Role and pharmacologic significance of cytochrome P-450 2D6 in oxidative metabolism of toremifene and tamoxifen

International Journal of Cancer

Volumn 132, Issue 6, 2013, Pages 1475-1485

  Kim, Juhyun ^a   Coss, Christopher C ^a   Barrett, Christina M ^a   Mohler, Michael L ^a   Bohl, Casey E ^a   Li, Chien Ming ^a   He, Yali ^a   Veverka, Karen A ^a   Dalton, James T ^a,b  

^a GTx Inc   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

CYP2D6; tamoxifen; tamoxifen metabolism; toremifene

Indexed keywords

4 HYDROXY; CYTOCHROME P450 2D6; CYTOCHROME P450 2D6 INHIBITOR; DRUG METABOLITE; ENZYME INHIBITOR; ESTROGEN RECEPTOR; N DESMETHYL; TAMOXIFEN; TOREMIFENE; UNCLASSIFIED DRUG;

ADULT; AEROBIC METABOLISM; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; ESTROGEN ACTIVITY; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HYDROXYLATION; IN VITRO STUDY; LOADING DRUG DOSE; MALE; METABOLITE; MOLECULAR MODEL; NORMAL HUMAN; OXIDATION; PRIORITY JOURNAL; SINGLE DRUG DOSE; STEADY STATE; TRANSACTIVATION;

ADULT; CYTOCHROME P-450 CYP2D6; HUMANS; MALE; OXIDATION-REDUCTION; SELECTIVE ESTROGEN RECEPTOR MODULATORS; STRUCTURE-ACTIVITY RELATIONSHIP; TAMOXIFEN; TOREMIFENE;

EID: 84872927511     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.27794     Document Type: Article

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