Modulation of MAPK and Akt signaling pathways in proximal segment of injured sciatic nerves

Neuroscience Letters

Volumn 534, Issue 1, 2013, Pages 205-210

  Sun, Guixin ^a   Li, Zengchun ^a   Wang, Xinhong ^b   Tang, Wenjie ^a   Wei, Youzhen ^a  

^a TONGJI UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Mitogen activated protein kinases; PI3K Akt; Regeneration; Schwann cells; Sciatic nerve injury

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRUSH TRAUMA; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME REGULATION; MALE; NERVE FIBER REGENERATION; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SCHWANN CELL; SCIATIC NERVE INJURY; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; GLYCOGEN SYNTHASE KINASE 3; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SCHWANN CELLS; SCIATIC NERVE; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84873060655     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.12.019     Document Type: Article

References (23)

1. Abe N., Borson S.H., Gambello M.J., Wang F., Cavalli V. Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves. Journal of Biological Chemistry 2010, 285:28034-28043.
2. Agthong S., Kaewsema A., Tanomsridejchai N., Chentanez V. Activation of MAPK ERK in peripheral nerve after injury. BMC Neuroscience 2006, 7:45.
3. Agthong S., Koonam J., Kaewsema A., Chentanez V. Inhibition of MAPK ERK impairs axonal regeneration without an effect on neuronal loss after nerve injury. Neurological Research 2009, 31:1068-1074.
4. Chattopadhyay S., Shubayev V.I. MMP-9 controls Schwann cell proliferation and phenotypic remodeling via IGF-1 and ErbB receptor-mediated activation of MEK/ERK pathway. Glia 2009, 57:1316-1325.
5. Da Costa C.R., Villadiego J., Sancho R., Fontana X., Packham G., Nateri A.S., Behrens A. Bag1-L is a phosphorylation-dependent coactivator of c-Jun during neuronal apoptosis. Molecular and Cellular Biology 2010, 30:3842-3852.
6. Eickholt B.J., Ahmed A.I., Davies M., Papakonstanti E.A., Pearce W., Starkey M.L., Bilancio A., Need A.C., Smith A.J., Hall S.M., Hamers F.P., Giese K.P., Bradbury E.J., Vanhaesebroeck B. Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase. PLoS One 2007, 2:e869.
7. Hoogeveen J.F., Troost D., Wondergem J., van der Kracht A.H., Haveman J. Hyperthermic injury versus crush injury in the rat sciatic nerve: a comparative functional, histopathological and morphometrical study. Journal of the Neurological Sciences 1992, 108:55-64.
8. Jiang Y., Jakobsen J. Different apoptotic reactions of dorsal root ganglion A- and B-cells after sciatic nerve axotomy: effect of p75 neurotrophin receptor. Chinese Medical Journal 2010, 123:2695-2700.
9. Koh P.O., Cho J.H., Won C.K., Lee H.J., Sung J.H., Kim M.O. Estradiol attenuates the focal cerebral ischemic injury through mTOR/p70S6 kinase signaling pathway. Neuroscience Letters 2008, 436:62-66.
10. Li X., Du Y., Fan X., Yang D., Luo G., Le W. c-Jun N-terminal kinase mediates lactacystin-induced dopamine neuron degeneration. Journal of Neuropathology and Experimental Neurology 2008, 67:933-944.
11. Liu H., Kim Y., Chattopadhyay S., Shubayev I., Dolkas J., Shubayev V.I. Matrix metalloproteinase inhibition enhances the rate of nerve regeneration in vivo by promoting dedifferentiation and mitosis of supporting Schwann cells. Journal of Neuropathology and Experimental Neurology 2010, 69:386-395.
12. McKay M.M., Morrison D.K. Integrating signals from RTKs to ERK/MAPK. Oncogene 2007, 26:3113-3121.
13. Narayanan S.P., Flores A.I., Wang F., Macklin W.B. Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination. Journal of Neuroscience 2009, 29:6860-6870.
14. Noel A., Barrier L., Rinaldi F., Hubert C., Fauconneau B., Ingrand S. Lithium chloride and staurosporine potentiate the accumulation of phosphorylated glycogen synthase kinase 3beta/Tyr216, resulting in glycogen synthase kinase 3beta activation in SH-SY5Y human neuroblastoma cell lines. Journal of Neuroscience Research 2011, 89:755-763.
15. Ogata T., Yamamoto S., Nakamura K., Tanaka S. Signaling axis in Schwann cell proliferation and differentiation. Molecular Neurobiology 2006, 33:51-62.
16. Shen A., Yang J., Gu Y., Zhou D., Sun L., Qin Y., Chen J., Wang P., Xiao F., Zhang L., Cheng C. Lipopolysaccharide-evoked activation of p38 and JNK leads to an increase in ICAM-1 expression in Schwann cells of sciatic nerves. FEBS Journal 2008, 275:4343-4353.
17. Shi T.J., Huang P., Mulder J., Ceccatelli S., Hokfelt T. Expression of p-Akt in sensory neurons and spinal cord after peripheral nerve injury. Neuro-signals 2009, 17:203-212.
18. Towers E., Gilley J., Randall R., Hughes R., Kristiansen M., Ham J. The proapoptotic dp5 gene is a direct target of the MLK-JNK-c-Jun pathway in sympathetic neurons. Nucleic Acids Research 2009, 37:3044-3060.
19. Vargas M.E., Barres B.A. Why is Wallerian degeneration in the CNS so slow?. Annual Review of Neuroscience 2007, 30:153-179.
20. Wakatsuki S., Yumoto N., Komatsu K., Araki T., Sehara-Fujisawa A. Roles of meltrin-beta/ADAM19 in progression of Schwann cell differentiation and myelination during sciatic nerve regeneration. Journal of Biological Chemistry 2009, 284:2957-2966.
21. Xu Z., Wang B.R., Wang X., Kuang F., Duan X.L., Jiao X.Y., Ju G. ERK1/2 and p38 mitogen-activated protein kinase mediate iNOS-induced spinal neuron degeneration after acute traumatic spinal cord injury. Life Sciences 2006, 79:1895-1905.
22. Yamazaki T., Sabit H., Oya T., Ishii Y., Hamashima T., Tokunaga A., Ishizawa S., Jie S., Kurashige Y., Matsushima T., Furuta I., Noguchi M., Sasahara M. Activation of MAP kinases, Akt and PDGF receptors in injured peripheral nerves. Journal of the Peripheral Nervous System 2009, 14:165-176.
23. Zelena J. Multiple axon terminals in reinnervated Pacinian corpuscles of adult rat. Journal of Neurocytology 1984, 13:665-684.