Pharmacokinetic study of schisandrin, schisandrol B, schisantherin A, deoxyschisandrin, and schisandrin B in rat plasma after oral administration of Shengmaisan formula by UPLC-MS

Journal of Separation Science

Volumn 36, Issue 3, 2013, Pages 485-491

  Sun, Hui ^a   Wu, Fangfang ^a   Zhang, Aihua ^a   Wei, Wenfeng ^a   Han, Ying ^a   Wang, Xijun ^a  

^a HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Multiple components; Pharmacokinetic; Shengmaisan; Traditional Chinese medicine; UPLC Q TOF MS

Indexed keywords

ACQUITY; BIOACTIVE COMPONENTS; CALIBRATION CURVES; CARDIO-VASCULAR DISEASE; HIGH DEFINITION; LIGNANS; LINEAR GRADIENT ELUTION; MICROMASS; MOBILE PHASE; MULTIPLE COMPONENTS; ORAL ADMINISTRATION; PHARMACOKINETIC PARAMETERS; PHARMACOKINETIC STUDIES; RAT PLASMA; SCHISANDRIN; SHENGMAISAN; TEST RANGE; TRADITIONAL CHINESE MEDICINE; UPLC-Q-TOF/MS;

FORMIC ACID; MEDICINE; PHARMACOKINETICS;

BODY FLUIDS;

DEOXYSCHISANDRIN; GOMISIN A; HERBACEOUS AGENT; PLANT MEDICINAL PRODUCT; SCHISANDRIN; SCHISANTHERIN A; SCHIZANDRIN B; SHENGMAISAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG STRUCTURE; ELUTION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; RAT; TIME OF FLIGHT MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION PROCESS;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOOCTANES; DIOXOLES; DRUGS, CHINESE HERBAL; LIGNANS; MALE; POLYCYCLIC COMPOUNDS; RATS; RATS, WISTAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

RATTUS;

EID: 84872848289     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201200887     Document Type: Article

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