-
1
-
-
0034213327
-
RhoGTPases and their effector proteins
-
Bishop A, Hall A. RhoGTPases and their effector proteins. Biochem J 2000;348:241-55.
-
(2000)
Biochem J
, vol.348
, pp. 241-255
-
-
Bishop, A.1
Hall, A.2
-
3
-
-
0842280665
-
Rac1 gene mutations in human brain tumours
-
DOI 10.1016/j.ejso.2003.10.018
-
Hwang SL, Hong YR, Sy WD, et al. Rac1 gene mutations in human brain tumours. Eur J Surg Oncol 2004;30:68-72. (Pubitemid 38180994)
-
(2004)
European Journal of Surgical Oncology
, vol.30
, Issue.1
, pp. 68-72
-
-
Hwang, S.L.1
Hong, Y.R.2
Sy, W.D.3
Lieu, A.S.4
Lin, C.L.5
Lee, K.S.6
Howng, S.L.7
-
4
-
-
0033007293
-
Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity
-
Johnson DI. Cdc42: an essential Rho-type GTPase controlling eukaryotic cell polarity. Microbiol Mol Biol Rev 1999;63:54-105. (Pubitemid 29116087)
-
(1999)
Microbiology and Molecular Biology Reviews
, vol.63
, Issue.1
, pp. 54-105
-
-
Johnson, D.I.1
-
5
-
-
0028786020
-
A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases
-
Burbelo PD, Drechsel D, Hall A. A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J Biol Chem 1995;270:29071-4.
-
(1995)
J Biol Chem
, vol.270
, pp. 29071-29074
-
-
Burbelo, P.D.1
Drechsel, D.2
Hall, A.3
-
6
-
-
0026612457
-
Intracellular localization of the P21rho proteins
-
Adamson P, Paterson HF, Hall A. Intracellular localization of the P21rho proteins. J Cell Biol 1992;119:617-27.
-
(1992)
J Cell Biol
, vol.119
, pp. 617-627
-
-
Adamson, P.1
Paterson, H.F.2
Hall, A.3
-
8
-
-
0344010182
-
RhoA induces MMP-9 expression at CD44 lamellipodial focal complexes and promotes HMEC-1 cell invasion
-
Abecassis I, Olofsson B, Schmid M, et al. RhoA induces MMP-9 expression at CD44 lamellipodial focal complexes and promotes HMEC-1 cell invasion. Exp Cell Res 2003;291:363-6.
-
(2003)
Exp Cell Res
, vol.291
, pp. 363-366
-
-
Abecassis, I.1
Olofsson, B.2
Schmid, M.3
-
9
-
-
0345731237
-
Cell migration: Rho GTPases lead the way
-
DOI 10.1016/j.ydbio.2003.06.003
-
Raftopoulou M, Hall A. Cell migration: RhoGTPases lead the way. Dev Biol 2004;265:23-32. (Pubitemid 38018819)
-
(2004)
Developmental Biology
, vol.265
, Issue.1
, pp. 23-32
-
-
Raftopoulou, M.1
Hall, A.2
-
10
-
-
21744432683
-
GDIs: Central regulatory molecules in Rho GTPase activation
-
DOI 10.1016/j.tcb.2005.05.001, PII S0962892405001273
-
DerMardirossian C, Bokoch G. GDIs: central regulatory molecules in RhoGTPase activation. Trends Cell Biol 2005;15:356-63. (Pubitemid 40943524)
-
(2005)
Trends in Cell Biology
, vol.15
, Issue.7
, pp. 356-363
-
-
DerMardirossian, C.1
Bokoch, G.M.2
-
11
-
-
1642273617
-
Rho-regulatory proteins in breast cancer cell motility and invasion
-
DOI 10.1023/B:BREA.0000018424.43445.f3
-
Lin M, van Golen K. Rho-regulatory proteins in breast cancer cell motility and invasion. Breast Cancer Res Treatment 2004;84:49-60. (Pubitemid 38388860)
-
(2004)
Breast Cancer Research and Treatment
, vol.84
, Issue.1
, pp. 49-60
-
-
Lin, M.1
Van Golen, K.L.2
-
12
-
-
0030759770
-
Crystal structure of a small G protein in complex with the GTPase- activating protein rhoGAP
-
DOI 10.1038/41805
-
Rittinger K, Walker PA, Eccleston JF, et al. Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP. Nature 1997;388:693-7. (Pubitemid 27366443)
-
(1997)
Nature
, vol.388
, Issue.6643
, pp. 693-697
-
-
Rittinger, K.1
Walker, P.A.2
Eccleston, J.F.3
Nurmahomed, K.4
Owen, D.5
Laue, E.6
Gamblin, S.J.7
Smerdon, S.J.8
-
13
-
-
68749114021
-
Deleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis
-
Yau TO, Leung TH, Lam S, et al. Deleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis. PLoS One 2009;4:e6566.
-
(2009)
PLoS One
, vol.4
-
-
Yau, T.O.1
Leung, T.H.2
Lam, S.3
-
14
-
-
0030018796
-
Structural differences in the minimal catalytic domains of the GTPase- activating proteins p120(GAP) and neurofibromin
-
DOI 10.1074/jbc.271.27.16409
-
Ahmadian MR, Wiesmuller L, Lautwein A, et al. Structural differences in the minimal catalytic domains of the GTPaseactivating proteins p120GAP and neurofibromin. J Biol Chem 1996;271:16409-15. (Pubitemid 26236267)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.27
, pp. 16409-16415
-
-
Ahmadian, M.R.1
Wiesmuller, L.2
Lautwein, A.3
Ralf Bischoff, F.4
Wittinghofer, A.5
-
15
-
-
0037213689
-
RhoGTPase-activating proteins in cell regulation
-
Moon SY, Zheng Y. RhoGTPase-activating proteins in cell regulation. Trends Cell Biol 2003;13:13-22.
-
(2003)
Trends Cell Biol
, vol.13
, pp. 13-22
-
-
Moon, S.Y.1
Zheng, Y.2
-
16
-
-
0032054663
-
GTPase-activating proteins and their complexes
-
DOI 10.1016/S0959-440X(98)80038-9
-
Gamblin SJ, Smerdon SJ. GTPase-activating proteins and their complexes. Curr Opin Struct Biol 1998;8:195-201. (Pubitemid 28221051)
-
(1998)
Current Opinion in Structural Biology
, vol.8
, Issue.2
, pp. 195-201
-
-
Gamblin, S.J.1
Smerdon, S.J.2
-
17
-
-
14844325701
-
Autoinhibition of p50 Rho GTPase-activating protein (GAP) is released by prenylated small GTPases
-
DOI 10.1074/jbc.M412563200
-
Moskwa P, Paclet MH, Dagher MC, et al. Autoinhibition of p50 RhoGTPase-activating protein (GAP) is released by prenylated small GTPases. J Biol Chem 2009;280:6716-20. (Pubitemid 40341226)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.8
, pp. 6716-6720
-
-
Moskwa, P.1
Paclet, M.-H.2
Dagher, M.-C.3
Ligeti, E.4
-
18
-
-
0027984138
-
GAPs for rho-related GTPases
-
DOI 10.1016/0168-9525(94)90114-7
-
Lamarche N, Hall A. GAPs for rho-related GTPases. Trends Genet 1994;10:436-40. (Pubitemid 24352650)
-
(1994)
Trends in Genetics
, vol.10
, Issue.12
, pp. 436-440
-
-
Lamarche, N.1
Hall, A.2
-
19
-
-
33747293858
-
RhoGTPase activating proteins in cancer phenotypes
-
Kandpal RP. RhoGTPase activating proteins in cancer phenotypes. Curr Protein Pept Sci 2006;7:355-65.
-
(2006)
Curr Protein Pept Sci
, vol.7
, pp. 355-365
-
-
Kandpal, R.P.1
-
20
-
-
3042796979
-
GAP control: Regulating the regulators of small GTPases
-
DOI 10.1016/j.tcb.2004.05.003, PII S0962892404001357
-
Bernards A, Settleman J. GAP control: regulating the regulators of small GTPases. Trends Cell Biol 2004;14:377-85. (Pubitemid 38891707)
-
(2004)
Trends in Cell Biology
, vol.14
, Issue.7
, pp. 377-385
-
-
Bernards, A.1
Settleman, J.2
-
21
-
-
33846969965
-
Current knowledge of the large RhoGAP family of proteins
-
DOI 10.1042/BC20060086
-
Tcherkezian J, Lamarche-Vane N. Current knowledge of the large RhoGAP family of proteins. Biol Cell 2007;99:67-86. (Pubitemid 46242033)
-
(2007)
Biology of the Cell
, vol.99
, Issue.2
, pp. 67-86
-
-
Tcherkezian, J.1
Lamarche-Vane, N.2
-
22
-
-
68549130674
-
Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility
-
Kim TY, Vigil D, Der CJ, et al. Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility. Cancer Metastasis Rev 2009;28:77-83.
-
(2009)
Cancer Metastasis Rev
, vol.28
, pp. 77-83
-
-
Kim, T.Y.1
Vigil, D.2
Der, C.J.3
-
23
-
-
34547451763
-
Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities
-
DOI 10.1073/pnas.0703033104
-
Qian X, Li G, Asmussen HK, et al. Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities. Proc Natl Acad Sci USA 2007;104:9012-17. (Pubitemid 47175428)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.21
, pp. 9012-9017
-
-
Qian, X.1
Li, G.2
Asmussen, H.K.3
Asnaghi, L.4
Vass, W.C.5
Braverman, R.6
Yamada, K.M.7
Popescu, N.C.8
Papageorge, A.G.9
Lowy, D.R.10
-
24
-
-
34248574289
-
Solution structures, dynamics, and lipid-binding of the sterile α-motif domain of the deleted in liver cancer 2
-
DOI 10.1002/prot.21361
-
Li H, Fung KL, Jin DY, et al. Solution structures, dynamics, and lipid-binding of the sterile alpha-motif domain of the deleted in liver cancer 2. Proteins 2007;67:1154-66. (Pubitemid 46753960)
-
(2007)
Proteins: Structure, Function and Genetics
, vol.67
, Issue.4
, pp. 1154-1166
-
-
Li, H.1
Fung, K.-L.2
Jin, D.-Y.3
Chung, S.S.M.4
Ching, Y.-P.5
Ng, I.O.-L.6
Sze, K.-H.7
Ko, B.C.B.8
Sun, H.9
-
25
-
-
40149083557
-
Deleted in liver cancer-1 (DLC-1): A tumor suppressor not just for liver
-
DOI 10.1016/j.biocel.2007.04.008, PII S1357272507001215
-
Liao YC, Lo SH. Deleted in liver cancer-1 (DLC-1): a tumor suppressor not just for liver. Int J Biochem Cell Biol 2008;40:843-7. (Pubitemid 351329658)
-
(2008)
International Journal of Biochemistry and Cell Biology
, vol.40
, Issue.5
, pp. 843-847
-
-
Liao, Y.-C.1
Lo, S.H.2
-
26
-
-
34347335591
-
The NMR structure of the murine DLC2 SAM domain reveals a variant fold that is similar to a four-helix bundle
-
Kwan JJ, Donaldson LW. The NMR structure of the murine DLC2 SAM domain reveals a variant fold that is similar to a four-helix bundle. BMC Struct Biol 2007;7:34.
-
(2007)
BMC Struct Biol
, vol.7
, pp. 34
-
-
Kwan, J.J.1
Donaldson, L.W.2
-
28
-
-
0042159795
-
Analysis of DLC-1 expression in human breast cancer
-
DOI 10.1007/s00432-003-0440-z
-
Plaumann M, Seitz S, Frege R, et al. Analysis of DLC-1 expression in human breast cancer. J Cancer Res Clin Oncol 2003;129:349-54. (Pubitemid 36963197)
-
(2003)
Journal of Cancer Research and Clinical Oncology
, vol.129
, Issue.6
, pp. 349-354
-
-
Plaumann, M.1
Seitz, S.2
Frege, R.3
Estevez-Schwarz, L.4
Scherneck, S.5
-
29
-
-
22244443056
-
The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells
-
DOI 10.1158/0008-5472.CAN-04-3043
-
Goodison S, Yuan J, Sloan D, et al. The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells. Cancer Res 2005;65:6042-53. (Pubitemid 40994388)
-
(2005)
Cancer Research
, vol.65
, Issue.14
, pp. 6042-6053
-
-
Goodison, S.1
Yuan, J.2
Sloan, D.3
Kim, R.4
Li, C.5
Popescu, N.C.6
Urquidi, V.7
-
30
-
-
25444499134
-
Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma
-
DOI 10.1158/0008-5472.CAN-05-1318
-
Wong CM, Yam J, Ching YP, et al. RhoGTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma. Cancer Res 2005;65:8861-8. (Pubitemid 41377375)
-
(2005)
Cancer Research
, vol.65
, Issue.19
, pp. 8861-8868
-
-
Wong, C.-M.1
Yam, J.W.-P.2
Ching, Y.-P.3
Yau, T.-O.4
Leung, T.H.-Y.5
Jin, D.-Y.6
Ng, I.O.-L.7
-
31
-
-
35648981592
-
DLC-1: A RhoGTPaseactivating protein and tumor suppressor
-
Durkin M, Yuan BZ, Zhou X, et al. DLC-1: a RhoGTPaseactivating protein and tumor suppressor. J Cell Mol Med 2007;11:1185-207.
-
(2007)
J Cell Mol Med
, vol.11
, pp. 1185-1207
-
-
Durkin, M.1
Yuan, B.Z.2
Zhou, X.3
-
32
-
-
34447132377
-
Deleted in liver cancer 3 (DLC-3), a novel Rho GTPase-activating protein, is downregulated in cancer and inhibits tumor cell growth
-
DOI 10.1038/sj.onc.1210244, PII 1210244
-
Durkin ME, Ullmannova V, Guan M, et al. Deleted in liver cancer 3 (DLC-3), a novel RhoGTPase-activating protein, is downregulated in cancer and inhibits tumor cell growth. Oncogene 2007;26:4580-9. (Pubitemid 47037045)
-
(2007)
Oncogene
, vol.26
, Issue.31
, pp. 4580-4589
-
-
Durkin, M.E.1
Ullmannova, V.2
Guan, M.3
Popescu, N.C.4
-
33
-
-
57149120776
-
The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma
-
Salhia B, Tran NL, Chan A, et al. The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma. Am J Pathol 2008;173:1828-38.
-
(2008)
Am J Pathol
, vol.173
, pp. 1828-1838
-
-
Salhia, B.1
Tran, N.L.2
Chan, A.3
-
34
-
-
36048999562
-
START-GAP3/DLC3 is a GAP for RhoA and Cdc42 and is localized in focal adhesions regulating cell morphology
-
DOI 10.1016/j.bbrc.2007.10.052, PII S0006291X07022188
-
Kawai K, Kiyota M, Seike J, et al. START-GAP3/DLC3 is a GAP for RhoA and Cdc42 and is localized in focal adhesions regulating cell morphology. Biochem Biophys Res Commun 2007;364:783-9. (Pubitemid 350087871)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.364
, Issue.4
, pp. 783-789
-
-
Kawai, K.1
Kiyota, M.2
Seike, J.3
Deki, Y.4
Yagisawa, H.5
-
35
-
-
0037855764
-
Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma
-
Ching YP, Wong CM, Chan SF, et al. Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma. J Biol Chem 2003;278:10824-30.
-
(2003)
J Biol Chem
, vol.278
, pp. 10824-10830
-
-
Ching, Y.P.1
Wong, C.M.2
Chan, S.F.3
-
36
-
-
29344433467
-
Mitochondrial targeting of growth suppressor protein DLC2 through the START domain
-
DOI 10.1016/j.febslet.2005.11.073, PII S001457930501450X
-
Ng DC, Chan SF, Kok KH, et al. Mitochondrial targeting of growth suppressor protein DLC2 through the START domain. FEBS Lett 2006;580:191-8. (Pubitemid 43005335)
-
(2006)
FEBS Letters
, vol.580
, Issue.1
, pp. 191-198
-
-
Ng, D.C.-H.1
Chan, S.-F.2
Kok, K.H.3
Yam, J.W.P.4
Ching, Y.-P.5
Ng, I.O.-L.6
Jin, D.-Y.7
-
37
-
-
34347333532
-
Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors
-
Ullmannova V, Popescu NC. Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors. Int J Oncol 2006;29:1127-32.
-
(2006)
Int J Oncol
, vol.29
, pp. 1127-1132
-
-
Ullmannova, V.1
Popescu, N.C.2
-
38
-
-
27244455897
-
Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity
-
DOI 10.1073/pnas.0504501102
-
Leung TH, Ching YP, Yam JW, et al. Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity. Proc Natl Acad Sci USA 2005;102:15207-12. (Pubitemid 41513360)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.42
, pp. 15207-15212
-
-
Leung, T.H.-Y.1
Ching, Y.-P.2
Yam, J.W.P.3
Wong, C.-M.4
Yau, T.-O.5
Jin, D.-Y.6
Ng, I.O.-L.7
-
39
-
-
60849110252
-
START-GAP2/DLC2 is localized in focal adhesions via its N-terminal region
-
Kawai K, Seike J, Iino T, et al. START-GAP2/DLC2 is localized in focal adhesions via its N-terminal region. Biochem Biophys Res Commun 2009;380:736-41.
-
(2009)
Biochem Biophys Res Commun
, vol.380
, pp. 736-741
-
-
Kawai, K.1
Seike, J.2
Iino, T.3
-
40
-
-
48949092298
-
Underexpression of deleted in liver cancer 2 (DLC2) is associated with overexpression of RhoA and poor prognosis in hepatocellular carcinoma
-
Xiaorong L, Wei W, Liyuan Q, et al. Underexpression of deleted in liver cancer 2 (DLC2) is associated with overexpression of RhoA and poor prognosis in hepatocellular carcinoma. BMC Cancer 2008;8:205.
-
(2008)
BMC Cancer
, vol.8
, pp. 205
-
-
Xiaorong, L.1
Wei, W.2
Liyuan, Q.3
-
41
-
-
58149385676
-
Integrative genomewide analysis reveals a robust genomic glioblastoma signature associated with copy number driving changes in gene expression
-
de Tayrac M, Etcheverry A, Aubry M, et al. Integrative genomewide analysis reveals a robust genomic glioblastoma signature associated with copy number driving changes in gene expression. Genes Chromosomes Cancer 2009;48:55-68.
-
(2009)
Genes Chromosomes Cancer
, vol.48
, pp. 55-68
-
-
De Tayrac, M.1
Etcheverry, A.2
Aubry, M.3
-
42
-
-
78349241737
-
Deleted in liver cancer 2 suppresses cell growth via the regulation of the Raf-1-ERK1/2- p70S6K signalling pathway
-
Leung TH, Yam JW, Chan LK, et al. Deleted in liver cancer 2 suppresses cell growth via the regulation of the Raf-1-ERK1/2- p70S6K signalling pathway. Liver Int 2010;30:1315-23.
-
(2010)
Liver Int
, vol.30
, pp. 1315-1323
-
-
Leung, T.H.1
Yam, J.W.2
Chan, L.K.3
|