메뉴 건너뛰기




Volumn 33, Issue 4, 2013, Pages 273-280

Simultaneous Determination of Sulfation and Glucuronidation of Flavones in FVB Mouse Intestine in Vitro and in Vivo

Author keywords

Flavones; Glucuronidation; Intestinal perfusion; S9 fraction; Sulfation

Indexed keywords

5,6 DIHYDROXYFLAVONE; 6 HYDROXYFLAVONE; 6,7 DIHYDROXYFLAVONE; 7 HYDROXYFLAVONE; BAICALEIN; CHRYSIN; FLAVONE DERIVATIVE; GLUCURONOSYLTRANSFERASE; HYDROXYL GROUP; PRIMULETIN; SULFOTRANSFERASE; UNCLASSIFIED DRUG;

EID: 84873078072     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1737     Document Type: Article
Times cited : (8)

References (25)
  • 1
    • 0141751872 scopus 로고    scopus 로고
    • Introduction to the proceedings of the Third International Scientific Symposium on Tea and Human Health: Role of Flavonoids in the Diet
    • Blumberg J. 2003. Introduction to the proceedings of the Third International Scientific Symposium on Tea and Human Health: Role of Flavonoids in the Diet. J. Nutr. 133: 3244S-3246S.
    • (2003) J. Nutr. , vol.133
    • Blumberg, J.1
  • 3
    • 0037371414 scopus 로고    scopus 로고
    • Metabolism of flavonoids via enteric recycling: role of intestinal disposition
    • Chen J, Lin H, Hu M. 2003. Metabolism of flavonoids via enteric recycling: role of intestinal disposition. J. Pharmacol. Exp. Ther. 304: 1228-1235.
    • (2003) J. Pharmacol. Exp. Ther. , vol.304 , pp. 1228-1235
    • Chen, J.1    Lin, H.2    Hu, M.3
  • 4
    • 49549089988 scopus 로고    scopus 로고
    • Intestinal absorption mechanisms of prenylated flavonoids present in the heat-processed Epimedium koreanum Nakai (Yin Yanghuo)
    • Chen Y, Zhao YH, Jia XB, Hu M. 2008. Intestinal absorption mechanisms of prenylated flavonoids present in the heat-processed Epimedium koreanum Nakai (Yin Yanghuo). Pharm. Res. 25: 2190-2199.
    • (2008) Pharm. Res. , vol.25 , pp. 2190-2199
    • Chen, Y.1    Zhao, Y.H.2    Jia, X.B.3    Hu, M.4
  • 5
    • 10344232459 scopus 로고    scopus 로고
    • Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix
    • Chi YS, Kim HP. 2005. Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix. Prostaglandins Leukot. Essent. Fatty Acids 72: 59-66.
    • (2005) Prostaglandins Leukot. Essent. Fatty Acids , vol.72 , pp. 59-66
    • Chi, Y.S.1    Kim, H.P.2
  • 6
    • 0033622054 scopus 로고    scopus 로고
    • Induction of UDP-glucuronosyltransferase by the flavonoids chrysin and quercetin in Caco-2 cells
    • Galijatovic A, Walle UK, Walle T. 2000. Induction of UDP-glucuronosyltransferase by the flavonoids chrysin and quercetin in Caco-2 cells. Pharm. Res. 17: 21-26.
    • (2000) Pharm. Res. , vol.17 , pp. 21-26
    • Galijatovic, A.1    Walle, U.K.2    Walle, T.3
  • 7
    • 0023924860 scopus 로고
    • Membrane permeability parameters for some amino acids and beta-lactam antibiotics: application of the boundary layer approach
    • Hu M, Sinko PJ, deMeere AL, Johnson DA, Amidon GL. 1988. Membrane permeability parameters for some amino acids and beta-lactam antibiotics: application of the boundary layer approach. J. Theor. Biol. 131: 107-114.
    • (1988) J. Theor. Biol. , vol.131 , pp. 107-114
    • Hu, M.1    Sinko, P.J.2    deMeere, A.L.3    Johnson, D.A.4    Amidon, G.L.5
  • 8
    • 0031849072 scopus 로고    scopus 로고
    • Determination of absorption characteristics of AG337, a novel thymidylate synthase inhibitor, using a perfused rat intestinal model
    • Hu M, Roland K, Ge L, Chen J, Li Y, Tyle P, Roy S. 1998. Determination of absorption characteristics of AG337, a novel thymidylate synthase inhibitor, using a perfused rat intestinal model. J. Pharm. Sci. 87: 886-890.
    • (1998) J. Pharm. Sci. , vol.87 , pp. 886-890
    • Hu, M.1    Roland, K.2    Ge, L.3    Chen, J.4    Li, Y.5    Tyle, P.6    Roy, S.7
  • 9
    • 0141742373 scopus 로고    scopus 로고
    • Metabolism of flavonoids via enteric recycling: mechanistic studies of disposition of apigenin in the Caco-2 cell culture model
    • Hu M, Chen J, Lin H. 2003. Metabolism of flavonoids via enteric recycling: mechanistic studies of disposition of apigenin in the Caco-2 cell culture model. J. Pharmacol. Exp. Ther. 307: 314-321.
    • (2003) J. Pharmacol. Exp. Ther. , vol.307 , pp. 314-321
    • Hu, M.1    Chen, J.2    Lin, H.3
  • 10
    • 3042681890 scopus 로고    scopus 로고
    • Disposition mechanisms of raloxifene in the human intestinal Caco-2 model
    • Jeong EJ, Lin H, Hu M. 2004. Disposition mechanisms of raloxifene in the human intestinal Caco-2 model. J. Pharmacol. Exp. Ther. 310: 376-385.
    • (2004) J. Pharmacol. Exp. Ther. , vol.310 , pp. 376-385
    • Jeong, E.J.1    Lin, H.2    Hu, M.3
  • 11
    • 23944497110 scopus 로고    scopus 로고
    • Disposition of formononetin via enteric recycling: metabolism and excretion in mouse intestinal perfusion and Caco-2 cell models
    • Jeong EJ, Jia X, Hu M. 2005. Disposition of formononetin via enteric recycling: metabolism and excretion in mouse intestinal perfusion and Caco-2 cell models. Mol. Pharm. 2: 319-328.
    • (2005) Mol. Pharm. , vol.2 , pp. 319-328
    • Jeong, E.J.1    Jia, X.2    Hu, M.3
  • 12
    • 4243139494 scopus 로고    scopus 로고
    • Disposition of flavonoids via enteric recycling: enzyme-transporter coupling affects metabolism of biochanin A and formononetin and excretion of their phase II conjugates
    • Jia X, Chen J, Lin H, Hu M. 2004. Disposition of flavonoids via enteric recycling: enzyme-transporter coupling affects metabolism of biochanin A and formononetin and excretion of their phase II conjugates. J. Pharmacol. Exp. Ther. 310: 1103-1113.
    • (2004) J. Pharmacol. Exp. Ther. , vol.310 , pp. 1103-1113
    • Jia, X.1    Chen, J.2    Lin, H.3    Hu, M.4
  • 13
    • 37549032699 scopus 로고    scopus 로고
    • Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms
    • Joseph TB, Wang SW, Liu X, Kulkarni KH, Wang J, Xu H, Hu M. 2007. Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms. Mol. Pharm. 4: 883-894.
    • (2007) Mol. Pharm. , vol.4 , pp. 883-894
    • Joseph, T.B.1    Wang, S.W.2    Liu, X.3    Kulkarni, K.H.4    Wang, J.5    Xu, H.6    Hu, M.7
  • 14
    • 7544251780 scopus 로고    scopus 로고
    • Sulfonation in pharmacology and toxicology
    • Kauffman FC. 2004. Sulfonation in pharmacology and toxicology. Drug Metab. Rev. 36: 823-843.
    • (2004) Drug Metab. Rev. , vol.36 , pp. 823-843
    • Kauffman, F.C.1
  • 15
    • 0036201358 scopus 로고    scopus 로고
    • Absorption and metabolism of flavonoids in the caco-2 cell culture model and a perused rat intestinal model
    • Liu Y, Hu M. 2002. Absorption and metabolism of flavonoids in the caco-2 cell culture model and a perused rat intestinal model. Drug Metab. Dispos. 30: 370-377.
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 370-377
    • Liu, Y.1    Hu, M.2
  • 16
    • 37549010675 scopus 로고    scopus 로고
    • Disposition of flavonoids via enteric recycling: determination of the UDP-glucuronosyltransferase isoforms responsible for the metabolism of flavonoids in intact Caco-2 TC7 cells using siRNA
    • Liu X, Tam VH, Hu M. 2007. Disposition of flavonoids via enteric recycling: determination of the UDP-glucuronosyltransferase isoforms responsible for the metabolism of flavonoids in intact Caco-2 TC7 cells using siRNA. Mol. Pharm. 4: 873-882.
    • (2007) Mol. Pharm. , vol.4 , pp. 873-882
    • Liu, X.1    Tam, V.H.2    Hu, M.3
  • 18
    • 77956261020 scopus 로고    scopus 로고
    • Identification of the position of mono-O-glucuronide of flavones and flavonols by analyzing shift in online UV spectrum (lambdamax) generated from an online diode array detector
    • Singh R, Wu B, Tang L, Liu Z, Hu M. 2010. Identification of the position of mono-O-glucuronide of flavones and flavonols by analyzing shift in online UV spectrum (lambdamax) generated from an online diode array detector. J. Agric. Food Chem. 58: 9384-9395.
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 9384-9395
    • Singh, R.1    Wu, B.2    Tang, L.3    Liu, Z.4    Hu, M.5
  • 19
    • 70350049066 scopus 로고    scopus 로고
    • Structure and concentration changes affect characterization of UGT isoform-specific metabolism of isoflavones
    • Tang L, Singh R, Liu Z, Hu M. 2009. Structure and concentration changes affect characterization of UGT isoform-specific metabolism of isoflavones. Mol. Pharm. 6: 1466-1482.
    • (2009) Mol. Pharm. , vol.6 , pp. 1466-1482
    • Tang, L.1    Singh, R.2    Liu, Z.3    Hu, M.4
  • 20
    • 77953245569 scopus 로고    scopus 로고
    • Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes
    • Tang L, Ye L, Singh R, Wu B, Lv C, Zhao J, Liu Z, Hu M. 2010. Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes. Mol. Pharm. 7: 664-679.
    • (2010) Mol. Pharm. , vol.7 , pp. 664-679
    • Tang, L.1    Ye, L.2    Singh, R.3    Wu, B.4    Lv, C.5    Zhao, J.6    Liu, Z.7    Hu, M.8
  • 21
    • 22344449177 scopus 로고    scopus 로고
    • Glucuronidation and sulfation of 7-hydroxycoumarin in liver matrices from human, dog, monkey, rat, and mouse
    • Wang Q, Jia R, Ye C, Garcia M, Li J, Hidalgo IJ. 2005. Glucuronidation and sulfation of 7-hydroxycoumarin in liver matrices from human, dog, monkey, rat, and mouse. In Vitro Cell. Dev. Biol. Anim. 41: 97-103.
    • (2005) In Vitro Cell. Dev. Biol. Anim. , vol.41 , pp. 97-103
    • Wang, Q.1    Jia, R.2    Ye, C.3    Garcia, M.4    Li, J.5    Hidalgo, I.J.6
  • 22
    • 33751113603 scopus 로고    scopus 로고
    • Disposition of flavonoids via enteric recycling: structural effects and lack of correlations between in vitro and in situ metabolic properties
    • Wang SW, Chen J, Jia X, Tam VH, Hu M. 2006. Disposition of flavonoids via enteric recycling: structural effects and lack of correlations between in vitro and in situ metabolic properties. Drug Metab. Dispos. 34: 1837-1848.
    • (2006) Drug Metab. Dispos. , vol.34 , pp. 1837-1848
    • Wang, S.W.1    Chen, J.2    Jia, X.3    Tam, V.H.4    Hu, M.5
  • 23
    • 42049115114 scopus 로고    scopus 로고
    • Variable isoflavone content of red clover products affects intestinal disposition of biochanin A, formononetin, genistein, and daidzein
    • Wang SW, Chen Y, Joseph T, Hu M. 2008. Variable isoflavone content of red clover products affects intestinal disposition of biochanin A, formononetin, genistein, and daidzein. J. Altern. Complement. Med. 14: 287-297.
    • (2008) J. Altern. Complement. Med. , vol.14 , pp. 287-297
    • Wang, S.W.1    Chen, Y.2    Joseph, T.3    Hu, M.4
  • 24
    • 66749132077 scopus 로고    scopus 로고
    • Disposition of flavonoids via enteric recycling: UGT1As deficiency in gunn rats is compensated by increases in UGT2Bs Activities
    • Wang SW, Kulkarni KH, Tang L, Wang J, Yin T, Daidoji T, Yokota H, Hu M. 2009. Disposition of flavonoids via enteric recycling: UGT1As deficiency in gunn rats is compensated by increases in UGT2Bs Activities. J. Pharmacol. Exp. Ther. 329(3): 1023-1031.
    • (2009) J. Pharmacol. Exp. Ther. , vol.329 , Issue.3 , pp. 1023-1031
    • Wang, S.W.1    Kulkarni, K.H.2    Tang, L.3    Wang, J.4    Yin, T.5    Daidoji, T.6    Yokota, H.7    Hu, M.8
  • 25
    • 78649639527 scopus 로고    scopus 로고
    • Breast cancer resistance protein (BCRP) and sulfotransferases contribute significantly to the disposition of genistein in mouse intestine
    • Zhu W, Xu H, Wang SW, Hu M. 2010. Breast cancer resistance protein (BCRP) and sulfotransferases contribute significantly to the disposition of genistein in mouse intestine. AAPS J. 12: 525-536.
    • (2010) AAPS J. , vol.12 , pp. 525-536
    • Zhu, W.1    Xu, H.2    Wang, S.W.3    Hu, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.