Underexpression of deleted in liver cancer 2 (DLC2) is associated with overexpression of RhoA and poor prognosis in hepatocellular carcinoma

BMC Cancer

Volumn 8, Issue , 2008, Pages

  Xiaorong, Li ^a   Wei, Wu ^a   Liyuan, Qian ^a   Kaiyan, Yang ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DELETED IN LIVER CANCER 2 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TUMOR SUPPRESSOR PROTEIN; STARD13 PROTEIN, HUMAN; TUMOR MARKER;

ADULT; AGED; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; MALE; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; WESTERN BLOTTING; BIOSYNTHESIS; CANCER STAGING; GENE EXPRESSION REGULATION; LIVER; LIVER TUMOR; METABOLISM; METASTASIS; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY;

ADULT; AGED; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASM STAGING; PROGNOSIS; RHOA GTP-BINDING PROTEIN; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

EID: 48949092298     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-8-305     Document Type: Article

References (17)

1. Akriviadis EA Llovet JM Efremidis SC Shouval D Canelo R Ringe B Meyers WC Hepatocellular carcinoma Br J Surg 1998, 85:1319-1331 9782009
2. Murray CJ Lopez AD Mortality by cause for eight regions of the world: global burden of disease study Lancet 1997, 349:1269-1276 9142060
3. Schafer DF Sorrell MF Hepatocellular carcinoma Lancet 1999, 353:1253-1256 10217098
4. Makuuchi M Takayama T Kubota K Kimura W Midorikawa Y Miyagawa S Kawasaki S Hepatic resection for hepatocellular carcinoma - Japanese experience Hepatogastroenterology 1998, 45:1267-1274 9730387
5. Fan ST Lo CM Liu CL Lam CM Yuen WK Yeung C Wong J Hepatectomy for hepatocellular carcinoma: Toward zero hospital deaths Ann Surg 1999, 229:322-330 1191696 10077043
6. Bishop AL Hall A Rho GTPases and their effector proteins Biochem J 2000, 348:241-255 1221060 10816416
7. Van Aelst L D'Souza-Schorey C Rho GTPases and signaling networks Genes Dev 1997, 11:2295-2322 9308960
8. Jaffe AB Hall A Rho GTPases in transformation and metastasis Adv Cancer Res 2002, 84:57-80 11883532
9. Kamai T Arai K Tsujii T Honda M Yoshida K Overexpression of RhoA mRNA is associated with advanced stage in testicular germ cell tumour BJU Int 2001, 87:227-231 11167647
10. Fritz G Just I Kaina B Rho GTPases are over-expressed in human tumors Int J Cancer 1999, 81:682-687 10328216
11. Kamai T Tsujii T Arai K Takagi K Asami H Ito Y Oshima H Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer Clin Cancer Res 2003, 9:2632-2641 12855641
12. Li XR Ji F Ouyang J Wu W Qian LY Yang KY Overexpression of RhoA is associated with poor prognosis in hepatocellular carcinoma Eur J Surg Oncol 2006, 32:1130-1134 16806792
13. Ching YP Wong CM Chan SF Leung TH Ng DC Jin DY Ng IO Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma J Biol Chem 2003, 278:10824-10830 12531887
14. Leung TH Ching YP Yam JW Wong CM Yau TO Jin DY Ng IO Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity Proc Natl Acad Sci USA 2005, 102:15207-15212 1250229 16217026
15. Ng DC Chan SF Kok KH Yam JW Ching YP Ng IO Jin DY Mitochondrial targeting of growth suppressor protein DLC2 through the START domain FEBS Lett 2006, 580:191-198 16364308
16. Wang W Yang LY Huang GW Lu WQ Yang ZL Yang JQ Liu HL Genomic analysis reveals RhoC as a potential marker in hepatocellular carcinoma with poor prognosis Br J Cancer 2004, 90:2349-2355 15150600
17. Ullmannova V Popescu NC Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors Int J Oncol 2006, 29:1127-1132 17016643