The influence of hydroxyurea on oxidative stress in sickle cell anemia

Revista Brasileira de Hematologia e Hemoterapia

Volumn 34, Issue 6, 2012, Pages 421-425

  Torres, Lidiane de Souza ^a   da Silva, Danilo Grünig Humberto ^a   Belini Junior, Edis ^a   de Almeida, Eduardo Alves ^a   Lobo, Clarisse Lopes de Castro ^b   Cançado, Rodolfo Delfini ^c   Ruiz, Milton Artur ^d   Bonini Domingos, Claudia Regina ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b Instituto de Hematologia 'Arthur de Siqueira Cavalcanti' HEMORIO   (Brazil)

^c FACULDADE DE CIÊNCIAS MÉDICAS DA SANTA CASA DE SÃO PAULO   (Brazil)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Anemia; Hemoglobinopathies; Hydroxyurea; Oxidative stress; Sickle cell

Indexed keywords

EID: 84873157287     PISSN: 15168484     EISSN: None     Source Type: Journal    
DOI: 10.5581/1516-8484.20120106     Document Type: Article

References (32)

1. Frenette PS, Atweh GF. Sickle cell disease: old discoveries, new concepts, and future promise. J Clin Invest. 2007;117(4): 850-8.
2. Higgs DR, Wood WG. Genetic complexity in sickle cell disease. Proc Natl Acad Sci USA. 2008;105(33):11595-11596. Comment on: Proc Natl Acad Sci USA. 2008;105(33):11869-74.
3. Figueiredo MS. Fatores moduladores da gravidade da evolução clínica da anemia falciforme. Rev Bras Hematol Hemoter. 2007;29(3):215-217.
4. Rees DC, Williams TN, Gladwin MT. Sickle-cell disease. Lancet. 2010;376(9757):2018-2031.
5. Kovacic P. Hydroxyurea (therapeutics and mechanism): metabolism, carbamoyl nitroso, nitroxyl, radicals, cell signaling and clinical applications. Med Hypotheses. 2011;76(1):24-31.
6. Chaves MA, Leonart MS, do Nascimento AJ. Oxidative process in erythrocytes of individuals with hemoglobin S. Hematology. 2008;13(3):187-192.
7. Kuypers FA. Red cell membrane lipids in hemoglobinopathies. Curr Mol Med. 2008;8(7):633-638.
8. Kato GJ, Hebbel RP, Steinberg MH, Gladwin MT. Vasculopathy in sickle cell disease: biology, pathophysiology, genetics, translational medicine, and new research directions. Am J Hematol. 2009;84(9):618-625.
9. Marengo-Rowe AJ. Rapid electrophoresis and quantitation of haemoglobin on cellulose acetate. J Clin Pathol. 1965;18(6):790-792.
10. Vella F. Acid agar gel electrophoresis oh human hemoglobins. Am J Clin Pathol. 1968;49(3):440-442.
11. Bio-Rad Laboratories. Instruction Manual: Variant β-thalassemia short program. Hercules, California: Bio-Rad Laboratories; 1999.
12. Sambrook J, Fritcsh EF, Manatis T. Molecular cloning: a laboratory manual. 2nd ed. New York: Cold Spring Harbor Laboratory Press; 1989.
13. Saiki RK, Scharf S, Faloona F, Mullis KB, Horn GT, Erlich HA, et al. Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science. 1985;230(4732):1350-1354.
14. Percário S. Dosagem do dialdeído malônico. Newslab. 2004;6:46-50.
15. Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med. 1999;26(9-10):1231-1237.
16. Rodríguez-Ariza A, Toribio F, López-Barea J. Rapid determination of glutathione status in fish liver using high-performance liquid chromatography and electrochemical detection. J Chromatogr B Biomed Appl. 1994;656(2):311-318.
17. Fibach E, Rachmilewitz E. The role of oxidative stress in hemolytic anemia. Curr Mol Med. 2008;8(7):609-619.
18. Green NS, Barral S. Genetic modifiers of HbF and response to hydroxyurea in sickle cell disease. Pediatric Blood Cancer. 2011;56(2):177-181.
19. Belcher JD, Beckman JD, Balla G, Balla J, Vercellotti G. Heme degradation and vascular injury. Antioxid Redox Signal. 2010;12(2):233-248.
20. Brasil. Ministério da Saúde. Agencia de Vigilância Sanitária - ANVISA. Manual de diagnóstico e tratamento de doenças falciformes [Internet]. Brasília: Ministério da Saúde; 2001.[cited 2011 Jan 12]. Available from: http://www.ebah.com.br/content/ABAAAA2R4AB/manual-diagnosticotratamento-doencas-falciformes
21. Steinberg MH. Management of sickle cell disease. N Engl J Med. 1999;340(13):1021-30.
22. Charache S, Terrin ML, Moore RD, Dover GJ, Barton FB, Eckert SV, et al. Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. N Engl J Med. 1995;332(20):1317-1322. Comment in: N Engl J Med. 1996;334(5):333-4; N Engl J Med. 1995;332(20):1372-4; N Engl J Med. 1995;333(15):1008-9; author reply 1009.
23. Silva LB, Gonçalves RP, Martins MF. Estudo da correlação entre os níveis de hemoglobina fetal e o prognóstico dos pacientes com anemia falciforme. Rev Bras Hematol Hemoter. 2009:31(6):417-20.
24. Kaul DK, Liu XD, Choong S, Belcher JD, Vercellotti GM, Hebbel RP. Anti-inflammatory therapy ameliorates leukocyte adhesion and microvascular flow abnormalities in transgenic sickle mice. Am J Physiol Heart Circ Physiol. 2004;287(1):H293-301.
25. Hernanz A, Fernández-Vivancos E, Montiel C, Vazquez JJ, Arnalich F. Changes in the intracellular homocysteine and glutathione content associated with aging. Life Sci. 2000;67(11):1317-24.
26. Chan AC, Chow CK, Chiu D. Interaction of antioxidants and their implication in genetic anemia. Proc Soc Exp Biol Med. 1999;222(3):274-82.
27. Reid M, Jahoor F. Glutathione in disease. Curr Opin Clin Nutr Metab Care. 2001;4(1):65-71.
28. Reid M, Badaloo A, Forrester T, Jahoor F. In vivo rates of erythrocyte glutathione synthesis in adults with sickle cell disease. Am J Physiol Endocrinol Metab. 2006;291(1):E73-9.
29. Kiessling K, Roberts N, Gibson JS, Ellory JC. A comparison in normal individuals and sickle cell patients of reduced glutathione precursors and their transport between plasma and red cells. Hematol J. 2000;1(4):243-9.
30. Cresenzi CL, Lee JI, Stipanuk MH. Cysteine is the metabolic signal responsible for dietary regulation of hepatic cysteine dioxygenase and glutamate cysteine ligase in intact rats. J Nutr. 2003;133(9):2697-702.
31. Ballatori N, Krance SM, Notenboom S, Shi S, Tieu K, Hammond CL. Glutathione dysregulation and the etiology and progression of human diseases. Biol Chem. 2009;390(3):191-214.
32. Liu YH, Wu WC, Lu YL, Lai YJ, Hou WC. Antioxidant and amine oxidase inhibitory activities of hydroxyrea. Biosci Biotechnol Biochem. 2010;74(6):1256-60.