Simvastatin attenuates pulmonary vascular remodelling by down-regulating matrix metalloproteinase-1 and -9 expression in a carotid artery-jugular vein shunt pulmonary hypertension model in rats

European Journal of Cardio-thoracic Surgery

Volumn 42, Issue 5, 2012, Pages

  Yao, Jianping ^a   Xiong, Mai ^a   Tang, Bing ^a   Chen, Guangxian ^a   Liang, Mengya ^a   Ma, Xiaofan ^a   Wang, Zhiping ^a   Wu, Zhongkai ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

Congenital heart disease; Matrix metalloproteinase 1; Matrix metalloproteinase 9; Pulmonary artery hypertension; Pulmonary vascular remodelling; Simvastatin

Indexed keywords

GELATINASE B; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERSTITIAL COLLAGENASE; MESSENGER RNA; PLACEBO; SIMVASTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; COMMON CAROTID ARTERY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; EXTERNAL JUGULAR VEIN; GENE EXPRESSION; LUNG HEMODYNAMICS; LUNG PARENCHYMA; MALE; MORPHOMETRICS; NONHUMAN; PARENCHYMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SYSTEMIC PULMONARY SHUNT; SYSTOLIC BLOOD PRESSURE; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ARTERIOVENOUS SHUNT, SURGICAL; BIOLOGICAL MARKERS; BLOOD PRESSURE; BLOTTING, WESTERN; CAROTID ARTERIES; DISEASE MODELS, ANIMAL; DOWN-REGULATION; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERTENSION, PULMONARY; JUGULAR VEINS; MALE; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 9; PULMONARY ARTERY; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; SIMVASTATIN; TREATMENT OUTCOME;

EID: 84873157227     PISSN: 10107940     EISSN: 1873734X     Source Type: Journal    
DOI: 10.1093/ejcts/ezs445     Document Type: Article

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