A sensitive column-switching HPLC method for aripiprazole and dehydroaripiprazole and its application to human pharmacokinetic studies

Journal of Separation Science

Volumn 33, Issue 21, 2010, Pages 3292-3298

  Akamine, Yumiko ^a   Yasui Furukori, Norio ^b   Kojima, Midori ^a   Inoue, Yoshimasa ^c   Uno, Tsukasa ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

^b HIROSAKI UNIVERSITY   (Japan)

^c MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Aripiprazole; Column switching; Dehydroaripiprazole; HPLC

Indexed keywords

ACTIVE METABOLITES; ANALYTICAL COLUMNS; ANTIPSYCHOTIC DRUG; ARIPIPRAZOLE; CHROMATOGRAPHIC SEPARATIONS; COLUMN SWITCHING; COLUMN-SWITCHING HPLC; CONCENTRATION RANGES; DEHYDROARIPIPRAZOLE; HPLC; HUMAN PHARMACOKINETICS; HUMAN PLASMAS; HUMAN VOLUNTEERS; INTERNAL STANDARDS; LIMITS OF DETECTION; PHARMACOKINETIC STUDIES; SIMULTANEOUS DETERMINATIONS; UV DETECTOR;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; METABOLITES; PHARMACOKINETICS; SWITCHING;

DRUG PRODUCTS;

7 [5 [4 (3 CHLORO 2 METHYLPHENYL) 1 PIPERAZINYL]PENTYLOXY] 3,4 DIHYDRO 2(1H) QUINOLINONE; ARIPIPRAZOLE; DEHYDROARIPIPRAZOLE; NEUROLEPTIC AGENT; UNCLASSIFIED DRUG;

ACCURACY; ADULT; ARTICLE; CLINICAL ARTICLE; COLUMN CHROMATOGRAPHY; DRUG STRUCTURE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

ADULT; ANTIPSYCHOTIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HUMANS; MALE; MOLECULAR STRUCTURE; PIPERAZINES; QUINOLONES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 78349298316     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201000457     Document Type: Article

References (18)

1. Raggi, M. A., Mandrioli, R., Pucci, V., Sabbioni, C., Med. Chem. Rev. 2004, 1, 299 - 316.
2. Harrison, T. S., Perry, C. M., Drugs 2004, 64, 1715 - 1736.
3. Shapiro, D. A., Renock, S., Arrington, E., Chiodo, L. A., Liu, L. X., Sibley, D. R., Roth, B. L., Mailman, R., Neuropsychopharmacology 2003, 28, 1400 - 1411.
4. Kerwin, R., Millet, B., Herman, E., Banki, C. M., Lublin, H., Pans, M., Hanssens, L., L'Italien, G., McQuade, R. D., Beuzen, J. N., Eur. Psychiatry 2007, 22, 433 - 443.
5. Mallikaarjun, S., Salazar, D. E., Bramer, S. L., J. Clin. Pharmacol. 2004, 44, 179 - 187.
6. ®, aripiprazole, tablets prescribing information, 2007.
7. Kubo, M., Koue, T., Inaba, A., Takeda, H., Maune, H., Fukuda, T., Azuma, J., Drug Metab. Pharmacokinet. 2005, 20, 55 - 64.
8. Shimokawa, Y., Akiyama, H., Kashiyama, E., Koga, T., Miyamoto, G., J. Chromatogr. B 2005, 821, 8 - 14.
9. Musenga, A., Saracino, M. A., Spinelli, D., Rizzato, E., Boncompagni, G., Kenndler, E., Raggi, M. A., Anal. Chim. Acta 2008, 612, 204 - 211.
10. Kirschbaum, K. M., Mueller, M. J., Zernig, G., Saria, A., Mobascher, A., Malevani, J., Hiemke, C., Clin. Chem. 2005, 51, 1718 - 1721.
11. Zuo, X. C., Wang, F., Xu, P., Zhu, R. H., Li, H. D., Chromatographia 2006, 64, 387 - 391.
12. Kirchherr, H., Kuehn-Velten, W. N., J. Chromatogr. B 2006, 843, 100 - 113.
13. Choong, E., Rudaz, S., Kottelat, A., Guillarme, D., Veuthey, J. L., Eap, C. B., J. Pharm. Biomed. Anal. 2009, 50, 1000 - 1008.
14. Song, M., Xu, X., Hang, T., Xu, X., Hang, T., Wen, A., Yang, L., Anal. Biochem. 2009, 385, 270 - 277.
15. Kubo, M., Mizooku, Y., Hirao, Y., Osumi, T., J. Chromatogr. B 2005, 822, 294 - 299.
16. Lancelin, F., Djebrani, K., Tabaouti, K., Kraoul, L., Brovedani, S., Paubel, P., Piketty, M. L., J. Chromatogr. B 2008, 867, 15 - 19.
17. US Department of Health and Human Services, Food and Drug Administration, Guidance for Industry Bioanalytical Method Validation, 2001.
18. Yasui-Furukori, N., Inoue, Y., Tateishi, T., J. Chromatogr. B 2003, 789, 239 - 245.