Activated microglia provide a neuroprotective role by balancing glial cell-line derived neurotrophic factor and tumor necrosis factor-α secretion after subacute cerebral ischemia

International Journal of Molecular Medicine

Volumn 31, Issue 1, 2013, Pages 172-178

  Wang, Jianping ^a   Yang, Zhitang ^a   Liu, Cong ^a   Zhao, Yuanzheng ^a   Chen, Yibing ^b  

^a ZHENGZHOU UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

Glial cell line derived neurotrophic factor; Microglia; N (6 oxo 5,6 dihydro phenanthridin 2 yl) N,N dimethylacetamide; Subacute cerebral ischemia; Tumor necrosis factor

Indexed keywords

CD11B ANTIGEN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL ACTIVATION; CELL LOSS; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE RELEASE; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL INHIBITION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT;

ANIMALS; ANTIGENS, CD11B; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MICROGLIA; PHENANTHRENES; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84873158967     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2012.1179     Document Type: Article

References (36)

1. Lv M, Liu Y, Zhang J, et al: Roles of inflammation response in microglia cell through Toll-like receptors 2/interleukin-23/interleukin-17 pathway in cerebral ischemia/reperfusion injury. Neuroscience 176: 162-172, 2011.
2. Block ML and Hong JS: Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 76: 77-98, 2005.
3. Liu B, Du L and Hong JS: Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation. J Pharmacol Exp Ther 293: 607-617, 2000.
4. Napoli I and Neumann H: Protective effects of microglia in multiple sclerosis. Exp Neurol 225: 24-28, 2010.
5. Petersen MA and Dailey ME: Diverse microglial motility behaviors during clearance of dead cells in hippocampal slices. Glia 46: 195-206, 2004.
6. Lalancette-Hebert M, Gowing G, Simard A, Weng YC and Kriz J: Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain. J Neurosci 27: 2596-2605, 2007.
7. Figueiredo C, Pais TF, Gomes JR and Chatterjee S: Neuron-microglia crosstalk up-regulates neuronal FGF-2 expression which mediates neuroprotection against excitotoxicity via JNK1/2. J Neurochem 107: 73-85, 2008.
8. Hamby AM, Suh SW, Kauppinen TM and Swanson RA: Use of a poly(ADP-ribose) polymerase inhibitor to suppress inflammation and neuronal death after cerebral ischemia-reperfusion. Stroke 38: 632-636, 2007.
9. Xi GM, Wang HQ, He GH, Huang CF and Wei GY: Evaluation of murine models of permanent focal cerebral ischemia. Chin Med J (Engl) 117: 389-394, 2004.
10. van der Kooij MA, Ohl F, Arndt SS, Kavelaars A, van Bel F and Heijnen CJ: Mild neonatal hypoxia-ischemia induces long-term motor- and cognitive impairments in mice. Brain Behav Immun 24: 850-856, 2010.
11. Brooks SP and Dunnett SB: Tests to assess motor phenotype in mice: a user's guide. Nat Rev Neurosci 10: 519-529, 2009.
12. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL and Bartkowski H: Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17: 472-476, 1986.
13. d'Avila JC, Lam TI, Bingham D, et al: Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor. J Neuroinflammation 9: 31, 2012.
14. Hanisch UK and Kettenmann H: Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10: 1387-1394, 2007.
15. Frank-Cannon TC, Alto LT, McAlpine FE and Tansey MG: Does neuroinflammation fan the flame in neurodegenerative diseases? Mol Neurodegener 4: 47, 2009.
16. Polazzi E and Monti B: Microglia and neuroprotection: from in vitro studies to therapeutic applications. Prog Neurobiol 92: 293-315, 2010.
17. Kaushal V and Schlichter LC: Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra. J Neurosci 28: 2221-2230, 2008.
18. Hassa PO and Hottiger MO: The functional role of poly(ADP-ribose) polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders. Cell Mol Life Sci 59: 1534-1553, 2002.
19. Hassa PO, Buerki C, Lombardi C, Imhof R and Hottiger MO: Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1. J Biol Chem 278: 45145-45153, 2003.
20. Kauppinen TM and Swanson RA: Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death. J Immunol 174: 2288-2296, 2005.
21. Kauppinen TM, Higashi Y, Suh SW, Escartin C, Nagasawa K and Swanson RA: Zinc triggers microglial activation. J Neurosci 28: 5827-5835, 2008.
22. Ullrich O, Diestel A, Eyupoglu IY and Nitsch R: Regulation of microglial expression of integrins by poly(ADP-ribose) polymerase-1. Nat Cell Biol 3: 1035-1042, 2001.
23. Yrjanheikki J, Keinanen R, Pellikka M, Hokfelt T and Koistinaho J: Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc Natl Acad Sci USA 95: 15769-15774, 1998.
24. Fan R, Xu F, Previti ML, et al: Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid. J Neurosci 27: 3057-3063, 2007.
25. Mabley JG, Jagtap P, Perretti M, et al: Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase. Inflamm Res 50: 561-569, 2001.
26. Mabley JG, Horvath EM, Murthy KG, et al: Gender differences in the endotoxin-induced inflammatory and vascular responses: potential role of poly(ADP-ribose) polymerase activation. J Pharmacol Exp Ther 315: 812-820, 2005.
27. Gash DM, Zhang Z, Ovadia A, et al: Functional recovery in parkinsonian monkeys treated with GDNF. Nature 380: 252-255, 1996.
28. Li L, Wu W, Lin LF, Lei M, Oppenheim RW and Houenou LJ: Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor. Proc Natl Acad Sci USA 92: 9771-9775, 1995.
29. Wang Y, Lin SZ, Chiou AL, Williams LR and Hoffer BJ: Glial cell line-derived neurotrophic factor protects against ischemia-induced injury in the cerebral cortex. J Neurosci 17: 4341-4348, 1997.
30. Boscia F, Esposito CL, Di Crisci A, de Franciscis V, Annunziato L and Cerchia L: GDNF selectively induces microglial activation and neuronal survival in CA1/CA3 hippocampal regions exposed to NMDA insult through Ret/ERK signalling. PLoS One 4: e6486, 2009.
31. Hung SY, Liou HC and Fu WM: The mechanism of heme oxygenase-1 action involved in the enhancement of neurotrophic factor expression. Neuropharmacology 58: 321-329, 2010.
32. Sarit BS, Lajos G, Abraham D, Ron A and Sigal FB: Inhibitory role of kinins on microglial nitric oxide and tumor necrosis factor-alpha production. Peptides 35: 172-181, 2012.
33. Boucsein C, Zacharias R, Farber K, Pavlovic S, Hanisch UK and Kettenmann H: Purinergic receptors on microglial cells: functional expression in acute brain slices and modulation of microglial activation in vitro. Eur J Neurosci 17: 2267-2276, 2003.
34. Nodin C, Zhu C, Blomgren K, Nilsson M and Blomstrand F: Decreased oxidative stress during glycolytic inhibition enables maintenance of ATP production and astrocytic survival. Neurochem Int 61: 291-301, 2012.
35. Lee GA, Lin CH, Jiang HH, Chao HJ, Wu CL and Hsueh CM: Microglia-derived glial cell line-derived neurotrophic factor could protect Sprague-Dawley rat astrocyte from in vitro ischemia-induced damage. Neurosci Lett 356: 111-114, 2004.
36. + T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS. Proc Natl Acad Sci USA 105: 15558-15563, 2008.