메뉴 건너뛰기




Volumn 64, Issue , 2013, Pages 59-70

Glioblastoma: Molecular analysis and clinical implications

Author keywords

animal models; brain tumor; glioma; targeted therapy

Indexed keywords

CRIZOTINIB; DNA; ERLOTINIB; IMATINIB; PERIFOSINE; TEMOZOLOMIDE; VATALANIB; VEMURAFENIB;

EID: 84873029078     PISSN: 00664219     EISSN: 1545326X     Source Type: Book Series    
DOI: 10.1146/annurev-med-100711-143028     Document Type: Review
Times cited : (77)

References (67)
  • 1
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • Wen PY, Kesari S. 2008. Malignant gliomas in adults. N. Engl. J. Med. 359:492-507
    • (2008) N. Engl. J. Med. , vol.359 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2
  • 2
    • 0029843049 scopus 로고    scopus 로고
    • The prognostic impact of prior low grade histology in patients with anaplastic gliomas: A case-control study
    • Dropcho EJ, Soong SJ. 1996. The prognostic impact of prior low grade histology in patients with anaplastic gliomas: a case-control study. Neurology 47:684-90
    • (1996) Neurology , vol.47 , pp. 684-690
    • Dropcho, E.J.1    Soong, S.J.2
  • 3
    • 20344407807 scopus 로고    scopus 로고
    • Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas
    • Ohgaki H, Kleihues P. 2005. Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J. Neuropathol. Exp. Neurol. 64:479-89
    • (2005) J. Neuropathol. Exp. Neurol. , vol.64 , pp. 479-489
    • Ohgaki, H.1    Kleihues, P.2
  • 5
    • 84949655795 scopus 로고
    • Cerebral astrocytomas and their derivatives
    • Scherer HJ. 1940. Cerebral astrocytomas and their derivatives. Am. J. Cancer 40:159-98
    • (1940) Am. J. Cancer , vol.40 , pp. 159-198
    • Scherer, H.J.1
  • 6
    • 79957905986 scopus 로고    scopus 로고
    • Molecular subclassification of diffuse gliomas: Seeing order in the chaos
    • Huse JT, Phillips HS, Brennan CW. 2011. Molecular subclassification of diffuse gliomas: seeing order in the chaos. Glia 59:1190-99
    • (2011) Glia , vol.59 , pp. 1190-1199
    • Huse, J.T.1    Phillips, H.S.2    Brennan, C.W.3
  • 7
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • The Cancer Genome Atlas Research Network.
    • The Cancer Genome Atlas Research Network. 2008. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455:1061-68
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 8
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons DW, Jones S, Zhang X, et al. 2008. An integrated genomic analysis of human glioblastoma multiforme. Science 321:1807-12
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3
  • 9
    • 0034598746 scopus 로고    scopus 로고
    • Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
    • Alizadeh AA, Eisen MB, Davis RE, et al. 2000. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403:503-11
    • (2000) Nature , vol.403 , pp. 503-511
    • Alizadeh, A.A.1    Eisen, M.B.2    Davis, R.E.3
  • 10
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou CM, Sorlie T, Eisen MB, et al. 2000. Molecular portraits of human breast tumours. Nature 406:747-52
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1    Sorlie, T.2    Eisen, M.B.3
  • 11
    • 0036132668 scopus 로고    scopus 로고
    • Molecular classification of human diffuse gliomas by multidimensional scaling analysis of gene expression profiles parallels morphology-based classification, correlates with survival, and reveals clinically-relevant novel glioma subsets
    • Fuller GN, Hess KR, Rhee CH, et al. 2002. Molecular classification of human diffuse gliomas by multidimensional scaling analysis of gene expression profiles parallels morphology-based classification, correlates with survival, and reveals clinically-relevant novel glioma subsets. Brain Pathol. 12:108-16
    • (2002) Brain Pathol. , vol.12 , pp. 108-116
    • Fuller, G.N.1    Hess, K.R.2    Rhee, C.H.3
  • 12
    • 0345240919 scopus 로고    scopus 로고
    • Reactivation of insulin-like growth factor binding protein 2 expression in glioblastoma multiforme: A revelation by parallel gene expression profiling
    • Fuller GN, Rhee CH, Hess KR, et al. 1999. Reactivation of insulin-like growth factor binding protein 2 expression in glioblastoma multiforme: a revelation by parallel gene expression profiling. Cancer Res. 59:4228-32
    • (1999) Cancer Res. , vol.59 , pp. 4228-4232
    • Fuller, G.N.1    Rhee, C.H.2    Hess, K.R.3
  • 13
    • 0742299049 scopus 로고    scopus 로고
    • Identification of combination gene sets for glioma classification
    • Kim S, Dougherty ER, Shmulevich I, et al. 2002. Identification of combination gene sets for glioma classification. Mol. Cancer Ther. 1:1229-36
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 1229-1236
    • Kim, S.1    Dougherty, E.R.2    Shmulevich, I.3
  • 14
    • 0035884608 scopus 로고    scopus 로고
    • Distinctive molecular profiles of high-grade and lowgrade gliomas based on oligonucleotide microarray analysis
    • Rickman DS, Bobek MP, Misek DE, et al. 2001. Distinctive molecular profiles of high-grade and lowgrade gliomas based on oligonucleotide microarray analysis. Cancer Res. 61:6885-91
    • (2001) Cancer Res. , vol.61 , pp. 6885-6891
    • Rickman, D.S.1    Bobek, M.P.2    Misek, D.E.3
  • 15
    • 0034544537 scopus 로고    scopus 로고
    • Identification of differentially expressed genes in human gliomas by DNA microarray and tissue chip techniques
    • Sallinen SL, Sallinen PK, Haapasalo HK, et al. 2000. Identification of differentially expressed genes in human gliomas by DNA microarray and tissue chip techniques. Cancer Res. 60:6617-22
    • (2000) Cancer Res. , vol.60 , pp. 6617-6622
    • Sallinen, S.L.1    Sallinen, P.K.2    Haapasalo, H.K.3
  • 16
    • 0042567193 scopus 로고    scopus 로고
    • Gene expression profiling identifies molecular subtypes of gliomas
    • Shai R, Shi T, Kremen TJ, et al. 2003. Gene expression profiling identifies molecular subtypes of gliomas. Oncogene 22:4918-23
    • (2003) Oncogene , vol.22 , pp. 4918-4923
    • Shai, R.1    Shi, T.2    Kremen, T.J.3
  • 17
    • 0036682413 scopus 로고    scopus 로고
    • Gene expression microarray analysis reveals YKL-40 to be a potential serum marker for malignant character in human glioma
    • Tanwar MK, GilbertMR, Holland EC. 2002. Gene expression microarray analysis reveals YKL-40 to be a potential serum marker for malignant character in human glioma. Cancer Res. 62:4364-68
    • (2002) Cancer Res. , vol.62 , pp. 4364-4368
    • Tanwar, M.K.1    Gilbert, M.R.2    Holland, E.C.3
  • 18
    • 33645694302 scopus 로고    scopus 로고
    • Different angiogenic phenotypes in primary and secondary glioblastomas
    • Karcher S, Steiner HH, Ahmadi R, et al. 2006. Different angiogenic phenotypes in primary and secondary glioblastomas. Int. J. Cancer 118:2182-89
    • (2006) Int. J. Cancer , vol.118 , pp. 2182-2189
    • Karcher, S.1    Steiner, H.H.2    Ahmadi, R.3
  • 19
    • 20244387732 scopus 로고    scopus 로고
    • Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme
    • Liang Y, Diehn M, Watson N, et al. 2005. Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme. Proc. Natl. Acad. Sci. USA 102:5814-19
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 5814-5819
    • Liang, Y.1    Diehn, M.2    Watson, N.3
  • 20
    • 31544467538 scopus 로고    scopus 로고
    • Distinct transcription profiles of primary and secondary glioblastoma subgroups
    • Tso CL, Freije WA, Day A, et al. 2006. Distinct transcription profiles of primary and secondary glioblastoma subgroups. Cancer Res. 66:159-67
    • (2006) Cancer Res. , vol.66 , pp. 159-167
    • Tso, C.L.1    Freije, W.A.2    Day, A.3
  • 21
    • 73649123907 scopus 로고    scopus 로고
    • An integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RGW, Hoadley KA, Purdom E, et al. 2009. An integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17:98-110
    • (2009) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.W.1    Hoadley, K.A.2    Purdom, E.3
  • 22
    • 77952108366 scopus 로고    scopus 로고
    • Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
    • Noushmehr H, Weisenberger DJ, Diefes K, et al. 2010. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 17:510-22
    • (2010) Cancer Cell , vol.17 , pp. 510-522
    • Noushmehr, H.1    Weisenberger, D.J.2    Diefes, K.3
  • 23
    • 33644820339 scopus 로고    scopus 로고
    • Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
    • Phillips HS, Kharbanda S, Chen R, et al. 2006. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 9:157-73
    • (2006) Cancer Cell , vol.9 , pp. 157-173
    • Phillips, H.S.1    Kharbanda, S.2    Chen, R.3
  • 24
    • 84859992638 scopus 로고    scopus 로고
    • Integrative subtype discovery in glioblastoma using iCluster
    • Shen R, Mo Q, Schultz N, et al. 2012. Integrative subtype discovery in glioblastoma using iCluster. PLoS One 7:e35226
    • (2012) PLoS One , vol.7
    • Shen, R.1    Mo, Q.2    Schultz, N.3
  • 25
    • 70849122697 scopus 로고    scopus 로고
    • Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations
    • Brennan C, Momota H, Hambardzumyan D, et al. 2009. Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations. PLoS One 4:e7752
    • (2009) PLoS One , vol.4
    • Brennan, C.1    Momota, H.2    Hambardzumyan, D.3
  • 26
    • 83455176258 scopus 로고    scopus 로고
    • Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma
    • Snuderl M, Fazlollahi L, Le LP, et al. 2011. Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma. Cancer Cell 20:810-17
    • (2011) Cancer Cell , vol.20 , pp. 810-817
    • Snuderl, M.1    Fazlollahi, L.2    Le, L.P.3
  • 27
    • 84857397985 scopus 로고    scopus 로고
    • Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response
    • Szerlip NJ, Pedraza A, Chakravarty D, et al. 2012. Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response. Proc. Natl. Acad. Sci. USA 109:3041-46
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 3041-3046
    • Szerlip, N.J.1    Pedraza, A.2    Chakravarty, D.3
  • 28
    • 79957927593 scopus 로고    scopus 로고
    • Genetic modeling of gliomas in mice: New tools to tackle old problems
    • Hambardzumyan D, Parada LF, Holland EC, et al. 2011. Genetic modeling of gliomas in mice: new tools to tackle old problems. Glia 59:1155-68
    • (2011) Glia , vol.59 , pp. 1155-1168
    • Hambardzumyan, D.1    Parada, L.F.2    Holland, E.C.3
  • 29
    • 77957667714 scopus 로고    scopus 로고
    • PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas
    • Ozawa T, Brennan CW, Wang L, et al. 2010. PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas. Genes Dev. 24:2205-18
    • (2010) Genes Dev. , vol.24 , pp. 2205-2218
    • Ozawa, T.1    Brennan, C.W.2    Wang, L.3
  • 30
    • 0032401819 scopus 로고    scopus 로고
    • Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus
    • Uhrbom L, Hesselager G, Nister M, et al. 1998. Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus. Cancer Res. 58:5275-79
    • (1998) Cancer Res. , vol.58 , pp. 5275-5279
    • Uhrbom, L.1    Hesselager, G.2    Nister, M.3
  • 31
    • 33745778950 scopus 로고    scopus 로고
    • Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses
    • AssanahM, Lochhead R, Ogden A, et al. 2006. Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses. J. Neurosci. 26:6781-90
    • (2006) J. Neurosci. , vol.26 , pp. 6781-6790
    • Assanah, M.1    Lochhead, R.2    Ogden, A.3
  • 32
    • 0035425048 scopus 로고    scopus 로고
    • PDGFautocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo
    • DaiC, Celestino JC, Okada Y, et al. 2001.PDGFautocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Genes Dev. 15:1913-25
    • (2001) Genes Dev. , vol.15 , pp. 1913-1925
    • Dai, C.1    Celestino, J.C.2    Okada, Y.3
  • 33
    • 3142713010 scopus 로고    scopus 로고
    • Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis
    • Shih AH, Dai C, Hu X, et al. 2004. Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis. Cancer Res. 64:4783-89
    • (2004) Cancer Res. , vol.64 , pp. 4783-4789
    • Shih, A.H.1    Dai, C.2    Hu, X.3
  • 34
    • 0036791177 scopus 로고    scopus 로고
    • Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt
    • Uhrbom L, Dai C, Celestino JC, et al. 2002. Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt. Cancer Res. 62:5551-58
    • (2002) Cancer Res. , vol.62 , pp. 5551-5558
    • Uhrbom, L.1    Dai, C.2    Celestino, J.C.3
  • 35
    • 79959921981 scopus 로고    scopus 로고
    • Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression
    • Fomchenko EI, Dougherty JD, Helmy KY, et al. 2011. Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression. PLoS One 6:e20605
    • (2011) PLoS One , vol.6
    • Fomchenko, E.I.1    Dougherty, J.D.2    Helmy, K.Y.3
  • 36
    • 79956361405 scopus 로고    scopus 로고
    • Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype
    • Lei L, Sonabend AM, Guarnieri P, et al. 2011. Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype. PLoS One 6:e20041
    • (2011) PLoS One , vol.6
    • Lei, L.1    Sonabend, A.M.2    Guarnieri, P.3
  • 37
    • 9144251024 scopus 로고    scopus 로고
    • Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model
    • Uhrbom L, Nerio E, Holland EC. 2004. Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model. Nat. Med. 10:1257-60
    • (2004) Nat. Med. , vol.10 , pp. 1257-1260
    • Uhrbom, L.1    Nerio, E.2    Holland, E.C.3
  • 38
    • 53749096014 scopus 로고    scopus 로고
    • Phase II study of imatinib in patients with recurrent gliomas of various histologies: A European Organisation for Research and Treatment of Cancer Brain Tumor Group Study
    • Raymond E, Brandes AA, Dittrich C, et al. 2008. Phase II study of imatinib in patients with recurrent gliomas of various histologies: a European Organisation for Research and Treatment of Cancer Brain Tumor Group Study. J. Clin. Oncol. 26:4659-65
    • (2008) J. Clin. Oncol. , vol.26 , pp. 4659-4665
    • Raymond, E.1    Brandes, A.A.2    Dittrich, C.3
  • 39
    • 23844457178 scopus 로고    scopus 로고
    • Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo
    • Momota H, Nerio E, Holland EC. 2005. Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo. Cancer Res. 65:7429-35
    • (2005) Cancer Res. , vol.65 , pp. 7429-7435
    • Momota, H.1    Nerio, E.2    Holland, E.C.3
  • 40
    • 79251575938 scopus 로고    scopus 로고
    • Perifosine and CCI 779 co-operate to induce cell death and decrease proliferation in PTEN-intact and PTEN-deficient PDGF-driven murine glioblastoma
    • Pitter KL, Galban CJ, Galban S, et al. 2011. Perifosine and CCI 779 co-operate to induce cell death and decrease proliferation in PTEN-intact and PTEN-deficient PDGF-driven murine glioblastoma. PLoS One 6:e14545
    • (2011) PLoS One , vol.6
    • Pitter, K.L.1    Galban, C.J.2    Galban, S.3
  • 41
    • 84857666591 scopus 로고    scopus 로고
    • Astrocyte-specific expression patterns associated with the PDGF-induced glioma microenvironment
    • Katz AM, Amankulor NM, Pitter K, et al. 2012. Astrocyte-specific expression patterns associated with the PDGF-induced glioma microenvironment. PLoS One 7:e32453
    • (2012) PLoS One , vol.7
    • Katz, A.M.1    Amankulor, N.M.2    Pitter, K.3
  • 42
    • 75349091751 scopus 로고    scopus 로고
    • Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells
    • Charles N, Ozawa T, Squatrito M, et al. 2010. Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells. Cell Stem Cell 6:141-52
    • (2010) Cell Stem Cell , vol.6 , pp. 141-152
    • Charles, N.1    Ozawa, T.2    Squatrito, M.3
  • 43
    • 60849117508 scopus 로고    scopus 로고
    • PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
    • Bleau AM, Hambardzumyan D, Ozawa T, et al. 2009. PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell 4:226-35
    • (2009) Cell Stem Cell , vol.4 , pp. 226-235
    • Bleau, A.M.1    Hambardzumyan, D.2    Ozawa, T.3
  • 44
    • 0037374550 scopus 로고    scopus 로고
    • Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model
    • Ding H, Shannon P, Lau N, et al. 2003. Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model. Cancer Res. 63:1106-13
    • (2003) Cancer Res. , vol.63 , pp. 1106-1113
    • Ding, H.1    Shannon, P.2    Lau, N.3
  • 45
    • 0032418416 scopus 로고    scopus 로고
    • A constitutively active epidermal growth factor receptor cooperates with disruption ofG1 cell-cycle arrest pathways to induce glioma-like lesions in mice
    • Holland EC, Hively WP, DePinho RA, et al. 1998. A constitutively active epidermal growth factor receptor cooperates with disruption ofG1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev. 12:3675-85
    • (1998) Genes Dev. , vol.12 , pp. 3675-3685
    • Holland, E.C.1    Hively, W.P.2    Depinho, R.A.3
  • 46
    • 0037382205 scopus 로고    scopus 로고
    • Genetic determinants of malignancy in a mouse model for oligodendroglioma
    • WeissWA, Burns MJ, Hackett C, et al. 2003. Genetic determinants of malignancy in a mouse model for oligodendroglioma. Cancer Res. 63:1589-95
    • (2003) Cancer Res. , vol.63 , pp. 1589-1595
    • Weiss, W.A.1    Burns, M.J.2    Hackett, C.3
  • 47
    • 62449252775 scopus 로고    scopus 로고
    • Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis
    • Zhu H, Acquaviva J, Ramachandran P, et al. 2009. Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. Proc. Natl. Acad. Sci. USA 106:2712-16
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 2712-2716
    • Zhu, H.1    Acquaviva, J.2    Ramachandran, P.3
  • 48
    • 23644443053 scopus 로고    scopus 로고
    • Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma
    • Zhu Y, Guignard F, Zhao D, et al. 2005. Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell 8:119-30
    • (2005) Cancer Cell , vol.8 , pp. 119-130
    • Zhu, Y.1    Guignard, F.2    Zhao, D.3
  • 49
    • 0033812187 scopus 로고    scopus 로고
    • Nf1; Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects
    • Reilly KM, Loisel DA, Bronson RT, et al. 2000. Nf1; Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nat. Genet. 26:109-13
    • (2000) Nat. Genet. , vol.26 , pp. 109-113
    • Reilly, K.M.1    Loisel, D.A.2    Bronson, R.T.3
  • 50
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RG, Hoadley KA, Purdom E, et al. 2010. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17:98-110
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3
  • 51
    • 57849109837 scopus 로고    scopus 로고
    • Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model
    • Alcantara Llaguno S, Chen J, Kwon CH, et al. 2009. Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell 15:45-56
    • (2009) Cancer Cell , vol.15 , pp. 45-56
    • Alcantara Llaguno, S.1    Chen, J.2    Kwon, C.H.3
  • 52
    • 84858796263 scopus 로고    scopus 로고
    • IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
    • Turcan S, Rohle D, Goenka A, et al. 2012. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature 483:479-83
    • (2012) Nature , vol.483 , pp. 479-483
    • Turcan, S.1    Rohle, D.2    Goenka, A.3
  • 53
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Talpaz M, Resta DJ, et al. 2001. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N. Engl. J. Med. 344:1031-37
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3
  • 54
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
    • Talpaz M, Shah NP, Kantarjian H, et al. 2006. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N. Engl. J. Med. 354:2531-41
    • (2006) N. Engl. J. Med. , vol.354 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 55
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
    • Pao W, Miller V, Zakowski M, et al. 2004. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc. Natl. Acad. Sci. USA 101:13306-11
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 56
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, et al. 2004. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350:2129-39
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 57
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    • Kwak EL, Bang YJ, Camidge DR, et al. 2010. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N. Engl. J. Med. 363:1693-703
    • (2010) N. Engl. J. Med. , vol.363 , pp. 1693-1703
    • Kwak, E.L.1    Bang, Y.J.2    Camidge, D.R.3
  • 58
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman PB, Hauschild A, Robert C, et al. 2011. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N. Engl. J. Med. 364:2507-16
    • (2011) N. Engl. J. Med. , vol.364 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 59
    • 79955582712 scopus 로고    scopus 로고
    • Phase II evaluation of gefitinib in patients with newly diagnosed Grade 4 astrocytoma:Mayo/North Central Cancer Treatment Group Study N0074
    • Uhm JH, Ballman KV, Wu W, et al. 2011. Phase II evaluation of gefitinib in patients with newly diagnosed Grade 4 astrocytoma:Mayo/North Central Cancer Treatment Group Study N0074. Int. J. Radiat. Oncol. Biol. Phys. 80:347-53
    • (2011) Int. J. Radiat. Oncol. Biol. Phys. , vol.80 , pp. 347-353
    • Uhm, J.H.1    Ballman, K.V.2    Wu, W.3
  • 60
    • 75049084471 scopus 로고    scopus 로고
    • Phase 2 trial of erlotinib plus sirolimus in adults with recurrent glioblastoma
    • Reardon DA, Desjardins A, Vredenburgh JJ, et al. 2010. Phase 2 trial of erlotinib plus sirolimus in adults with recurrent glioblastoma. J. Neurooncol. 96:219-30
    • (2010) J. Neurooncol. , vol.96 , pp. 219-230
    • Reardon, D.A.1    Desjardins, A.2    Vredenburgh, J.J.3
  • 61
    • 59149086517 scopus 로고    scopus 로고
    • Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma
    • Prados MD, Chang SM, Butowski N, et al. 2009. Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma. J. Clin. Oncol. 27:579-84
    • (2009) J. Clin. Oncol. , vol.27 , pp. 579-584
    • Prados, M.D.1    Chang, S.M.2    Butowski, N.3
  • 62
    • 43749094544 scopus 로고    scopus 로고
    • MGMT promoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patients
    • Brandes AA, Franceschi E, Tosoni A, et al. 2008. MGMT promoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patients. J. Clin. Oncol. 26:2192-97
    • (2008) J. Clin. Oncol. , vol.26 , pp. 2192-2197
    • Brandes, A.A.1    Franceschi, E.2    Tosoni, A.3
  • 63
    • 84866487544 scopus 로고    scopus 로고
    • Phase II study of Gleevec plus hydroxyurea in adults with progressive or recurrent low-grade glioma
    • Reardon DA, Desjardins A, Vredenburgh JJ, et al. 2012. Phase II study of Gleevec plus hydroxyurea in adults with progressive or recurrent low-grade glioma. Cancer 118:4759-67
    • (2012) Cancer , vol.118 , pp. 4759-4767
    • Reardon, D.A.1    Desjardins, A.2    Vredenburgh, J.J.3
  • 64
    • 71649102124 scopus 로고    scopus 로고
    • Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma
    • Reardon DA, Dresemann G, Taillibert S, et al. 2009. Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma. Br. J. Cancer 101:1995-2004
    • (2009) Br. J. Cancer , vol.101 , pp. 1995-2004
    • Reardon, D.A.1    Dresemann, G.2    Taillibert, S.3
  • 66
    • 79952711945 scopus 로고    scopus 로고
    • Gene expression profile correlates with T-cell infiltration and relative survival in glioblastoma patients vaccinated with dendritic cell immunotherapy
    • Prins RM, Soto H, Konkankit V, et al. 2011. Gene expression profile correlates with T-cell infiltration and relative survival in glioblastoma patients vaccinated with dendritic cell immunotherapy. Clin. Cancer Res. 17:1603-15
    • (2011) Clin. Cancer Res. , vol.17 , pp. 1603-1615
    • Prins, R.M.1    Soto, H.2    Konkankit, V.3
  • 67
    • 84862908734 scopus 로고    scopus 로고
    • Rapid radiographic and clinical improvement after treatment of a MET-amplified recurrent glioblastoma with a mesenchymal-epithelial transition inhibitor
    • Chi AS, Batchelor TT, Kwak EL, et al. 2012. Rapid radiographic and clinical improvement after treatment of a MET-amplified recurrent glioblastoma with a mesenchymal-epithelial transition inhibitor. J. Clin. Oncol. 30:e30-33
    • (2012) J. Clin. Oncol. , vol.30
    • Chi, A.S.1    Batchelor, T.T.2    Kwak, E.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.