Creativity, innovation and lean sigma: A controversial combination?

Drug Discovery Today

Volumn 16, Issue 1-2, 2011, Pages 50-57

  Johnstone, Craig ^a   Pairaudeau, Garry ^a   Pettersson, Jonas A ^b  

^a ASTRAZENECA   (United Kingdom)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CREATIVITY; DRUG COST; DRUG DEVELOPMENT; DRUG INDUSTRY; DRUG QUALITY; DRUG RESEARCH; METHODOLOGY; ORGANIZATION; PROCESS DEVELOPMENT; QUALITY CONTROL; REVIEW; STANDARDIZATION;

EID: 78651365936     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2010.11.005     Document Type: Review

References (39)

1. S.M. Paul How to improve R&D productivity: the pharmaceutical industry's grand challenge Nat. Rev. Drug Discov. 9 2010 203 214
2. D. Cavalla, and R. Minhas Does R&D pay? Drug Discov. Today 15 2010 230 234
3. C. Hammond, and C.J. O'Donnell Lean six sigma - its application to drug discovery Drug Disc. World Spring 2008 11 18 (Pubitemid 351566179)
4. S. Andersson Making medicinal chemistry more effective - application of lean sigma to improve processes speed and quality Drug Discov. Today 14 2009 598 604
5. K. Russell Improving pharmaceutical R&D using lean sigma PharmaFocus Asia 7 2008 48 51
6. H.N. Weller Application of Lean manufacturing concepts to drug discovery: rapid analogue library synthesis J. Comb. Chem. 8 2006 664 669
7. A. Sewing Helping science to succeed: improving processes in R&D Drug Discov. Today 13 2008 227 233
8. A. Sewing Evolution in thinking and processes? Drug Discov. Today. Technol. 5 2008 e9 e14
9. T. Barnhart Lean in R&D: the surprising fit Future State Spring 2008 1 3
10. M. Allen, and M.J. Wigglesworth Innovation leading the way: application of lean manufacturing to sample management J. Biomol. Screen. 14 2009 515 522
11. F. Ullman, and R. Boutellier A case study of lean drug discovery: from project driven research to innovation studios and process factories Drug Discov. Today 13 2008 543 550
12. E.W. Petrillo Lean thinking for drug discovery - better productivity for pharma Drug Disc. World Spring 2007 9 14
13. S. Carney How can we avoid the productivity gap? Drug Discov. Today 10 2005 1011 1013 (Pubitemid 41074134)
14. S.W. Carleysmith Implementing lean sigma in pharmaceutical research and development: a review by practitioners R&D Manag. 39 2009 95 105
15. B. Hindo 3M: struggle between efficiency and creativity Business Week September 2007
16. T. Hoffmann, and C. Bishop The future of discovery chemistry: quo vadis? Academic to industrial - the maturation of medicinal chemistry to chemical biology Drug Discov. Today 15 2010 260 264
17. D. Silverstein The Innovator's Toolkit 2009 John Wiley and Sons
18. B.A. Hennessey, and T.M. Amabile Reward, intrinsic motivation, and creativity Am. Psychol. 53 1998 674 675
19. M. Sundgren, and A. Styhre Leadership as de-paradoxification, leading new drug development work at three pharmaceutical companies Leadership 2 2006 31 52
20. T.M. Amabile, and M. Khaire Creativity and the role of the leader HBR 2008 101 109
21. J. Shook How to change a culture: lessons from NUMMI MIT Sloan Manag. Rev. 51 2010 63 68
22. D. Pink Drive: The Surprising Truth About What Motivates Us 2009 Riverhead Books
23. T.M. Amabile How to kill creativity HBR 76 1998 76 87
24. E.F. Schmid, and D.A. Smith Is pharmaceutical R&D just a game of chance or can strategy make a difference? Drug Discov. Today 9 2004 18 26
25. D. Reinertsen, and L. Shaeffer Making R&D lean Res.-Technol. Manage. 48 2005 51 57
26. J.P. Kotter Leading Change 1996 Harvard Business Press
27. E.H. Schein Organizational Culture and Leadership 2004 Jossey Bass
28. S.J.F. Macdonald, and P.W. Smith Lead optimization in 12 months? True confessions of a chemistry team Drug Discov. Today 6 2001 947 953
29. P. Hines Staying Lean: Thriving Not Just Surviving 2009 Pitman Publishing
30. G. Byrne Using a lean six sigma approach to drive innovation Strategy Leadersh. 35 2007 5 10
31. F. Kofman Conscious Business: How to Build Value Through Values 2006 Sounds True
32. J.K. Liker The Toyota Way 2004 McGraw-Hill 140-148
33. P. Mudie, and A. Pirrie Services Marketing Management 2006 Butterworth-Heinemann pp. 157-159
34. Yergey, J. (2010) Merck experience of application of lean-sigma principles to DMPK workflows in support of drug discovery. 239th Amercian Chemical Society National Meeting, San Francisco, CA, Paper 304.
35. McKerrcher, D. et al. (2009) Improving design and enhancing analysis: IDEAs on hypothesis-based multidisciplinary design and analysis. 15th RSC-SCI Medicinal Chemistry Symposium, Cambridge, UK, Poster 19.
36. Sloan, L.S. (2010) Accelerating research through continuous improvement. 239th Amercian Chemical Society National Meeting, San Francisco, CA, Paper 303.
37. Savin, K.A. (2010) Lean-6-sigma and the improvement of processes in early lead generation drug discovery efforts. 239th Amercian Chemical Society National Meeting, San Francisco, CA, Paper 301.
38. Street, S. (2010) Keeping with the times - integrated strategies to improve speed and survival in drug discovery. Global Drug Discovery and Development Innovation Forum, Edinburgh, UK. Oral presentation.
39. Johnstone, C. (2009) Lean thinking in drug discovery. 10th Drug Discovery Leaders Summit, Montreux, Switzerland. Oral presentation.