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Volumn 1277, Issue 1, 2013, Pages 76-83

β-Lactam antimicrobials: What have you done for me lately?

Author keywords

Pipeline; Resistance; lactam; lactamase; lactamase inhibitor

Indexed keywords

BAL 30072; BAL 30376; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; SIDEROPHORE; UNCLASSIFIED DRUG;

EID: 84872833161     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2012.06809.x     Document Type: Article
Times cited : (12)

References (92)
  • 1
    • 84856581006 scopus 로고    scopus 로고
    • 200th anniversary article: the perpetual challenge of infectious diseases
    • Fauci, A.S. & D.M. Morens 2012. 200th anniversary article: the perpetual challenge of infectious diseases. N. Engl. J. Med. 366: 454-461.
    • (2012) N. Engl. J. Med. , vol.366 , pp. 454-461
    • Fauci, A.S.1    Morens, D.M.2
  • 2
    • 84872852521 scopus 로고    scopus 로고
    • Infectious Diseases Society of America. Antibiotic-resistant infections increasingly common among healthy people [press release]. Alexandria, VA October 9, 2003.
    • Infectious Diseases Society of America. 2003. Antibiotic-resistant infections increasingly common among healthy people [press release]. Alexandria, VA October 9, 2003.
    • (2003)
  • 3
    • 84872843421 scopus 로고    scopus 로고
    • Infectious Diseases Society of America. July Bad bugs, no drugs. as antibiotic discovery stagnates ... a public health crisis brews. Available at. Accessed 3 July 2012.
    • Infectious Diseases Society of America. July 2004. Bad bugs, no drugs. as antibiotic discovery stagnates ... a public health crisis brews. Available at: http://www.idsociety.org/uploadedFiles/IDSA/Policy_and_Advocacy/Current_Topics_and_Issues/Antimicrobial_Resistance/10x20/Images/Bad%20Bugs%20no%20Drugs.pdf. Accessed 3 July 2012.
    • (2004)
  • 4
    • 33144473431 scopus 로고    scopus 로고
    • Bad bugs need drugs: what's in the development pipeline? an update from the antimicrobial availability task force of the Infectious Diseases Society of America
    • Talbot, G.H., J. Bradley, J.E. Edwards, et al. 2006. Bad bugs need drugs: what's in the development pipeline? an update from the antimicrobial availability task force of the Infectious Diseases Society of America. Clin. Infect. Dis. 42: 657-668.
    • (2006) Clin. Infect. Dis. , vol.42 , pp. 657-668
    • Talbot, G.H.1    Bradley, J.2    Edwards, J.E.3
  • 5
    • 57749107808 scopus 로고    scopus 로고
    • Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America
    • Boucher, H.W., G.H. Talbot, J.S. Bradley, et al. 2009. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin. Infect. Dis. 48: 1-12.
    • (2009) Clin. Infect. Dis. , vol.48 , pp. 1-12
    • Boucher, H.W.1    Talbot, G.H.2    Bradley, J.S.3
  • 6
    • 77950255824 scopus 로고    scopus 로고
    • The 10 x '20 initiative: pursuing a global commitment to develop 10 new antibacterial drugs by 2020
    • Gilbert, D.N., R.J. Guidos, H.W. Boucher, et al. 2010. The 10 x '20 initiative: pursuing a global commitment to develop 10 new antibacterial drugs by 2020. Clin. Infect. Dis. 50: 1081-1083.
    • (2010) Clin. Infect. Dis. , vol.50 , pp. 1081-1083
    • Gilbert, D.N.1    Guidos, R.J.2    Boucher, H.W.3
  • 7
    • 84872862378 scopus 로고    scopus 로고
    • World Health Organization. Containing antimicrobial resistance. WHO Policy Perspectives on Medicines, Geneva, No. 10. Available at. Accessed 1 July 2012.
    • World Health Organization. 2005. Containing antimicrobial resistance. WHO Policy Perspectives on Medicines, Geneva, No. 10. Available at: http://whqlibdoc.who.int/hq/2005/WHO_PSM_2005.1.pdf. Accessed 1 July 2012.
    • (2005)
  • 8
    • 84872844808 scopus 로고    scopus 로고
    • European Centre for Disease Prevention and Control (ECDC) and European Medicines Agency (EMEA). ECDC/EMEA Joint Technical Report-The bacterial challenge: time to react. Available at. Accessed 1 July 2012.
    • European Centre for Disease Prevention and Control (ECDC) and European Medicines Agency (EMEA). 2009. ECDC/EMEA Joint Technical Report-The bacterial challenge: time to react. Available at:http://www.emea.europa.eu/docs/en_GB/document_library/Report/2009/11/WC500008770.pdf. Accessed 1 July 2012.
    • (2009)
  • 9
    • 84872872155 scopus 로고    scopus 로고
    • Transatlantic Taskforce on Antimicrobial Resistance. Recommendations for future collaboration between the U.S. and EU. Available at. Accessed 1 July 2012.
    • Transatlantic Taskforce on Antimicrobial Resistance. 2011. Recommendations for future collaboration between the U.S. and EU. Available at: http://www.ecdc.europa.eu/en/activities/diseaseprogrammes/TATFAR/Documents/210911_TATFAR_Report.pdf. Accessed 1 July 2012.
    • (2011)
  • 10
    • 84872858678 scopus 로고    scopus 로고
    • Pew Health Group. Antibiotic innovation: the threat and the pipeline (Antibiotics and Innovation Project). Available at. Accessed July 1, 2012.
    • Pew Health Group. 2012. Antibiotic innovation: the threat and the pipeline (Antibiotics and Innovation Project). Available at: http://www.pewhealth.org/reports-analysis/issue-briefs/antibiotic-innovation-the-threat-and-the-pipeline-85899379645. Accessed July 1, 2012.
    • (2012)
  • 11
    • 84872853941 scopus 로고    scopus 로고
    • Gonorrhea superbug warning: it's antibiotic resistant and a global public health threat
    • Available at. Accessed July 1, 2012.
    • Walton, A.G. 2012. Gonorrhea superbug warning: it's antibiotic resistant and a global public health threat. Forbes Magazine. Available at: http://www.forbes.com/sites/alicegwalton/2012/06/07/gonorrhea-superbug-warning-its-antibiotic-resistant-and-a-global-public-health-threat/. Accessed July 1, 2012.
    • (2012) Forbes Magazine.
    • Walton, A.G.1
  • 12
    • 84872869671 scopus 로고    scopus 로고
    • Rare drug-resistant bacteria spotted in U.S. hospital. Swift treatment, stronger infection control prevented spread. US News and World Report. Available at. Accessed July 1, 2012.
    • Reinberg, S. 2012. Rare drug-resistant bacteria spotted in U.S. hospital. Swift treatment, stronger infection control prevented spread. US News and World Report. Available at: http://health.usnews.com/health-news/news/articles/2012/06/21/rare-drug-resistant-bacteria-spotted-in-us-hospital. Accessed July 1, 2012.
    • (2012)
    • Reinberg, S.1
  • 13
    • 69949174478 scopus 로고    scopus 로고
    • Has the era of untreatable infections arrived
    • Livermore, D.M. 2009. Has the era of untreatable infections arrived J. Antimicrob. Chemother. 64(Suppl. 1): i29-i36.
    • (2009) J. Antimicrob. Chemother. , vol.64 , Issue.SUPPL. 1
    • Livermore, D.M.1
  • 14
    • 58949091766 scopus 로고    scopus 로고
    • Emergence of extensively drug-resistant and pandrug-resistant gram-negative bacilli in Europe
    • Souli, M., I. Galani & H. Giamarellou 2008. Emergence of extensively drug-resistant and pandrug-resistant gram-negative bacilli in Europe. Eur. Surveill. 13: 584-593.
    • (2008) Eur. Surveill. , vol.13 , pp. 584-593
    • Souli, M.1    Galani, I.2    Giamarellou, H.3
  • 15
    • 54949148412 scopus 로고    scopus 로고
    • Antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007
    • Hidron, A.I., J.R. Edwards, J. Patel, et al. 2008. Antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007. Infect. Control Hosp. Epidemiol. 29: 996-1011.
    • (2008) Infect. Control Hosp. Epidemiol. , vol.29 , pp. 996-1011
    • Hidron, A.I.1    Edwards, J.R.2    Patel, J.3
  • 16
    • 59449088862 scopus 로고    scopus 로고
    • Antibiotic-resistant bugs in the 21st century-A clinical super-challenge
    • Arias, C.A. & B.E. Murray 2009. Antibiotic-resistant bugs in the 21st century-A clinical super-challenge. N. Engl. J. Med. 360: 439-443.
    • (2009) N. Engl. J. Med. , vol.360 , pp. 439-443
    • Arias, C.A.1    Murray, B.E.2
  • 17
    • 0030681046 scopus 로고    scopus 로고
    • Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implications
    • Chambers, H.F. 1997. Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implications. Clin. Microbiol. Rev. 10: 781-791.
    • (1997) Clin. Microbiol. Rev. , vol.10 , pp. 781-791
    • Chambers, H.F.1
  • 18
    • 84860459763 scopus 로고    scopus 로고
    • Activity of ceftobiprole against Streptococcus pneumoniae isolates exhibiting high-level resistance to ceftriaxone
    • Davies, T.A., R.K. Flamm & A.S. Lynch 2012. Activity of ceftobiprole against Streptococcus pneumoniae isolates exhibiting high-level resistance to ceftriaxone. Int. J. Antimicrob. Agents 39: 534-538.
    • (2012) Int. J. Antimicrob. Agents , vol.39 , pp. 534-538
    • Davies, T.A.1    Flamm, R.K.2    Lynch, A.S.3
  • 19
    • 77952298917 scopus 로고    scopus 로고
    • Hospital-acquired infections due to gram-negative bacteria
    • Peleg, A. Y. & D.C. Hooper 2010. Hospital-acquired infections due to gram-negative bacteria. N. Engl. J. Med. 362: 1804-1813.
    • (2010) N. Engl. J. Med. , vol.362 , pp. 1804-1813
    • Peleg, A.Y.1    Hooper, D.C.2
  • 20
    • 74249108028 scopus 로고    scopus 로고
    • Three decades of β-lactamase inhibitors
    • Drawz, S.M. & R.A. Bonomo 2010. Three decades of β-lactamase inhibitors. Clin. Microbiol. Rev. 23: 160-201.
    • (2010) Clin. Microbiol. Rev. , vol.23 , pp. 160-201
    • Drawz, S.M.1    Bonomo, R.A.2
  • 21
    • 79960262635 scopus 로고    scopus 로고
    • Cephalosporin susceptibility among Neisseria gonorrhoeae isolates-United States, 2000-2010
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention. 2011. Cephalosporin susceptibility among Neisseria gonorrhoeae isolates-United States, 2000-2010. MMWR 60: 873-877.
    • (2011) MMWR , vol.60 , pp. 873-877
  • 22
    • 78650967538 scopus 로고    scopus 로고
    • Ceftriaxone-resistant Neisseria gonorrhoeae, Japan
    • Ohnishi M., T. Saika, S. Hoshina, et al. 2011. Ceftriaxone-resistant Neisseria gonorrhoeae, Japan. Emerg. Infect. Dis. 17: 148-149.
    • (2011) Emerg. Infect. Dis. , vol.17 , pp. 148-149
    • Ohnishi, M.1    Saika, T.2    Hoshina, S.3
  • 23
    • 0029071785 scopus 로고
    • A functional classification scheme for β-lactamases and its correlation with molecular structure
    • Bush, K., G.A. Jacoby & A.A. Medeiros 1995. A functional classification scheme for β-lactamases and its correlation with molecular structure. Antimicrob. Agents Chemother. 39: 1211-1233.
    • (1995) Antimicrob. Agents Chemother. , vol.39 , pp. 1211-1233
    • Bush, K.1    Jacoby, G.A.2    Medeiros, A.A.3
  • 24
    • 19944434187 scopus 로고    scopus 로고
    • Mechanisms of disease: the new β-lactamases
    • Jacoby, G.A. & L.S. Munoz-Price 2005. Mechanisms of disease: the new β-lactamases. N. Engl. J. Med. 352: 380-391.
    • (2005) N. Engl. J. Med. , vol.352 , pp. 380-391
    • Jacoby, G.A.1    Munoz-Price, L.S.2
  • 25
    • 77149165713 scopus 로고    scopus 로고
    • Updated functional classification of β-lactamases
    • Bush, K. & G.A. Jacoby 2010. Updated functional classification of β-lactamases. Antimicrob. Agents Chemother. 54: 969-976.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 969-976
    • Bush, K.1    Jacoby, G.A.2
  • 26
    • 77957770819 scopus 로고    scopus 로고
    • Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae
    • Bush, K. 2010. Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae. Curr. Opin. Microbiol. 13: 558-564.
    • (2010) Curr. Opin. Microbiol. , vol.13 , pp. 558-564
    • Bush, K.1
  • 27
    • 33748678285 scopus 로고    scopus 로고
    • The CTX-M beta-lactamase pandemic
    • Canton, R. & T. Coque 2006. The CTX-M beta-lactamase pandemic. Curr. Opin. Microbiol. 9: 466-475.
    • (2006) Curr. Opin. Microbiol. , vol.9 , pp. 466-475
    • Canton, R.1    Coque, T.2
  • 29
    • 39049128343 scopus 로고    scopus 로고
    • Extended-spectrum β-lactamase-producing Enterobacteriaceae: an emerging public-health concern
    • Pitout, J.D. & K.B. Laupland 2008. Extended-spectrum β-lactamase-producing Enterobacteriaceae: an emerging public-health concern. Lancet Infect. Dis. 8: 159-166.
    • (2008) Lancet Infect. Dis. , vol.8 , pp. 159-166
    • Pitout, J.D.1    Laupland, K.B.2
  • 30
    • 84872839561 scopus 로고    scopus 로고
    • Extended-spectrum β-lactamase (ESBL) in vitro activity in urinary tract infections-European TEST program results, 2004-2011. C2-147. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 9-12, San Francisco, CA, USA
    • Bouchillon, S., M. Hackel, B. Johnson, et al. 2012. Extended-spectrum β-lactamase (ESBL) in vitro activity in urinary tract infections-European TEST program results, 2004-2011. C2-147. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 9-12, San Francisco, CA, USA
    • (2012)
    • Bouchillon, S.1    Hackel, M.2    Johnson, B.3
  • 31
    • 35848969143 scopus 로고    scopus 로고
    • First report of the emergence of CTX-M-type extended-spectrum beta-lactamases (ESBLs) as the predominant ESBL isolated in a U.S. health care system
    • Lewis, J, M. Herrera, B. Wickes, et al. 2007. First report of the emergence of CTX-M-type extended-spectrum beta-lactamases (ESBLs) as the predominant ESBL isolated in a U.S. health care system. Antimicrob Agents Chemother. 51: 4015-4021.
    • (2007) Antimicrob Agents Chemother. , vol.51 , pp. 4015-4021
    • Lewis, J.1    Herrera, M.2    Wickes, B.3
  • 32
    • 67651124629 scopus 로고    scopus 로고
    • Emergence of extended-spectrum β-lactamase-producing Escherichia coli in community hospitals throughout North Carolina: a harbinger of a wider problem in the United States
    • Freeman, J.T., D.J. Sexton & D.J. Anderson 2009. Emergence of extended-spectrum β-lactamase-producing Escherichia coli in community hospitals throughout North Carolina: a harbinger of a wider problem in the United States Clin. Infect. Dis. 49: e30-e32.
    • (2009) Clin. Infect. Dis. , vol.49
    • Freeman, J.T.1    Sexton, D.J.2    Anderson, D.J.3
  • 33
    • 84858650295 scopus 로고    scopus 로고
    • In vitro antimicrobial resistance of urinary Escherichia coli isolates among U.S. outpatients from 2000 to 2010
    • Sanchez, G.V., R.N. Master, J.A. Karlowsky & J.M. Bordon 2012. In vitro antimicrobial resistance of urinary Escherichia coli isolates among U.S. outpatients from 2000 to 2010. Antimicrob. Agents Chemother. 56: 2181-2183.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 2181-2183
    • Sanchez, G.V.1    Master, R.N.2    Karlowsky, J.A.3    Bordon, J.M.4
  • 34
    • 84863342359 scopus 로고    scopus 로고
    • Clinical and microbiologic characteristics of cephalosporin-resistant Escherichia coli at three centers in the United States
    • Park, Y.S., J.M. Adams-Haduch & K.A. Shutt, et al. 2012. Clinical and microbiologic characteristics of cephalosporin-resistant Escherichia coli at three centers in the United States. Antimicrob. Agents Chemother. 56: 1870-1876.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 1870-1876
    • Park, Y.S.1    Adams-Haduch, J.M.2    Shutt, K.A.3
  • 35
    • 84860204494 scopus 로고    scopus 로고
    • Molecular epidemiological analysis of Escherichia coli sequence type ST131 (O25: H4) and blaCTX-M-15 among extended-spectrum-β-lactamase-producing E. coli from the United States, 2000 to 2009
    • Johnson, J.R., C. Urban, S.J. Weissman, et al. 2012. Molecular epidemiological analysis of Escherichia coli sequence type ST131 (O25: H4) and blaCTX-M-15 among extended-spectrum-β-lactamase-producing E. coli from the United States, 2000 to 2009. Antimicrob. Agents Chemother. 56: 2364-2370.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 2364-2370
    • Johnson, J.R.1    Urban, C.2    Weissman, S.J.3
  • 36
    • 84862776869 scopus 로고    scopus 로고
    • Identification of CTX-M β-lactamases among Escherichia coli from the community in New York City
    • Tiruvury, H.T., J.R. Johnson, N. Mariano, et al. 2012. Identification of CTX-M β-lactamases among Escherichia coli from the community in New York City. Diagn. Microbiol. Infect. Dis. 72: 248-252.
    • (2012) Diagn. Microbiol. Infect. Dis. , vol.72 , pp. 248-252
    • Tiruvury, H.T.1    Johnson, J.R.2    Mariano, N.3
  • 37
    • 84860111419 scopus 로고    scopus 로고
    • Wild coastline birds as reservoirs of broad-spectrum-β-lactamase-producing Enterobacteriaceae in Miami Beach, Florida
    • Poirel, L., A. Potron, C. De La Cuesta, et al. 2012. Wild coastline birds as reservoirs of broad-spectrum-β-lactamase-producing Enterobacteriaceae in Miami Beach, Florida. Antimicrob. Agents Chemother. 56: 2756-2758.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 2756-2758
    • Poirel, L.1    Potron, A.2    De La Cuesta, C.3
  • 38
    • 81555206715 scopus 로고    scopus 로고
    • Molecular characterization of resistance to extended-spectrum cephalosporins in clinical Escherichia coli isolates from companion animals in the United States
    • Shaheen, B.W., R. Nayak & S.L. Foley 2011. Molecular characterization of resistance to extended-spectrum cephalosporins in clinical Escherichia coli isolates from companion animals in the United States. Antimicrob. Agents Chemother. 55: 5666-5675.
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 5666-5675
    • Shaheen, B.W.1    Nayak, R.2    Foley, S.L.3
  • 39
    • 84860198785 scopus 로고    scopus 로고
    • Molecular characterization of extended-spectrum-β-lactamase-producing and plasmid-mediated AmpC β-lactamase-producing Escherichia coli isolated from stray dogs in South Korea
    • Tamang, M.D., H-M. Nam, G-C. Jang, et al. 2012. Molecular characterization of extended-spectrum-β-lactamase-producing and plasmid-mediated AmpC β-lactamase-producing Escherichia coli isolated from stray dogs in South Korea. Antimicrob. Agents Chemother. 56: 2705-2712.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 2705-2712
    • Tamang, M.D.1    Nam, H.-M.2    Jang, G.-C.3
  • 40
    • 33751566651 scopus 로고    scopus 로고
    • Bacteremia due to extended-spectrum β-lactamase-producing Escherichia coli in the CTX-M era: a new clinical challenge
    • Rodríguez-Baño, J., M.D. Navarro, L. Romero, et al. 2006. Bacteremia due to extended-spectrum β-lactamase-producing Escherichia coli in the CTX-M era: a new clinical challenge. Clin. Infect. Dis. 43: 1407-1414.
    • (2006) Clin. Infect. Dis. , vol.43 , pp. 1407-1414
    • Rodríguez-Baño, J.1    Navarro, M.D.2    Romero, L.3
  • 41
    • 84862576883 scopus 로고    scopus 로고
    • Decreased susceptibility to noncarbapenem antimicrobials in extended-spectrum-β-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates in Toronto, Canada
    • Lowe, C.F., A. McGeer & M.P. Muller 2012. Decreased susceptibility to noncarbapenem antimicrobials in extended-spectrum-β-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates in Toronto, Canada. Antimicrob. Agents Chemother. 56: 3977-3980.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 3977-3980
    • Lowe, C.F.1    McGeer, A.2    Muller, M.P.3
  • 43
    • 23244466039 scopus 로고    scopus 로고
    • Emerging metallo-β-lactamase-mediated resistances: a summary report from the worldwide SENTRY antimicrobial surveillance program
    • Fritsche, T.R., H.S. Sader, M.A. Toleman, et al. 2005. Emerging metallo-β-lactamase-mediated resistances: a summary report from the worldwide SENTRY antimicrobial surveillance program. Clin. Infect. Dis. 41(Suppl 4): S276-S278.
    • (2005) Clin. Infect. Dis. , vol.41 , Issue.SUPPL 4
    • Fritsche, T.R.1    Sader, H.S.2    Toleman, M.A.3
  • 44
    • 77955917495 scopus 로고    scopus 로고
    • Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study
    • Kumarasamy, K.K., M.A. Toleman, T.R. Walsh, et al. 2010. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect. Dis. 10: 597-602.
    • (2010) Lancet Infect. Dis. , vol.10 , pp. 597-602
    • Kumarasamy, K.K.1    Toleman, M.A.2    Walsh, T.R.3
  • 45
    • 84872856723 scopus 로고    scopus 로고
    • Detection of Enterobacteriaceae isolates carrying metallo-beta-lactamase-United States
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention. 2010. Detection of Enterobacteriaceae isolates carrying metallo-beta-lactamase-United States. MMWR 59: 749-750.
    • (2010) MMWR , vol.59 , pp. 749-750
  • 46
    • 84865045150 scopus 로고    scopus 로고
    • Carbapenem-resistant Enterobacteriaceae containing New Delhi metallo-beta-lactamase in two patients-Rhode Island
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention. 2012. Carbapenem-resistant Enterobacteriaceae containing New Delhi metallo-beta-lactamase in two patients-Rhode Island. MMWR 61: 446-448.
    • (2012) MMWR , vol.61 , pp. 446-448
  • 47
    • 84860146519 scopus 로고    scopus 로고
    • Diverse sequence types of Klebsiella pneumoniae contribute to the dissemination of blaNDM-1 in India, Sweden, and the United Kingdom
    • Giskea, C.G., I. Fröding, & C.M. Hasan, et al. 2012. Diverse sequence types of Klebsiella pneumoniae contribute to the dissemination of blaNDM-1 in India, Sweden, and the United Kingdom. Antimicrob. Agents Chemother. 56: 2735-2738.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 2735-2738
    • Giskea, C.G.1    Fröding, I.2    Hasan, C.M.3
  • 48
    • 84872865578 scopus 로고    scopus 로고
    • Carbapenem-resistant Enterobacteriaceae infection: new guidelines. Available at. Accessed July 5, 2012
    • Dantes, R. & A. Guh 2012. Carbapenem-resistant Enterobacteriaceae infection: new guidelines. Available at: http://www.medscape.com/viewarticle/765966. Accessed July 5, 2012
    • (2012)
    • Dantes, R.1    Guh, A.2
  • 49
    • 84872858330 scopus 로고    scopus 로고
    • Commissioner of Food and Drug Administration. Remarks at the National Press Club Speaker Luncheon. Available at. Accessed July 2, 2012.
    • Hamburg, M.A., Commissioner of Food and Drug Administration. 2012. Remarks at the National Press Club Speaker Luncheon. Available at: http://www.fda.gov/NewsEvents/Speeches/ucm229195.htm. Accessed July 2, 2012.
    • (2012)
    • Hamburg, M.A.1
  • 50
    • 84872861155 scopus 로고    scopus 로고
    • US Food and Drug Administration. New FDA task force will support innovation in antibacterial drug development. Available at. Accessed September 27, 2012
    • US Food and Drug Administration. New FDA task force will support innovation in antibacterial drug development. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm320643.htm. Accessed September 27, 2012
  • 51
    • 84872857562 scopus 로고    scopus 로고
    • Clinical Trials Transformation Initiative. Available at. Accessed September 27, 2012.
    • Clinical Trials Transformation Initiative. 2012. Available at: https://www.ctti-clinicaltrials.org/. Accessed September 27, 2012.
    • (2012)
  • 52
    • 84872852878 scopus 로고    scopus 로고
    • Brookings Institution. Brookings Council on Antibacterial Drug Development Meeting #1. Available at. Accessed September 27, 2012.
    • Brookings Institution. 2012. Brookings Council on Antibacterial Drug Development Meeting #1. Available at: http://www.brookings.edu/events/2012/08/30-antibacterial-drug-development. Accessed September 27, 2012.
    • (2012)
  • 53
    • 84866648642 scopus 로고    scopus 로고
    • Progress on developing endpoints for registrational clinical trials of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections: update from the Biomarkers Consortium of the Foundation for the National Institutes of Health
    • Talbot, G.H., J.H. Powers, T.R. Fleming, et al. 2012. Progress on developing endpoints for registrational clinical trials of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections: update from the Biomarkers Consortium of the Foundation for the National Institutes of Health. Clin. Infect. Dis. 55: 1114-1121.
    • (2012) Clin. Infect. Dis. , vol.55 , pp. 1114-1121
    • Talbot, G.H.1    Powers, J.H.2    Fleming, T.R.3
  • 54
    • 84872849455 scopus 로고    scopus 로고
    • Pew Health Group. Bill summary: the Generating Antibiotic Incentives Now Act (H.R. 2182). Available at. Accessed July 2, 2012.
    • Pew Health Group. 2012. Bill summary: the Generating Antibiotic Incentives Now Act (H.R. 2182). Available at: http://www.pewtrusts.org/news_room_detail.aspx?id=85899364156. Accessed July 2, 2012.
    • (2012)
  • 56
    • 67649183229 scopus 로고    scopus 로고
    • Current and novel antibiotics against resistant gram-positive bacteria
    • Perez, F., R.A. Salata & R.A. Bonomo 2008. Current and novel antibiotics against resistant gram-positive bacteria. Infect Drug Resist. 1: 27-44.
    • (2008) Infect Drug Resist. , vol.1 , pp. 27-44
    • Perez, F.1    Salata, R.A.2    Bonomo, R.A.3
  • 57
    • 34248191869 scopus 로고    scopus 로고
    • In-vitro profile of a new beta-lactam, ceftobiprole, with activity against methicillin-resistant Staphylococcus aureus
    • Jones, M.E. 2007. In-vitro profile of a new beta-lactam, ceftobiprole, with activity against methicillin-resistant Staphylococcus aureus. Clin. Microbiol. Infect. 13(Suppl 2): 17-24.
    • (2007) Clin. Microbiol. Infect. , vol.13 , Issue.SUPPL 2 , pp. 17-24
    • Jones, M.E.1
  • 58
    • 84861162170 scopus 로고    scopus 로고
    • Summary of ceftaroline activity against pathogens in the United States, 2010: report from the assessing worldwide antimicrobial resistance evaluation (AWARE) surveillance program
    • Flamm, R.K., H.S. Sader, D.J. Farrell & R.N. Jones 2012. Summary of ceftaroline activity against pathogens in the United States, 2010: report from the assessing worldwide antimicrobial resistance evaluation (AWARE) surveillance program. Antimicrob. Agents Chemother. 56: 2933-2940.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 2933-2940
    • Flamm, R.K.1    Sader, H.S.2    Farrell, D.J.3    Jones, R.N.4
  • 59
    • 39749117473 scopus 로고    scopus 로고
    • A randomized, double-blind trial comparing ceftobiprole medocaril with vancomycin plus ceftazidime for the treatment of patients with complicated skin and skin-structure infections
    • Noel, G.J., K. Bush, P. Bagchi, et al. 2008. A randomized, double-blind trial comparing ceftobiprole medocaril with vancomycin plus ceftazidime for the treatment of patients with complicated skin and skin-structure infections. Clin. Infect. Dis. 46: 647-655.
    • (2008) Clin. Infect. Dis. , vol.46 , pp. 647-655
    • Noel, G.J.1    Bush, K.2    Bagchi, P.3
  • 60
    • 77955957827 scopus 로고    scopus 로고
    • Integrated analysis of CANVAS 1 and 2: phase 3, multicenter, randomized, double-blind studies to evaluate the safety and efficacy of ceftaroline versus vancomycin plus aztreonam in complicated skin and skin-structure infection
    • Corey, G.R., M. Wilcox, G.H. Talbot, et al 2010. Integrated analysis of CANVAS 1 and 2: phase 3, multicenter, randomized, double-blind studies to evaluate the safety and efficacy of ceftaroline versus vancomycin plus aztreonam in complicated skin and skin-structure infection. Clin. Infect. Dis. 51: 641-650.
    • (2010) Clin. Infect. Dis. , vol.51 , pp. 641-650
    • Corey, G.R.1    Wilcox, M.2    Talbot, G.H.3
  • 61
    • 79959740064 scopus 로고    scopus 로고
    • Antibiotics in the clinical pipeline in 2011
    • Butler, MS. & M.A. Cooper 2011. Antibiotics in the clinical pipeline in 2011. J. Antibiot 64: 413-425.
    • (2011) J. Antibiot , vol.64 , pp. 413-425
    • Butler, M.S.1    Cooper, M.A.2
  • 62
    • 80255135542 scopus 로고    scopus 로고
    • New antimicrobial agents on the horizon
    • Bush, K. & M.J. Pucci 2011. New antimicrobial agents on the horizon. Biochem. Pharmacol. 82: 1528-1539.
    • (2011) Biochem. Pharmacol. , vol.82 , pp. 1528-1539
    • Bush, K.1    Pucci, M.J.2
  • 63
  • 64
    • 84872871552 scopus 로고    scopus 로고
    • 10 x '20 Progress: development of new drugs active against resistant gram-negative bacilli. Poster LB-27. 49th Annual Meeting of the Infectious Diseases Society of America and the HIV Medicine Association. Boston, Massachusetts, 20-23, October.
    • Boucher, H., D. Gilbert, D. Benjamin, et al. 2011. 10 x '20 Progress: development of new drugs active against resistant gram-negative bacilli. Poster LB-27. 49th Annual Meeting of the Infectious Diseases Society of America and the HIV Medicine Association. Boston, Massachusetts, 20-23, October.
    • (2011)
    • Boucher, H.1    Gilbert, D.2    Benjamin, D.3
  • 65
    • 84861148194 scopus 로고    scopus 로고
    • The combination of doripenem and colistin is bactericidal and synergistic against colistin-resistant, carbapenemase-producing Klebsiella pneumoniae
    • Jernigan, M.G., E.G. Press, M.H. Nguyen, et al. 2012. The combination of doripenem and colistin is bactericidal and synergistic against colistin-resistant, carbapenemase-producing Klebsiella pneumoniae. Antimicrob. Agents Chemother. 56: 3395-3398.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 3395-3398
    • Jernigan, M.G.1    Press, E.G.2    Nguyen, M.H.3
  • 66
    • 84866601287 scopus 로고    scopus 로고
    • Mecillinam/clavulanate combination: a possible option for the treatment of community-acquired uncomplicated urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli
    • Lampri, N., I. Galani, G. Poulakou, et al. 2012. Mecillinam/clavulanate combination: a possible option for the treatment of community-acquired uncomplicated urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli. J. Antimicrob. Chemother. 67: 2424-2428.
    • (2012) J. Antimicrob. Chemother. , vol.67 , pp. 2424-2428
    • Lampri, N.1    Galani, I.2    Poulakou, G.3
  • 67
    • 77957708554 scopus 로고    scopus 로고
    • Complicated urinary tract infections: practical solutions for the treatment of multiresistant Gram-negative bacteria
    • Pallett A. & K. Hand 2010. Complicated urinary tract infections: practical solutions for the treatment of multiresistant Gram-negative bacteria. J. Antimicrob. Chemother. 65(Suppl 3): iii25-iii33.
    • (2010) J. Antimicrob. Chemother. , vol.65 , Issue.SUPPL 3 , pp. 325-333
    • Pallett, A.1    Hand, K.2
  • 68
    • 84865424472 scopus 로고    scopus 로고
    • Activity of ceftaroline-avibactam tested against gram-negative organism populations, including strains expressing one or more β-lactamases and methicillin-resistant Staphylococcus aureus carrying various staphylococcal cassette chromosome mec types
    • Castanheira, M., H.S. Sader, D.J. Farrell, et al. 2012. Activity of ceftaroline-avibactam tested against gram-negative organism populations, including strains expressing one or more β-lactamases and methicillin-resistant Staphylococcus aureus carrying various staphylococcal cassette chromosome mec types. Antimicrob. Agents Chemother. 56: 4779-4785.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 4779-4785
    • Castanheira, M.1    Sader, H.S.2    Farrell, D.J.3
  • 69
    • 84455161611 scopus 로고    scopus 로고
    • Pharmacodynamics of β-lactamase inhibition by NXL104 in combination with ceftaroline: examining organisms with multiple types of β-lactamases
    • Louie, A., M. Castanheira, W. Liu, et al. 2012. Pharmacodynamics of β-lactamase inhibition by NXL104 in combination with ceftaroline: examining organisms with multiple types of β-lactamases. Antimicrob. Agents Chemother. 56: 258-270.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 258-270
    • Louie, A.1    Castanheira, M.2    Liu, W.3
  • 70
    • 84857173233 scopus 로고    scopus 로고
    • In vitro antibacterial activity of the ceftazidime-avibactam (NXL104) combination against Pseudomonas aeruginosa clinical isolates
    • Levasseur, P., A.-M. Girard & M. Claudon 2012. In vitro antibacterial activity of the ceftazidime-avibactam (NXL104) combination against Pseudomonas aeruginosa clinical isolates. Antimicrob. Agents Chemother. 56: 1606-1608.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 1606-1608
    • Levasseur, P.1    Girard, A.-M.2    Claudon, M.3
  • 71
    • 77955378731 scopus 로고    scopus 로고
    • Pharmacokinetics (PK) and safety of CXA-101, a new anti-pseudomonal cephalosporin, in healthy adult male and female subjects receiving single- and multiple-dose intravenous infusions
    • Ge, Y., M.J. Whitehouse, I. Friedland & G.H. Talbot 2010. Pharmacokinetics (PK) and safety of CXA-101, a new anti-pseudomonal cephalosporin, in healthy adult male and female subjects receiving single- and multiple-dose intravenous infusions. Antimicrob. Agents Chemother. 54: 3427-3431.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 3427-3431
    • Ge, Y.1    Whitehouse, M.J.2    Friedland, I.3    Talbot, G.H.4
  • 72
    • 84862573378 scopus 로고    scopus 로고
    • In vitro activity of MK-7655, a novel β-lactamase inhibitor, in combination with imipenem against carbapenem-resistant gram-negative bacteria
    • Hirsch, E.B., K.R. Ledesma, K.T. Chang, et al. 2012. In vitro activity of MK-7655, a novel β-lactamase inhibitor, in combination with imipenem against carbapenem-resistant gram-negative bacteria. Antimicrob. Agents Chemother. 56: 3753-3757.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 3753-3757
    • Hirsch, E.B.1    Ledesma, K.R.2    Chang, K.T.3
  • 73
    • 84872839045 scopus 로고    scopus 로고
    • Activity of ceftazidime (CAZ)/NXL104 (CAZ104) versus CAZ alone and other comparators against 4548 gram-negative bacilli-Results from CANWARD 2009-2010. E-1816. 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 17-20, 2011, Chicago, IL, USA
    • Lagacé-Wiens, P., P. Simner, F. Tailor, et al. 2011. Activity of ceftazidime (CAZ)/NXL104 (CAZ104) versus CAZ alone and other comparators against 4548 gram-negative bacilli-Results from CANWARD 2009-2010. E-1816. 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 17-20, 2011, Chicago, IL, USA
    • (2011)
    • Lagacé-Wiens, P.1    Simner, P.2    Tailor, F.3
  • 74
    • 84872865568 scopus 로고    scopus 로고
    • In vitro activity of ceftaroline-avibactam against frequently isolated bacterial pathogens from patients in Canadian hospitals. E-191. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 9-12, 2012, San Francisco, CA, USA
    • Karlowsky, J., A. Walkty, M. Baxter, et al. 2012. In vitro activity of ceftaroline-avibactam against frequently isolated bacterial pathogens from patients in Canadian hospitals. E-191. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 9-12, 2012, San Francisco, CA, USA
    • (2012)
    • Karlowsky, J.1    Walkty, A.2    Baxter, M.3
  • 75
    • 84872834497 scopus 로고    scopus 로고
    • Ceftazidime avibactam (ceftazidime/NXL104) versus imipenem cilastatin for complicated urinary tract infections in hospitalized adults. L2-909. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 9-12, 2012, San Francisco, CA, USA
    • Vazquez, J., L. González Patzán, D. Stricklin, et al. 2012. Ceftazidime avibactam (ceftazidime/NXL104) versus imipenem cilastatin for complicated urinary tract infections in hospitalized adults. L2-909. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 9-12, 2012, San Francisco, CA, USA
    • (2012)
    • Vazquez, J.1    González Patzán, L.2    Stricklin, D.3
  • 76
    • 77956123209 scopus 로고    scopus 로고
    • Affinity of the new cephalosporin CXA-101 to penicillin-binding proteins of Pseudomonas aeruginosa
    • Published online.
    • Moyá, B., L. Zamorano, C. Juan, et al. 2010. Affinity of the new cephalosporin CXA-101 to penicillin-binding proteins of Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 54: 3933-3937. Published online.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 3933-3937
    • Moyá, B.1    Zamorano, L.2    Juan, C.3
  • 77
    • 69949120875 scopus 로고    scopus 로고
    • Activity of cephalosporin CXA-101 (FR264205) against Pseudomonas aeruginosa and Burkholderia cepacia group strains and isolates
    • Livermore, D. M., S. Mushtaq, Y. Ge & M. Wagner 2009. Activity of cephalosporin CXA-101 (FR264205) against Pseudomonas aeruginosa and Burkholderia cepacia group strains and isolates. Int. J. Antimicrob. Agents 34: 402-406.
    • (2009) Int. J. Antimicrob. Agents , vol.34 , pp. 402-406
    • Livermore, D.M.1    Mushtaq, S.2    Ge, Y.3    Wagner, M.4
  • 78
    • 75749148334 scopus 로고    scopus 로고
    • Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains
    • Juan, C., L. Zamorano, J. Peŕrez, et al. 2010. Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains. Antimicrob. Agents Chemother. 54: 846-851.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 846-851
    • Juan, C.1    Zamorano, L.2    Peŕrez, J.3
  • 79
    • 84872836936 scopus 로고    scopus 로고
    • In vitro activity of ceftolozane/tazobactam tested against 1,705 gram-negative pathogens isolated from patients in Canadian hospitals in 2011: CANWARD surveillance study. E-200. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 9-12, 2012, San Francisco, CA, USA
    • Zhanel, G. G., H. Adam, A. Walkty, et al. 2012. In vitro activity of ceftolozane/tazobactam tested against 1, 705 gram-negative pathogens isolated from patients in Canadian hospitals in 2011: CANWARD surveillance study. E-200. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 9-12, 2012, San Francisco, CA, USA
    • (2012)
    • Zhanel, G.G.1    Adam, H.2    Walkty, A.3
  • 80
    • 84872849663 scopus 로고    scopus 로고
    • Response to imipenem plus MK-7655, a novel β-lactamase inhibitor, in a surveillance study population of P. aeruginosa from SMART 2009. C2-724. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 9-12, 2012, San Francisco, CA, USA
    • Young, K., M. Hackel, C. Lascols, et al. 2012. Response to imipenem plus MK-7655, a novel β-lactamase inhibitor, in a surveillance study population of P. aeruginosa from SMART 2009. C2-724. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 9-12, 2012, San Francisco, CA, USA
    • (2012)
    • Young, K.1    Hackel, M.2    Lascols, C.3
  • 81
    • 84872854546 scopus 로고    scopus 로고
    • amp; Activity of MK-7655 with imipenem vs. β-lactamase producers. E-192. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 9-12, 2012, San Francisco, CA, USA
    • Livermore, D. M., M. Warner & S. Mushtaq 2012. Activity of MK-7655 with imipenem vs. β-lactamase producers. E-192. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 9-12, 2012, San Francisco, CA, USA
    • (2012)
    • Livermore, D.M.1    Warner, M.2    Mushtaq, S.3
  • 82
    • 79953187968 scopus 로고    scopus 로고
    • In vitro and in vivo properties of BAL30376, a β-lactam and dual β-lactamase inhibitor combination with enhanced activity against gram-negative bacilli that express multiple β-lactamases
    • Page, M.G.P, C. Dantier, E. Desarbre, et al. 2011. In vitro and in vivo properties of BAL30376, a β-lactam and dual β-lactamase inhibitor combination with enhanced activity against gram-negative bacilli that express multiple β-lactamases. Antimicrob. Agents Chemother. 55: 1510-1519.
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 1510-1519
    • Page, M.G.P.1    Dantier, C.2    Desarbre, E.3
  • 83
    • 84872851521 scopus 로고    scopus 로고
    • Basilea Pharmaceutica. Pipeline. Available at Accessed July 28, 2012.
    • Basilea Pharmaceutica. 2012. Pipeline. Available at: http://www.basilea.com/Development/Pipeline./ Accessed July 28, 2012.
    • (2012)
  • 85
    • 84872845272 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of the novel sulfactam antibiotic BAL30072 after single ascending dose infusions in healthy volunteers. A2-572. 51st Interscience Conference on Antimicrobial Agents and Chemotherapy ICAAC, September 17-20, Chicago, IL, USA
    • Schmitt-Hoffmann, A., B. Roos, J. Maares, et al. 2011. Pharmacokinetics and safety of the novel sulfactam antibiotic BAL30072 after single ascending dose infusions in healthy volunteers. A2-572. 51st Interscience Conference on Antimicrobial Agents and Chemotherapy ICAAC, September 17-20, Chicago, IL, USA
    • (2011)
    • Schmitt-Hoffmann, A.1    Roos, B.2    Maares, J.3
  • 86
    • 84872839261 scopus 로고    scopus 로고
    • Antimicrobial activity of BAL30072, alone and in combination with meropenem tested against gram-negative bacteria causing serious infections in hospitals from China, India, Latin America and South East Asia-Pacific. E-193. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 9-12, 2012 San Francisco, CA, USA
    • Rhomberg, P.R., K.A. Fedler, R.K. Flamm, et al. 2012. Antimicrobial activity of BAL30072, alone and in combination with meropenem tested against gram-negative bacteria causing serious infections in hospitals from China, India, Latin America and South East Asia-Pacific. E-193. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 9-12, 2012 San Francisco, CA, USA
    • (2012)
    • Rhomberg, P.R.1    Fedler, K.A.2    Flamm, R.K.3
  • 87
    • 84872863940 scopus 로고    scopus 로고
    • Discovery of RPX7009, a broad-spectrum beta-lactamase inhibitor with utility vs. class A serine carbapenemases. F-848. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 9-12, 2012 San Francisco, CA, USA
    • Hecker, S.J., K.R. Reddy, M. Totrov, et al. 2012. Discovery of RPX7009, a broad-spectrum beta-lactamase inhibitor with utility vs. class A serine carbapenemases. F-848. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 9-12, 2012 San Francisco, CA, USA
    • (2012)
    • Hecker, S.J.1    Reddy, K.R.2    Totrov, M.3
  • 88
    • 84872871911 scopus 로고    scopus 로고
    • Microbiological characterization of beta-lactamase inhibitor RPX7009. F-850. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 9-12, 2012, San Francisco, CA, USA
    • Lomovskaya, O., P. King, D. Sun, et al. 2012. Microbiological characterization of beta-lactamase inhibitor RPX7009. F-850. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 9-12, 2012, San Francisco, CA, USA
    • (2012)
    • Lomovskaya, O.1    King, P.2    Sun, D.3
  • 89
    • 84872859369 scopus 로고    scopus 로고
    • Anacor Pharmaceuticals announces that its partner GSK has voluntarily paused enrollment of ongoing GSK '052 phase 1 and 2 clinical trials. [press release]. Available at. Accessed 5 July 2012.
    • Anacor Pharmaceuticals announces that its partner GSK has voluntarily paused enrollment of ongoing GSK '052 phase 1 and 2 clinical trials. [press release]. 2012. Available at: http://www.anacor.com/gsk052.php. Accessed 5 July 2012.
    • (2012)
  • 90
    • 84872867274 scopus 로고    scopus 로고
    • In vitro activity profile of PMX-30063 against recent clinical isolates of gram-positive and gram-negative pathogens. Available at. Accessed July 5, 2012.
    • Korczak, B. & R. Scott 2012. In vitro activity profile of PMX-30063 against recent clinical isolates of gram-positive and gram-negative pathogens. Available at: http://files.shareholder.com/downloads/ABEA-4ITCYZ/1730124406x0x492675/7e5d6f23-496d-472b-9052-ac057a054a8d/ECCMID_2011-Gram_Pos_Neg_Activity.pdf. Accessed July 5, 2012.
    • (2012)
    • Korczak, B.1    Scott, R.2
  • 91
    • 84872839898 scopus 로고    scopus 로고
    • A Phase 1 trial to evaluate the tolerability, safety and pharmacokinetics of multi-dose intravenous regimens of PMX-30063. P-1515. 21st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) May 7-10, 2011 Milan, Italy
    • Korczak, B. & E. McAllister 2011. A Phase 1 trial to evaluate the tolerability, safety and pharmacokinetics of multi-dose intravenous regimens of PMX-30063. P-1515. 21st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) May 7-10, 2011 Milan, Italy
    • (2011)
    • Korczak, B.1    McAllister, E.2
  • 92
    • 84872849387 scopus 로고    scopus 로고
    • amp; A phase 2 randomized, double-blinded, dose-ranging, active controlled efficacy and safety evaluation of Brilacidin (PMX-30063) for the treatment of acute skin & skin structure infections (absssi) caused by Staphylococcus aureus (SA). L1-1662. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 9-12, 2012 San Francisco, CA, USA
    • Jorgensen D., R. Scott, R. Echols & B. Korczak 2012. A phase 2 randomized, double-blinded, dose-ranging, active controlled efficacy and safety evaluation of Brilacidin (PMX-30063) for the treatment of acute skin & skin structure infections (absssi) caused by Staphylococcus aureus (SA). L1-1662. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 9-12, 2012 San Francisco, CA, USA
    • (2012)
    • Jorgensen, D.1    Scott, R.2    Echols, R.3    Korczak, B.4


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