Using the human melanocortin-2 receptor as a model for analyzing hormone/receptor interactions between a mammalian MC2 receptor and ACTH(1-24)

General and Comparative Endocrinology

Volumn 181, Issue 1, 2013, Pages 203-210

  Liang, Liang ^a   Angleson, Joseph K ^a   Dores, Robert M ^a  

^a UNIVERSITY OF DENVER   (United States)

Author keywords

ACTH; HPA; Human melanocortin 2 receptor

Indexed keywords

MELANOCORTIN 2 RECEPTOR; MELANOCORTIN 2 RECEPTOR ACCESSORY PROTEIN 1; RECEPTOR PROTEIN; TETRACOSACTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; BINDING SITE; GENE EXPRESSION; GENE MUTATION; HORMONE ACTION; HORMONE DETERMINATION; HORMONE RECEPTOR INTERACTION; HORMONE STRUCTURE; HUMAN; MELANOCORTIN 2 RECEPTOR GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR GENE; REVIEW;

EID: 84873061026     PISSN: 00166480     EISSN: 10956840     Source Type: Journal    
DOI: 10.1016/j.ygcen.2012.11.011     Document Type: Review

References (42)

1. Agulleiro M.J., Roy S., Sanchez E., Puchol S., Gallo-Payet N., Cerda-Reverter J.M. Role of melanocortin receptor accessory proteins in the function of zebrafish melanocortin receptor type 2. Mol. Cell. Endocrinol. 2010, 320:145-152.
2. Baker B. The evolution of ACTH, MSH, and LPH-structure, function, and development. Horm. Evol. 1980, 2:643-722.
3. Buckley D.I., Ramachandran J. Characterization of corticotropin receptors on adrenocortical cells. Proc. Natl. Acad. Sci. U S A 1981, 78:7431-7435.
4. Buckley D.I., Yamashiro D., Ramachandran J. Synthesis of a corticotropin analogue that retains full biological activity after iodination. Endocrinology 1981, 109:5-9.
5. Chen M., Aprahamian C.J., Kesterson R.A., Harmon C.M., Yang Y. Molecular identification of the human melanocortin-2 receptor responsible for ligand binding and signaling. Biochemistry 2007, 46:11389-11397.
6. Chepurny O.G., Holz G.G. A novel cyclic adenosine monophosphate responsive luciferase reporter incorporating a nonpalindromic cyclic adenosine monophosphate response element provides optimal performance for use in G protein coupled receptor drug discovery efforts. J. Biomol. Screen. 2007, 12:740-746.
7. Chung T.T., Webb T.R., Chan L.F., Cooray S.N., Metherell L.A., King P.J., Chapple J.P., Clark A.J.L. The majority of ACTH receptor (MC2R) mutations found in Familial Glucocorticoid Deficiency type 1 lead to defective trafficking of the receptor to the cell surface. J. Clin. Endocrinol. Metab. 2008, 93:4948-4954.
8. Clark A.J.L., McLoughlin L., Grossman A. Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor. Lancet 1993, 341:461-462.
9. Clark A.J.L., Cammas F. The ACTH receptor. Baillieres Clin. Endocrinol. Metab. 1996, 10:29-47.
10. Cone R.D. Studies on the physiological functions of the melanocortin system. Endocr. Rev. 2006, 27:736-749.
11. Cooray S.N., Chung T.-T., Mazhar K., Szidonya L., Clark A.J.L. Bioluminescence resonance energy transfer reveals the adrenocorticotropin (ACTH)-induced conformational change of the activated ACTH receptor complex in living cells. Endocrinology 2011, 152:495-502.
12. Costa J.L., Bui S., Reed P., Dores R.M., Hochgeschwender U., Brennan M.B. Mutational analysis of evolutionarily conserved ACTH residues. Gen. Comp. Endocrinol. 2004, 136:12-16.
13. Cote M., Guillon G., Payet M., Gallo-Payet N. Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. J. Clin. Endocrinol. Metab. 2001, 86:4495-4503.
14. Dores R.M., Lecaude S. Trends in the evolution of the proopiomelanocortin gene. Gen. Comp. Endocrinol. 2005, 142:81-93.
15. Dores R.M., Rubin D.A., Quinn T.W. Mini-review: is it possible to construct phylogenetic trees using polypeptide hormone sequences. Gen. Comp. Endocrinol. 1996, 103:1-12.
16. Eberle A., Schwyzer R. Hormone-receptor interactions. Demonstration of the two message sequences (active sites) in α-melanotropin. Helv. Chim. Acta 1975, 58:1528-1535.
17. Eipper B.A., Mains R.E. Structure and biosynthesis of pro- adrenocorticotropin/endorphin and related peptides. Endocr. Rev. 1980, 1:1-27.
18. Forti F.L., Dias M.H.S., Armelin H.A. ACTH receptor: ectopic expression, activity and signaling. Mol. Cell. Biochem. 2006, 293:147-160.
19. Fridmanis D., Petrovska R., Kalnina I., Slaidina M., Peculis R., Schioth H.B., Klovins J. Identification of domains responsible for specific membrane transport and ligand specificity of the ACTH receptor (MC2R). Mol. Cell. Endocrinol. 2010, 321:175-183.
20. Gallo-Payet N., Grazzini E., Cote M., Bilodeau L., Chorvatova A., Payet M.D., Chouinard L., Guillon G. Role of calcium in the mechanism of action of ACTH in human adrenocortical cells. J. Clin. Invest. 1996, 98:460-466.
21. Gallo-Payet N., Payet M.D. Mechanism of action of ACTH: beyond cAMP. Microsc. Res. Tech. 2003, 61:275-287.
22. Haskell-Luevano C., Sawyer T.K., Trumpp-Kallmeyer S., Bikker J.A., Humblet C., Gantz I., Hruby V.J. Three-dimensional molecular model of the hMC1R receptor melanocortin receptor: complexes with melanotropin peptide agonists. Drug Des. Discov. 1996, 14:197-211.
23. Hinkle P.M., Sebag J.A. Structure and function of the melanocortin 2 receptor accessory protein. Mol. Cell. Endocrinol. 2009, 300:25-31.
24. Kilianova Z., Basora N., Kilian P., Payet M.D., Gallo-Payet N. Human menaocortin receptor 2 expression and functionality: effects of protein kinase A and protein kinase C on desensitization and internalization. Endocrinology 2006, 147:2325-2337.
25. Kojima I., Kojima K., Rasmussen H. Role of calcium and cAMP in the action of adrenocorticotropin on aldosterone secretion. J. Biol. Chem. 1985, 260:4248-4256.
26. Li C.H., Geschwind I.I., Cole R.D., Raake I.D., Harris J.I., Dixon J.S. Amino-acid sequence of alpha-corticotrophin. Nature 1955, 176:687-689.
27. Liang L., Sebag J.A., Eagelston L., Serasinghe M.N., Veo K., Reinick C., Angleson J., Hinkle P.M., Dores R.M. Functional expression of frog and rainbow trout melanocortin 2 receptors using heterologous MRAP1s. Gen. Comp. Endocrinol. 2011, 174:5-14.
28. Metherell L.A., Chapple J.P., Cooray S., David A., Becker C., Ruschendorf F., Naville D., Begeot M., Khoo B., Nurnberg P., Huebner A., Cheethan M.E., Clark A.J. Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2. Nat. Genet. 2005, 37:166-170.
29. Metherell L.A., Naville D., Halaby G., Begeot M., Huebner A., Nürnberg G., Nürnberg P., Green J., Tomlinson J.W., Krone N.P., Lin L., Racine M., Berney D.M., Achermann J.C., Arlt W., Clark A.J. Non-classic lipoid congenital adrenal hyperplasia masquerading as familial glucocorticoid deficiency. J. Clin. Endocrinol. Metab. 2009, 94:3865-3871.
30. Mountjoy K.G., Robbins L.S., Mortrud M.T., Cone R.D. The cloning of a family of genes that encode the melanocortin receptors. Science 1992, 257:1248-1251.
31. Nakanishi S., Inoue A., Kita T., Nakamura M., Chung A.C.Y., Cohen S.N., Numa S. Nucleotide sequence of cloned cDNA for bovine corticotropin-beta-lipotropin precursor. Nature 1979, 278:423-427.
32. Pogozheva I.D., Chai B.-X., Lomize A.L., Fong T.M., Weinberg D.H., Nargund R.P., Mulholland M.W., Grantz I., Mosberg H.I. Interactions of human melanocortin 4 receptors with nonpeptide and peptide agonists. Biochemistry 2005, 44:11329-11341.
33. Rachel M., El Mourabit H., Buronfosse A., Blondet A., Naville D., Begeot M., Penhoat A. Expression of the human melanocortin-2 receptor in different eukaryotic cells. Peptides 2005, 26:1842-1847.
34. Reinick C.L., Liang L., Angleson J.K., Dores R.M. Functional expression of Squalus acanthias Melanocortin 5 Receptor in CHO Cells, ligand selectivity and interaction with MRAP. Eur. J. Pharm. 2012, 680:1-7.
35. Roy S., Rachel M., Gallo-Payet N. Differential regulation of the human adrenocorticotropin receptor [melanocortin-2 receptor (MC2R)] by human MC2R accessory protein isoforms α and β in isogenic human embryonic kidney 293 cells. Mol. Endocrinol. 2007, 21:1656-1669.
36. Roy S., Roy S.J., Pinard S., Tailler L.-D., Rachel M., Parent J.-l., Gallo-Payet N. Mechanisms of melanocortin-2 receptor (MC2R) internalization and recycling in human embryonic kidney (HEK) cells: identification of key Ser/Thr (S/T) amino acids. Mol. Endocrinol. 2011, 25:1961-1977.
37. Roy S., Roy S.J., Pinard S., Aqulleiro M.J., Cerda-Reverter J.M., Parent J.-L., Gallo-Payet N. The C-terminal domains of melanocortin-2 receptor (MC2R) accessory proteins (MRAP1) influence their localization and ACTH-induced cAMP production. Gen. Comp. Endcrinol 2012, 176:265-274.
38. Schwyzer R. ACTH: a short introductory review. Ann. N Y Acad. Sci. 1977, 297:3-26.
39. Sebag J.A., Hinkle P.M. Melanocortin-2 receptor accessory protein MRAP forms antiparallel homodimers. Proc. Natl. Acad. Sci. U S A 2007, 104:20244-20249.
40. Sebag J.A., Hinkle P.M. Regions of melanocortin (MC2) receptor accessory protein necessary for duel topology and MC2 receptor trafficking and signaling. J. Biol. Chem. 2009, 284:610-618.
41. Seelig S., Lindley B.D., Sayers G. A new approach to the structure-activity relationship for ACTH analogs using isolated adrenal cortex cells. Methods in Enzymol 1975, 39:347-359. Academic Press, New York.
42. Webb T.R., Clark J.L. Minireview: the melanocortin 2 receptor accessory proteins. Mol. Endocrinol. 2010, 24:475-484.