The effect of OPRM1 and COMT genotypes on the analgesic response to intravenous fentanyl labor analgesia

Anesthesia and Analgesia

Volumn 116, Issue 2, 2013, Pages 386-391

  Landau, Ruth ^a   Liu, Shih Kai ^a,b   Blouin, Jean Louis ^c   Carvalho, Brendan ^d  

^a UNIVERSITY OF WASHINGTON   (United States)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^d STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE; FENTANYL; MU 1 OPIATE RECEPTOR; MU OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ADULT; ADVERSE OUTCOME; ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; DNA PURIFICATION; FEMALE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; OBSTETRIC ANALGESIA; PAIN ASSESSMENT; PHARMACOGENETICS; PHENOTYPE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ANALGESIA, OBSTETRICAL; ANALGESICS, OPIOID; CATECHOL O-METHYLTRANSFERASE; DNA; FEMALE; FENTANYL; GENOTYPE; HUMANS; PAIN MEASUREMENT; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; RECEPTORS, OPIOID, MU; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84872865255     PISSN: 00032999     EISSN: 15267598     Source Type: Journal    
DOI: 10.1213/ANE.0b013e318273f2c7     Document Type: Article

References (12)

1. Evron S, Ezri T. Options for systemic labor analgesia. Curr Opin Anaesthesiol 2007;20:181-5
2. Landau R, Kraft JC. Pharmacogenetics in obstetric anesthesia. Curr Opin Anaesthesiol 2010;23:323-9
3. Landau R, Kern C, Columb MO, Smiley RM, Blouin JL. Genetic variability of the mu-opioid receptor influences intrathecal fentanyl analgesia requirements in laboring women. Pain 2008;139:5-14
4. Wong CA, McCarthy RJ, Blouin J, Landau R. Observational study of the effect of mu-opioid receptor genetic polymorphism on intrathecal opioid labor analgesia and post-cesarean delivery analgesia. Int J Obstet Anesth 2010;19:246-53
5. Zubieta JK, Heitzeg MM, Smith YR, Bueller JA, Xu K, Xu Y, Koeppe RA, Stohler CS, Goldman D.comT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science 2003;299:1240-3
6. Jensen KB, Lonsdorf TB, Schalling M, Kosek E, Ingvar M. Increased sensitivity to thermal pain following a single opiate dose is influenced by the COMT val(158)met polymorphism. PLoS ONE 2009;4:e6016
7. Rakvåg TT, Klepstad P, Baar C, Kvam TM, Dale O, Kaasa S, Krokan HE, Skorpen F. The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients. Pain 2005;116:73-8
8. Nelson KE, Rauch T, Terebuh V, D'Angelo R. A comparison of intrathecal fentanyl and sufentanil for labor analgesia. Anesthesiology 2002;96:1070-3
9. Reyes-Gibby CC, Shete S, Rakvåg T, Bhat SV, Skorpen F, Bruera E, Kaasa S, Klepstad P. Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene. Pain 2007;130:25-30
10. Kolesnikov Y, Gabovits B, Levin A, Voiko E, Veske A.combined catechol-O-methyltransferase and mu-opioid receptor gene polymorphisms affect morphine postoperative analgesia and central side effects. Anesth Analg 2011;112:448-53
11. Landau R, Ortner C, Carvalho B. Challenges in interpreting joined allelic combinations of OPRM1 and COMT genes. Anesth Analg 2011;113:432
12. Capogna G, Camorcia M, Stirparo S, Valentini G, Garassino A, Farcomeni A. Multidimensional evaluation of pain during early and late labor: a comparison of nulliparous and multiparous women. Int J Obstet Anesth 2010;19:167-70