Activity of ceftobiprole against Streptococcus pneumoniae isolates exhibiting high-level resistance to ceftriaxone

International Journal of Antimicrobial Agents

Volumn 39, Issue 6, 2012, Pages 534-538

  Davies, Todd A ^a   Flamm, Robert K ^a,b   Lynch, A Simon ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (United States)

^b JMI LABORATORIES   (United States)

Author keywords

Lactams; Cephalosporins; murM; Penicillin binding proteins; Serotypes

Indexed keywords

ADENINE; CEFTOBIPROLE; CEFTRIAXONE; GUANINE; PENICILLIN BINDING PROTEIN; PENICILLIN G;

ALLELE; AMINO ACID SUBSTITUTION; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; BACTERIAL GENE; BACTERIUM ISOLATE; CONFERENCE PAPER; CONTROLLED STUDY; GENE MUTATION; GENOTYPE; MINIMUM INHIBITORY CONCENTRATION; MURM GENE; NONHUMAN; PBP1A GENE; PBP2B GENE; PBP2X GENE; PRIORITY JOURNAL; PROTEIN MOTIF; SEQUENCE ANALYSIS; STREPTOCOCCUS PNEUMONIAE; WILD TYPE;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAM RESISTANCE; BETA-LACTAMS; CEFTRIAXONE; CEPHALOSPORINS; GENOTYPE; HUMANS; MICROBIAL SENSITIVITY TESTS; PENICILLIN-BINDING PROTEINS; PENICILLINS; PEPTIDE SYNTHASES; SEQUENCE ANALYSIS, DNA; STREPTOCOCCUS PNEUMONIAE;

EID: 84860459763     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2012.02.016     Document Type: Conference Paper

References (15)

1. Y. Sanbongi, T. Ida, M. Ishikawa, Y. Osaki, H. Kataoka, and T. Suzuki Complete sequences of six penicillin-binding protein genes from 40 Streptococcus pneumoniae clinical isolates collected in Japan Antimicrob Agents Chemother 48 2004 2244 2250 (Pubitemid 38691625)
2. A.M. Smith, and K.P. Klugman Alterations in MurM, a cell wall muropeptide branching enzyme, increase high-level penicillin and cephalosporin resistance in Streptococcus pneumoniae Antimicrob Agents Chemother 45 2001 2393 2396 (Pubitemid 32664488)
3. T.A. Davies, W. Shang, and K. Bush Activities of ceftobiprole and other β-lactams against Streptococcus pneumoniae clinical isolates from the United States with defined substitutions in penicillin-binding proteins PBP 1a, PBP 2b, and PBP 2x Antimicrob Agents Chemother 50 2006 2530 2532 (Pubitemid 43993197)
4. S.R. Filipe, E. Severina, and A. Tomasz Distribution of the mosaic structured murM genes among natural populations of Streptococcus pneumoniae J Bacteriol 182 2000 6798 6805 (Pubitemid 32249264)
5. S.R. Filipe, and A. Tomasz Inhibition of the expression of penicillin resistance in Streptococcus pneumoniae by inactivation of cell wall muropeptide branching genes Proc Natl Acad Sci USA 97 2000 4891 4896 (Pubitemid 30238653)
6. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; 21st informational supplement. Document M100-S21. Wayne, PA: CLSI; 2010.
7. P. Hebeisen, I. Heinze-Krauss, P. Angehrn, P. Hohl, M.G.P. Page, and R.L. Then In vitro and in vivo properties of Ro 63-9141, a novel broad-spectrum cephalosporin with activity against methicillin-resistant staphylococci Antimicrob Agents Chemother 45 2001 825 836 (Pubitemid 32182033)
8. K.A. Nichol, G.G. Zhanel, and D.J. Hoban Penicillin-binding protein 1A, 2B, and 2X alterations in Canadian isolates of penicillin-resistant Streptococcus pneumoniae Antimicrob Agents Chemother 46 2002 3261 3264
9. L. Chesnel, R. Carapito, J. Croizé, O. Dideberg, T. Vernet, and A. Zapun Identical penicillin-binding domains in penicillin-binding proteins of Streptococcus pneumoniae clinical isolates with different levels of β-lactam resistance Antimicrob Agents Chemother 49 2005 2895 2902 (Pubitemid 40917608)
10. F. Cafini, R. del Campo, L. Alou, D. Sevillano, M.I. Morosini, and F. Baquero Alterations of the penicillin-binding proteins and murM alleles of clinical Streptococcus pneumoniae isolates with high-level resistance to amoxicillin in Spain J Antimicrob Chemother 57 2006 224 229 (Pubitemid 43160162)
11. I. Zerfaß, R. Hakenbeck, and D. Denapaite An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338 Antimicrob Agents Chemother 53 2009 1107 1115
12. A.M. Smith, and K.P. Klugman Site-specific mutagenesis analysis of PBP 1A from a penicillin-cephalosporin-resistant pneumococcal isolate Antimicrob Agents Chemother 47 2003 387 389 (Pubitemid 36070392)
13. A.M. Smith, and K.P. Klugman Amino acid mutations essential to production of an altered PBP 2X conferring high-level β-lactam resistance in a clinical isolate of Streptococcus pneumoniae Antimicrob Agents Chemother 49 2005 4622 4627 (Pubitemid 41552592)
14. F. Soriano, F. Cafini, L. Aguilar, D. Tarragó, L. Alou, and M.-J. Giménez Breakthrough in penicillin resistance? Streptococcus pneumoniae isolates with penicillin/cefotaxime MICs of 16 mg/l and their genotypic and geographical relatedness J Antimicrob Chemother 62 2008 1234 1240
15. R. del Campo, F. Cafini, M.I. Morosini, A. Fenoll, J. Liñares, and L. Alou Combinations of PBPs and MurM protein variants in early and contemporary high-level penicillin-resistant Streptococcus pneumoniae isolates in Spain J Antimicrob Chemother 57 2006 983 986