci 10(1):55.
32. Mesulam M-M (1998) From sensation to cognition. Brain 121(Pt 6):1013-1052. (Pubitemid 28257716)
33. Salomon R, et al. (2011) Global functional connectivity deficits in schizophrenia depend on behavioral state. J Neurosci 31(36):12972-12981.
34. Kitzbichler MG, Henson RN, Smith ML, Nathan PJ, Bullmore ET (2011) Cognitive effort drives workspace configuration of human brain functional networks. J Neurosci 31(22):8259-8270.
35. DeYoung CG, Shamosh NA, Green AE, Braver TS, Gray JR (2009) Intellect as distinct from openness: Differences revealed by fMRI of working memory. J Pers Soc Psychol 97(5):883-892.
36. Xiong J, Gao J-H, Lancaster JL, Fox PT (1995) Clustered pixels analysis for functional MRI activation studies of the human brain. Hum Brain Mapp 3(4):287-301.