Hepatitis B virus X protein modulates remodelling of minichromosomes related to hepatitis B virus replication in HepG2 cells

International Journal of Molecular Medicine

Volumn 31, Issue 1, 2013, Pages 197-204

  Luo, Li ^a   Chen, Shu ^a   Gong, Qian ^a   Luo, Na ^a   Lei, Yu ^b   Guo, Jinjun ^a   He, Song ^a  

^a THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

HBx mutant; Hepatitis B virus; Hepatitis B virus X protein; Histone H3; Histone modifications

Indexed keywords

CIRCULAR DNA; HEPATITIS B VIRUS X PROTEIN; HISTONE H3; RNA; VIRUS ANTIGEN;

ACETYLATION; ARTICLE; CHROMATIN; CONTROLLED STUDY; DNA METHYLATION; DNA TRANSFECTION; EPIGENETICS; GENOME; HEPATITIS B; HEPATITIS B VIRUS; HEPATOMA CELL; HISTONE MODIFICATION; HUMAN; HUMAN CELL; MINICHROMOSOME; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; VIRUS REPLICATION; VIRUS TRANSCRIPTION; WILD TYPE;

ACETYLATION; BLOTTING, SOUTHERN; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMOSOMES, HUMAN; DNA, CIRCULAR; DNA, VIRAL; HEP G2 CELLS; HEPATITIS B VIRUS; HISTONES; HUMANS; IMMUNOPRECIPITATION; METHYLATION; PHOSPHORYLATION; PLASMIDS; TRANS-ACTIVATORS; TRANSFECTION; VIRUS REPLICATION;

EID: 84873149342     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2012.1165     Document Type: Article

References (43)

1. Dienstag JL: Hepatitis B virus infection. N Engl J Med 359: 1486-1500, 2008.
2. Seeger C and Mason WS: Hepatitis B virus biology. Microbiol Mol Biol Rev 64: 51-68, 2000.
3. Murakami S: Hepatitis B virus X protein: a multifunctional viral regulator. J Gastroenterol 36: 651-660, 2001.
4. Scaglioni PP, Melegari M and Wands JR: Posttranscriptional regulation of hepatitis B virus replication by the precore protein. J Virol 71: 345-353, 1997.
5. Melegari M, Scaglioni PP and Wands JR: Cloning and characterization of a novel hepatitis B virus × binding protein that inhibits viral replication. J Virol 72: 1737-1743, 1998.
6. Keasler VV, Hodgson AJ, Madden CR and Slagle BL: Enhancement of hepatitis B virus replication by the regulatory X protein in vitro and in vivo. J Virol 81: 2656-2662, 2007.
7. Bouchard MJ, Wang LH and Schneider RJ: Calcium signaling by HBx protein in hepatitis B virus DNA replication. Science 294: 2376-2378, 2001.
8. Tang H, Delgermaa L, Huang F, et al: The transcriptional transactivation function of HBx protein is important for its augmentation role in hepatitis B virus replication. J Virol 79: 5548-5556, 2005.
9. Yang PL, Althage A, Chung J and Chisari FV: Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection. Proc Natl Acad Sci USA 99: 13825-13830, 2002.
10. Keasler VV, Hodgson AJ, Madden CR and Slagle BL: Hepatitis B virus HBx protein localized to the nucleus restores HBx-deficient virus replication in HepG2 cells and in vivo in hydrodynamically-injected mice. Virology 390: 122-129, 2009.
11. Newbold JE, Xin H, Tencza M, Sherman G, Dean J, Bowden S and Locarnini S: The covalently closed duplex form of the hepadnavirus genome exists in situ as a heterogeneous population of viral minichromosomes. J Virol 69: 3350-3357, 1995.
12. Gao W and Hu J: Formation of hepatitis B virus covalently closed circular DNA: removal of genome-linked protein. J Virol 81: 6164-6174, 2007.
13. Levrero M, Pollicino T, Petersen J, Belloni L, Raimondo G and Dandri M: Control of cccDNA function in hepatitis B virus infection. J Hepatol 51: 581-592, 2009.
14. Bock CT, Schwinn S, Locarnini S, Fyfe J, Manns MP, Trautwei C and Zentgraf H: Structural organization of the hepatitis B virus minichromosome. J Mol Biol 307: 183-196, 2001.
15. Pollicino T, Belloni L, Raffa G, Pediconi N, Squadrito G, Raimondo G and Levrero M: Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones. Gastroenterology 130: 823-837, 2006.
16. Bouchard MJ, Wang L and Schneider RJ: Activation of focal adhesion kinase by hepatitis B virus HBx protein: multiple functions in viral replication. J Virol 80: 4406-4414, 2006.
17. Cougot D, Wu Y, Cairo S, et al: The hepatitis B virus X protein functionally interacts with CREB-binding protein/p300 in the regulation of CREB-mediated transcription. J Biol Chem 282: 4277-4287, 2007.
18. Harju S, McQueen KJ and Peterson KR: Chromatin structure and control of beta-like globin gene switching. Exp Biol Med (Maywood) 227: 683-700, 2002.
19. Gong Q, Chen S, Guo J, et al: Chromosome remodeling related to hepatitis B virus replication in HepG2 cells. DNA Cell Biol 30: 347-354, 2011.
20. Slagle BL, Lee TH, Medina D, Finegold MJ and Butel JS: Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene. Mol Carcinog 15: 261-269, 1996.
21. Belloni L, Pollicino T, De Nicola F, et al: Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function. Proc Natl Acad Sci USA 106: 19975-19979, 2009.
22. Sambrook J and Russel DW: Molecular Cloning: A Laboratory Manual. 3rd edition. Cold Spring Harbor Laboratory Press, New York, pp138-140, pp151-153, 2001.
23. Brechot C, Kremsdorf D, Soussan P, Pineau P, Dejean A, Paterlini-Brechot P and Tiollais P: Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC): molecular mechanisms and novel paradigms. Pathol Biol (Paris) 58: 278-287, 2010.
24. Lucifora J, Arzberger S, Durantel D, et al: Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection. J Hepatol 55: 996-1003, 2011.
25. Pollicino T, Squadrito G, Cerenzia G, et al: Hepatitis B virus maintains its pro-oncogenic properties in the case of occult HBV infection. Gastroenterology 126: 102-110, 2004.
26. Stoll-Becker S, Repp R, Glebe D, et al: Transcription of hepatitis B virus in peripheral blood mononuclear cells from persistently infected patients. J Virol 71: 5399-5407, 1997.
27. Hake SB, Xiao A and Allis CD: Linking the epigenetic 'language' of covalent histone modifications to cancer. Br J Cancer 90: 761-769, 2004.
28. Strahl BD and Allis CD: The language of covalent histone modifications. Nature 403: 41-45, 2000.
29. Dillon SC, Zhang X, Trievel RC and Cheng X: The SET-domain protein superfamily: protein lysine methyltransferases. Genome Biol 6: 227, 2005.
30. Hamamoto R, Furukawa Y, Morita M, et al: SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. Nat Cell Biol 6: 731-740, 2004.
31. Yang L, He J, Chen L and Wang G: Hepatitis B virus X protein upregulates expression of SMYD3 and C-MYC in HepG2 cells. Med Oncol 26: 445-451, 2009.
32. Park IY, Sohn BH, Yu E, et al: Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein. Gastroenterology 132: 1476-1494, 2007.
33. Rouleau J, MacLeod AR and Szyf M: Regulation of the DNA methyltransferase by the Ras-AP-1 signaling pathway. J Biol Chem 270: 1595-1601, 1995.
34. Peterson EJ, Bogler O and Taylor SM: p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding. Cancer Res 63: 6579-6582, 2003.
35. Zheng DL, Zhang L, Cheng N, et al: Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A. J Hepatol 50: 377-387, 2009.
36. Melegari M, Wolf SK and Schneider RJ: Hepatitis B virus DNA replication is coordinated by core protein serine phosphorylation and HBx expression. J Virol 79: 9810-9820, 2005.
37. Chadee DN, Hendzel MJ, Tylipski CP, Allis CD, Bazett-Jones DP, Wright JA and Davie JR: Increased Ser-10 phosphorylation of histone H3 in mitogen-stimulated and oncogene-transformed mouse fibroblasts. J Biol Chem 274: 24914-24920, 1999.
38. Min L, He B and Hui L: Mitogen-activated protein kinases in hepatocellular carcinoma development. Semin Cancer Biol 21: 10-20, 2011.
39. Wang GG, Allis CD and Chi P: Chromatin remodeling and cancer, Part I: Covalent histone modifications. Trends Mol Med 13: 363-372, 2007.
40. Hirota T, Lipp JJ, Toh BH and Peters JM: Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin. Nature 438: 1176-1180, 2005.
41. Nowak SJ and Corces VG: Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation. Trends Genet 20: 214-220, 2004.
42. Herceg Z and Paliwal A: Epigenetic mechanisms in hepatocellular carcinoma: how environmental factors influence the epigenome. Mutat Res 727: 55-61, 2011.
43. Shon JK, Shon BH, Park IY, et al: Hepatitis B virus-X protein recruits histone deacetylase 1 to repress insulin-like growth factor binding protein 3 transcription. Virus Res 139: 14-21, 2009.