Increased Th1 immune response in SERPINB3 transgenic mice during acute liver failure

Experimental Biology and Medicine

Volumn 237, Issue 12, 2012, Pages 1474-1482

  Villano, Gianmarco ^a   Lunardi, Francesca ^a   Turato, Cristian ^b   Schiff, Sami ^a   Tono, Natascia ^b   Campagna, Francesca ^a   Gatta, Angelo ^a   Amodio, Piero ^a   Calabrese, Fiorella ^a   Pontisso, Patrizia ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

Author keywords

C57BL 6J mouse; Hepatic encephalopathy; Inflammation; Proinflammatory cytokines; Squamous Cell Carcinoma Antigen 1

Indexed keywords

ALANINE AMINOTRANSFERASE; AMMONIA; BETA ACTIN; CYTOCHROME P450; CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MESSENGER RNA; PARACETAMOL; PHOSPHATE BUFFERED SALINE; SERINE PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR B3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACUTE LIVER FAILURE; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATAXIA; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; GLIA CELL; HEPATIC ENCEPHALOPATHY; HUMAN; IMMUNOHISTOCHEMISTRY; LETHARGY; MICROGLIA; MOUSE; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TH1 CELL; TISSUE INJURY;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; APOPTOSIS; BRAIN; CELL PROLIFERATION; CYTOKINES; GENE EXPRESSION REGULATION; HEPATIC ENCEPHALOPATHY; INFLAMMATION; LIVER; LIVER FAILURE, ACUTE; MICE; MICE, TRANSGENIC; MICROGLIA; SERPINS; TH1 CELLS;

EID: 84873029877     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1258/ebm.2012.012135     Document Type: Article

References (41)

1. Cordoba J, Blei AT. Brain edema and hepatic encephalopathy. Semin Liver Dis 1996;16:271-80
2. Gill RQ, Sterling RK. Acute liver failure. J Clin Gastroenterol 2001;33:191-8
3. Lee WM. Acetaminophen and the US Acute Liver Failure Study Group: lowering the risks of hepatic failure. Hepatology 2004;40:6-9
4. Butterworth RF. Pathophysiology of hepatic encephalopathy: a new look at ammonia. Metab Brain Dis 2002;17:221-7
5. Vaquero J, Butterworth RF. Mechanisms of brain edema in acute liver failure and impact of novel therapeutic interventions. Neurol Res 2007;29:683-90
6. Butterworth RF. Hepatic encephalopathy: a central neuroinflammatory disorder? Hepatology 2011;53:1372-6
7. Cauli O, López-Larrubia P, Rodrigo R, Agusti A, Boix J, Nieto-Charques L, Cerdán S, Felipo V. Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats. Gastroenterology 2011;140:638-45
8. Chavarria L, Oria M, Romero-Gimenez J, Alonso J, Lope-Piedrafita S, Cordoba J. Diffusion tensor imaging supports the cytotoxic origin of brain edema in a rat model of acute liver failure. Gastroenterology 2010;138:1566-73
9. Rolando N, Wade J, Davalos M, Wendon J, Philpott-Howard J, Williams R. The systemic inflammatory response syndrome in acute liver failure. Hepatology 2000;32:734-9
10. Jiang W, Desjardins P, Butterworth RF. Cerebral inflammation contributes to encephalopathy and brain edema in acute liver failure: protective effect of minocycline. J Neurochem 2009;109:485-93
11. Jalan R, Olde Damink SW, Hayes PC, Deutz NE, Lee A. Pathogenesis of intracranial hypertension in acute liver failure: inflammation, ammonia and cerebral blood flow. J Hepatol 2004;41:613-20
12. Wright G, Shawcross D, Olde Damink SW, Jalan R. Brain cytokine flux in acute liver failure and its relationship with intracranial hypertension. Metab Brain Dis 2007;22:375-88
13. Nguyen JH, Yamamoto S, Steers J, Sevlever D, Lin W, Shimojima N, Castanedes-Casey M, Genco P, Golde T, Richelson E, Dickson D, McKinney M, Eckman CB. Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice. J Hepatol 2006;44:1105-14
14. Quarta S, Vidalino L, Turato C, Ruvoletto M, Calabrese F, Valente M, Cannito S, Fassina G, Parola M, Gatta A, Pontisso P. SerpinB3 induces epithelial-mesenchymal transition. J Pathol 2010;221:343-56
15. Thakker-Varia S, Elkabes S, Schick C, Silverman GA, Peng L, Sherwood AC, Black IB. Gene expression in activated brain microglia: identification of a proteinase inhibitor that increases microglial cell number. Mol Brain Res 1998;56:99-107
16. Silverman GA, Bird PI, Carrell RW, Church FC, Coughlin PB, Gettins PG, Irving JA, Lomas DA, Luke CJ, Moyer RW, Pemberton PA, Remold-O'Donnell E, Salvesen GS, Travis J, Whisstock JC. The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature. J Biol Chem 2001;276:33293-96
17. Kato H, Torigoe T. Radioimmunoassay for tumor antigen of human cervical squamous cell carcinoma. Cancer 1977;40:1621-8
18. Izuhara K, Ohta S, Kanaji S, Shiraishi H, Arima K. Recent progress in understanding the diversity of the human ov-serpin/clade B serpin family. Cell Mol Life Sci 2008;65:2541-53
19. Kato H. Expression and function of squamous cell carcinoma antigen. Anticancer Res 1996;16:2149-53
20. Cataltepe S, Gornstein ER, Schick C, Kamachi Y, Chatson K, Fries J, Silverman GA, Upton MP. Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas. J Histochem Cytochem 2000;48:113-22
21. Turato C, Buendia MA, Fabre M, Redon MJ, Branchereau S, Quarta S, Ruvoletto M, Perilongo G, Grotzer MA, Gatta A, Pontisso P. Over-expression of SERPINB3 in hepatoblastoma: a possible insight into the genesis of this tumour? Eur J Cancer 2012;48:1219-26
22. Chechlinska M, Kowalewska M, Brzoska-Wojtowicz E, Radziszewski J, Ptaszynski K, Rys J, Kaminska J, Nowak R. Squamous cell carcinoma antigen 1 and 2 expression in cultured normal peripheral blood mononuclear cells and in vulvar squamous cell carcinoma. Tumor Biol 2010;31:559-67
23. Guido M, Roskams T, Pontisso P, Fassan M, Thung SN, Giacomelli L, Sergio A, Farinati F, Cillo U, Rugge M. Squamous cell carcinoma antigen in human liver carcinogenesis. J Clin Pathol 2008;61:445-7
24. Villano G, Quarta S, Ruvoletto MG, Turato C, Vidalino L, Biasiolo A, Tono N, Lunardi F, Calabrese F, Dall'Olmo L, Dedja A, Fassina G, Gatta A, Pontisso P. Role of squamous cell carcinoma antigen-1 on liver cells after partial hepatectomy in transgenic mice. Int J Mol Med 2010;25:137-43
25. Lunardi F, Villano G, Perissinotto E, Agostini C, Rea F, Gnoato M, Bradaschia A, Valente M, Pontisso P, Calabrese F. Overexpression of Serpinb3 promotes epithelial proliferation and lung fibrosis in mice. Lab Invest 2011;9:945-54
26. Mahadevan SB, McKiernan PJ, Davies P, Kelly DA. Paracetamol induced hepatotoxicity. Arch Dis Child 2006;91:598-603
27. Snawder JE, Roe AL, Benson RW, Roberts DW. Loss of CYP2E1 and CYP1A2 activity as a function of acetaminophen dose: relation to toxicity. Biochem Biophys Res Commun 1994;203:532-9
28. Rogers LK, Moorthy B, Smith CV. Acetaminophen binds to mouse hepatic and renal DNA at human therapeutic doses. Chem Res Toxicol 1997;10:470-6
29. Pontisso P, Calabrese F, Benvegnù L, Lise M, Belluco C, Ruvoletto MG, Marino M, Valente M, Nitti D, Gatta A, Fassina G. Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma. Br J Cancer 2004;90:833-7
30. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J Cell Biol 1992;119:493-501
31. Streit WJ, Walter SA, Pennell NA. Reactive microgliosis. Prog Neurobiol 1999;57:563-81
32. Hickey WF, Kimura H. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 1988;239:290-2
33. Fischer HG, Reichmann G. Brain dendritic cells and macrophages/ microglia in central nervous system inflammation. J Immunol 2001;166:2717-26
34. Leon LR. Hypothermia in systemic inflammation: role of cytokines. Front Biosci 2004;9:1877-88
35. Nagaki M, Iwai H, Naiki T, Ohnishi H, Muto Y, Moriwaki H. High levels of serum interleukin-10 and tumor necrosis factor-alpha are associated with fatality in fulminant hepatitis. J Infect Dis 2000;182:1103-8
36. Riordan SM, Williams R. Mechanisms of hepatocyte injury, multiorgan failure, and prognostic criteria in acute liver failure. Semin Liver Dis 2003;23:203-15
37. Vidalino L, Doria A, Quarta S, Zen M, Gatta A, Pontisso P. SERPINB3, apoptosis and autoimmunity. Autoimm Rev 2009;9:108-12
38. Suminami Y, Nagashima S, Murakami A, Nawata S, Gondo T, Hirakawa H, Numa F, Silverman GA, Kato H. Suppression of a squamous cell carcinoma (SCC)-related serpin, SCC antigen, inhibits tumor growth with increased intratumor infiltration of natural killer cells. Cancer Res 2001;61:1776-80
39. Turato C, Calabrese F, Biasiolo A, Quarta S, Ruvoletto M, Tono N, Paccagnella D, Fassina G, Merkel C, Harrison TJ, Gatta A, Pontisso P. SERPINB3 modulates TGF-beta expression in chronic liver disease. Lab Invest 2010;90:1016-23
40. Calabrese F, Lunardi F, Giacometti C, Marulli G, Gnoato M, Pontisso P, Saetta M, Valente ML, Rea F, Perissinotto E, Agostini C. Overexpression of squamous cell carcinoma antigen in idiopathic pulmonary fibrosis: clinico-pathological correlations. Torax 2008;63:795-802
41. Kowalewska M, Chechlinska M, Markowicz S, Kober P, Nowak R. The relevance of RT-PCR detection of disseminated tumour cells is hampered by the expression of markers regarded as tumour-specific in activated lymphocytes. Eur J Cancer 2006;42:2671-4