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Volumn 7, Issue , 2013, Pages

A model of HIV drug resistance driven by heterogeneities in host immunity and adherence patterns

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 84873169284     PISSN: None     EISSN: 17520509     Source Type: Journal    
DOI: 10.1186/1752-0509-7-11     Document Type: Article
Times cited : (16)

References (72)
  • 1
    • 34547798122 scopus 로고    scopus 로고
    • Stopping antiretroviral therapy
    • 10.1097/QAD.0b013e3281c61394, 17690564
    • Taylor S, Boffito M, Khoo S, Smit E, Back D. Stopping antiretroviral therapy. AIDS 2007, 21:1673-1682. 10.1097/QAD.0b013e3281c61394, 17690564.
    • (2007) AIDS , vol.21 , pp. 1673-1682
    • Taylor, S.1    Boffito, M.2    Khoo, S.3    Smit, E.4    Back, D.5
  • 2
    • 81855160859 scopus 로고    scopus 로고
    • Pre-Exposure Prophylaxis and Antiretroviral Resistance: HIV Prevention at a Cost?
    • 10.1093/cid/cir684, 3246871, 21976467
    • Hurt CB, Eron JJ, Cohen MS. Pre-Exposure Prophylaxis and Antiretroviral Resistance: HIV Prevention at a Cost?. Clin Infect Dis 2011, 53:1265-1270. 10.1093/cid/cir684, 3246871, 21976467.
    • (2011) Clin Infect Dis , vol.53 , pp. 1265-1270
    • Hurt, C.B.1    Eron, J.J.2    Cohen, M.S.3
  • 7
    • 79951770159 scopus 로고    scopus 로고
    • What do mathematical models tell us about the emergence and spread of drug-resistant HIV?
    • 10.1097/COH.0b013e328343ad03, 3096989, 21505388
    • Baggaley RF, Powers KA, Boily MC. What do mathematical models tell us about the emergence and spread of drug-resistant HIV?. Curr Opin HIV AIDS 2011, 6:131. 10.1097/COH.0b013e328343ad03, 3096989, 21505388.
    • (2011) Curr Opin HIV AIDS , vol.6 , pp. 131
    • Baggaley, R.F.1    Powers, K.A.2    Boily, M.C.3
  • 8
    • 41149091104 scopus 로고    scopus 로고
    • Potential Impact of Antiretroviral Chemoprophylaxis on HIV-1 Transmission in Resource-Limited Settings
    • 10.1371/journal.pone.0000875, 1975470, 17878928
    • Abbas UL, Anderson RM, Mellors JW. Potential Impact of Antiretroviral Chemoprophylaxis on HIV-1 Transmission in Resource-Limited Settings. PLoS One 2007, 2:e875. 10.1371/journal.pone.0000875, 1975470, 17878928.
    • (2007) PLoS One , vol.2
    • Abbas, U.L.1    Anderson, R.M.2    Mellors, J.W.3
  • 9
    • 79954559071 scopus 로고    scopus 로고
    • Factors Influencing the Emergence and Spread of HIV Drug Resistance Arising from Rollout of Antiretroviral Pre-Exposure Prophylaxis (PrEP)
    • 10.1371/journal.pone.0018165, 3078109, 21525976
    • Abbas UL, Hood G, Wetzel AW, Mellors JW. Factors Influencing the Emergence and Spread of HIV Drug Resistance Arising from Rollout of Antiretroviral Pre-Exposure Prophylaxis (PrEP). PLoS One 2011, 6:e18165. 10.1371/journal.pone.0018165, 3078109, 21525976.
    • (2011) PLoS One , vol.6
    • Abbas, U.L.1    Hood, G.2    Wetzel, A.W.3    Mellors, J.W.4
  • 10
    • 84859743112 scopus 로고    scopus 로고
    • Modeling dynamic interactions between pre-exposure prophylaxis interventions & treatment programs: predicting HIV transmission & resistance
    • 3216499, 22355530
    • Supervie V, Barrett M, Kahn JS, Musuka G, Moeti TL, Busang L, Blower S. Modeling dynamic interactions between pre-exposure prophylaxis interventions & treatment programs: predicting HIV transmission & resistance. Sci Rep 2011, 1:11. 3216499, 22355530.
    • (2011) Sci Rep , vol.1 , pp. 11
    • Supervie, V.1    Barrett, M.2    Kahn, J.S.3    Musuka, G.4    Moeti, T.L.5    Busang, L.6    Blower, S.7
  • 11
    • 77955454024 scopus 로고    scopus 로고
    • HIV, transmitted drug resistance, and the paradox of preexposure prophylaxis
    • 10.1073/pnas.1006061107, 2901470, 20616092
    • Supervie V, García-Lerma JG, Heneine W, Blower S. HIV, transmitted drug resistance, and the paradox of preexposure prophylaxis. Proc Natl Acad Sci 2010, 107:12381-12386. 10.1073/pnas.1006061107, 2901470, 20616092.
    • (2010) Proc Natl Acad Sci , vol.107 , pp. 12381-12386
    • Supervie, V.1    García-Lerma, J.G.2    Heneine, W.3    Blower, S.4
  • 12
    • 77956200568 scopus 로고    scopus 로고
    • Hidden Drug Resistant HIV to Emerge in the Era of Universal Treatment Access in Southeast Asia
    • 10.1371/journal.pone.0010981, 2882328, 20544022
    • Hoare A, Kerr SJ, Ruxrungtham K, Ananworanich J, Law MG, Cooper DA, Phanuphak P, Wilson DP. Hidden Drug Resistant HIV to Emerge in the Era of Universal Treatment Access in Southeast Asia. PLoS One 2010, 5:e10981. 10.1371/journal.pone.0010981, 2882328, 20544022.
    • (2010) PLoS One , vol.5
    • Hoare, A.1    Kerr, S.J.2    Ruxrungtham, K.3    Ananworanich, J.4    Law, M.G.5    Cooper, D.A.6    Phanuphak, P.7    Wilson, D.P.8
  • 13
    • 76449087202 scopus 로고    scopus 로고
    • The effect of intrinsic stochasticity on transmitted HIV drug resistance patterns
    • 10.1016/j.jtbi.2009.09.017, 19766126
    • Marks AJ, Pillay D, McLean AR. The effect of intrinsic stochasticity on transmitted HIV drug resistance patterns. J Theor Biol 2010, 262:1-13. 10.1016/j.jtbi.2009.09.017, 19766126.
    • (2010) J Theor Biol , vol.262 , pp. 1-13
    • Marks, A.J.1    Pillay, D.2    McLean, A.R.3
  • 14
    • 0029985351 scopus 로고    scopus 로고
    • Population Dynamics of Immune Responses to Persistent Viruses
    • 10.1126/science.272.5258.74, 8600540
    • Nowak MA, Bangham CRM. Population Dynamics of Immune Responses to Persistent Viruses. Science 1996, 272:74-79. 10.1126/science.272.5258.74, 8600540.
    • (1996) Science , vol.272 , pp. 74-79
    • Nowak, M.A.1    Bangham, C.R.M.2
  • 15
    • 33750596128 scopus 로고    scopus 로고
    • Physical Theory of the Competition that Allows HIV to Escape from the Immune System
    • Wang G, Deem MW. Physical Theory of the Competition that Allows HIV to Escape from the Immune System. Phys Rev Lett 2006, 97:188106.
    • (2006) Phys Rev Lett , vol.97 , pp. 188106
    • Wang, G.1    Deem, M.W.2
  • 16
    • 79952458645 scopus 로고    scopus 로고
    • Paradoxical suppression of poly-specific broadly neutralizing antibodies in the presence of strain-specific neutralizing antibodies following HIV infection
    • 10.1016/j.jtbi.2011.01.050, 21315731
    • Ciupe SM, De Leenheer P, Kepler TB. Paradoxical suppression of poly-specific broadly neutralizing antibodies in the presence of strain-specific neutralizing antibodies following HIV infection. J Theor Biol 2011, 277:55-66. 10.1016/j.jtbi.2011.01.050, 21315731.
    • (2011) J Theor Biol , vol.277 , pp. 55-66
    • Ciupe, S.M.1    De Leenheer, P.2    Kepler, T.B.3
  • 17
    • 2442689168 scopus 로고    scopus 로고
    • Paradoxes of adherence and drug resistance to HIV antiretroviral therapy
    • 10.1093/jac/dkh162, 15044425
    • Bangsberg DR, Moss AR, Deeks SG. Paradoxes of adherence and drug resistance to HIV antiretroviral therapy. J Antimicrob Chemother 2004, 53:696-699. 10.1093/jac/dkh162, 15044425.
    • (2004) J Antimicrob Chemother , vol.53 , pp. 696-699
    • Bangsberg, D.R.1    Moss, A.R.2    Deeks, S.G.3
  • 18
    • 84868664375 scopus 로고    scopus 로고
    • Antiretroviral dynamics determines HIV evolution and predicts therapy outcome
    • 10.1038/nm.2892, 3490032, 22941277
    • Rosenbloom DIS, Hill AL, Rabi SA, Siliciano RF, Nowak MA. Antiretroviral dynamics determines HIV evolution and predicts therapy outcome. Nat Med 2012, 18:1378-1385. 10.1038/nm.2892, 3490032, 22941277.
    • (2012) Nat Med , vol.18 , pp. 1378-1385
    • Rosenbloom, D.I.S.1    Hill, A.L.2    Rabi, S.A.3    Siliciano, R.F.4    Nowak, M.A.5
  • 19
    • 21544447528 scopus 로고    scopus 로고
    • Modeling Long-Term HIV Dynamics and Antiretroviral Response: Effects of Drug Potency, Pharmacokinetics, Adherence, and Drug Resistance
    • 10.1097/01.qai.0000165907.04710.da, 15980686
    • Wu H, Huang Y, Acosta EP, Rosenkranz SL, Kuritzkes DR, Eron JJ, Perelson AS, Gerber JG. Modeling Long-Term HIV Dynamics and Antiretroviral Response: Effects of Drug Potency, Pharmacokinetics, Adherence, and Drug Resistance. J Acquir Immune Defic Syndr 2005, 39:272-283. 10.1097/01.qai.0000165907.04710.da, 15980686.
    • (2005) J Acquir Immune Defic Syndr , vol.39 , pp. 272-283
    • Wu, H.1    Huang, Y.2    Acosta, E.P.3    Rosenkranz, S.L.4    Kuritzkes, D.R.5    Eron, J.J.6    Perelson, A.S.7    Gerber, J.G.8
  • 20
    • 84870262204 scopus 로고    scopus 로고
    • A dynamic Bayesian nonlinear mixed-effects model of HIV response incorporating medication adherence, drug resistance and covariates
    • 10.1214/10-AOAS376, 3498098, 23162677
    • Huang Y, Wu H, Holden-Wiltse J, Acosta EP. A dynamic Bayesian nonlinear mixed-effects model of HIV response incorporating medication adherence, drug resistance and covariates. Ann Appl Stat 2011, 5:551-577. 10.1214/10-AOAS376, 3498098, 23162677.
    • (2011) Ann Appl Stat , vol.5 , pp. 551-577
    • Huang, Y.1    Wu, H.2    Holden-Wiltse, J.3    Acosta, E.P.4
  • 21
    • 0034701490 scopus 로고    scopus 로고
    • Adherence and drug resistance: predictions for therapy outcome
    • Wahl LM, Nowak MA. Adherence and drug resistance: predictions for therapy outcome. Proc R Soc Lond B Biol Sci 2000, 267:835-843.
    • (2000) Proc R Soc Lond B Biol Sci , vol.267 , pp. 835-843
    • Wahl, L.M.1    Nowak, M.A.2
  • 22
    • 0024343414 scopus 로고
    • How often is medication taken as prescribed? A novel assessment technique
    • 10.1001/jama.1989.03420220087032, 2716163
    • Cramer JA. How often is medication taken as prescribed? A novel assessment technique. JAMA 1989, 261:3273-3277. 10.1001/jama.1989.03420220087032, 2716163.
    • (1989) JAMA , vol.261 , pp. 3273-3277
    • Cramer, J.A.1
  • 23
    • 30544439172 scopus 로고    scopus 로고
    • Modeling and simulation of adherence: Approaches and applications in therapeutics
    • 10.1208/aapsj070240, 2750977, 16353919
    • Kenna LA, Labbé L, Barrett JS, Pfister M. Modeling and simulation of adherence: Approaches and applications in therapeutics. AAPS J 2005, 7:E390-E407. 10.1208/aapsj070240, 2750977, 16353919.
    • (2005) AAPS J , vol.7
    • Kenna, L.A.1    Labbé, L.2    Barrett, J.S.3    Pfister, M.4
  • 26
    • 80052554881 scopus 로고    scopus 로고
    • Kinetics of the viral cycle influence pharmacodynamics of antiretroviral therapy
    • 10.1186/1745-6150-6-42, 3203257, 21910865
    • Sedaghat AR, Wilke CO. Kinetics of the viral cycle influence pharmacodynamics of antiretroviral therapy. Biol Direct 2011, 6:42. 10.1186/1745-6150-6-42, 3203257, 21910865.
    • (2011) Biol Direct , vol.6 , pp. 42
    • Sedaghat, A.R.1    Wilke, C.O.2
  • 28
    • 0001365997 scopus 로고
    • Estimates of error rates for codes on burst-noise channels
    • Elliott E. Estimates of error rates for codes on burst-noise channels. Bell Syst Tech J 1963, 42:1977-1997.
    • (1963) Bell Syst Tech J , vol.42 , pp. 1977-1997
    • Elliott, E.1
  • 29
    • 84869152342 scopus 로고
    • Capacity of a burst-noise channel
    • Gilbert EN. Capacity of a burst-noise channel. Bell Syst Tech J 1960, 39:1253-1265.
    • (1960) Bell Syst Tech J , vol.39 , pp. 1253-1265
    • Gilbert, E.N.1
  • 30
    • 33645429016 scopus 로고
    • Exact stochastic simulation of coupled chemical reactions
    • Gillespie DT. Exact stochastic simulation of coupled chemical reactions. J Phys Chem 1977, 81:2340-2361.
    • (1977) J Phys Chem , vol.81 , pp. 2340-2361
    • Gillespie, D.T.1
  • 31
    • 34249950625 scopus 로고    scopus 로고
    • Stochastic Simulation of Chemical Kinetics
    • 10.1146/annurev.physchem.58.032806.104637, 17037977
    • Gillespie DT. Stochastic Simulation of Chemical Kinetics. Annu Rev Phys Chem 2007, 58:35-55. 10.1146/annurev.physchem.58.032806.104637, 17037977.
    • (2007) Annu Rev Phys Chem , vol.58 , pp. 35-55
    • Gillespie, D.T.1
  • 33
    • 0036371443 scopus 로고    scopus 로고
    • Modelling viral and immune system dynamics
    • 10.1038/nri700, 11905835
    • Perelson AS. Modelling viral and immune system dynamics. Nat Rev Immunol 2002, 2:28-36. 10.1038/nri700, 11905835.
    • (2002) Nat Rev Immunol , vol.2 , pp. 28-36
    • Perelson, A.S.1
  • 34
    • 0034730045 scopus 로고    scopus 로고
    • Correlates of cytotoxic T-lymphocyte-mediated virus control: implications for immuno-suppressive infections and their treatment
    • Wodarz D, Nowak MA. Correlates of cytotoxic T-lymphocyte-mediated virus control: implications for immuno-suppressive infections and their treatment. Philos Trans R Soc B Biol Sci 2000, 355:1059-1070.
    • (2000) Philos Trans R Soc B Biol Sci , vol.355 , pp. 1059-1070
    • Wodarz, D.1    Nowak, M.A.2
  • 35
    • 0026742797 scopus 로고
    • The influence of lymphocyte counts and disease progression on circulating and inducible anti-HIV-1 cytotoxic T-cell activity in HIV-1-infected subjects
    • 10.1097/00002030-199210000-00004, 1361339
    • Grant MD, Smaill FM, Singal DP, Rosenthal KL. The influence of lymphocyte counts and disease progression on circulating and inducible anti-HIV-1 cytotoxic T-cell activity in HIV-1-infected subjects. AIDS 1992, 6:1085. 10.1097/00002030-199210000-00004, 1361339.
    • (1992) AIDS , vol.6 , pp. 1085
    • Grant, M.D.1    Smaill, F.M.2    Singal, D.P.3    Rosenthal, K.L.4
  • 38
    • 78650084232 scopus 로고    scopus 로고
    • The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation
    • 3235490, 21051598, The International HIV Controllers Study
    • The International HIV Controllers Study The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation. Science 2010, 330:1551-1557. 3235490, 21051598, The International HIV Controllers Study.
    • (2010) Science , vol.330 , pp. 1551-1557
  • 41
    • 73449117263 scopus 로고    scopus 로고
    • Modeling Latently Infected Cell Activation: Viral and Latent Reservoir Persistence, and Viral Blips in HIV-infected Patients on Potent Therapy
    • 10.1371/journal.pcbi.1000533, 2752194, 19834532
    • Rong L, Perelson AS. Modeling Latently Infected Cell Activation: Viral and Latent Reservoir Persistence, and Viral Blips in HIV-infected Patients on Potent Therapy. PLoS Comput Biol 2009, 5:e1000533. 10.1371/journal.pcbi.1000533, 2752194, 19834532.
    • (2009) PLoS Comput Biol , vol.5
    • Rong, L.1    Perelson, A.S.2
  • 42
    • 0344845009 scopus 로고    scopus 로고
    • Complex patterns of viral load decay under antiretroviral therapy: influence of pharmacokinetics and intracellular delay
    • 10.1016/j.jtbi.2003.09.002, 14637059
    • Dixit NM, Perelson AS. Complex patterns of viral load decay under antiretroviral therapy: influence of pharmacokinetics and intracellular delay. J Theor Biol 2004, 226:95-109. 10.1016/j.jtbi.2003.09.002, 14637059.
    • (2004) J Theor Biol , vol.226 , pp. 95-109
    • Dixit, N.M.1    Perelson, A.S.2
  • 43
    • 78651417113 scopus 로고    scopus 로고
    • Pharmacological considerations for tenofovir and emtricitabine to prevent HIV infection
    • 10.1093/jac/dkq447, 3019086, 21118913
    • Anderson PL, Kiser JJ, Gardner EM, Rower JE, Meditz A, Grant RM. Pharmacological considerations for tenofovir and emtricitabine to prevent HIV infection. J Antimicrob Chemother 2011, 66:240-250. 10.1093/jac/dkq447, 3019086, 21118913.
    • (2011) J Antimicrob Chemother , vol.66 , pp. 240-250
    • Anderson, P.L.1    Kiser, J.J.2    Gardner, E.M.3    Rower, J.E.4    Meditz, A.5    Grant, R.M.6
  • 44
    • 22344455482 scopus 로고    scopus 로고
    • Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens
    • 10.1097/01.qai.0000167155.44980.e8, 16010161
    • Hawkins T, Veikley W, St Claire RL, Guyer B, Clark N, Kearney BP. Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens. J Acquir Immune Defic Syndr 2005, 39:406-411. 10.1097/01.qai.0000167155.44980.e8, 16010161.
    • (2005) J Acquir Immune Defic Syndr , vol.39 , pp. 406-411
    • Hawkins, T.1    Veikley, W.2    St Claire, R.L.3    Guyer, B.4    Clark, N.5    Kearney, B.P.6
  • 46
    • 79956291343 scopus 로고    scopus 로고
    • Dose-response curve slope is a missing dimension in the analysis of HIV-1 drug resistance
    • Sampah MES, Shen L, Jilek BL, Siliciano RF. Dose-response curve slope is a missing dimension in the analysis of HIV-1 drug resistance. Proc Natl Acad Sci 2011,
    • (2011) Proc Natl Acad Sci
    • Sampah, M.E.S.1    Shen, L.2    Jilek, B.L.3    Siliciano, R.F.4
  • 47
    • 0016379917 scopus 로고
    • Relationships between inhibition Constants and Fractional Inhibition in Enzyme-Catalyzed Reactions with Different Numbers of Reactants, Different Reaction Mechanisms, and Different Types and Mechanisms of Inhibition
    • Chou T-C. Relationships between inhibition Constants and Fractional Inhibition in Enzyme-Catalyzed Reactions with Different Numbers of Reactants, Different Reaction Mechanisms, and Different Types and Mechanisms of Inhibition. Curr Mol Pharmacol 1974, 10:235-247.
    • (1974) Curr Mol Pharmacol , vol.10 , pp. 235-247
    • Chou, T.-C.1
  • 48
    • 44449120726 scopus 로고    scopus 로고
    • No HIV stage is dominant in driving the HIV epidemic in sub-Saharan Africa
    • 10.1097/QAD.0b013e3282f8af84, 18520349
    • Abu-Raddad LJ, Longini IA. No HIV stage is dominant in driving the HIV epidemic in sub-Saharan Africa. AIDS 2008, 22:1055-1061. 10.1097/QAD.0b013e3282f8af84, 18520349.
    • (2008) AIDS , vol.22 , pp. 1055-1061
    • Abu-Raddad, L.J.1    Longini, I.A.2
  • 49
    • 2142807626 scopus 로고    scopus 로고
    • Brief but efficient: acute HIV infection and the sexual transmission of HIV
    • 10.1086/386333, 15122514
    • Pilcher C, Tien H, Eron J, Vernazza P, Leu S, Stewart P, Goh L, Cohen M. Brief but efficient: acute HIV infection and the sexual transmission of HIV. J Infect Dis 2004, 189:1785-1792. 10.1086/386333, 15122514.
    • (2004) J Infect Dis , vol.189 , pp. 1785-1792
    • Pilcher, C.1    Tien, H.2    Eron, J.3    Vernazza, P.4    Leu, S.5    Stewart, P.6    Goh, L.7    Cohen, M.8
  • 50
    • 33646085538 scopus 로고    scopus 로고
    • Higher Set Point Plasma Viral Load and More-Severe Acute HIV Type 1 (HIV-1) Illness Predict Mortality among High-Risk HIV-1-Infected African Women.
    • 10.1086/503258, 16586394
    • Lavreys L, Baeten JM, Chohan V, McClelland RS, Hassan WM, Richardson BA, Mandaliya K, Ndinya-Achola JO, Overbaugh J. Higher Set Point Plasma Viral Load and More-Severe Acute HIV Type 1 (HIV-1) Illness Predict Mortality among High-Risk HIV-1-Infected African Women. Clin Infect Dis 2006, 42:1333-1339. 10.1086/503258, 16586394.
    • (2006) Clin Infect Dis , vol.42 , pp. 1333-1339
    • Lavreys, L.1    Baeten, J.M.2    Chohan, V.3    McClelland, R.S.4    Hassan, W.M.5    Richardson, B.A.6    Mandaliya, K.7    Ndinya-Achola, J.O.8    Overbaugh, J.9
  • 52
    • 46249122148 scopus 로고    scopus 로고
    • Natural History and Risk Factors Associated with Early and Established HIV Type 1 Infection among Reproductive-Age Women in Malawi
    • 10.1086/588478, 18462100
    • Kumwenda JJ, Makanani B, Taulo F, Nkhoma C, Kafulafula G, Li Q, Kumwenda N, Taha TE. Natural History and Risk Factors Associated with Early and Established HIV Type 1 Infection among Reproductive-Age Women in Malawi. Clin Infect Dis 2008, 46:1913-1920. 10.1086/588478, 18462100.
    • (2008) Clin Infect Dis , vol.46 , pp. 1913-1920
    • Kumwenda, J.J.1    Makanani, B.2    Taulo, F.3    Nkhoma, C.4    Kafulafula, G.5    Li, Q.6    Kumwenda, N.7    Taha, T.E.8
  • 54
    • 0033588891 scopus 로고    scopus 로고
    • Viral Dynamics of Acute HIV-1 Infection
    • 10.1084/jem.190.6.841, 2195636, 10499922
    • Little SJ, McLean AR, Spina CA, Richman DD, Havlir DV. Viral Dynamics of Acute HIV-1 Infection. J Exp Med 1999, 190:841-850. 10.1084/jem.190.6.841, 2195636, 10499922.
    • (1999) J Exp Med , vol.190 , pp. 841-850
    • Little, S.J.1    McLean, A.R.2    Spina, C.A.3    Richman, D.D.4    Havlir, D.V.5
  • 55
    • 0034615789 scopus 로고    scopus 로고
    • Modeling Plasma Virus Concentration during Primary HIV Infection
    • 10.1006/jtbi.2000.1076, 10716909
    • Stafford MA, Corey L, Cao Y, Daar ES, Ho DD, Perelson AS. Modeling Plasma Virus Concentration during Primary HIV Infection. J Theor Biol 2000, 203:285-301. 10.1006/jtbi.2000.1076, 10716909.
    • (2000) J Theor Biol , vol.203 , pp. 285-301
    • Stafford, M.A.1    Corey, L.2    Cao, Y.3    Daar, E.S.4    Ho, D.D.5    Perelson, A.S.6
  • 56
    • 0032492107 scopus 로고    scopus 로고
    • Target cell limited and immune control models of HIV infection: a comparison
    • 10.1006/jtbi.1997.0548, 9514649
    • De Boer RJ, Perelson AS. Target cell limited and immune control models of HIV infection: a comparison. J Theor Biol 1998, 190:201-214. 10.1006/jtbi.1997.0548, 9514649.
    • (1998) J Theor Biol , vol.190 , pp. 201-214
    • De Boer, R.J.1    Perelson, A.S.2
  • 64
    • 9844249672 scopus 로고    scopus 로고
    • AIDS prognosis based on HIV-1 RNA, CD4+ T-cell count and function: markers with reciprocal predictive value over time after seroconversion
    • 10.1097/00002030-199715000-00003, 9412697
    • De Wolf F, Spijkerman I, Schellekens PT, Langendam M, Kuiken C, Bakker M, Roos M, Coutinho R, Miedema F, Goudsmit J. AIDS prognosis based on HIV-1 RNA, CD4+ T-cell count and function: markers with reciprocal predictive value over time after seroconversion. AIDS 1997, 11:1799. 10.1097/00002030-199715000-00003, 9412697.
    • (1997) AIDS , vol.11 , pp. 1799
    • De Wolf, F.1    Spijkerman, I.2    Schellekens, P.T.3    Langendam, M.4    Kuiken, C.5    Bakker, M.6    Roos, M.7    Coutinho, R.8    Miedema, F.9    Goudsmit, J.10
  • 65
    • 0030070991 scopus 로고    scopus 로고
    • Prognosis in HIV-1 Infection Predicted by the Quantity of Virus in Plasma
    • 10.1126/science.272.5265.1167, 8638160
    • Mellors JW, Rinaldo CR, Gupta P, White RM, Todd JA, Kingsley LA. Prognosis in HIV-1 Infection Predicted by the Quantity of Virus in Plasma. Science 1996, 272:1167-1170. 10.1126/science.272.5265.1167, 8638160.
    • (1996) Science , vol.272 , pp. 1167-1170
    • Mellors, J.W.1    Rinaldo, C.R.2    Gupta, P.3    White, R.M.4    Todd, J.A.5    Kingsley, L.A.6
  • 67
    • 0037530011 scopus 로고    scopus 로고
    • Determining the antiviral activity of tenofovir disoproxil fumarate in treatment-naive chronically HIV-1-infected individuals
    • 10.1097/00002030-200305230-00006, 12819516
    • Louie M, Hogan C, Hurley A, Simon V, Chung C, Padte N, Lamy P, Flaherty J, Coakley D, Di Mascio M. Determining the antiviral activity of tenofovir disoproxil fumarate in treatment-naive chronically HIV-1-infected individuals. AIDS 2003, 17:1151. 10.1097/00002030-200305230-00006, 12819516.
    • (2003) AIDS , vol.17 , pp. 1151
    • Louie, M.1    Hogan, C.2    Hurley, A.3    Simon, V.4    Chung, C.5    Padte, N.6    Lamy, P.7    Flaherty, J.8    Coakley, D.9    Di Mascio, M.10
  • 68
    • 0034806946 scopus 로고    scopus 로고
    • Phase I/II trial of the pharmacokinetics, safety, and antiretroviral activity of tenofovir disoproxil fumarate in human immunodeficiency virus-infected adults
    • 10.1128/AAC.45.10.2733-2739.2001, 90724, 11557462
    • Barditch-Crovo P, Deeks SG, Collier A, Safrin S, Coakley DF, Miller M, Kearney BP, Coleman RL, Lamy PD, Kahn JO. Phase I/II trial of the pharmacokinetics, safety, and antiretroviral activity of tenofovir disoproxil fumarate in human immunodeficiency virus-infected adults. Antimicrob Agents Chemother 2001, 45:2733. 10.1128/AAC.45.10.2733-2739.2001, 90724, 11557462.
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 2733
    • Barditch-Crovo, P.1    Deeks, S.G.2    Collier, A.3    Safrin, S.4    Coakley, D.F.5    Miller, M.6    Kearney, B.P.7    Coleman, R.L.8    Lamy, P.D.9    Kahn, J.O.10
  • 69
    • 34247380296 scopus 로고    scopus 로고
    • Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection
    • 10.1186/1742-4690-4-25, 1852805, 17417971
    • Van Rompay KK, Johnson JA, Blackwood EJ, Singh RP, Lipscomb J, Matthews TB, Marthas ML, Pedersen NC, Bischofberger N, Heneine W, North TW. Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection. Retrovirology 2007, 4:25. 10.1186/1742-4690-4-25, 1852805, 17417971.
    • (2007) Retrovirology , vol.4 , pp. 25
    • Van Rompay, K.K.1    Johnson, J.A.2    Blackwood, E.J.3    Singh, R.P.4    Lipscomb, J.5    Matthews, T.B.6    Marthas, M.L.7    Pedersen, N.C.8    Bischofberger, N.9    Heneine, W.10    North, T.W.11
  • 70
    • 36849064140 scopus 로고    scopus 로고
    • Variation in HIV-1 set-point viral load: Epidemiological analysis and an evolutionary hypothesis
    • 10.1073/pnas.0708559104, 2077275, 17954909
    • Fraser C, Hollingsworth TD, Chapman R, De Wolf F, Hanage WP. Variation in HIV-1 set-point viral load: Epidemiological analysis and an evolutionary hypothesis. Proc Natl Acad Sci 2007, 104:17441-17446. 10.1073/pnas.0708559104, 2077275, 17954909.
    • (2007) Proc Natl Acad Sci , vol.104 , pp. 17441-17446
    • Fraser, C.1    Hollingsworth, T.D.2    Chapman, R.3    De Wolf, F.4    Hanage, W.P.5


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