메뉴 건너뛰기




Volumn 30, Issue 9, 2010, Pages 1315-1323

Deleted in liver cancer 2 suppresses cell growth via the regulation of the Raf-1-ERK1/2-p70S6K signalling pathway

Author keywords

Cell growth suppression; DLC2 (deleted in liver cancer 2); Hepatocellular carcinoma; Raf 1 ERK1 2 p70S6K signalling

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; PAXILLIN; RAF PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

EID: 78349241737     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2010.02307.x     Document Type: Article
Times cited : (21)

References (31)
  • 1
    • 0037855764 scopus 로고    scopus 로고
    • Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma
    • Ching YP, Wong CM, Chan SF, et al. Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma. J Biol Chem 2003; 278: 10824-30.
    • (2003) J Biol Chem , vol.278 , pp. 10824-30
    • Ching, Y.P.1    Wong, C.M.2    Chan, S.F.3
  • 2
    • 27244455897 scopus 로고    scopus 로고
    • Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity
    • Leung TH, Ching YP, Yam JW, et al. Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity. Proc Natl Acad Sci USA 2005; 102: 15207-12.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 15207-12
    • Leung, T.H.1    Ching, Y.P.2    Yam, J.W.3
  • 3
    • 0029101360 scopus 로고
    • An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1
    • Olson MF, Ashworth A, Hall A. An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 1995; 269: 1270-2.
    • (1995) Science , vol.269 , pp. 1270-2
    • Olson, M.F.1    Ashworth, A.2    Hall, A.3
  • 4
    • 0027280575 scopus 로고
    • ADP-ribosylation of the rhoA gene product by botulinum C3 exoenzyme causes Swiss 3T3 cells to accumulate in the G1 phase of the cell cycle
    • Yamamoto M, Marui N, Sakai T, et al. ADP-ribosylation of the rhoA gene product by botulinum C3 exoenzyme causes Swiss 3T3 cells to accumulate in the G1 phase of the cell cycle. Oncogene 1993; 8: 1449-55.
    • (1993) Oncogene , vol.8 , pp. 1449-55
    • Yamamoto, M.1    Marui, N.2    Sakai, T.3
  • 6
    • 0035736485 scopus 로고    scopus 로고
    • Timing of cyclin D1 expression within G1 phase is controlled by Rho
    • Welsh CF, Roovers K, Villanueva J, et al. Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nat Cell Biol 2001; 3: 950-7.
    • (2001) Nat Cell Biol , vol.3 , pp. 950-7
    • Welsh, C.F.1    Roovers, K.2    Villanueva, J.3
  • 7
    • 0042934304 scopus 로고    scopus 로고
    • RhoA influences the nuclear localization of extracellular signal-regulated kinases to modulate p21Waf/Cip1 expression
    • Zuckerbraun BS, Shapiro RA, Billiar TR, Tzeng E. RhoA influences the nuclear localization of extracellular signal-regulated kinases to modulate p21Waf/Cip1 expression. Circulation 2003; 108: 876-81.
    • (2003) Circulation , vol.108 , pp. 876-81
    • Zuckerbraun, B.S.1    Shapiro, R.A.2    Billiar, T.R.3    Tzeng, E.4
  • 8
    • 15644378138 scopus 로고    scopus 로고
    • Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells
    • Hirai A, Nakamura S, Noguchi Y, et al. Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells. J Biol Chem 1997; 272: 13-6.
    • (1997) J Biol Chem , vol.272 , pp. 13-6
    • Hirai, A.1    Nakamura, S.2    Noguchi, Y.3
  • 9
    • 0033618378 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1)
    • Laufs U, Marra D, Node K, Liao JK. 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1). J Biol Chem 1999; 274: 21926-31.
    • (1999) J Biol Chem , vol.274 , pp. 21926-31
    • Laufs, U.1    Marra, D.2    Node, K.3    Liao, J.K.4
  • 10
    • 0032720680 scopus 로고    scopus 로고
    • MAP kinase cascade is required for p27 downregulation and S phase entry in fibroblasts and epithelial cells
    • Rivard N, Boucher MJ, Asselin C, L'Allemain G. MAP kinase cascade is required for p27 downregulation and S phase entry in fibroblasts and epithelial cells. Am J Physiol 1999; 277 (Part 1): C652-64.
    • (1999) Am J Physiol , vol.277 , Issue.PART 1
    • Rivard, N.1    Boucher, M.J.2    Asselin, C.3    L'Allemain, G.4
  • 11
    • 0031453368 scopus 로고    scopus 로고
    • Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27
    • Weber JD, Hu W, Jefcoat SCJR., et al. Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27. J Biol Chem 1997; 272: 32966-71.
    • (1997) J Biol Chem , vol.272 , pp. 32966-71
    • Weber, J.D.1    Hu, W.2    Jefcoat, S.C.J.R.3
  • 12
    • 0032984348 scopus 로고    scopus 로고
    • Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
    • Sebolt-Leopold JS, Dudley DT, Herrera R, et al. Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nat Med 1999; 5: 810-6.
    • (1999) Nat Med , vol.5 , pp. 810-6
    • Sebolt-Leopold, J.S.1    Dudley, D.T.2    Herrera, R.3
  • 13
    • 23944435911 scopus 로고    scopus 로고
    • Evaluation of extracellular signal regulated kinase expression and its relation to treatment of hepatocellular carcinoma
    • Osada S, Kanematsu M, Imai H, et al. Evaluation of extracellular signal regulated kinase expression and its relation to treatment of hepatocellular carcinoma. J Am Coll Surg 2005; 201: 405-11.
    • (2005) J Am Coll Surg , vol.201 , pp. 405-11
    • Osada, S.1    Kanematsu, M.2    Imai, H.3
  • 15
    • 34347370458 scopus 로고    scopus 로고
    • MEK/ERK-dependent uPAR expression is required for motility via phosphorylation of P70S6K in human hepatocarcinoma cells
    • Bessard A, Fremin C, Ezan F, et al. MEK/ERK-dependent uPAR expression is required for motility via phosphorylation of P70S6K in human hepatocarcinoma cells. J Cell Physiol 2007; 212: 526-36.
    • (2007) J Cell Physiol , vol.212 , pp. 526-36
    • Bessard, A.1    Fremin, C.2    Ezan, F.3
  • 16
    • 11144236505 scopus 로고    scopus 로고
    • mTOR and P70 S6 kinase expression in primary liver neoplasms
    • Sahin F, Kannangai R, Adegbola O, et al. mTOR and P70 S6 kinase expression in primary liver neoplasms. Clin Cancer Res 2004; 10: 8421-5.
    • (2004) Clin Cancer Res , vol.10 , pp. 8421-5
    • Sahin, F.1    Kannangai, R.2    Adegbola, O.3
  • 17
    • 73349090909 scopus 로고    scopus 로고
    • Rapamycin and CCI-779 inhibit the mammalian target of rapamycin signalling in hepatocellular carcinoma
    • Hui IC, Tung EK, Sze KM, et al. Rapamycin and CCI-779 inhibit the mammalian target of rapamycin signalling in hepatocellular carcinoma. Liver Int 2010; 30: 65-75.
    • (2010) Liver Int , vol.30 , pp. 65-75
    • Hui, I.C.1    Tung, E.K.2    Sze, K.M.3
  • 18
    • 4344621091 scopus 로고    scopus 로고
    • Sequential activation of RhoA and FAK/paxillin leads to ATP release and actin reorganization in human endothelium
    • Hirakawa M, Oike M, Karashima Y, Ito Y. Sequential activation of RhoA and FAK/paxillin leads to ATP release and actin reorganization in human endothelium. J Physiol 2004; 558 (Part 2): 479-88.
    • (2004) J Physiol , vol.558 , Issue.PART 2 , pp. 479-88
    • Hirakawa, M.1    Oike, M.2    Karashima, Y.3    Ito, Y.4
  • 19
    • 0029892628 scopus 로고    scopus 로고
    • Rho stimulates tyrosine phosphorylation of focal adhesion kinase, p130 and paxillin
    • Flinn HM, Ridley AJ. Rho stimulates tyrosine phosphorylation of focal adhesion kinase, p130 and paxillin. J Cell Sci 1996; 109 (Part 5): 1133-41.
    • (1996) J Cell Sci , vol.109 , Issue.PART 5 , pp. 1133-41
    • Flinn, H.M.1    Ridley, A.J.2
  • 20
    • 0034610997 scopus 로고    scopus 로고
    • Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cells
    • Petit V, Boyer B, Lentz D, et al. Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cells. J Cell Biol 2000; 148: 957-70.
    • (2000) J Cell Biol , vol.148 , pp. 957-70
    • Petit, V.1    Boyer, B.2    Lentz, D.3
  • 21
    • 0029948080 scopus 로고    scopus 로고
    • Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn
    • Cary LA, Chang JF, Guan JL. Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn. J Cell Sci 1996; 109 (Part 7): 1787-94.
    • (1996) J Cell Sci , vol.109 , Issue.PART 7 , pp. 1787-94
    • Cary, L.A.1    Chang, J.F.2    Guan, J.L.3
  • 22
    • 33847073342 scopus 로고    scopus 로고
    • DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma
    • Kim TY, Lee JW, Kim HP, et al. DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma. Biochem Biophys Res Commun 2007; 355: 72-7.
    • (2007) Biochem Biophys Res Commun , vol.355 , pp. 72-7
    • Kim, T.Y.1    Lee, J.W.2    Kim, H.P.3
  • 23
    • 0034644537 scopus 로고    scopus 로고
    • Ras and Rho GTPases
    • Cell
    • Bar-Sagi D, Hall A. Ras and Rho GTPases: a family reunion. Cell 2000; 103: 227-38.
    • (2000) a family reunion , vol.103 , pp. 227-38
    • Bar-Sagi, D.1    Hall, A.2
  • 25
    • 2942707853 scopus 로고    scopus 로고
    • Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition
    • Mammoto A, Huang S, Moore KOHP, Ingber DE. Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition. J Biol Chem 2004; 279: 26323-30.
    • (2004) J Biol Chem , vol.279 , pp. 26323-30
    • Mammoto, A.1    Huang, S.2    Moore, K.O.H.P.3    Ingber, D.E.4
  • 26
    • 0035860840 scopus 로고    scopus 로고
    • Increased expression and activity of RhoA are associated with increased DNA synthesis and reduced p27(Kip1) expression in the vasculature of hypertensive rats
    • Seasholtz TM, Zhang T, Morissette MR, et al. Increased expression and activity of RhoA are associated with increased DNA synthesis and reduced p27(Kip1) expression in the vasculature of hypertensive rats. Circ Res 2001; 89: 488-95.
    • (2001) Circ Res , vol.89 , pp. 488-95
    • Seasholtz, T.M.1    Zhang, T.2    Morissette, M.R.3
  • 27
    • 19644388719 scopus 로고    scopus 로고
    • Pharmacologic inhibition of RAF →MEK→ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1
    • Gysin S, Lee SH, Dean NM, Mcmahon M. Pharmacologic inhibition of RAF →MEK→ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1. Cancer Res 2005; 65: 4870-80.
    • (2005) Cancer Res , vol.65 , pp. 4870-80
    • Gysin, S.1    Lee, S.H.2    Dean, N.M.3    Mcmahon, M.4
  • 28
    • 0037810249 scopus 로고    scopus 로고
    • Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors
    • Leukemia
    • Chang F, Steelman LS, Lee JT, et al. Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia 2003; 17: 1263-93.
    • (2003) potential targeting for therapeutic intervention , vol.17 , pp. 1263-93
    • Chang, F.1    Steelman, L.S.2    Lee, J.T.3
  • 30
    • 0035860701 scopus 로고    scopus 로고
    • Function of the Rho family GTPases in Ras-stimulated Raf activation
    • Li W, Chong H, Guan KL. Function of the Rho family GTPases in Ras-stimulated Raf activation. J Biol Chem 2001; 276: 34728-37.
    • (2001) J Biol Chem , vol.276 , pp. 34728-37
    • Li, W.1    Chong, H.2    Guan, K.L.3
  • 31
    • 68749114021 scopus 로고    scopus 로고
    • Deleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis
    • Yau TO, Leung TH, Lam S, et al. Deleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis. PLoS One 2009; 4: e6566.
    • (2009) PLoS One , vol.4
    • Yau, T.O.1    Leung, T.H.2    Lam, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.