Role of the mmr efflux pump in drug resistance in mycobacterium tuberculosis

Antimicrobial Agents and Chemotherapy

Volumn 57, Issue 2, 2013, Pages 751-757

  Rodrigues, Liliana ^a   Villellas, Cristina ^a,b   Bailo, Rebeca ^a   Viveiros, Miguel ^b,c   Aínsa, José A ^a,b  

^a UNIVERSITY OF ZARAGOZA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSIDADE NOVA DE LISBOA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIFLAVINE; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; CETRIMIDE; ETHIDIUM BROMIDE; GENOMIC DNA; ISONIAZID; MEMBRANE PROTEIN; MMR EFFLUX PUMP; SAFRANIN; TETRAPHENYLPHOSPHONIUM; UNCLASSIFIED DRUG; VERAPAMIL;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; DRUG DETERMINATION; FLUOROMETRY; GENE OVEREXPRESSION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PLASMID; PRIORITY JOURNAL;

ACRIFLAVINE; ANTI-INFECTIVE AGENTS, LOCAL; ANTINEOPLASTIC AGENTS; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; CETRIMONIUM COMPOUNDS; DRUG RESISTANCE, BACTERIAL; ENZYME INHIBITORS; ETHIDIUM; GENE KNOCKOUT TECHNIQUES; ISONIAZID; MEMBRANE TRANSPORT PROTEINS; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; NITRILES; ONIUM COMPOUNDS; ORGANOPHOSPHORUS COMPOUNDS; PHENAZINES; VERAPAMIL;

EID: 84872872321     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01482-12     Document Type: Article

References (34)

1. Stop TB Partnership. 2010. The global plan to stop TB 2011-2015. World Health Organization, Geneva, Switzerland.
2. World Health Organization. 2012. Global tuberculosis report 2012. World Health Organization, Geneva, Switzerland.
3. Almeida Da Silva PE, Palomino JC. 2011. Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: Classical and new drugs. J. Antimicrob. Chemother. 66:1417-1430.
4. Ramaswamy S, Musser JM. 1998. Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update. Tuber. Lung Dis. 79:3-29.
5. Srivastava S, Pasipanodya JG, Meek C, Leff R, Gumbo T. 2011. Multidrug-resistant tuberculosis not due to noncompliance but to betweenpatient pharmacokinetic variability. J. Infect. Dis. 204:1951-1959.
6. Piddock LJ. 2006. Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin. Microbiol. Rev. 19:382-402.
7. Ramón-García S, Martín C, Thompson CJ, Aínsa JA. 2009. Role of the Mycobacterium tuberculosis P55 efflux pump in intrinsic drug resistance, oxidative stress responses, and growth. Antimicrob. Agents Chemother. 53:3675-3682.
8. Ramón-García S, Mick V, Dainese E, Martín C, Thompson CJ, De Rossi E, Manganelli R, Aínsa JA. 2012. Functional and genetic characterization of the tap efflux pump in Mycobacterium bovis BCG. Antimicrob. Agents Chemother. 56:2074-2083.
9. Machado D, Couto I, Perdigão J, Rodrigues L, Portugal I, Baptista P, Veigas B, Amaral L, Viveiros M. 2012. Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis. PLoS One 7:e34538. doi:10.1371/journal.pone.0034538.
10. Amaral L, Viveiros M, Kristiansen JE. 2006. "Non-antibiotics": Alternative therapy for the management of MDRTB and MRSA in economically disadvantaged countries. Curr. Drug Targets 7:887-891.
11. Rodrigues L, Aínsa JA, Amaral L, Viveiros M. 2011. Inhibition of drug efflux in mycobacteria with phenothiazines and other putative efflux inhibitors. Recent Pat. Antiinfect. Drug Discov. 6:118-127.
12. Viveiros M, Martins M, Rodrigues L, Machado D, Couto I, Ainsa J, Amaral L. 2012. Inhibitors of mycobacterial efflux pumps as potential boosters for TB drugs. Expert Rev. Anti Infect. Ther. 10:983-998.
13. De Rossi E, Aínsa JA, Riccardi G. 2006. Role of mycobacterial efflux transporters in drug resistance: An unresolved question. FEMS Microbiol. Rev. 30:36-52.
14. Louw GE, Warren RM, Gey van Pittius NC, McEvoy CR, Van Helden PD, Victor TC. 2009. A balancing act: Efflux/influx in mycobacterial drug resistance. Antimicrob. Agents Chemother. 53:3181-3189.
15. De Rossi E, Branzoni M, Cantoni R, Milano A, Riccardi G, Ciferri O. 1998. mmr, a Mycobacterium tuberculosis gene conferring resistance to small cationic dyes and inhibitors. J. Bacteriol. 180:6068-6071.
16. Li XZ, Zhang L, Nikaido H. 2004. Efflux pump-mediated intrinsic drug resistance in Mycobacterium smegmatis. Antimicrob. Agents Chemother. 48:2415-2423.
17. Balganesh M, Dinesh N, Sharma S, Kuruppath S, Nair AV, Sharma U. 2012. Efflux pumps of Mycobacterium tuberculosis play a significant role in antituberculosis activity of potential drug candidates. Antimicrob. Agents Chemother. 56:2643-2651.
18. Gupta AK, Katoch VM, Chauhan DS, Sharma R, Singh M, Venkatesan K, Sharma VD. 2010. Microarray analysis of efflux pump genes in multidrug-resistant Mycobacterium tuberculosis during stress induced by common anti-tuberculous drugs. Microb. Drug Resist. 16:21-28.
19. Rodrigues L, Machado D, Couto I, Amaral L, Viveiros M. 2012. Contribution of efflux activity to isoniazid resistance in the Mycobacterium tuberculosis complex. Infect. Genet. Evol. 12:695-700.
20. van Kessel JC, Hatfull GF. 2007. Recombineering in Mycobacterium tuberculosis. Nat. Methods 4:147-152.
21. van Kessel JC, Hatfull GF. 2008. Mycobacterial recombineering. Methods Mol. Biol. 435:203-215.
22. Stover CK, de LA Cruz VF, Fuerst TR, Burlein JE, Benson LA, Bennett LT, Gansal GP, Young JF, Lee MH, Hatfull GF, Snapper SB, Barletts RG, Jacobs WR, Jr, Bloom BR. 1991. New use of BCG for recombinant vaccines. Nature 351:456-460.
23. Aínsa JA, Martín C, Cabeza M, De la Cruz F, Mendiola MV. 1996. Construction of a family of Mycobacterium/Escherichia coli shuttle vectors derived from pAL5000 and pACYC184: Their use for cloning an antibioticresistance gene from Mycobacterium fortuitum. Gene 176:23-26.
24. Sambrook J, Russell DW. 2001. Molecular cloning: A laboratory manual, 3rd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
25. Parish T, Stoker NG. 1998. Mycobacterial protocols. In Parish T, Stoker NG (ed), Methods in molecular biology, vol 101. Humana Press, Totowa, NJ.
26. Soto CY, Andreu N, Gibert I, Luquin M. 2002. Simple and rapid differentiation of Mycobacterium tuberculosis H37Ra from M. tuberculosis clinical isolates through two cytochemical tests using neutral red and Nile blue stains. J. Clin. Microbiol. 40:3021-3024.
27. Palomino JC, Martin A, Camacho M, Guerra H, Swings J, Portaels F. 2002. Resazurin microtiter assay plate: Simple and inexpensive method for detection of drug resistance in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 46:2720-2722.
28. Reddy VM, Dubuisson T, Einck L, Wallis RS, Jakubiec W, Ladukto L, Campbell S, Nacy CA. 2012. SQ109 and PNU-100480 interact to kill Mycobacterium tuberculosis in vitro. J. Antimicrob. Chemother. 67:1163-1166.
29. Rodrigues L, Wagner D, Viveiros M, Sampaio D, Couto I, Vavra M, Kern WV, Amaral L. 2008. Thioridazine and chlorpromazine inhibition of ethidium bromide efflux in Mycobacterium avium and Mycobacterium smegmatis. J. Antimicrob. Chemother. 6:1076-1082.
30. Machado L, Spengler G, Evaristo M, Handzlik J, Molnár J, Viveiros M, Kiec-Kononowicz K, Amaral L. 2011. Biological activity of twenty-three hydantoin derivatives on intrinsic efflux pump system of Salmonella enterica serovar Enteritidis NCTC 13349. In Vivo 25:769-772.
31. Paixão L, Rodrigues L, Couto I, Martins M, Fernandes P, de Carvalho CC, Monteiro GA, Sansonetty F, Amaral L, Viveiros M. 2009. Fluorometric determination of ethidium bromide efflux kinetics in Escherichia coli. J. Biol. Eng. 3:18. doi:10.2174/187221209787259910.
32. da Silva PE, Von Groll A, Martin A, Palomino JC. 2011. Efflux as a mechanism for drug resistance in Mycobacterium tuberculosis. FEMS Immunol. Med. Microbiol. 63:1-9.
33. Chen LC, Yeh HY, Yeh CY, Arias CR, Soo VW. 2012. Identifying co-targets to fight drug resistance based on a random walk model. BMC Syst. Biol. 6:5. doi:10.1186/1752-0509-6-5.
34. Rodrigues L, Ramos J, Couto I, Amaral L, Viveiros M. 2011. Ethidium bromide transport across Mycobacterium smegmatis cell-wall: Correlation with antibiotic resistance. BMC Microbiol. 11:35. doi:10.1186/1471-2180-11-35.