Sodium tungstate activates glycogen synthesis through a non-canonical mechanism involving G-proteins

FEBS Letters

Volumn 587, Issue 3, 2013, Pages 291-296

  Zafra, Delia ^a   Nocito, Laura ^a   Domínguez, Jorge ^a   Guinovart, Joan J ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Diabetes; G protein; Glycogen; MAP kinase; Metabolism; Sodium tungstate

Indexed keywords

ANTIDIABETIC AGENT; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN; TUNGSTATE SODIUM; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME MECHANISM; FEMALE; GENE DISRUPTION; GLYCOGEN SYNTHESIS; LIVER CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLYCOGEN; HEPATOCYTES; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; HYPOGLYCEMIC AGENTS; PHOSPHORYLATION; RAS PROTEINS; RATS; RATS, WISTAR; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TRANSFECTION; TUNGSTEN COMPOUNDS;

EID: 84872919211     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.11.034     Document Type: Article

References (25)

1. A. Barbera, J. Fernandez-Alvarez, A. Truc, R. Gomis, and J.J. Guinovart Effects of tungstate in neonatally streptozotocin-induced diabetic rats: mechanism leading to normalization of glycaemia Diabetologia 40 1997 143 149 (Pubitemid 27060285)
2. A. Barbera, J.E. Rodriguez-Gil, and J.J. Guinovart Insulin-like actions of tungstate in diabetic rats. Normalization of hepatic glucose metabolism J. Biol. Chem. 269 1994 20047 20053
3. M.C. Munoz, A. Barbera, J. Dominguez, J. Fernandez-Alvarez, R. Gomis, and J.J. Guinovart Effects of tungstate, a new potential oral antidiabetic agent, in Zucker diabetic fatty rats Diabetes 50 2001 131 138 (Pubitemid 32047991)
4. L. Nocito, D. Zafra, J. Calbó, J. Domínguez, and J.J. Guinovart Tungstate reduces the expression of gluconeogenic enzymes in STZ rats PLoS ONE 7 2012 e42305
5. M.D. Giron, N. Sevillano, A.M. Vargas, J. Dominguez, J.J. Guinovart, and R. Salto The glucose-lowering agent sodium tungstate increases the levels and translocation of GLUT4 in L6 myotubes through a mechanism associated with ERK1/2 and MEF2D Diabetologia 51 2008 1285 1295
6. J. Rodriguez-Gallardo, R.A. Silvestre, E.M. Egido, and J. Marco Effects of sodium tungstate on insulin and glucagon secretion in the perfused rat pancreas Eur. J. Pharmacol. 402 2000 199 204 (Pubitemid 30625327)
7. J. Fernandez-Alvarez, A. Barbera, B. Nadal, S. Barcelo-Batllori, S. Piquer, M. Claret, J.J. Guinovart, and R. Gomis Stable and functional regeneration of pancreatic beta-cell population in nSTZ-rats treated with tungstate Diabetologia 47 2004 470 477 (Pubitemid 38491243)
8. J.E. Dominguez The antidiabetic agent sodium tungstate activates glycogen synthesis through an insulin receptor-independent pathway J. Biol. Chem. 278 2003 42785 42794 (Pubitemid 37345888)
9. J. Ballester, J. Dominguez, M.C. Munoz, M. Sensat, T. Rigau, J.J. Guinovart, and J.E. Rodriguez-Gil Tungstate treatment improves Leydig cell function in streptozotocin-diabetic rats J. Androl. 26 2005 706 715 (Pubitemid 41476629)
10. A. Gomez-Ramos, J. Dominguez, D. Zafra, H. Corominola, R. Gomis, J.J. Guinovart, and J. Avila Sodium tungstate decreases the phosphorylation of tau through GSK3 inactivation J. Neurosci. Res. 83 2006 264 273 (Pubitemid 43184390)
11. C. Reynet, M. Caron, J. Magre, G. Cherqui, E. Clauser, J. Picard, and J. Capeau Mutation of tyrosine residues 1162 and 1163 of the insulin receptor affects hormone and receptor internalization Mol. Endocrinol. 4 1990 304 311
12. J. Massague, and J.J. Guinovart Insulin control of rat hepatocyte glycogen synthase and phosphorylase in the absence of glucose FEBS Lett. 82 1977 317 320 (Pubitemid 8206193)
13. P. Villalonga, C. Lopez-Alcala, A. Chiloeches, J. Gil, R. Marais, O. Bachs, and N. Agell Calmodulin prevents activation of Ras by PKC in 3T3 fibroblasts J. Biol. Chem. 277 2002 37929 37935
14. T.M. Chan, and J.H. Exton A rapid method for the determination of glycogen content and radioactivity in small quantities of tissue or isolated hepatocytes Anal. Biochem. 71 1976 96 105
15. P. Crespo, T.G. Cachero, N. Xu, and J.S. Gutkind Dual effect of beta-adrenergic receptors on mitogen-activated protein kinase. Evidence for a beta gamma-dependent activation and a G alpha s-cAMP-mediated inhibition J. Biol. Chem. 270 1995 25259 25265
16. T.C. Becker, R.J. Noel, W.S. Coats, A.M. Gomez-Foix, T. Alam, R.D. Gerard, and C.B. Newgard Use of recombinant adenovirus for metabolic engineering of mammalian cells Methods Cell Biol 43 Pt A 1994 161 189
17. R.R. Gomis, J.C. Ferrer, and J.J. Guinovart Shared control of hepatic glycogen synthesis by glycogen synthase and glucokinase Biochem. J. 351 Pt 3 2000 811 816
18. M.M. McKay, and D.K. Morrison Integrating signals from RTKs to ERK/MAPK Oncogene 26 2007 3113 3121 (Pubitemid 46763008)
19. W.J. Koch, B.E. Hawes, L.F. Allen, and R.J. Lefkowitz Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras Proc. Natl. Acad. Sci. USA 91 1994 12706 12710
20. C.M. Moxham, and C.C. Malbon Insulin action impaired by deficiency of the G-protein subunit G ialpha2 Nature 379 1996 840 844 (Pubitemid 26067728)
21. J.H. Guo, H.Y. Wang, and C.C. Malbon Conditional, tissue-specific expression of Q205L Galphai2 in vivo mimics insulin activation of c-Jun N-terminal kinase and p38 kinase J. Biol. Chem. 273 1998 16487 16493 (Pubitemid 28311432)
22. C. Murga, S. Fukuhara, and J.S. Gutkind Novel Molecular Mediators in the Pathway Connecting G-protein-coupled receptors to MAP kinase cascades Trends Endocrinol. Metab. 10 1999 122 127 (Pubitemid 29284345)
23. P. Crespo, N. Xu, W.F. Simonds, and J.S. Gutkind Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits Nature 369 1994 418 420 (Pubitemid 24184058)
24. S. Ros, M. Garcia-Rocha, J. Calbo, and J.J. Guinovart Restoration of hepatic glycogen deposition reduces hyperglycaemia, hyperphagia and gluconeogenic enzymes in a streptozotocin-induced model of diabetes in rats Diabetologia 54 2011 2639 2648
25. R. Yang, and C.B. Newgard Hepatic expression of a targeting subunit of protein phosphatase-1 in streptozotocin-diabetic rats reverses hyperglycemia and hyperphagia despite depressed glucokinase expression J. Biol. Chem. 278 2003 23418 23425 (Pubitemid 36830158)