Molecular modelling study of HIV p17gag (MA) protein shell utilising data from electron microscopy and X-ray crystallography

Journal of Molecular Biology

Volumn 298, Issue 5, 2000, Pages 841-857

  Forster, M J ^a   Mulloy, B ^a   Nermut, M V ^a  

^a NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

Author keywords

Electron microscopy; HIV; MA; Matrix protein; Molecular modelling

Indexed keywords

GAG PROTEIN; MATRIX PROTEIN; VIRUS GLYCOPROTEIN; VIRUS PROTEIN; WATER;

ARTICLE; ELECTRON MICROSCOPY; HUMAN IMMUNODEFICIENCY VIRUS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; VIRION; VIRUS PARTICLE; X RAY CRYSTALLOGRAPHY;

EID: 0034685614     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3715     Document Type: Article

References (64)

1. Organization of HIV-1 capsid proteins on a lipid monolayer
2. Local rule-based theory of virus shell assembly
3. Head-to-tail dimers and interdomain flexibility revealed by the crystal structure of HIV-1 capsid protein (p24) complexed with a monoclonal antibody Fab
4. CHARMM: A program for macromolecular energy, minimisation and molecular dynamics calculation
5. Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41
6. Self-assembly in vitro of purified CA-NC proteins from Rous sarcoma virus and human immunodeficiency virus type 1
7. Principles of virion structure, function, and assembly
8. Physical principles in the construction of regular viruses
9. Core structure of gp41 from the HIV envelope glycoprotein
10. Retroviral matrix proteins: A structural perspective
11. A second generation force field for the simulation of proteins and nucleic acids
12. The structure of small viruses
13. Quality assessment of NMR structures: A statistical survey
14. Accurate modeling of the intramolecular electrostatic energy of proteins
15. Solvation energy in protein folding and binding
16. HIV-1 gag proteins: Diverse functions in the virus life cycle
17. Cryo-electron microscopy reveals ordered domains in the immature HIV-1 particle
18. Structure of the carboxyl-terminal dimerization domain of the HIV-1capsid protein
19. Recent advances and remaining problems in HIV assembly
20. Assembly and morphology of HIV: Potential effect of structure on viral function
21. Fine structure of human immunodeficiency virus (HIV) and immunolocalization of structural proteins
22. Morphogenesis and morphology of HIV. Structure-function relations
23. Determination of the size of HIV using adenovirus type 2 as an internal length marker
24. Assembly and release of HIV-1 precursor pr55gag virus-like particles from recombinant baculovirus-infected cells
25. The life-cycle of human immunodeficiency virus type 1
26. A morphological and immunolabelling study of freeze-substituted human and simian immunodeficiency viruses
27. N-terminal extension of human immunodeficiency virus capsid protein converts the in vitro assembly phenotype from tubular to spherical particles
28. Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: Implications for membrane association and assembly
29. Mapping the protein universe
30. Calculation of the free energy of association for protein complexes
31. The molecular basis of HIV capsid assembly
32. HIV protease inhibitors: Advances in therapy and adverse reactions, including metabolic complications
33. Morphogenesis and maturation of retroviruses
34. Intracellular transport of retroviral capsid components
35. Mutations in the matrix protein of human immunodeficiency virus type 1 inhibit surface expression and virion incorporation of viral envelope glycoproteins in CD +4 T lymphocytes
36. Computer emulation of thin section electron microscopy predicts an envelope-associated icosahedral capsid for human immunodeficiency virus
37. Satisfying hydrogen bonding potential in proteins
38. Structural similarity between the p17 matrix of HIV and interferon gamma
39. Detection of a trimeric human immunodeficiency virus type 1 gag intermediate is dependent on sequences in the matrix protein, p17
40. Comparative morphology and structural classification of retro-viruses
41. Further evidence of icosohedral symmetry in human and simian immunodeficiency virus
42. Fullerene-like organization of HIV gag-protein shell in virus-like particles produced by recombinant baculovirus
43. Further evidence for hexagonal organization of HIV gag protein in prebudding assemblies and immature virus-like particles
44. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons
45. The organization of the envelope projections on the surface of HIV
46. An efficient Newton-like method for molecularmechanics energy minimization of large molecules
47. Crystal structure of SIV matrix antigen and implications for virus assembly
48. Energetics of quasiequivalence: Computational analysis of protein-protein interactions in icosahedral viruses
49. Efficient HIV-1 replication can occur in the absence of the viral matrix protein
50. Membrane-induced alterations in HIV-1 gag and matrix protein-protein interactions
51. Local rules simulation of the kinetics of virus capsid self assembly
52. Membrane binding of human immunodeficiency virus type 1 matrix protein in vivo supports a conformational myristyl switch mechanism
53. Envelope structure model of human immunodeficiency virus type 1
54. Structural biology of HIV
55. Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assembly
56. WHAT IF: A molecular modeling and drug design program
57. Atomic structure of the ectodomain from HIV-1 gp41
58. Towards the structure of the human immunodeficiency virus: Divide and conquer?
59. Situs: A package for docking crystal structures into low-resolution maps for electron microscopy
60. The antigenic structure of the HIV gp120 envelope glycoprotein
61. The crystal structure of the SIV gp41 ectodomain at 1.47 Å resolution
62. Supramolecular organization of immature and mature murine leukemia virus revealed by electron cryo-microscopy: Implications for retroviral assembly mechanisms
63. Identification of a membrane-binding domain within the amino-terminal region of human immunodeficiency virus type 1 gag protein which interacts with acidic phospholipids
64. To build a virus capsid. An equilibrium model of the self assembly of polyhedral protein complexes