메뉴 건너뛰기




Volumn 27, Issue 7, 2012, Pages 329-335

Evidence for a genetic role in varicose veins and chronic venous insufficiency

Author keywords

Genetics; Genome wide scan; Varicose veins; Venous

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BLOOD CLOTTING FACTOR 13; ESTROGEN; ESTROGEN RECEPTOR BETA; RNA; THROMBOMODULIN; TRANSCRIPTION FACTOR FOXC2; TUMOR NECROSIS FACTOR ALPHA;

EID: 84872872357     PISSN: 02683555     EISSN: 14333031     Source Type: Journal    
DOI: 10.1258/phleb.2011.011030     Document Type: Review
Times cited : (54)

References (56)
  • 1
    • 0032977870 scopus 로고    scopus 로고
    • Prevalence of varicose veins and chronic venous insufficiency in men and women in the general population: Edinburgh Vein Study
    • Evans CJ, Fowkes FG, Ruckley CV, Lee AJ. Prevalence of varicose veins and chronic venous insufficiency in men and women in the general population: Edinburgh Vein Study. J Epidemiol Community Health 1999;53:149-53
    • (1999) J Epidemiol Community Health , vol.53 , pp. 149-153
    • Evans, C.J.1    Fowkes, F.G.2    Ruckley, C.V.3    Lee, A.J.4
  • 2
    • 70350517364 scopus 로고    scopus 로고
    • Pathogenesis of primary varicose veins
    • Lim CS, Davies AH. Pathogenesis of primary varicose veins. Br J Surg 2009;96:1231-42
    • (2009) Br J Surg , vol.96 , pp. 1231-1242
    • Lim, C.S.1    Davies, A.H.2
  • 7
    • 76549252567 scopus 로고    scopus 로고
    • Differential diagnosis and treatment of pathologically enlarged veins
    • Pratt GH. Differential diagnosis and treatment of pathologically enlarged veins. Med Clin North Am 1950;34: 897-908
    • Med Clin North Am 1950 , vol.34 , pp. 897-908
    • Pratt, G.H.1
  • 9
    • 0032133974 scopus 로고    scopus 로고
    • Genetic analysis of varicose vein of lower extremities
    • Guo Q, Guo C. Genetic analysis of varicose vein of lower extremities. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 1998;15:221-3
    • (1998) Zhonghua Yi Xue Yi Chuan Xue Za Zhi , vol.15 , pp. 221-223
    • Guo, Q.1    Guo, C.2
  • 10
    • 70349566991 scopus 로고    scopus 로고
    • Effect of family history on the incidence of varicose veins: A population-based follow-up study in Finland
    • Ahti TM, Makivaara LA, Luukkaala T, Hakama M, Laurikka JO. Effect of family history on the incidence of varicose veins: a population-based follow-up study in Finland. Angiology 2009;60:487-91
    • (2009) Angiology , vol.60 , pp. 487-491
    • Ahti, T.M.1    Makivaara, L.A.2    Luukkaala, T.3    Hakama, M.4    Laurikka, J.O.5
  • 11
    • 77953412765 scopus 로고    scopus 로고
    • Heritability of chronic venous disease
    • Fiebig A, Krusche P, Wolf A, et al. Heritability of chronic venous disease. Hum Genet 2010;127:669-74
    • (2010) Hum Genet , vol.127 , pp. 669-674
    • Fiebig, A.1    Krusche, P.2    Wolf, A.3
  • 12
    • 35648995843 scopus 로고    scopus 로고
    • Identification of differentially expressed genes in human varicose veins: Involvement of matrix gla protein in extracellular matrix remodeling
    • Cario-Toumaniantz C, Boularan C, Schurgers LJ, et al. Identification of differentially expressed genes in human varicose veins: involvement of matrix gla protein in extracellular matrix remodeling. J Vasc Res 2007;44:444-59
    • (2007) J Vasc Res , vol.44 , pp. 444-459
    • Cario-Toumaniantz, C.1    Boularan, C.2    Schurgers, L.J.3
  • 13
    • 13244281948 scopus 로고    scopus 로고
    • Identification of differentially expressed genes in primary varicose veins
    • Kim DI, Eo HS, Joh JH. Identification of differentially expressed genes in primary varicose veins. J Surg Res 2005;123:222-6
    • (2005) J Surg Res , vol.123 , pp. 222-226
    • Kim, D.I.1    Eo, H.S.2    Joh, J.H.3
  • 14
    • 1442280821 scopus 로고    scopus 로고
    • Primary varicose veins: Altered transcription of VEGF and its receptors (KDR, flt-1, soluble flt-1) with saphenofemoral junction incompetence
    • Hollingsworth SJ, Powell G, Barker SG, Cooper DG. Primary varicose veins: altered transcription of VEGF and its receptors (KDR, flt-1, soluble flt-1) with saphenofemoral junction incompetence. Eur J Vasc Endovasc Surg 2004;27:259-68
    • (2004) Eur J Vasc Endovasc Surg , vol.27 , pp. 259-268
    • Hollingsworth, S.J.1    Powell, G.2    Barker, S.G.3    Cooper, D.G.4
  • 15
    • 20144388019 scopus 로고    scopus 로고
    • Gene expression profiles in varicose veins using complementary DNA microarray
    • Lee S, Lee W, Choe Y, et al. Gene expression profiles in varicose veins using complementary DNA microarray. Dermatol Surg 2005;31:391-5
    • (2005) Dermatol Surg , vol.31 , pp. 391-395
    • Lee, S.1    Lee, W.2    Choe, Y.3
  • 16
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
    • Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 2003;33(Suppl 1):245-54
    • (2003) Nat Genet , vol.33 , Issue.SUPPL. 1 , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 17
    • 42549126341 scopus 로고    scopus 로고
    • Epigenetic regulation of vascular endothelial gene expression
    • Matouk CC, Marsden PA. Epigenetic regulation of vascular endothelial gene expression. Circ Res 2008;102: 873-87
    • (2008) Circ Res , vol.102 , pp. 8873-8887
    • Matouk, C.C.1    Marsden, P.A.2
  • 18
    • 28544441191 scopus 로고    scopus 로고
    • Improved understanding of gene expression regulation using systems biology
    • Kuczenski RS, Aggarwal K, Lee KH. Improved understanding of gene expression regulation using systems biology. Expert Rev Proteomics 2005;2:915-24
    • (2005) Expert Rev Proteomics , vol.2 , pp. 915-924
    • Kuczenski, R.S.1    Aggarwal, K.2    Lee, K.H.3
  • 19
    • 34548813411 scopus 로고    scopus 로고
    • Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis
    • Liu Y, Ringner M. Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis. Genome Biol 2007;8:R77
    • (2007) Genome Biol , vol.8
    • Liu, Y.1    Ringner, M.2
  • 20
    • 0021343570 scopus 로고
    • A polymorphic locus near the human insulin gene is associated with insulindependent diabetes mellitus
    • Bell GI, Horita S, Karam JH. A polymorphic locus near the human insulin gene is associated with insulindependent diabetes mellitus. Diabetes 1984;33:176-83
    • (1984) Diabetes , vol.33 , pp. 176-183
    • Bell, G.I.1    Horita, S.2    Karam, J.H.3
  • 21
    • 18444378418 scopus 로고    scopus 로고
    • Analysis of the phenotypic abnormalities in lymphoedema-distichiasis syndrome in 74 patients with FOXC2 mutations or linkage to 16q24
    • Brice G, Mansour S, Bell R, et al. Analysis of the phenotypic abnormalities in lymphoedema-distichiasis syndrome in 74 patients with FOXC2 mutations or linkage to 16q24. J Med Genet 2002;39:478-83
    • (2002) J Med Genet , vol.39 , pp. 478-483
    • Brice, G.1    Mansour, S.2    Bell, R.3
  • 22
    • 34247168398 scopus 로고    scopus 로고
    • Mutations in FOXC2 are strongly associated with primary valve failure in veins of the lower limb
    • Mellor RH, Brice G, Stanton AW, et al. Mutations in FOXC2 are strongly associated with primary valve failure in veins of the lower limb. Circulation 2007;115:1912-20
    • (2007) Circulation , vol.115 , pp. 1912-1920
    • Mellor, R.H.1    Brice, G.2    Stanton, A.W.3
  • 23
    • 0035098326 scopus 로고    scopus 로고
    • Thrombomodulin promoter mutations, venous thrombosis, and varicose veins
    • Le Flem L, Mennen L, Aubry ML, et al. Thrombomodulin promoter mutations, venous thrombosis, and varicose veins. Arterioscler Thromb Vasc Biol 2001;21:445-51
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 445-451
    • Le Flem, L.1    Mennen, L.2    Aubry, M.L.3
  • 24
    • 0032893645 scopus 로고    scopus 로고
    • Mutations in promoter region of thrombomodulin and venous thromboembolic disease
    • Le Flem L, Picard V, Emmerich J, et al. Mutations in promoter region of thrombomodulin and venous thromboembolic disease. Arterioscler Thromb Vasc Biol 1999;19:1098-104
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , pp. 1098-1104
    • Le Flem, L.1    Picard, V.2    Emmerich, J.3
  • 26
    • 23744438772 scopus 로고    scopus 로고
    • Hemochromatosis C282Y gene mutation increases the risk of venous leg ulceration
    • Zamboni P, Tognazzo S, Izzo M, et al. Hemochromatosis C282Y gene mutation increases the risk of venous leg ulceration. J Vasc Surg 2005;42:309-14
    • (2005) J Vasc Surg , vol.42 , pp. 309-314
    • Zamboni, P.1    Tognazzo, S.2    Izzo, M.3
  • 27
    • 78650384117 scopus 로고    scopus 로고
    • Interplay of iron metallobiology, metalloproteinases, and FXIII, and role of their gene variants in venous leg ulcer
    • Singh AV, Subhashree L, Milani P, Gemmati D, Zamboni P. Interplay of iron metallobiology, metalloproteinases, and FXIII, and role of their gene variants in venous leg ulcer. Int J Low Extrem Wounds 2010;9:166-79
    • (2010) Int J Low Extrem Wounds , vol.9 , pp. 166-179
    • Singh, A.V.1    Subhashree, L.2    Milani, P.3    Gemmati, D.4    Zamboni, P.5
  • 28
    • 70549104772 scopus 로고    scopus 로고
    • DNA-array of gene variants in venous leg ulcers: Detection of prognostic indicators
    • Gemmati D, Federici F, Catozzi L, et al. DNA-array of gene variants in venous leg ulcers: detection of prognostic indicators. J Vasc Surg 2009;50:1444-51
    • (2009) J Vasc Surg , vol.50 , pp. 1444-1451
    • Gemmati, D.1    Federici, F.2    Catozzi, L.3
  • 29
    • 0036861543 scopus 로고    scopus 로고
    • Treatment of non-healing leg ulcers with fibrin-stabilizing factor XIII: A case report
    • Hildenbrand T, Idzko M, Panther E, Norgauer J, Herouy Y. Treatment of non-healing leg ulcers with fibrin-stabilizing factor XIII: a case report. Dermatol Surg 2002;28: 1098-9
    • (2002) Dermatol Surg , vol.28 , pp. 1098-1099
    • Hildenbrand, T.1    Idzko, M.2    Panther, E.3    Norgauer, J.4    Herouy, Y.5
  • 30
    • 0030466703 scopus 로고    scopus 로고
    • Factor XIII in ulcerative leg disease: Background and preliminary clinical results
    • Wozniak G, Dapper F, Alemany J. Factor XIII in ulcerative leg disease: background and preliminary clinical results. Semin Thromb Hemost 1996;22:445-50
    • (1996) Semin Thromb Hemost , vol.22 , pp. 445-450
    • Wozniak, G.1    Dapper, F.2    Alemany, J.3
  • 31
    • 4744349315 scopus 로고    scopus 로고
    • Factor XIII V34L polymorphism modulates the risk of chronic venous leg ulcer progression and extension
    • Gemmati D, Tognazzo S, Serino ML, et al. Factor XIII V34L polymorphism modulates the risk of chronic venous leg ulcer progression and extension. Wound Repair Regen 2004;12:512-7
    • (2004) Wound Repair Regen , vol.12 , pp. 512-517
    • Gemmati, D.1    Tognazzo, S.2    Serino, M.L.3
  • 32
    • 33747885218 scopus 로고    scopus 로고
    • Influence of gene polymorphisms in ulcer healing process after superficial venous surgery
    • Gemmati D, Tognazzo S, Catozzi L, et al. Influence of gene polymorphisms in ulcer healing process after superficial venous surgery. J Vasc Surg 2006;44:554-62
    • (2006) J Vasc Surg , vol.44 , pp. 554-562
    • Gemmati, D.1    Tognazzo, S.2    Catozzi, L.3
  • 33
    • 0030669690 scopus 로고    scopus 로고
    • Estrogen accelerates cutaneous wound healing associated with an increase in TGF-beta1 levels
    • Ashcroft GS, Dodsworth J, van Boxtel E, et al. Estrogen accelerates cutaneous wound healing associated with an increase in TGF-beta1 levels. Nat Med 1997;3:1209-15
    • (1997) Nat Med , vol.3 , pp. 1209-1215
    • Ashcroft, G.S.1    Dodsworth, J.2    van Boxtel, E.3
  • 34
    • 0032870946 scopus 로고    scopus 로고
    • Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response
    • Ashcroft GS, Greenwell-Wild T, Horan MA, Wahl SM, Ferguson MW. Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response. Am J Pathol 1999;155:1137-46
    • (1999) Am J Pathol , vol.155 , pp. 1137-1146
    • Ashcroft, G.S.1    Greenwell-Wild, T.2    Horan, M.A.3    Wahl, S.M.4    Ferguson, M.W.5
  • 35
    • 37249030347 scopus 로고    scopus 로고
    • Polymorphisms spanning the 0N exon and promoter of the estrogen receptor-beta (ERbeta) gene ESR2 are associated with venous ulceration
    • Ashworth JJ, Smyth JV, Pendleton N, et al. Polymorphisms spanning the 0N exon and promoter of the estrogen receptor-beta (ERbeta) gene ESR2 are associated with venous ulceration. Clin Genet 2008;73:55-61
    • (2008) Clin Genet , vol.73 , pp. 55-61
    • Ashworth, J.J.1    Smyth, J.V.2    Pendleton, N.3
  • 36
    • 0034740493 scopus 로고    scopus 로고
    • Influence of TNF alpha gene polymorphisms on TNFalpha production and disease
    • Hajeer AH, Hutchinson IV. Influence of TNF alpha gene polymorphisms on TNFalpha production and disease. Hum Immunol 2001;62:1191-9
    • (2001) Hum Immunol , vol.62 , pp. 1191-1199
    • Hajeer, A.H.1    Hutchinson, I.V.2
  • 37
    • 0031916466 scopus 로고    scopus 로고
    • Levels of tumor necrosis factoralpha (TNF-alpha) and soluble TNF receptors in chronic venous leg ulcers-correlations to healing status
    • Wallace HJ, Stacey MC. Levels of tumor necrosis factoralpha (TNF-alpha) and soluble TNF receptors in chronic venous leg ulcers-correlations to healing status. J Invest Dermatol 1998;110:292-6
    • (1998) J Invest Dermatol , vol.110 , pp. 292-296
    • Wallace, H.J.1    Stacey, M.C.2
  • 38
    • 33645018036 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha gene polymorphism associated with increased susceptibility to venous leg ulceration
    • Wallace HJ, Vandongen YK, Stacey MC. Tumor necrosis factor-alpha gene polymorphism associated with increased susceptibility to venous leg ulceration. J Invest Dermatol 2006;126:921-5
    • (2006) J Invest Dermatol , vol.126 , pp. 921-925
    • Wallace, H.J.1    Vandongen, Y.K.2    Stacey, M.C.3
  • 41
    • 0242408365 scopus 로고    scopus 로고
    • The prevalence of hyperhomocysteinemia, methylene tetrahydrofolate reductase C677T mutation, and vitamin B12 and folate deficiency in patients with chronic venous insufficiency
    • Sam RC, Burns PJ, Hobbs SD, et al. The prevalence of hyperhomocysteinemia, methylene tetrahydrofolate reductase C677T mutation, and vitamin B12 and folate deficiency in patients with chronic venous insufficiency. J Vasc Surg 2003;38:904-8
    • (2003) J Vasc Surg , vol.38 , pp. 904-908
    • Sam, R.C.1    Burns, P.J.2    Hobbs, S.D.3
  • 42
    • 64949171474 scopus 로고    scopus 로고
    • Higher prevalence of thrombophilia in patients with varicose veins and venous ulcers than controls
    • Darvall KA, Sam RC, Adam DJ, Silverman SH, Fegan C., Bradbury AW. Higher prevalence of thrombophilia in patients with varicose veins and venous ulcers than controls. J Vasc Surg 2009;49:1235-41
    • (2009) J Vasc Surg , vol.49 , pp. 1235-1241
    • Darvall, K.A.1    Sam, R.C.2    Adam, D.J.3    Silverman, S.H.4    Fegan, C.5    Bradbury, A.W.6
  • 43
    • 0042667105 scopus 로고    scopus 로고
    • Chronic venous insufficiency: The genetic influence
    • Pistorius MA. Chronic venous insufficiency: the genetic influence. Angiology 2003;54(Suppl. 1): S5-12
    • (2003) Angiology , vol.54 , Issue.SUPPL. 1
    • Pistorius, M.A.1
  • 44
    • 0032952468 scopus 로고    scopus 로고
    • Freely associating
    • Freely associating. Nat Genet 1999;22:1-2
    • (1999) Nat Genet , vol.22 , pp. 1-2
  • 45
    • 34548789547 scopus 로고    scopus 로고
    • Genetic association studies; the good, the bad, and the ugly
    • Donahue MP, Kraus WE. Genetic association studies; the good, the bad, and the ugly. Am Heart J 2007;154:610-2
    • (2007) Am Heart J , vol.154 , pp. 610-612
    • Donahue, M.P.1    Kraus, W.E.2
  • 46
    • 34547623750 scopus 로고    scopus 로고
    • Genomewide association analysis of coronary artery disease
    • Samani NJ, Erdmann J, Hall AS, et al. Genomewide association analysis of coronary artery disease. N Engl J Med 2007;357:443-53
    • (2007) N Engl J Med , vol.357 , pp. 443-453
    • Samani, N.J.1    Erdmann, J.2    Hall, A.S.3
  • 47
    • 34250010480 scopus 로고    scopus 로고
    • A common variant on chromosome 9p21 affects the risk of myocardial infarction
    • Helgadottir A, Thorleifsson G, Manolescu A, et al. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science 2007;316:1491-3
    • (2007) Science , vol.316 , pp. 1491-1493
    • Helgadottir, A.1    Thorleifsson, G.2    Manolescu, A.3
  • 48
    • 77949775636 scopus 로고    scopus 로고
    • Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice
    • Visel A, Zhu Y, May D, et al. Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature 2010;464:409-13
    • (2010) Nature , vol.464 , pp. 409-413
    • Visel, A.1    Zhu, Y.2    May, D.3
  • 49
    • 77649166974 scopus 로고    scopus 로고
    • ANRIL expression is associated with atherosclerosis risk at chromosome 9p21
    • Holdt LM, Beutner F, Scholz M, et al. ANRIL expression is associated with atherosclerosis risk at chromosome 9p21. Arterioscler Thromb Vasc Biol;30:620-7
    • Arterioscler Thromb Vasc Biol , vol.30 , pp. 620-627
    • Holdt, L.M.1    Beutner, F.2    Scholz, M.3
  • 50
    • 65949104586 scopus 로고    scopus 로고
    • Genomewide association studies and human disease
    • Hardy J, Singleton A. Genomewide association studies and human disease. N Engl J Med 2009;360:1759-68
    • (2009) N Engl J Med , vol.360 , pp. 1759-1768
    • Hardy, J.1    Singleton, A.2
  • 51
    • 77950339092 scopus 로고    scopus 로고
    • Integrating pathway analysis and genetics of gene expression for genome-wide association studies
    • Zhong H, Yang X, Kaplan LM, Molony C, Schadt EE. Integrating pathway analysis and genetics of gene expression for genome-wide association studies. Am J Hum Genet 2010;86:581-91
    • (2010) Am J Hum Genet , vol.86 , pp. 581-591
    • Zhong, H.1    Yang, X.2    Kaplan, L.M.3    Molony, C.4    Schadt, E.E.5
  • 52
    • 77649182951 scopus 로고    scopus 로고
    • Genome-wide association studies in atherothrombosis
    • Lotta LA. Genome-wide association studies in atherothrombosis. Eur J Intern Med 2010;21:74-8
    • (2010) Eur J Intern Med , vol.21 , pp. 74-78
    • Lotta, L.A.1
  • 53
    • 79953204259 scopus 로고    scopus 로고
    • Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
    • Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nature Genetics 43:333-8
    • Nature Genetics , vol.43 , pp. 333-338
    • Schunkert, H.1    König, I.R.2    Kathiresan, S.3    Reilly, M.P.4    Assimes, T.L.5
  • 54
    • 38449117820 scopus 로고    scopus 로고
    • Designing candidate gene and genome-wide case-control association studies
    • Zondervan KT, Cardon LR. Designing candidate gene and genome-wide case-control association studies. Nat Protoc 2007;2:2492-501
    • (2007) Nat Protoc , vol.2 , pp. 2492-2501
    • Zondervan, K.T.1    Cardon, L.R.2
  • 55
    • 0036370492 scopus 로고    scopus 로고
    • Chronic venous insufficiency-epidemiology
    • Staffa R. Chronic venous insufficiency-epidemiology. Bratisl Lek Listy 2002;103:166-8
    • (2002) Bratisl Lek Listy , vol.103 , pp. 166-168
    • Staffa, R.1
  • 56
    • 26944485074 scopus 로고    scopus 로고
    • Eliminating the improbable: Sherlock Holmes and standards of evidence in the genomic age
    • Herrington D. Eliminating the improbable: Sherlock Holmes and standards of evidence in the genomic age. Circulation 2005;112:2081-4
    • (2005) Circulation , vol.112 , pp. 2081-2084
    • Herrington, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.