Examinations on the cytotoxicity of some 2,5-disubstitutes-1,2,4-triazoles and 1,3,4-thiadiazoles and their precursors towards guinea hen cells

Journal of the University of Chemical Technology and Metallurgy

Volumn 47, Issue 3, 2012, Pages 251-256

  Mavrova, A ^a   Wesselinova, D ^b  

^a UNIVERSITY OF CHEMICAL TECHNOLOGY AND METALLURGY   (Bulgaria)

^b BULGARIAN ACADEMY OF SCIENCES   (Bulgaria)

Author keywords

1,2,4 triazoles; 1,3,4 thiadiazoles; Cytotoxicity; Lymphocytes; Pts56 virus; Thiosemicarbazide

Indexed keywords

EID: 84872865708     PISSN: 13117629     EISSN: 13143859     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. O. B. Ircan, B. Kahvec, M. Kuc, Synthesis and Anticancer Evaluation of Some New Unsymmetrical 3,5-Diaryl-4H-1,2,4-Triazole Derivatives, Turk. J. Chem., 30, 2006, 29-33.
2. R. Romagnoli, P. G. Baraldi, O. Cruz-Lopez, C. L. Cara, M. D. Carrion, A. Brancale, E. Hamel, L. Chen, R. Bortolozzi, G. Basso and G. Viola, Synthesis and Antitumor Activity of 1,5-Disubstituted 1,2,4-Triazoles as Cis-Restricted Combretastatin Analogues, J. Med. Chem., 53, 10, 2010, 4248-4258.
3. Y. A. Al-Soud, N. A Al-Masoudi, A. El-Rahman, S Ferwanah, Synthesis and properties of new substituted 1,2,4-triazoles: potential antitumor agents, Bioorg. & Med. Chem., 11, 8, 2003, 1701-1708.
4. D. Kumar, M. K. Narayanam, K-H. Chang, K. Shah; Synthesis of Novel Indolyl-1,2,4-triazoles as Potent and Selective Anticancer Agents, Chemical Biology & Drug Design, 77, 3, 2011, 182-188.
5. D. Sunil, P. Shetty; Synthesis, characterization and anti- cancer activity of 1,2,4-Triazolo [3,4-b]-1,3,4-thiadiazoles on Hep G2 cell lines, Der Pharma Chemica, 1, 2, 2009, 19-26.
6. B. S. Holla, B.Veerendra, M.K.Shivananda, B. Poojary, Synthesis characterization and anticancer activity studies on some Mannich bases derived from 1,2,4-triazoles, Eur. J. Med. Chem., 38,7-8, 2003, 759-67.
7. K. M. Amin, M. I. El-Zahar, M. M. Anwar, M. M. Kamel, M. H. Mohamed, Synthesis and anticancer activity of novel tetralin-6-ylpyridine and tetralin-6-ylpyrimidine derivates, Acta Polon Pharm. -Drug Res., 66, 3, 2009, 279-291.
8. R. M. Issa, M. Gaber, N. Abd-Elhamed Al-Wakiel, S. K. Fathalla, Synthesis, Spectral, Thermal and Biological Studies of Mn(II), Co(II), Ni(II) and Cu(II) Complexes with 1-(((5-Mercapto-1H-1,2,4-triazol-3-yl)imino)-methyl)naphthalene-2-ol, Chinese J. Chem., 30, 3, 2012, 547-556.
9. M. S. R. Murty, K. R. Ram, R. R. Venkateswara, J. S. Yadav, J. V. Rao, L. R. Velatooru, Synthesis of New S-alkylated-3-mercapto-l,2,4-triazole Derivatives Bearing Cyclic Amine Moiety as Potent Anticancer Agents, Lett. Drug Design & Discov., 9, 3, 2012, 276-281.
10. D. Kumar, N. M. Kumar, K H. Chang, K. Shah, Synthesis and anticancer activity of 5-(3-indolyl)-1,3,4-thiadiazoles, Eur J Med Chem., 45, 10, 2010, 4664-8.
11. W. Rzeski, J. Matysiak, M. Kandefer-Szerszep, Anticancer, neuroprotective activities and computational studies of 2-amino-l,3,4-thiadiazole based compounds, Bioorg. Med. Chem., 15, 9, 2007, 3201-3207.
12. M. N. Noolvi, H. M. Patel, N. Singh, A. K Gadad, S. S. Cameotra, A. Badiger, Synthesis and anticancer evaluation of novel 2-cyclopropylimidazo[2,l-b][l,3,4]-thiadiazole derivatives, Eur. J. Med. Chem., 46, 9, 2011, 4411-8.
13. M. A. Shaaban, M.M. Ghorab, H.I. Heiba, M. M. Kamel, N.H. Zaher, M. I. Mostafa, Novel thiophenes, thienopyrimidines, and triazolothienopyrimidines for the evaluation of anticancer and augmentation effects of gamma-radiation, Arch. Pharm. (Weinheim), 343, 7, 2010, 404-10.
14. C. Medower, L. Wen, W.W Johnson, Cytochrome P450 oxidation of the thiophene-containing anticancer drug 3-[(quinolin-4-ylmethyl)-amino]-thiophene-2-carboxylic acid (4-trifluoromethoxy-phenyl)-amide to an electrophilic intermediate, Chem. Res. Toxicol., 21, 8, 2008, 1570-1577.
15. T. A. Farghaly and Z. A. Abdallah, Synthesis, azo-hydrazone tautomerism and antitumor screening of N-(3-ethoxycarbonyl-4,5,6,7-tetrahydro-benzo[b]thien-2-yl)-2-arylhydrazono-3-oxobutanamide derivatives, ARKIVOC (XVII), 2008, 295-305.
16. A. Ts. Mavrova, D. Wesselinova, Y. Tsenov, P. Denkova, Synthesis, cytotoxicity and effects on immunocompe-tent cells of novel 1,2,4-triazoles and 1,3,4-thiadiazoles, J. Eur. Med. Chem., 44, 1, 2009, 63-69.
17. O. Inanami, K. Sugihara, T. Okui, M. Hajashi, T. Tsuitani, M. Kuwabara, Hypoxia and etanidazole alter radiation-induced apoptosis in HL60 cells but not in MOLT-4 cells, J. Rad. Biol., 78, 2002, 267-274.