Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: A cohort study

Respiratory Research

Volumn 14, Issue 1, 2013, Pages

  Moreno Macías, Hortensia ^a   Dockery, Douglas W ^b   Schwartz, Joel ^b   Gold, Diane R ^b   Laird, Nan M ^b   Sienra Monge, Juan J ^c   Del Río Navarro, Blanca E ^c   Ramírez Aguilar, Matiana ^d   Barraza Villarreal, Albino ^e   Li, Huiling ^f   London, Stephanie J ^f   Romieu, Isabelle ^g  

^a DEPARTAMENTO DE QUÍMICA   (Mexico)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c HOSPITAL INFANTIL DE MÉXICO FEDERICO GÓMEZ   (Mexico)

^d HOSPITAL GENERAL DE MÉXICO   (Mexico)

^e INSTITUTO NACIONAL DE SALUD PÚBLICA   (Mexico)

^f NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^g INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

Air pollution; Antioxidant genes; Asthmatic children; Mexico City; Vitamin C

Indexed keywords

ASCORBIC ACID; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE P1; ANTIOXIDANT; ENZYME; GLUTATHIONE S-TRANSFERASE M1; GLUTATHIONE TRANSFERASE; GSTP1 PROTEIN, HUMAN; NQO1 PROTEIN, HUMAN; OZONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

ALLELE; ANTIOXIDANT ACTIVITY; ARTICLE; ASTHMA; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ENVIRONMENTAL EXPOSURE; ETHNICITY; FEMALE; GENE; GENE FREQUENCY; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; GSTM1 GENE; GSTP1 GENE; HUMAN; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; MEXICO; NQO1 GENE; OZONE LAYER; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; VITAMIN INTAKE; VITAMIN SUPPLEMENTATION; AGE; ASCORBIC ACID DEFICIENCY; CONTROLLED CLINICAL TRIAL; DIET SUPPLEMENTATION; ENZYMOLOGY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; HEALTH; LUNG; MAXIMAL MID EXPIRATORY FLOW; PATHOPHYSIOLOGY; PHENOTYPE; RISK ASSESSMENT; RISK FACTOR; STATISTICAL MODEL;

AGE FACTORS; ANTIOXIDANTS; ASCORBIC ACID; ASCORBIC ACID DEFICIENCY; ASTHMA; CHILD; COHORT STUDIES; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; ENVIRONMENTAL EXPOSURE; ENZYMES; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HUMANS; LINEAR MODELS; LUNG; MALE; MAXIMAL MIDEXPIRATORY FLOW RATE; MEXICO; NAD(P)H DEHYDROGENASE (QUINONE); OZONE; PHENOTYPE; POLYMORPHISM, GENETIC; RISK ASSESSMENT; RISK FACTORS; URBAN HEALTH;

MLCS; MLOWN;

EID: 84873165311     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-14-14     Document Type: Article

References (38)

1. Mudway IS, Kelly FJ: Ozone and the lung: a sensitive issue. Mol Aspects Med. 2000, 21: 1-48. 10.1016/S0098-2997(00)00003-0.
2. Brown JS: Acute effects of exposure to ozone in humans: How low can levels be and still produce effects?. Am J Respir Crit Care Med. 2009, 180 (3): 200-201. 10.1164/rccm.200906-0834ED.
3. Bowler RP, Crapo JD: Oxidative Stress in allergic respiratory diseases. J Allergy Clin Immunol. 2002, 110: 349-356. 10.1067/mai.2002.126780.
4. Trenga CA, Koenig JQ, Williams PV: Dietary antioxidants and ozone-induced bronchial hyperresponsiveness in adults with asthma. Arch Environ Health. 2001, 56: 242-249. 10.1080/00039890109604448.
5. Keranis E, Makris D, Rodopoulou P, Martinou H, Papamakarios G, Daniil Z, Zintzaras E, Giurgoulianis KI: Impact of dietary shift to higher antioxidant foods in COPD: a randomized trial. Eur Respir J. 2010, 36 (4): 774-80. 10.1183/09031936.00113809.
6. Goodrich GG, Goodman PH, Buhecha SK, Pritsos CA: Functional polymorphism of detoxification gene NQO1 predicts intensity of empirical treatment of childhood asthma. Mutat Res. 2009, 674: 55-61. 10.1016/j.mrgentox.2008.10.009.
7. Reddy P, Naidoo RN, Robins TG, Mentz G, London SJ, Li H, Naidoo R: GSTM1, GSTP1, and NQO1 polymorphisms and susceptibility to atopy and airway hyperresponsiveness among South African schoolchildren. Lung. 2010, 188: 409-414. 10.1007/s00408-010-9246-3.
8. Riedl MA, Nel AE: Importance of oxidative stress in the pathogenesis and treatment of asthma. Curr Opin Allergy Clin Immunol. 2008, 8: 49-56. 10.1097/ACI.0b013e3282f3d913.
9. Romieu I, Sienra-Monge JJ, Ramírez-Aguilar M, Moreno-Macías H, Reyes-Ruiz NI, Del Río-Navarro BE, Hernández-Avila M, London SJ: Genetic Polimorphism of GSTM1 and antioxidant supplementation influence lung function in relation to ozone exposure in asthmatic children in Mexico City. Thorax. 2004, 59: 8-10.
10. Romieu I, Sienra-Monge JJ, Ramirez-Aguilar M, Moreno-Macias H, Reyes NI, Del Rio BE, Ruiz X, Hatch G, Slade R, Hernández-Avila M: Antioxidants supplementation and lung function among asthmatic children exposed to high levels of air pollutants. Am J Resprit Crit Care Med. 2002, 166: 703-709. 10.1164/rccm.2112074.
11. Barraza-Villarreal A, Sunyer J, Hernandez-Cadena L, Escamilla-Nuñez C, Sienra-Monge JJ, Ramirez-Aguilar M, Cortez-Lugo M, Holguin F, Diaz-Sanchez D, Olin AC, Romieu I: Air pollution, airway inflammation and lung function in a cohort study of Mexico City schoolchildren. Environ Health Perspect. 2008, 116: 832-838. 10.1289/ehp.10926.
12. American Thoracic Society: Standardization of Spirometry, 1994 Update. Am J Respir Crit Care Med. 1995, 152: 1107-1136.
13. Weinmann GG, Weidenbach-Gerbase M, Foster WM, Zacur H, Frank R: Evidence for ozone-induced small-airway dysfunction: lack of menstrual-cycle and gender effects. Am J Respir Crit Care Med. 1995, 152 (3): 988-96.
14. Tager IB, Balmes J, Lurmann F, Nqo L, Alcorn S, Künzil N: Chronic exposure to ambient ozone and lung function in young adults. Epidemiology. 2005, 16 (6): 751-9. 10.1097/01.ede.0000183166.68809.b0.
15. Galizia A, Kinney PL: Long-term residence in areas of high ozone: associations with respiratory health in a nationwide sample of nonsmoking young adults [dsee comments]. Environ Health Perspect. 1999, 107: 675-9. 10.1289/ehp.99107675.
16. GINA (Global Initiative for Asthma): Global Initiative for Asthma (GINA). Workshop report, Global Stratey for Asthma Management and Prevention. 2010, http://www.ginasthma.org/Guidelineitem.asp?l1=2&l2=1&intId=60 ,
17. Willett WC: Nutritional Epidemiology. 1998, New York: Oxford University Press
18. Willett W, Stampfer MJ: Total energy intake: Implications for epidemiologic analyses. Am J Epidemiol. 1986, 124: 17-27.
19. David GL, Romieu I, Sienra-Monge JJ, Collins WJ, Ramirez-Aguilra M, del Rio-Navarro BE, Reyes-Ruiz NI, Morris RW, Marzec JM, London SJ: Nicotinamide adenine dinucleotide (phosphate) reduced: Quinone oxidoreductase and glutathione S-transferase M1 plymorphisms and childhood asthma. Am J Respir Crit Care Med. 2003, 168: 1199-1204. 10.1164/rccm.200305-684OC.
20. Tang H, Peng J, Wang P, Risch NJ: Estimation of individual admixture: Analytical and study design considerations. Genet Epidemiol. 2005, 28: 289-301. 10.1002/gepi.20064.
21. Hancock DB, Romieu I, Shi M, Sienra-Monge JJ, Wu H, Chiu GY, Li H, del Rio Navarro BE, Willis-Owen SA, Weiss ST, Raby BA, Gao H, Eng C, Chapela R, Burchard EG, Tang H, Sullivan PF, London SJ: Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in Mexican children. PLoS Genet. 2009, 5 (8): e1000623-10.1371/journal.pgen.1000623.
22. Lam TK, Ruczinski I, Helzlsouer K, Shugart Y, Li KE, Clipp S, Strickland PT, Alberg AJ: Copy number variants of GSTM1 and GSTT1 in relation to lung cancer risk in a prospective cohort study. Ann Epidemil. 2009, 19: 546-552. 10.1016/j.annepidem.2009.03.003.
23. Watson MA, Stewart RK, Smith GB, Massey TE, Bell DA: Human Glutathione S-transferase P1 polymorphisms: Relationship to lung tissue enzyme activity and population frecuency distribution. Carcinogenesis. 1998, 19: 275-280. 10.1093/carcin/19.2.275.
24. Chen C, Arjomandi M, Tager IB, Holland N, Balmes JR: Effects of antioxidant enzyme polymorphisms on ozone-induced lung function changes. Eur Respir J. 2007, 30: 677-683. 10.1183/09031936.00160806.
25. Melén E, Nyberg F, Lindgren CM, Berglind N, Zucchelli M, Nordling E, Hallberg J, Svartengren M, Morgenstern R, Kere J, Bellander T, Wickman M, Pershagen G: Interactions between Glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease. Environ Health Perspect. 2008, 116: 1077-1084. 10.1289/ehp.11117.
26. Tamer L, Calikoğlu M, Ates NA, Yildirim H, Ercan B, Saritas E, Unlü A, Atik U: Glutathione-s-transferase gene polymorphisms (GSTT1, GSTM1, GSTP1) as increased risk factors for asthma. Respirology. 2004, 9: 493-498. 10.1111/j.1440-1843.2004.00657.x.
27. Islam T, Berhane K, McConnell R, Gauderman WJ, Avol E, Peters JM, Gilliland FD: Glutathione-S-transferase (GST) P1, GSTM1, exercise, ozone and asthma incidence in school children. Thorax. 2009, 64: 197-202. 10.1136/thx.2008.099366.
28. Lee YL, Lin YC, Lee YC, Wang JY, Hsiue TR, Guo YL: Glutathione Stransferase P1 gene polymorphism and air pollution as interactive risk factors for childhood asthma. Clin Exp Allergy. 2004, 34: 1707-1713. 10.1111/j.1365-2222.2004.02099.x.
29. Smit HA, Grreivink L, Tabak C: Dietary influences on chronic obstructive lung disease and asthma: a review of the epidemiological evidence. Proc Nutr Soc. 1999, 58: 197-202.
30. Secretaría del Medio Ambiente: Sistema Metropolitano Atmosférico (SIMAT). http://www.calidadaire.df.gob.mx/calidadaire/index.php?opcion=2&opcioninfoproductos=26 ,
31. Rothman KJ, Greenland S: Modern Epidemiology. 1998, Philadelphia: Lippincott Williams & Wilkins, 257-2
32. Romieu I, Ramirez-Aguilar M, Sienra-Monge JJ, Moreno-Macias H, Rio-Navarro BE, David G, Marzec J, Hernandez-Avila M, London SJ: GSTM1 and GSTP1 and respiratory health in asthmatic children exposed to ozone. Eur Respir J. 2006, 28: 953-959. 10.1183/09031936.06.00114905.
33. Ramírez-Aguilar M, Barraza-Villareal A, Moreno-Macías H, Winer AM, Cicero-Fernández P, Vélez-Márquez MG, Cortéz Lugo M, Sienra Monge JJ, Romieu I: Assessment of personal exposure to ozone in asthmatic children residing in Mexico City. Salud Publica Mex. 2008, 50: 67-75. 10.1590/S0036-36342008000100013.
34. Subar AF, Thompson FE, Kipnis V, Midthune D, Hurwitz P, McNutt S, McInstosh A, Rosenfeld S: Comparative validation of the Block, Willett and National Cancer Institute Food Frequency Questionnaires. Am J Epidemiol. 2001, 154: 1089-99. 10.1093/aje/154.12.1089.
35. Smit HA: Chronic obstructive pulmonary disease, asthma and protective effects of food intake: from hypothesis to evidence?. Respir Res. 2001, 2: 261-264. 10.1186/rr65.
36. Kim JH, Ellwood PE, Asher MI: Diet and asthma: looking back, moving forward. Respir Res. 2009, 10: 49-10.1186/1465-9921-10-49.
37. Polonikov AV, Ivanov VP, Solodilova MA, Panfilov VI: Tobacco smoking, fruit and vegetable intake modify association between -21A > T polymorphism catalase gene and risk of bronchial asthma. J Asthma. 2009, 46 (3): 217-24. 10.1080/02770900802492103.
38. Romieu I, Barraza-Villarreal A, Escamilla-Núñez C, Texcalac-Sangrador JL, Hernández-Cadena L, Díaz-Sánchez D, De Battle J, Del Río-Navarro BE: Dietary intake, lung function and airway inflammation in Mexico City school children exposed to air pollutants. Respir Res. 2009, 10: 122-10.1186/1465-9921-10-122.