Treatment with a combination of the ErbB (HER) family blocker afatinib and the IGF-IR inhibitor, NVP-AEW541 induces synergistic growth inhibition of human pancreatic cancer cells

BMC Cancer

Volumn 13, Issue , 2013, Pages

  Ioannou, Nikolaos ^a   Seddon, Alan M ^a   Dalgleish, Angus ^b   Mackintosh, David ^a   Modjtahedi, Helmout ^a  

^a KINGSTON UNIVERSITY   (United Kingdom)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Afatinib; EGFR; IGF IR; NVP AEW541; Pancreatic cancer

Indexed keywords

AFATINIB; EPIDERMAL GROWTH FACTOR RECEPTOR; INSULIN; NVP AEW 541; SOMATOMEDIN B; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; SULFORHODAMINE B;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELLULAR DISTRIBUTION; COLORIMETRY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG POTENTIATION; DRUG TARGETING; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC 50; INTRACELLULAR SIGNALING; PANCREAS CANCER; PROTEIN EXPRESSION; S PHASE CELL CYCLE CHECKPOINT; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG THERAPY, COMBINATION; HUMANS; PANCREATIC NEOPLASMS; PYRIMIDINES; PYRROLES; QUINAZOLINES; RECEPTOR, ERBB-3; RECEPTOR, IGF TYPE 1;

EID: 84873045081     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-13-41     Document Type: Article

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