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Volumn 145, Issue 3, 2013, Pages 776-783

A herbal formula containing roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) inhibits inflammatory mediators in LPS-stimulated RAW 264.7 macrophages through inhibition of nuclear factor κb (NFκB) pathway

Author keywords

Anti inflammation; Danshen; Gegen; NF B; Pueraria lobata; Salvia miltiorrhiza

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; PROSTAGLANDIN E2; PUERARIA LOBATA EXTRACT; SALVIA MILTIORRHIZA EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84872954613     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.12.011     Document Type: Article
Times cited : (44)

References (33)
  • 1
    • 0028932270 scopus 로고
    • Nonsteroidal anti-inflammatory drugs inhibit expression of the inducible nitric oxide synthase gene
    • E.E. Aeberhard Nonsteroidal anti-inflammatory drugs inhibit expression of the inducible nitric oxide synthase gene Biochemical and Biophysical Research Communications 208 1995 1053 1059
    • (1995) Biochemical and Biophysical Research Communications , vol.208 , pp. 1053-1059
    • Aeberhard, E.E.1
  • 2
    • 2542455472 scopus 로고    scopus 로고
    • INOS-mediated nitric oxide production and its regulation
    • DOI 10.1016/j.lfs.2003.10.042, PII S0024320504002887
    • F. Aktan iNOS-mediated nitric oxide production and its regulation Life Sciences 75 2004 639 653 (Pubitemid 38686696)
    • (2004) Life Sciences , vol.75 , Issue.6 , pp. 639-653
    • Aktan, F.1
  • 3
    • 0030615201 scopus 로고    scopus 로고
    • Nuclear factor-κB - A pivotal transcription factor in chronic inflammatory diseases
    • DOI 10.1056/NEJM199704103361506
    • P.J. Barnes, and M. Karin Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases New England Journal of Medicine 336 1997 1066 1071 (Pubitemid 27163860)
    • (1997) New England Journal of Medicine , vol.336 , Issue.15 , pp. 1066-1071
    • Barnes, P.J.1    Karin, M.2
  • 4
    • 78650679237 scopus 로고    scopus 로고
    • Antihypertensive effect of total flavone extracts from Puerariae Radix
    • R.L. Cai Antihypertensive effect of total flavone extracts from Puerariae Radix Journal of Ethnopharmacology 133 2011 177 183
    • (2011) Journal of Ethnopharmacology , vol.133 , pp. 177-183
    • Cai, R.L.1
  • 5
    • 79955604190 scopus 로고    scopus 로고
    • Anti-inflammatory therapeutics for the treatment of atherosclerosis
    • I.F. Charo, and R. Taub Anti-inflammatory therapeutics for the treatment of atherosclerosis Nature Reviews. Drug Discovery 10 2011 365 376
    • (2011) Nature Reviews. Drug Discovery , vol.10 , pp. 365-376
    • Charo, I.F.1    Taub, R.2
  • 6
    • 33646567844 scopus 로고    scopus 로고
    • Salvianolic acid B attenuates cyclooxygenase-2 expression in vitro in LPS-treated human aortic smooth muscle cells and in vivo in the apolipoprotein-E-deficient mouse aorta
    • Y.L. Chen Salvianolic acid B attenuates cyclooxygenase-2 expression in vitro in LPS-treated human aortic smooth muscle cells and in vivo in the apolipoprotein-E-deficient mouse aorta Journal of Cellular Biochemistry 98 2006 618 631
    • (2006) Journal of Cellular Biochemistry , vol.98 , pp. 618-631
    • Chen, Y.L.1
  • 7
    • 84866741459 scopus 로고    scopus 로고
    • The roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) inhibit atherogenic events: A study of the combination effects of the 2-herb formula
    • D.W. Cheung The roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) inhibit atherogenic events: a study of the combination effects of the 2-herb formula Journal of Ethnopharmacology 143 2012 859 866
    • (2012) Journal of Ethnopharmacology , vol.143 , pp. 859-866
    • Cheung, D.W.1
  • 8
    • 79952191296 scopus 로고    scopus 로고
    • Long-term treatment with Danshen-Gegen decoction protects the myocardium against ischemia/reperfusion injury via the redox-sensitive protein kinase C-epsilon/mK(ATP) pathway in rats
    • P.Y. Chiu Long-term treatment with Danshen-Gegen decoction protects the myocardium against ischemia/reperfusion injury via the redox-sensitive protein kinase C-epsilon/mK(ATP) pathway in rats Rejuvenation Research 14 2011 173 184
    • (2011) Rejuvenation Research , vol.14 , pp. 173-184
    • Chiu, P.Y.1
  • 9
    • 13744259982 scopus 로고    scopus 로고
    • Molecular mechanisms of inhibitory activities of tanshinones on lipopolysaccharide-induced nitric oxide generation in RAW 264.7 cells
    • H.S. Choi Molecular mechanisms of inhibitory activities of tanshinones on lipopolysaccharide-induced nitric oxide generation in RAW 264.7 cells Archives of Pharmacal Research 27 2004 1233 1237
    • (2004) Archives of Pharmacal Research , vol.27 , pp. 1233-1237
    • Choi, H.S.1
  • 11
    • 33750466230 scopus 로고    scopus 로고
    • Introduction to NF-κB: Players, pathways, perspectives
    • DOI 10.1038/sj.onc.1209954, PII 1209954
    • T.D. Gilmore Introduction to NF-kappaB: players, pathways, perspectives Oncogene 25 2006 6680 6684 (Pubitemid 44657845)
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6680-6684
    • Gilmore, T.D.1
  • 12
    • 80054935481 scopus 로고    scopus 로고
    • Evaluation of antidiabetic potential of selected traditional Chinese medicines in STZ-induced diabetic mice
    • K. He Evaluation of antidiabetic potential of selected traditional Chinese medicines in STZ-induced diabetic mice Journal of Ethnopharmacology 137 2011 1135 1142
    • (2011) Journal of Ethnopharmacology , vol.137 , pp. 1135-1142
    • He, K.1
  • 14
    • 80051526767 scopus 로고    scopus 로고
    • Puerarin inhibits iNOS, COX-2 and CRP expression via suppression of NF-kappaB activation in LPS-induced RAW264.7 macrophage cells
    • W. Hu Puerarin inhibits iNOS, COX-2 and CRP expression via suppression of NF-kappaB activation in LPS-induced RAW264.7 macrophage cells Pharmacological Reports 63 2011 781 789
    • (2011) Pharmacological Reports , vol.63 , pp. 781-789
    • Hu, W.1
  • 15
    • 33745997334 scopus 로고    scopus 로고
    • Tanshinone IIA inhibits LPS-induced NF-kappaB activation in RAW 264.7 cells: Possible involvement of the NIK-IKK, ERK1/2, p38 and JNK pathways
    • S.I. Jang Tanshinone IIA inhibits LPS-induced NF-kappaB activation in RAW 264.7 cells: possible involvement of the NIK-IKK, ERK1/2, p38 and JNK pathways European Journal of Pharmacology 542 2006 1 7
    • (2006) European Journal of Pharmacology , vol.542 , pp. 1-7
    • Jang, S.I.1
  • 16
    • 84861535775 scopus 로고    scopus 로고
    • Salvianolic acid B exerts vasoprotective effects through the modulation of heme oxygenase-1 and arginase activities
    • Y. Joe Salvianolic acid B exerts vasoprotective effects through the modulation of heme oxygenase-1 and arginase activities Journal of Pharmacology and Experimental Therapeutics 341 2012 850 858
    • (2012) Journal of Pharmacology and Experimental Therapeutics , vol.341 , pp. 850-858
    • Joe, Y.1
  • 17
    • 80255137560 scopus 로고    scopus 로고
    • Salviae Miltiorrhizae Radix and Puerariae Lobatae Radix herbal formula mediates anti-atherosclerosis by modulating key atherogenic events both in vascular smooth muscle cells and endothelial cells
    • C.M. Koon, K.S. Woo, P.C. Leung, and K.P. Fung Salviae Miltiorrhizae Radix and Puerariae Lobatae Radix herbal formula mediates anti-atherosclerosis by modulating key atherogenic events both in vascular smooth muscle cells and endothelial cells Journal of Ethnopharmacology 138 2011 175 183
    • (2011) Journal of Ethnopharmacology , vol.138 , pp. 175-183
    • Koon, C.M.1    Woo, K.S.2    Leung, P.C.3    Fung, K.P.4
  • 18
    • 77957764454 scopus 로고    scopus 로고
    • Mechanisms of the relaxant effect of a danshen and gegen formulation on rat isolated cerebral basilar artery
    • F.F. Lam Mechanisms of the relaxant effect of a danshen and gegen formulation on rat isolated cerebral basilar artery Journal of Ethnopharmacology 132 2010 186 192
    • (2010) Journal of Ethnopharmacology , vol.132 , pp. 186-192
    • Lam, F.F.1
  • 20
    • 1842453964 scopus 로고    scopus 로고
    • Cyclooxygenase-2 and inflammation in atherosclerosis
    • DOI 10.1016/j.coph.2003.12.003, PII S1471489204000268
    • M.F. Linton, and S. Fazio Cyclooxygenase-2 and inflammation in atherosclerosis Current Opinion in Pharmacology 4 2004 116 123 (Pubitemid 38444045)
    • (2004) Current Opinion in Pharmacology , vol.4 , Issue.2 , pp. 116-123
    • Linton, M.F.1    Fazio, S.2
  • 21
    • 0032509889 scopus 로고    scopus 로고
    • Mechanisms of disease: Chemokines - Chemotactic cytokines that mediate inflammation
    • DOI 10.1056/NEJM199802123380706
    • A.D. Luster Chemokines - Chemotactic cytokines that mediate inflammation New England Journal of Medicine 338 1998 436 445 (Pubitemid 28135672)
    • (1998) New England Journal of Medicine , vol.338 , Issue.7 , pp. 436-445
    • Luster, A.D.1
  • 22
    • 28244461566 scopus 로고    scopus 로고
    • Isoflavone genistein and daidzein up-regulate LPS-induced inducible nitric oxide synthase activity through estrogen receptor pathway in RAW264.7 cells
    • DOI 10.1016/j.bcp.2005.10.002, PII S0006295205006519
    • M. Nakaya, H. Tachibana, and K. Yamada Isoflavone genistein and daidzein up-regulate LPS-induced inducible nitric oxide synthase activity through estrogen receptor pathway in RAW264.7 cells Biochemical Pharmacology 71 2005 108 114 (Pubitemid 41713532)
    • (2005) Biochemical Pharmacology , vol.71 , Issue.1-2 , pp. 108-114
    • Nakaya, M.1    Tachibana, H.2    Yamada, K.3
  • 23
    • 80054941986 scopus 로고    scopus 로고
    • The anti-hypertensive effect of Danshen (Salvia miltiorrhiza) and Gegen (Pueraria lobata) formula in rats and its underlying mechanisms of vasorelaxation
    • C.F. Ng The anti-hypertensive effect of Danshen (Salvia miltiorrhiza) and Gegen (Pueraria lobata) formula in rats and its underlying mechanisms of vasorelaxation Journal of Ethnopharmacology 137 2011 1366 1372
    • (2011) Journal of Ethnopharmacology , vol.137 , pp. 1366-1372
    • Ng, C.F.1
  • 24
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis - An inflammatory disease
    • DOI 10.1056/NEJM199901143400207
    • R. Ross Atherosclerosis - an inflammatory disease New England Journal of Medicine 340 1999 115 126 (Pubitemid 29054847)
    • (1999) New England Journal of Medicine , vol.340 , Issue.2 , pp. 115-126
    • Ross, R.1
  • 26
    • 0034746919 scopus 로고    scopus 로고
    • NF-κB: A key role in inflammatory diseases
    • P.P. Tak, and G.S. Firestein NF-kappaB: a key role in inflammatory diseases Journal of Clinical Investigation 107 2001 7 11 (Pubitemid 32047405)
    • (2001) Journal of Clinical Investigation , vol.107 , Issue.1 , pp. 7-11
    • Tak, P.P.1    Firestein, G.S.2
  • 27
    • 65549153251 scopus 로고    scopus 로고
    • The efficacy and tolerability of adjunctive alternative herbal medicine (Salvia miltiorrhiza and Pueraria lobata) on vascular function and structure in coronary patients
    • W.Y. Tam The efficacy and tolerability of adjunctive alternative herbal medicine (Salvia miltiorrhiza and Pueraria lobata) on vascular function and structure in coronary patients Journal of Alternative and Complementary Medicine 15 2009 415 421
    • (2009) Journal of Alternative and Complementary Medicine , vol.15 , pp. 415-421
    • Tam, W.Y.1
  • 28
    • 0029094831 scopus 로고
    • A simple, rapid and sensitive fluorimetric assay for the measurement of cell-mediated cytotoxicity
    • L. Virag, C. Kerekgyarto, and J. Fachet A simple, rapid and sensitive fluorimetric assay for the measurement of cell-mediated cytotoxicity Journal of Immunological Methods 185 1995 199 208
    • (1995) Journal of Immunological Methods , vol.185 , pp. 199-208
    • Virag, L.1    Kerekgyarto, C.2    Fachet, J.3
  • 29
    • 3543079885 scopus 로고    scopus 로고
    • Effects of Radix Puerariae flavones on liver lipid metabolism in ovariectomized rats
    • J.F. Wang Effects of Radix Puerariae flavones on liver lipid metabolism in ovariectomized rats World Journal of Gastroenterology 10 2004 1967 1970
    • (2004) World Journal of Gastroenterology , vol.10 , pp. 1967-1970
    • Wang, J.F.1
  • 30
    • 77953197744 scopus 로고    scopus 로고
    • Anti-inflammatory activity of salvianolic acid B in microglia contributes to its neuroprotective effect
    • S.X. Wang Anti-inflammatory activity of salvianolic acid B in microglia contributes to its neuroprotective effect Neurochemical Research 35 2010 1029 1037
    • (2010) Neurochemical Research , vol.35 , pp. 1029-1037
    • Wang, S.X.1
  • 31
    • 79960016920 scopus 로고    scopus 로고
    • Anti-oxidative and TNF-alpha suppressive activities of puerarin derivative (4AC) in RAW264.7 cells and collagen-induced arthritic rats
    • C. Xiao Anti-oxidative and TNF-alpha suppressive activities of puerarin derivative (4AC) in RAW264.7 cells and collagen-induced arthritic rats European Journal of Pharmacology 666 2011 242 250
    • (2011) European Journal of Pharmacology , vol.666 , pp. 242-250
    • Xiao, C.1
  • 32
    • 83755195393 scopus 로고    scopus 로고
    • DBZ blocks LPS-induced monocyte activation and foam cell formation via inhibiting nuclear factor-kB
    • X. Xie DBZ blocks LPS-induced monocyte activation and foam cell formation via inhibiting nuclear factor-kB Cellular Physiology and Biochemistry 28 2011 649 662
    • (2011) Cellular Physiology and Biochemistry , vol.28 , pp. 649-662
    • Xie, X.1
  • 33
    • 27844511101 scopus 로고    scopus 로고
    • Danshen: An overview of its chemistry, pharmacology, pharmacokinetics, and clinical use
    • DOI 10.1177/0091270005282630
    • L. Zhou, Z. Zuo, and M.S. Chow Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use Journal of Clinical Pharmacology 45 2005 1345 1359 (Pubitemid 41643896)
    • (2005) Journal of Clinical Pharmacology , vol.45 , Issue.12 , pp. 1345-1359
    • Zhou, L.1    Zuo, Z.2    Chow, M.S.S.3


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