메뉴 건너뛰기




Volumn 12, Issue 5, 2012, Pages 395-401

Cathepsins and pancreatic cancer: The 2012 update

Author keywords

Cathepsin; Cathepsin inhibitor; Pancreatic cancer; Protease

Indexed keywords

3 TRANS(PROPYLCARBAMOYL)OXIRANE 2 CARBONYL ISOLEUCYL PROLINE METHYL ESTER; CA 074ME; CATHEPSIN; CATHEPSIN B; CATHEPSIN B INHIBITOR; CATHEPSIN D; CATHEPSIN E; CATHEPSIN H; CATHEPSIN L; CATHEPSIN S; UNCLASSIFIED DRUG;

EID: 84873084257     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1016/j.pan.2012.07.011     Document Type: Review
Times cited : (18)

References (70)
  • 1
    • 77951709577 scopus 로고    scopus 로고
    • Preoperative/neoadjuvant therapy in pancreatic cancer: A systematic review and meta-analysis of response and resection percentages
    • Apr 20
    • Gillen S, Schuster T, Meyer Zum Büschenfelde C, Friess H, Kleeff J. Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages. PLoS Med 2010 Apr 20; 7(4): e1000267.
    • (2010) PLoS Med , vol.7 , Issue.4
    • Gillen, S.1    Schuster, T.2    Meyer Zum Büschenfelde, C.3    Friess, H.4    Kleeff, J.5
  • 3
    • 79952201671 scopus 로고    scopus 로고
    • Intraoperative radio-frequency ablation combined with 125 iodine seed implantation for unre-sectable pancreatic cancer
    • Oct 28
    • Zou YP, Li WM, Zheng F, Li F.C., Huang H., Du JD, et al Intraoperative radio-frequency ablation combined with 125 iodine seed implantation for unre-sectable pancreatic cancer. World J Gastroenterol 2010 Oct 28; 16(40): 5104-10.
    • (2010) World J Gastroenterol , vol.16 , Issue.40 , pp. 5104-5110
    • Zou, Y.P.1    Li, W.M.2    Zheng, F.3    Li, F.C.4    Huang, H.5    Du, J.D.6
  • 4
    • 69049094889 scopus 로고    scopus 로고
    • Outcome of upfront combination chemotherapy followed by chemoradiation for locally advanced pancreatic adenocarcinoma
    • Nov
    • Reni M, Cereda S, Balzano G., Passoni P, Rognone A, Zerbi A., et al Outcome of upfront combination chemotherapy followed by chemoradiation for locally advanced pancreatic adenocarcinoma. Cancer Chemother Pharmacol 2009 Nov; 64(6): 1253-9.
    • (2009) Cancer Chemother Pharmacol , vol.64 , Issue.6 , pp. 1253-1259
    • Reni, M.1    Cereda, S.2    Balzano, G.3    Passoni, P.4    Rognone, A.5    Zerbi, A.6
  • 5
    • 74649084777 scopus 로고    scopus 로고
    • A systematic review of resectability and survival after concurrent chemoradiation in primarily unresectable pancreatic cancer
    • Jan
    • Morganti AG, Massaccesi M, La Torre G, Caravatta L, Piscopo A., Tambaro R, et al A systematic review of resectability and survival after concurrent chemoradiation in primarily unresectable pancreatic cancer. Ann Surg Oncol 2010 Jan; 17(1): 194-205.
    • (2010) Ann Surg Oncol , vol.17 , Issue.1 , pp. 194-205
    • Morganti, A.G.1    Massaccesi, M.2    La Torre, G.3    Caravatta, L.4    Piscopo, A.5    Tambaro, R.6
  • 7
    • 79958177923 scopus 로고    scopus 로고
    • Targeting phosphoinositide 3-kinase pathways in pancreatic cancer-from molecular signalling to clinical trials
    • Jun
    • Falasca M, Selvaggi F, Buus R., Sulpizio S, Edling C. Targeting phosphoinositide 3-kinase pathways in pancreatic cancer-from molecular signalling to clinical trials. Anticancer Agents Med Chem 2011 Jun; 11(5): 456-63.
    • (2011) Anticancer Agents Med Chem , vol.11 , Issue.5 , pp. 456-463
    • Falasca, M.1    Selvaggi, F.2    Buus, R.3    Sulpizio, S.4    Edling, C.5
  • 8
    • 33749017931 scopus 로고    scopus 로고
    • Cysteine cathepsins: Multifunctional enzymes in cancer
    • DOI 10.1038/nrc1949, PII NRC1949
    • Mohamed MM, Sloane BF Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer 2006 Oct; 6(10): 764-75. Review. (Pubitemid 44450465)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.10 , pp. 764-775
    • Mohamed, M.M.1    Sloane, B.F.2
  • 9
    • 84873095639 scopus 로고    scopus 로고
    • Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice
    • Dec 9. Epub ahead of print
    • Gopinathan A, Denicola GM, Frese K.K., Cook N., Karreth FA, Mayerle J, et al Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice. Gut 2011 Dec 9. Epub ahead of print.
    • (2011) Gut
    • Gopinathan, A.1    Denicola, G.M.2    Frese, K.K.3    Cook, N.4    Karreth, F.A.5    Mayerle, J.6
  • 10
    • 79959665788 scopus 로고    scopus 로고
    • In vivo diagnosis of murine pancreatic intraepithelial neoplasia and early-stage pancreatic cancer by molecular imaging
    • June
    • Eser S, Messer M, Eser P., Von Werder A, Seidler B, Bajbouj M., et al In vivo diagnosis of murine pancreatic intraepithelial neoplasia and early-stage pancreatic cancer by molecular imaging. PNAS 2011 June; 108(14): 9945-50.
    • (2011) PNAS , vol.108 , Issue.14 , pp. 9945-9950
    • Eser, S.1    Messer, M.2    Eser, P.3    Von Werder, A.4    Seidler, B.5    Bajbouj, M.6
  • 11
    • 84865479170 scopus 로고    scopus 로고
    • Detection of pancreatic cancer tumours and precursor lesions by cathepsin E activity in mouse models
    • Nov 22. Epub ahead of print
    • Cruz-Monserrate Z., Abd-Elgaliel WR, Grote T., Deng D, Ji B, Arumugam T., et al Detection of pancreatic cancer tumours and precursor lesions by cathepsin E activity in mouse models. Gut 2011 Nov 22. Epub ahead of print.
    • (2011) Gut
    • Cruz-Monserrate, Z.1    Abd-Elgaliel, W.R.2    Grote, T.3    Deng, D.4    Ji, B.5    Arumugam, T.6
  • 12
    • 84860557891 scopus 로고    scopus 로고
    • Targeting cathepsins: A new glimmer of hope for pancreatic cancer therapy?
    • Jun Epub 2012 Jan 27
    • Michl P. Targeting cathepsins: a new glimmer of hope for pancreatic cancer therapy? Gut 2012 Jun; 61(6): 790-1. Epub 2012 Jan 27.
    • (2012) Gut , vol.61 , Issue.6 , pp. 790-791
    • Michl, P.1
  • 14
    • 33344457969 scopus 로고    scopus 로고
    • Cathepsin-regulated apoptosis
    • DOI 10.1007/s10495-006-3486-y
    • Chwieralski CE, Welte T, Bühling F. Cathepsin-regulated apoptosis. Apoptosis 2006 Feb; 11(2): 143-9. Review. (Pubitemid 43291015)
    • (2006) Apoptosis , vol.11 , Issue.2 , pp. 143-149
    • Chwieralski, C.E.1    Welte, T.2    Buhling, F.3
  • 15
    • 37549070672 scopus 로고    scopus 로고
    • Cysteine cathepsin proteases as pharmacological targets in cancer
    • Jan Epub 2007 Nov 26
    • Palermo C, Joyce JA Cysteine cathepsin proteases as pharmacological targets in cancer. Trends Pharmacol Sci 2008 Jan; 29(1): 22-8. Epub 2007 Nov 26.
    • (2008) Trends Pharmacol Sci , vol.29 , Issue.1 , pp. 22-28
    • Palermo, C.1    Joyce, J.A.2
  • 20
    • 78649643612 scopus 로고    scopus 로고
    • Missorting of cathepsin B into the secretory compartment of CI-MPR/IGFIIdeficient mice does not induce spontaneous trypsinogen activation but leads to enhanced trypsin activity during experimental pancreatitisewithout affecting disease severity
    • Oct
    • Meister T, Niehues R, Hahn D., Domschke W, Sendler M, Lerch M.M., et al Missorting of cathepsin B into the secretory compartment of CI-MPR/ IGFIIdeficient mice does not induce spontaneous trypsinogen activation but leads to enhanced trypsin activity during experimental pancreatitisewithout affecting disease severity. J Physiol Pharmacol 2010 Oct; 61(5): 565-75.
    • (2010) J Physiol Pharmacol , vol.61 , Issue.5 , pp. 565-575
    • Meister, T.1    Niehues, R.2    Hahn, D.3    Domschke, W.4    Sendler, M.5    Lerch, M.M.6
  • 22
    • 2342551977 scopus 로고    scopus 로고
    • Cysteine cathepsins (proteases) - On the main stage of cancer?
    • DOI 10.1016/S1535-6108(04)00117-5, PII S1535610804001175
    • Turk V, Kos J, Turk B. Cysteine cathepsins (proteases)eon the main stage of cancer? Cancer Cell. 2004 May; 5(5): 409-10. (Pubitemid 38610242)
    • (2004) Cancer Cell , vol.5 , Issue.5 , pp. 409-410
    • Turk, V.1    Kos, J.2    Turk, B.3
  • 23
    • 65249111669 scopus 로고    scopus 로고
    • Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms
    • May Epub 2009 Feb 6
    • Dudeja V, Mujumdar N, Phillips P., Chugh R, Borja-Cacho D, Dawra RK, et al Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms. Gastroenterology 2009 May; 136(5): 1772-82. Epub 2009 Feb 6.
    • (2009) Gastroenterology , vol.136 , Issue.5 , pp. 1772-1782
    • Dudeja, V.1    Mujumdar, N.2    Phillips, P.3    Chugh, R.4    Borja-Cacho, D.5    Dawra, R.K.6
  • 24
    • 0038215389 scopus 로고    scopus 로고
    • Pericellular cathepsin B and malignant progression
    • DOI 10.1023/A:1023007717757
    • Roshy S, Sloane BF, Moin K. Pericellular cathepsin B and malignant progression. Cancer Metastasis Rev 2003 Jun-Sep; 22(2-3): 271-86. Review. (Pubitemid 36561062)
    • (2003) Cancer and Metastasis Reviews , vol.22 , Issue.2-3 , pp. 271-286
    • Roshy, S.1    Sloane, B.F.2    Moin, K.3
  • 26
    • 0028618307 scopus 로고
    • Pericellular pH affects distribution and secretion of cathepsin B in malignant cells
    • Dec 15
    • Rozhin J, Sameni M, Ziegler G., Sloane BF Pericellular pH affects distribution and secretion of cathepsin B in malignant cells. Cancer Res 1994 Dec 15; 54(24): 6517-25.
    • (1994) Cancer Res , vol.54 , Issue.24 , pp. 6517-6525
    • Rozhin, J.1    Sameni, M.2    Ziegler, G.3    Sloane, B.F.4
  • 27
    • 77955964441 scopus 로고    scopus 로고
    • Deletion of cathepsin H perturbs angiogenicswitching, vascularizationandgrowthoftumorsinamouse model of pancreatic islet cell cancer
    • Aug
    • Gocheva V, Chen X, Peters C., Reinheckel T, Joyce JA Deletion of cathepsin H perturbs angiogenicswitching, vascularizationandgrowthoftumorsinamouse model of pancreatic islet cell cancer. Biol Chem 2010 Aug; 391(8): 937-45.
    • (2010) Biol Chem , vol.391 , Issue.8 , pp. 937-945
    • Gocheva, V.1    Chen, X.2    Peters, C.3    Reinheckel, T.4    Joyce, J.A.5
  • 28
    • 0027955103 scopus 로고
    • Pancreatic trypsinogen and cathepsin B in human pancreatic carcinomas and associated metastatic lesions
    • Ohta T, Terada T, Nagakawa T., Tajima H, Itoh H, Fonseca L., et al Pancreatic trypsinogen and cathepsin B in human pancreatic carcinomas and associated metastatic lesions. Br J Cancer 1994 Jan; 69(1): 152-6. (Pubitemid 24021839)
    • (1994) British Journal of Cancer , vol.69 , Issue.1 , pp. 152-156
    • Ohta, T.1    Terada, T.2    Nagakawa, T.3    Tajima, H.4    Itoh, H.5    Fonseca, L.6    Miyazaki, I.7
  • 30
    • 4644236863 scopus 로고    scopus 로고
    • Prognostic impact of cysteine proteases cathepsin B and cathepsin L in pancreatic adenocarcinoma
    • DOI 10.1097/00006676-200410000-00005
    • Niedergethmann M, Wostbrock B, Sturm J.W., Willeke F., Post S, Hildenbrand R. Prognostic impact of cysteine proteases cathepsin B and cathepsin L in pancreatic adenocarcinoma. Pancreas 2004 Oct; 29(3): 204-11. (Pubitemid 39304977)
    • (2004) Pancreas , vol.29 , Issue.3 , pp. 204-211
    • Niedergethmann, M.1    Wostbrock, B.2    Sturm, J.W.3    Willeke, F.4    Post, S.5    Hildenbrand, R.6
  • 31
    • 0033748329 scopus 로고    scopus 로고
    • Angiogenesis and cathepsin expression are prognostic factors in pancreatic adenocarcinoma after curative resection
    • Aug
    • Niedergethmann M, Hildenbrand R, Wolf G., Werbeke CS, Richter A, Post S. Angiogenesis and cathepsin expression are prognostic factors in pancreatic adenocarcinoma after curative resection. Int J Pancreatol 2000 Aug; 28(1): 31-9.
    • (2000) Int J Pancreatol , vol.28 , Issue.1 , pp. 31-39
    • Niedergethmann, M.1    Hildenbrand, R.2    Wolf, G.3    Werbeke, C.S.4    Richter, A.5    Post, S.6
  • 32
    • 0034719070 scopus 로고    scopus 로고
    • Cystatin C and cathepsin B in CSF from patients with inflammatory neurologic diseases
    • Nagai A, Murakawa Y, Terashima M., Shimode K, Umegae N, Takeuchi H., et al Cystatin C and cathepsin B in CSF from patients with inflammatory neurologic diseases. Neurology 2000 Dec 26; 55(12): 1828-32. (Pubitemid 32103964)
    • (2000) Neurology , vol.55 , Issue.12 , pp. 1828-1832
    • Nagai, A.1    Murakawa, Y.2    Terashima, M.3    Shimode, K.4    Umegae, N.5    Takeuchi, H.6    Kobayashi, S.7
  • 33
    • 1842538729 scopus 로고    scopus 로고
    • Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis
    • DOI 10.1038/sj.onc.1207338
    • Yanamandra N, Gumidyala KV, Waldron K.G., Gujrati M., Olivero WC, Dinh DH, et al Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis. Oncogene 2004 Mar 18; 23(12): 2224-30. (Pubitemid 38482537)
    • (2004) Oncogene , vol.23 , Issue.12 , pp. 2224-2230
    • Yanamandra, N.1    Gumidyala, K.V.2    Waldron, K.G.3    Gujrati, M.4    Olivero, W.C.5    Dinh, D.H.6    Rao, J.S.7    Mohanam, S.8
  • 34
    • 0033406453 scopus 로고    scopus 로고
    • Inhibitory effects of antisense cathepsin B cDNA transfection on invasion and motility in a human osteosarcoma cell line
    • Krueger S, Haeckel C, Buehling F., Roessner A. Inhibitory effects of antisense cathepsin B cDNA transfection on invasion and motility in a human osteosarcoma cell line. Cancer Res 1999 Dec 1; 59(23): 6010-4. (Pubitemid 30004966)
    • (1999) Cancer Research , vol.59 , Issue.23 , pp. 6010-6014
    • Krueger, S.1    Haeckel, C.2    Buehling, F.3    Roessner, A.4
  • 35
    • 15744371624 scopus 로고    scopus 로고
    • Bone microenvironment modulates expression and activity of cathepsin B in prostate cancer
    • DOI 10.1593/neo.04349
    • Podgorski I, Linebaugh BE, Sameni M, Jedeszko C., Bhagat S, Cher ML, et al Bone microenvironment modulates expression and activity of cathepsin B in prostate cancer. Neoplasia 2005 Mar; 7(3): 207-23. (Pubitemid 40411633)
    • (2005) Neoplasia , vol.7 , Issue.3 , pp. 207-223
    • Podgorski, I.1    Linebaugh, B.E.2    Sameni, M.3    Jedeszko, C.4    Bhagat, S.5    Cher, M.L.6    Sloane, B.F.7
  • 36
    • 0030667637 scopus 로고    scopus 로고
    • Influence of 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) on the localization of cathepsin B and cathepsin L in human lung tumor cells
    • Ulbricht B, Henny H, Horstmann H., Spring H, Faigle W, Spiess E. Influence of 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) on the localization of cathepsin B and cathepsin L in human lung tumor cells. Eur J Cell Biol 1997 Nov; 74(3): 294-301. (Pubitemid 27490221)
    • (1997) European Journal of Cell Biology , vol.74 , Issue.3 , pp. 294-301
    • Ulbricht, B.1    Henny, H.2    Horstmann, H.3    Spring, H.4    Faigle, W.5    Spiess, E.6
  • 37
    • 14944345444 scopus 로고    scopus 로고
    • Sp1 regulates cathepsin B transcription and invasiveness in murine B16 melanoma cells
    • Szpaderska AM, Silberman S, Ahmed Y., Frankfater A. Sp1 regulates cathepsin B transcription and invasiveness in murine B16 melanoma cells. Anticancer Res 2004 Nov-Dec;24(6): 3887-91. (Pubitemid 40468681)
    • (2004) Anticancer Research , vol.24 , Issue.6 , pp. 3887-3891
    • Szpaderska, A.M.1    Silberman, S.2    Ahmed, Y.3    Frankfater, A.4
  • 38
    • 0029007093 scopus 로고
    • Pericellular mobilization of the tissuedestructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophages
    • Apr 25
    • Reddy VY, Zhang QY, Weiss SJ Pericellular mobilization of the tissuedestructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophages. Proc Natl Acad Sci U S A 1995 Apr 25; 92(9): 3849-53.
    • (1995) Proc Natl Acad Sci u S A , vol.92 , Issue.9 , pp. 3849-3853
    • Reddy, V.Y.1    Zhang, Q.Y.2    Weiss, S.J.3
  • 41
    • 34548130842 scopus 로고    scopus 로고
    • Cathepsin B gene polymorphism Val26 is not associated with idiopathic chronic pancreatitis in European patients [4]
    • DOI 10.1136/gut.2007.122507
    • Weiss FU, Behn CO, Simon P, Ruthenbürger M, Halangk W., Lerch MM Cathepsin B gene polymorphism Val26 is not associated with idiopathic chronic pancreatitis in European patients. Gut 2007 Sep; 56(9): 1322-3. No abstract available. (Pubitemid 47300439)
    • (2007) Gut , vol.56 , Issue.9 , pp. 1322-1323
    • Weiss, F.U.1    Behn, C.-O.2    Simon, P.3    Ruthenburger, M.4    Halangk, W.5    Lerch, M.M.6
  • 42
    • 33747773624 scopus 로고    scopus 로고
    • Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis
    • DOI 10.1136/gut.2005.087403
    • Mahurkar S, Idris MM, Reddy D.N., Bhaskar S., Rao GV, Thomas V, et al Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis. Gut 2006 Sep; 55(9): 1270-5. Epub 2006 Feb 21. (Pubitemid 44304037)
    • (2006) Gut , vol.55 , Issue.9 , pp. 1270-1275
    • Mahurkar, S.1    Idris, M.M.2    Reddy, D.N.3    Bhaskar, S.4    Rao, G.V.5    Thomas, V.6    Singh, L.7    Chandak, G.R.8
  • 43
    • 0028855066 scopus 로고
    • Intracellular degradation of the C-peptide of proinsulin, in human insulinoma: Identification of sides of cleavage and evidence for the role of cathepsin B
    • Mar
    • Conlon JM, Höög A, Grimelius L. Intracellular degradation of the C-peptide of proinsulin, in human insulinoma: identification of sides of cleavage and evidence for the role of cathepsin B. Pancreas 1995 Mar; 10(2): 167-72.
    • (1995) Pancreas , vol.10 , Issue.2 , pp. 167-172
    • Conlon, J.M.1    Höög, A.2    Grimelius, L.3
  • 44
    • 0024306927 scopus 로고
    • Immunocytochemical localization of cathepsins B and H in human pancreatic endocrine cells and insulinoma cells
    • DOI 10.1007/BF00315963
    • Im B, Kominami E, Grube D., Uchiyama Y. Immunocytochemical localization of cathepsins B and H in human pancreatic endocrine cells and insulinoma cells. Histochemistry 1989; 93(2): 111-8. (Pubitemid 20001176)
    • (1989) Histochemistry , vol.93 , Issue.2 , pp. 111-118
    • Im, B.1    Kominami, E.2    Grube, D.3    Uchiyama, Y.4
  • 45
    • 70449334456 scopus 로고    scopus 로고
    • Preliminary research on the pathological role of cathepsin-B in subcutaneous heteroplastic pancreatic carcinoma in nude mice
    • Oct 20
    • Zhang C, Sun JB, Liu D.C., Cui YQ, Liu S, Sun HC Preliminary research on the pathological role of cathepsin-B in subcutaneous heteroplastic pancreatic carcinoma in nude mice. Chin Med J (Engl) 2009 Oct 20; 122(20): 2489-96.
    • (2009) Chin Med J (Engl) , vol.122 , Issue.20 , pp. 2489-2496
    • Zhang, C.1    Sun, J.B.2    Liu, D.C.3    Cui, Y.Q.4    Liu, S.5    Sun, H.C.6
  • 46
    • 15544384612 scopus 로고    scopus 로고
    • Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells
    • Feb Review
    • Nomura T, Katunuma N. Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells. J Med Invest 2005 Feb; 52(1-2): 1-9. Review.
    • (2005) J Med Invest , vol.52 , Issue.1-2 , pp. 1-9
    • Nomura, T.1    Katunuma, N.2
  • 47
    • 2442476459 scopus 로고    scopus 로고
    • Lysosomes in cell death
    • DOI 10.1038/sj.onc.1207512
    • Guicciardi ME, Leist M, Gores GJ Lysosomes in cell death. Oncogene 2004; 23: 2881-90. (Pubitemid 38638850)
    • (2004) Oncogene , vol.23 , Issue.REV. ISS. 2 , pp. 2881-2890
    • Guicciardi, M.E.1    Leist, M.2    Gores, G.J.3
  • 49
    • 10844252383 scopus 로고    scopus 로고
    • Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry
    • DOI 10.1158/0008-5472.CAN-04-3262
    • Shen J, Person MD, Zhu J, Abbruzzese J.L., Li D. Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry. Cancer Res 2004 Dec 15; 64(24): 9018-26. (Pubitemid 39665512)
    • (2004) Cancer Research , vol.64 , Issue.24 , pp. 9018-9026
    • Shen, J.1    Person, M.D.2    Zhu, J.3    Abbruzzese, J.L.4    Li, D.5
  • 52
    • 0033669914 scopus 로고    scopus 로고
    • Clinical significance of cathepsin E in pancreatic juice in the diagnosis of pancreatic ductal adenocarcinoma
    • Nov
    • Uno K, Azuma T, Nakajima M., Yasuda K, Hayakumo T, Mukai H., et al Clinical significance of cathepsin E in pancreatic juice in the diagnosis of pancreatic ductal adenocarcinoma. Gastroenterol Hepatol 2000 Nov; 15(11): 1333-8.
    • (2000) Gastroenterol Hepatol , vol.15 , Issue.11 , pp. 1333-1338
    • Uno, K.1    Azuma, T.2    Nakajima, M.3    Yasuda, K.4    Hayakumo, T.5    Mukai, H.6
  • 53
    • 10944255781 scopus 로고    scopus 로고
    • Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays
    • DOI 10.1038/sj.onc.1208117
    • Fukushima N, Sato N, Prasad N., Leach SD, Hruban RH, Goggins M. Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays. Oncogene 2004; 23: 9042-51. (Pubitemid 40013071)
    • (2004) Oncogene , vol.23 , Issue.56 , pp. 9042-9051
    • Fukushima, N.1    Sato, N.2    Prasad, N.3    Leach, S.D.4    Hruban, R.H.5    Goggins, M.6
  • 54
    • 0029882779 scopus 로고    scopus 로고
    • Isolation of tissue-type plasminogen activator, cathepsin H, and non-specific cross-reacting antigen from SK-PC-1 pancreas cancer cells using subtractive hybridization
    • DOI 10.1016/0014-5793(96)00352-3
    • Paciucci R, Berrozpe G, Torà M, Navarro E, Garcia de Herreros A, Real FX. Isolation of tissue-type plasminogen activator, cathepsin H, and non-specific cross-reacting antigen from SK-PC-1 pancreas cancer cells using substrate hybridization. FEBS Lett 1996 Apr 29; 385(1-2): 72-6. (Pubitemid 26155086)
    • (1996) FEBS Letters , vol.385 , Issue.1-2 , pp. 72-76
    • Paciucci, R.1    Berrozpe, G.2    Tora, M.3    Navarro, E.4    De Herreros, A.G.5    Real, F.X.6
  • 55
    • 0034015358 scopus 로고    scopus 로고
    • Alterations in cathepsin H activity and protein patterns in human colorectal carcinomas
    • del Re E.C., Shuja S, Cai J., Murnane MJ Alterations in cathepsin H activity and protein patterns in human colorectal carcinomas. Br J Cancer 2000 Apr; 82(7): 1317-26. (Pubitemid 30145352)
    • (2000) British Journal of Cancer , vol.82 , Issue.7 , pp. 1317-1326
    • Del Re, E.C.1    Shuja, S.2    Cai, J.3    Murnane, M.J.4
  • 56
    • 0037192819 scopus 로고    scopus 로고
    • Analysis of a truncated form of cathepsin H in human prostate tumor cells
    • DOI 10.1074/jbc.M109557200
    • Waghray A, Keppler D, Sloane B.F., Schuger L., Chen YQ Analysis of a truncated form of cathepsin H in human prostate tumor cells. Biol Chem 2002 Mar 29; 277(13): 11533-8. Epub 2002 Jan 16. (Pubitemid 34952924)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.13 , pp. 11533-11538
    • Waghray, A.1    Keppler, D.2    Sloane, B.F.3    Schuger, L.4    Chen, Y.Q.5
  • 57
    • 75149137394 scopus 로고    scopus 로고
    • Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice
    • Feb Epub 2009 Nov 10
    • Wartmann T, Mayerle J, Kähne T, Sahin-Tóth M, Ruthenbürger M, Matthias R, et al. Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice. Gastroenterology 2010 Feb; 138(2): 726-37. Epub 2009 Nov 10.
    • (2010) Gastroenterology , vol.138 , Issue.2 , pp. 726-737
    • Wartmann, T.1    Mayerle, J.2    Kähne, T.3    Sahin-Tóth, M.4    Ruthenbürger, M.5    Matthias, R.6
  • 58
    • 34548689404 scopus 로고    scopus 로고
    • Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation
    • DOI 10.1158/1541-7786.MCR-07-0160
    • Goulet B, Sansregret L, Leduy L., Bogyo M, Weber E, Chauhan S.S., et al Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation. Mol Cancer Res 2007 Sep; 5(9): 899-907. (Pubitemid 47416667)
    • (2007) Molecular Cancer Research , vol.5 , Issue.9 , pp. 899-907
    • Goulet, B.1    Sansregret, L.2    Leduy, L.3    Bogyo, M.4    Weber, E.5    Chauhan, S.S.6    Nepveu, A.7
  • 60
    • 83355164482 scopus 로고    scopus 로고
    • Antibody targeting of cathepsin S induces antibody-dependent cellular cytotoxicity
    • Dec
    • Kwok HF, Buick RJ, Kuehn D, Gormley J.A., Doherty D., Jaquin TJ, et al Antibody targeting of cathepsin S induces antibody-dependent cellular cytotoxicity. Mol Cancer 2011 Dec; 10(14): 147.
    • (2011) Mol Cancer , vol.10 , Issue.14 , pp. 147
    • Kwok, H.F.1    Buick, R.J.2    Kuehn, D.3    Gormley, J.A.4    Doherty, D.5    Jaquin, T.J.6
  • 61
    • 34547640302 scopus 로고    scopus 로고
    • Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer
    • DOI 10.1158/0008-5472.CAN-07-0602
    • Bell-McGuinn K.M., Garfall AL, Bogyo M, Hanahan D., Joyce JA Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer. Cancer Res 2007 Aug; 67(15): 7378-85. (Pubitemid 47206568)
    • (2007) Cancer Research , vol.67 , Issue.15 , pp. 7378-7385
    • Bell-McGuinn, K.M.1    Garfall, A.L.2    Bogyo, M.3    Hanahan, D.4    Joyce, J.A.5
  • 62
  • 63
    • 49749117101 scopus 로고    scopus 로고
    • Over-expression of cysteine proteinase inhibitor cystatin 6 promotes pancreatic cancer growth
    • Aug
    • Hosokawa M, Kashiwaya K, Eguchi H., Ohigashi H, Ishikawa O, Furihata M., et al Over-expression of cysteine proteinase inhibitor cystatin 6 promotes pancreatic cancer growth. Cancer Sci 2008 Aug; 99(8): 1626-32.
    • (2008) Cancer Sci , vol.99 , Issue.8 , pp. 1626-1632
    • Hosokawa, M.1    Kashiwaya, K.2    Eguchi, H.3    Ohigashi, H.4    Ishikawa, O.5    Furihata, M.6
  • 64
    • 0023899398 scopus 로고
    • Immunocytochemical localization of cathepsins B, H and their endogenous inhibitor, cystatin beta, in islet endocrine cells of rat pancreas
    • Jun
    • Watanabe M, Watanabe T, Ishii Y., Matsuba H, Kimura S, Fujita T., et al Immunocytochemical localization of cathepsins B, H and their endogenous inhibitor, cystatin beta, in islet endocrine cells of rat pancreas. J Histochem Cytochem 1988 Jun; 36(7): 783-91.
    • (1988) J Histochem Cytochem , vol.36 , Issue.7 , pp. 783-791
    • Watanabe, M.1    Watanabe, T.2    Ishii, Y.3    Matsuba, H.4    Kimura, S.5    Fujita, T.6
  • 65
    • 78149358974 scopus 로고    scopus 로고
    • Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model
    • Nov Epub 2010 May 4
    • Elie BT, Gocheva V, Shree T., Dalrymple SA, Holsinger LJ, Joyce JA Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model. Biochimie 2010 Nov; 92(11): 1618-24. Epub 2010 May 4.
    • (2010) Biochimie , vol.92 , Issue.11 , pp. 1618-1624
    • Elie, B.T.1    Gocheva, V.2    Shree, T.3    Dalrymple, S.A.4    Holsinger, L.J.5    Joyce, J.A.6
  • 66
    • 80051471238 scopus 로고    scopus 로고
    • Cathepsin K: Its skeletal actions and role as a therapeutic target in osteoporosis
    • Jun 14
    • Costa AG, Cusano NE, Silva B.C., Cremers S., Bilezikian JP Cathepsin K: its skeletal actions and role as a therapeutic target in osteoporosis. Nat Rev Rheumatol 2011 Jun 14; 7(8): 447-56.
    • (2011) Nat Rev Rheumatol , vol.7 , Issue.8 , pp. 447-456
    • Costa, A.G.1    Cusano, N.E.2    Silva, B.C.3    Cremers, S.4    Bilezikian, J.P.5
  • 67
    • 67649628133 scopus 로고    scopus 로고
    • Cathepsin K inhibitors for osteoporosis and potential off-target effects
    • May
    • Brömme D., Lecaille F. Cathepsin K inhibitors for osteoporosis and potential off-target effects. Expert Opin Investig Drugs 2009 May; 18(5): 585-600.
    • (2009) Expert Opin Investig Drugs , vol.18 , Issue.5 , pp. 585-600
    • Brömme, D.1    Lecaille, F.2
  • 69
    • 79952278967 scopus 로고    scopus 로고
    • The cathepsin K inhibitor odanacatib suppresses bone resorption in women with breast cancer and established bone metastases: Results of a 4-week, double-blind, randomized, controlled trial
    • Dec 1
    • Jensen AB, Wynne C, Ramirez G., He W, Song Y, Berd Y., et al The cathepsin K inhibitor odanacatib suppresses bone resorption in women with breast cancer and established bone metastases: results of a 4-week, double-blind, randomized, controlled trial. Clin Breast Cancer 2010 Dec 1; 10(6): 452-8.
    • (2010) Clin Breast Cancer , vol.10 , Issue.6 , pp. 452-458
    • Jensen, A.B.1    Wynne, C.2    Ramirez, G.3    He, W.4    Song, Y.5    Berd, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.