Structure and function of the melanocortin2 receptor accessory protein (MRAP)

Molecular and Cellular Endocrinology

Volumn 300, Issue 1-2, 2009, Pages 25-31

  Hinkle, Patricia M ^a   Sebag, Julien A ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

ACTH; cAMP; Dual topology; GPCR; Melanocortin receptor; MRAP

Indexed keywords

ALANINE; CORTICOTROPIN; CORTICOTROPIN RECEPTOR; CYCLIC AMP; MELANOCORTIN2 RECEPTOR ACCESSORY PROTEIN; MUTANT PROTEIN; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

CELL MEMBRANE; HORMONE RECEPTOR INTERACTION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; CELL LINE; HUMANS; MEMBRANE PROTEINS; PROTEIN STRUCTURE, QUATERNARY;

EID: 59649095662     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2008.10.041     Document Type: Review

References (43)

1. Behrens M., Bartelt J., Reichling C., Winnig M., Kuhn C., and Meyerhof W. Members of RTP and REEP gene families influence functional bitter taste receptor expression. J. Biol. Chem. 281 (2006) 20650-20659
2. Beltzer J.P., Fiedler K., Fuhrer C., Geffen I., Handschin C., Wessels H.P., and Spiess M. Charged residues are major determinants of the transmembrane orientation of a signal-anchor sequence. J. Biol. Chem. 266 (1991) 973-978
3. Bermak J.C., Li M., Bullock C., and Zhou Q.Y. Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein. Nat. Cell Biol. 3 (2001) 492-498
4. Bernier V., Bichet D.G., and Bouvier M. Pharmacological chaperone action on G-protein-coupled receptors. Curr. Opin. Pharmacol. 4 (2004) 528-533
5. Biebermann H., Krude H., Elsner A., Chubanov V., Gudermann T., and Gruters A. Autosomal-dominant mode of inheritance of a melanocortin-4 receptor mutation in a patient with severe early-onset obesity is due to a dominant-negative effect caused by receptor dimerization. Diabetes 52 (2003) 2984-2988
6. Buckley D.I., and Ramachandran J. Characterization of corticotropin receptors on adrenocortical cells. Proc. Natl. Acad. Sci. U.S.A. 78 (1981) 7431-7435
7. Chan L.F., Clark A.J., and Metherell L.A. Familial glucocorticoid deficiency: advances in the molecular understanding of ACTH action. Horm. Res. 69 (2008) 75-82
8. Chida D., Nakagawa S., Nagai S., Sagara H., Katsumata H., Imaki T., Suzuki H., Mitani F., Ogishima T., Shimizu C., Kotaki H., Kakuta S., Sudo K., Koike T., Kubo M., and Iwakura Y. Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 18205-18210
9. Christopoulos A., Christopoulos G., Morfis M., Udawela M., Laburthe M., Couvineau A., Kuwasako K., Tilakaratne N., and Sexton P.M. Novel receptor partners and function of receptor activity-modifying proteins. J. Biol. Chem. 278 (2003) 3293-3297
10. Clark A.J., and Metherell L.A. Mechanisms of disease: the adrenocorticotropin receptor and disease. Nat. Clin. Pract. Endocrinol. Metab. 2 (2006) 282-290
11. Clark A.J., Metherell L.A., Cheetham M.E., and Huebner A. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. Trends Endocrinol. Metab. 16 (2005) 451-457
12. Conn P.M., Ulloa-Aguirre A., Ito J., and Janovick J.A. G protein-coupled receptor trafficking in health and disease: lessons learned to prepare for therapeutic mutant rescue in vivo. Pharmacol. Rev. 59 (2007) 225-250
13. Cooray S.N., Almiro Do Vale I., Leung K.Y., Webb T.R., Chapple J.P., Egertova M., Cheetham M.E., Elphick M.R., and Clark A.J. The melanocortin 2 receptor accessory protein exists as a homodimer and is essential for the function of the melanocortin 2 receptor in the mouse y1 cell line. Endocrinology 149 (2008) 1935-1941
14. Cooray S.N., Chan L., Metherell L., Storr H., and Clark A.J. Adrenocorticotropin resistance syndromes. Endocr. Dev. 13 (2008) 99-116
15. Dwyer N.D., Troemel E.R., Sengupta P., and Bargmann C.I. Odorant receptor localization to olfactory cilia is mediated by ODR-4, a novel membrane-associated protein. Cell 93 (1998) 455-466
16. Forti F.L., Dias M.H., and Armelin H.A. ACTH receptor: ectopic expression, activity and signaling. Mol. Cell Biochem. 293 (2006) 147-160
17. Gantz I., and Fong T.M. The melanocortin system. Am. J. Physiol. Endocrinol. Metab. 284 (2003) E468-474
18. Hartmann E., Rapoport T.A., and Lodish H.F. Predicting the orientation of eukaryotic membrane-spanning proteins. Proc. Natl. Acad. Sci. U.S.A. 86 (1989) 5786-5790
19. Hay D.L., Poyner D.R., and Sexton P.M. GPCR modulation by RAMPs. Pharmacol. Ther. 109 (2006) 173-197
20. Imamine H., Mizuno H., Sugiyama Y., Ohro Y., Sugiura T., and Togari H. Possible relationship between elevated plasma ACTH and tall stature in familial glucocorticoid deficiency. Tohoku J. Exp. Med. 205 (2005) 123-131
21. Kerppola T.K. Visualization of molecular interactions by fluorescence complementation. Nat. Rev. Mol. Cell Biol. 7 (2006) 449-456
22. Kuwasako K., Kitamura K., Nagoshi Y., Cao Y.N., and Eto T. Identification of the human receptor activity-modifying protein 1 domains responsible for agonist binding specificity. J. Biol. Chem. 278 (2003) 22623-22630
23. Mandrika I., Petrovska R., and Wikberg J. Melanocortin receptors form constitutive homo- and heterodimers. Biochem. Biophys. Res. Commun. 326 (2005) 349-354
24. Metherell L.A., Chapple J.P., Cooray S., David A., Becker C., Ruschendorf F., Naville D., Begeot M., Khoo B., Nurnberg P., Huebner A., Cheetham M.E., and Clark A.J. Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2. Nat. Genet. 37 (2005) 166-170
25. Modan-Moses D., Ben-Zeev B., Hoffmann C., Falik-Zaccai T.C., Bental Y.A., Pinhas-Hamiel O., and Anikster Y. Unusual presentation of familial glucocorticoid deficiency with a novel MRAP mutation. J. Clin. Endocrinol. Metab. 91 (2006) 3713-3717
26. Mountjoy K.G., Robbins L.S., Mortrud M.T., and Cone R.D. The cloning of a family of genes that encode the melanocortin receptors. Science 257 (1992) 1248-1251
27. Noon L.A., Franklin J.M., King P.J., Goulding N.J., Hunyady L., and Clark A.J. Failed export of the adrenocorticotrophin receptor from the endoplasmic reticulum in non-adrenal cells: evidence in support of a requirement for a specific adrenal accessory factor. J. Endocrinol. 174 (2002) 17-25
28. Parameswaran N., and Spielman W.S. RAMPs: the past, present and future. Trends Biochem. Sci. 31 (2006) 631-638
29. Petaja-Repo U.E., Hogue M., Laperriere A., Walker P., and Bouvier M. Export from the endoplasmic reticulum represents the limiting step in the maturation and cell surface expression of the human delta opioid receptor. J. Biol. Chem. 275 (2000) 13727-13736
30. Roy S., Rached M., and Gallo-Payet N. Differential regulation of the human adrenocorticotropin receptor [melanocortin-2 receptor (MC2R)] by human MC2R accessory protein isoforms alpha and beta in isogenic human embryonic kidney 293 cells. Mol. Endocrinol. 21 (2007) 1656-1669
31. Rumie H., Metherell L.A., Clark A.J., Beauloye V., and Maes M. Clinical and biological phenotype of a patient with familial glucocorticoid deficiency type 2 caused by a mutation of melanocortin 2 receptor accessory protein. Eur. J. Endocrinol. 157 (2007) 539-542
32. Saito H., Kubota M., Roberts R.W., Chi Q., and Matsunami H. RTP family members induce functional expression of mammalian odorant receptors. Cell 119 (2004) 679-691
33. Schimmer B.P. Adenylate cyclase activity in adrenocorticotropic hormone-sensitive and mutant adrenocortical tumor cell lines. J. Biol. Chem. 247 (1972) 3134-3138
34. Schimmer B.P., Cordova M., Cheng H., Tsao A., and Morris Q. A genome-wide assessment of adrenocorticotropin action in the Y1 mouse adrenal tumor cell line. Mol. Cell Endocrinol. 265-266 (2007) 102-107
35. Sebag J.A., and Hinkle P.M. Melanocortin-2 receptor accessory protein MRAP forms antiparallel homodimers. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 20244-20249
36. Sebag, J.A., Hinkle, P.M., 2008. Regions of melanocortin2 receptor accessory protein necessary for dual topology and MC2 receptor trafficking and signaling. J. Biol. Chem. 2008 Nov 3. [Epub ahead of print] PMID: 18981183.
37. Sexton P.M., Morfis M., Tilakaratne N., Hay D.L., Udawela M., Christopoulos G., and Christopoulos A. Complexing receptor pharmacology: modulation of family B G protein-coupled receptor function by RAMPs. Ann. N. Y. Acad. Sci. 1070 (2006) 90-104
38. Shaner N.C., Campbell R.E., Steinbach P.A., Giepmans B.N., Palmer A.E., and Tsien R.Y. Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat. Biotechnol. 22 (2004) 1567-1572
39. Udawela M., Christopoulos G., Morfis M., Christopoulos A., Ye S., Tilakaratne N., and Sexton P.M. A critical role for the short intracellular C terminus in receptor activity-modifying protein function. Mol. Pharmacol. 70 (2006) 1750-1760
40. Viklund H., and Elofsson A. Best alpha-helical transmembrane protein topology predictions are achieved using hidden Markov models and evolutionary information. Protein Sci. 13 (2004) 1908-1917
41. von Heijne G. The distribution of positively charged residues in bacterial inner membrane proteins correlates with the trans-membrane topology. EMBO J. 5 (1986) 3021-3027
42. Xu A., Choi K.L., Wang Y., Permana P.A., Xu L.Y., Bogardus C., and Cooper G.J. Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cells. Biochem. Biophys. Res. Commun. 293 (2002) 1161-1167
43. Yang Y., Chen M., Kesterson Jr. R.A., and Harmon C.M. Structural insights into the role of the ACTH receptor cysteine residues on receptor function. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 (2007) R1120-1126