Molecular characterization of resistance to extended-spectrum cephalosporins in clinical Escherichia coli isolates from companion animals in the United States

Antimicrobial Agents and Chemotherapy

Volumn 55, Issue 12, 2011, Pages 5666-5675

  Shaheen, Bashar W ^a   Nayak, Rajesh ^a   Foley, Steven L ^a   Kweon, Ohgew ^a   Deck, Joanna ^a   Park, Miseon ^a   Rafii, Fatemeh ^a   Boothe, Dawn M ^b  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b AUBURN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CEFOTAXIME; CEFTAZIDIME; CEPHALOSPORIN DERIVATIVE; EXTENDED SPECTRUM BETA LACTAMASE; EXTENDED SPECTRUM CEPHALOSPORIN; UNCLASSIFIED DRUG; VALINE;

ANIMAL EXPERIMENT; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIUM CONJUGATION; BACTERIUM ISOLATE; CONTROLLED STUDY; ESCHERICHIA COLI; GENE MUTATION; GENE SEQUENCE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR BIOLOGY; NONHUMAN; PHENOTYPE; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SUBSTITUTION REACTION; UNITED STATES; VETERINARY MEDICINE;

ANIMALS; ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; CAT DISEASES; CATS; CEPHALOSPORIN RESISTANCE; CEPHALOSPORINS; CONJUGATION, GENETIC; DOG DISEASES; DOGS; ELECTROPHORESIS, GEL, PULSED-FIELD; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; ESCHERICHIA COLI PROTEINS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PETS; PLASMIDS; UNITED STATES;

EID: 81555206715     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00656-11     Document Type: Article

References (50)

1. Bonnet, R. 2004. Growing group of extended-spectrum β-lactamases: the CTX-M enzymes. Antimicrob. Agents Chemother. 48:1-14. (Pubitemid 38040170)
2. Bradford, P. A. 2001. Extended-spectrum β-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. Clin. Microbiol. Rev. 14:933-951. (Pubitemid 32979636)
3. Brinas, L., et al. 2005. Mechanisms of resistance to expanded-spectrum cephalosporins in Escherichia coli isolates recovered in a Spanish hospital. J. Antimicrob. Chemother. 56:1107-1110. (Pubitemid 43009828)
4. Brinas, L., et al. 2005. Monitoring and characterization of extended-spectrum β-lactamases in Escherichia coli strains from healthy and sick animals in Spain in 2003. Antimicrob. Agents Chemother. 49:1262-1264. (Pubitemid 40327766)
5. Brinas, L., M. Zarazaga, Y. Saenz, F. Ruiz-Larrea, and C. Torres. 2002. β-Lactamases in ampicillin-resistant Escherichia coli isolates from foods, humans, and healthy animals. Antimicrob. Agents Chemother. 46:3156-3163.
6. Carattoli, A., et al. 2005. Identification of plasmids by PCR-based replicon typing. J. Microbiol. Methods 63:219-228. (Pubitemid 41597366)
7. Carattoli, A., et al. 2005. Extended-spectrum β-lactamases in Escherichia coli isolated from dogs and cats in Rome, Italy, from 2001 to 2003. Antimicrob. Agents Chemother. 49:833-835. (Pubitemid 40175711)
8. Caroff, N., E. Espaze, D. Gautreau, H. Richet, and A. Reynaud. 2000. Analysis of the effects of -42 and -32 ampC promoter mutations in clinical isolates of Escherichia coli hyperproducing AmpC. J. Antimicrob. Chemother. 45:783-788. (Pubitemid 30348947)
9. Cartelle, M., et al. 2004. High-level resistance to ceftazidime conferred by a novel enzyme, CTX-M-32, derived from CTX-M-1 through a single Asp240- Gly substitution. Antimicrob. Agents Chemother. 48:2308-2313. (Pubitemid 38691639)
10. Chaibi, E. B., D. Sirot, G. Paul, and R. Labia. 1999. Inhibitor-resistant TEM β-lactamases: phenotypic, genetic and biochemical characteristics. J. Antimicrob. Chemother. 43:447-458. (Pubitemid 29182292)
11. Chen, Y. M., P. J. Wright, C. S. Lee, and G. F. Browning. 2003. Uropathogenic virulence factors in isolates of Escherichia coli from clinical cases of canine pyometra and feces of healthy bitches. Vet. Microbiol. 94:57-69. (Pubitemid 36556166)
12. Chmelnitsky, I., Y. Carmeli, A. Leavitt, M. J. Schwaber, and S. Navon- Venezia. 2005. CTX-M-2 and a new CTX-M-39 enzyme are the major extended- spectrum β-lactamases in multiple Escherichia coli clones isolated in Tel Aviv, Israel. Antimicrob. Agents Chemother. 49:4745-4750. (Pubitemid 41552608)
13. CLSI. 2008. Performance standards for antimicrobial disk and dilution susceptibility testing for bacteria isolated from animals, 3rd ed. Approved standard M31-A3. Clinical and Laboratory Standards Institute, Wayne, PA.
14. Cooke, C. L., R. S. Singer, S. S. Jang, and D. C. Hirsh. 2002. Enrofloxacin resistance in Escherichia coli isolated from dogs with urinary tract infections. J. Am. Vet. Med. Assoc. 220:190-192. (Pubitemid 34061961)
15. Costa, D., et al. 2008. Prevalence of antimicrobial resistance and resistance genes in faecal Escherichia coli isolates recovered from healthy pets. Vet. Microbiol. 127:97-105. (Pubitemid 350267038)
16. Costa, D., et al. 2006. Detection of Escherichia coli harbouring extended-spectrum β-lactamases of the CTX-M, TEM and SHV classes in faecal samples of wild animals in Portugal. J. Antimicrob. Chemother. 58:1311-1312. (Pubitemid 44884163)
17. Ewers, C., et al. 2010. Emergence of human pandemic O25:H4-ST131 CTXM- 15 extended-spectrum-β-lactamase-producing Escherichia coli among companion animals. J. Antimicrob. Chemother. 65:651-660.
18. Feria, C., E. Ferreira, J. D. Correia, J. Goncalves, and M. Canica. 2002. Patterns and mechanisms of resistance to β-lactams and β-lactamase inhibitors in uropathogenic Escherichia coli isolated from dogs in Portugal. J. Antimicrob. Chemother. 49:77-85. (Pubitemid 34102976)
19. CMY-2 from multiple Salmonella plasmid backbones. Antimicrob. Agents Chemother. 48:2845-2852.
20. Gonullu, N., et al. 2008. Dissemination of CTX-M-15 β-lactamase genes carried on Inc FI and FII plasmids among clinical isolates of Escherichia coli in a university hospital in Istanbul, Turkey. J. Clin. Microbiol. 46:1110-1112. (Pubitemid 351380010)
21. Gonzalez-Sanz, R., S. Herrera-Leon, M. de la Fuente, M. Arroyo, and M. A. Echeita. 2009. Emergence of extended-spectrum β-lactamases and AmpC- type β-lactamases in human Salmonella isolated in Spain from 2001 to 2005. J. Antimicrob. Chemother. 64:1181-1186.
22. Guardabassi, L., S. Schwarz, and D. H. Lloyd. 2004. Pet animals as reservoirs of antimicrobial-resistant bacteria. J. Antimicrob. Chemother. 54:321-332. (Pubitemid 39177449)
23. Hagman, R., and I. Kuhn. 2002. Escherichia coli strains isolated from the uterus and urinary bladder of bitches suffering from pyometra: comparison by restriction enzyme digestion and pulsed-field gel electrophoresis. Vet. Microbiol. 84:143-153. (Pubitemid 33135539)
24. Hopkins, K. L., et al. 2006. Replicon typing of plasmids carrying CTX-M or CMY β-lactamases circulating among Salmonella and Escherichia coli isolates. Antimicrob. Agents Chemother. 50:3203-3206. (Pubitemid 44396441)
25. Knox, J. R. 1995. Extended-spectrum and inhibitor-resistant TEM-type β-lactamases: mutations, specificity, and three-dimensional structure. Antimicrob. Agents Chemother. 39:2593-2601.
26. Li, X. Z., M. Mehrotra, S. Ghimire, and L. Adewoye. 2007. β-lactam resistance and β-lactamases in bacteria of animal origin. Vet. Microbiol. 121: 197-214. (Pubitemid 46413620)
27. Liebana, E., et al. 2004. Characterization of β-lactamases responsible for resistance to extended-spectrum cephalosporins in Escherichia coli and Salmonella enterica strains from food-producing animals in the United Kingdom. Microb. Drug Resist. 10:1-9. (Pubitemid 38529711)
28. Livermore, D. M. 1995. β-Lactamases in laboratory and clinical resistance. Clin. Microbiol. Rev. 8:557-584.
29. Ma, J., et al. 2009. High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6′)-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. Antimicrob. Agents Chemother. 53:519-524.
30. Machado, E., et al. 2006. Dissemination in Portugal of CTX-M-15-, OXA-1-, and TEM-1-producing Enterobacteriaceae strains containing the aac(6′)- Ib-cr gene, which encodes an aminoglycoside- and fluoroquinolone-modifying enzyme. Antimicrob. Agents Chemother. 50:3220-3221. (Pubitemid 44396445)
31. Martinez-Martinez, L., et al. 2000. Activities of imipenem and cephalosporins against clonally related strains of Escherichia coli hyperproducing chromosomal β-lactamase and showing altered porin profiles. Antimicrob. Agents Chemother. 44:2534-2536. (Pubitemid 30650909)
32. Mataseje, L. F., et al. 2009. Characterization of Canadian cefoxitin-resistant non-typhoidal Salmonella isolates, 2005-06. J. Antimicrob. Chemother. 64: 723-730.
33. Miro, E., et al. 2002. Prevalence of clinical isolates of Escherichia coli producing inhibitor-resistant β-lactamases at a University Hospital in Barcelona, Spain, over a 3-year period. Antimicrob. Agents Chemother. 46:3991-3994. (Pubitemid 35403281)
34. Moreno, A., H. Bello, D. Guggiana, M. Dominguez, and G. Gonzalez. 2008. Extended-spectrum β-lactamases belonging to CTX-M group produced by Escherichia coli strains isolated from companion animals treated with enrofloxacin. Vet. Microbiol. 129:203-208.
35. Mulvey, M. R., et al. 2005. Molecular characterization of cefoxitin-resistant Escherichia coli from Canadian hospitals. Antimicrob. Agents Chemother. 49:358-365. (Pubitemid 40065813)
36. Nicolas-Chanoine, M. H., et al. 2008. Intercontinental emergence of Escherichia coli clone O25:H4-ST131 producing CTX-M-15. J. Antimicrob. Chemother. 61:273-281.
37. O'Keefe, A., T. A. Hutton, D. M. Schifferli, and S. C. Rankin. 2010. First detection of CTX-M and SHV extended-spectrum β-lactamases in Escherichia coli urinary tract isolates from dogs and cats in the United States. Antimicrob. Agents Chemother. 54:3489-3492.
38. Pace, C. N., and J. M. Scholtz. 1998. A helix propensity scale based on experimental studies of peptides and proteins. Biophys. J. 75:422-427. (Pubitemid 28311831)
39. Pai, H., M. R. Kim, M. R. Seo, T. Y. Choi, and S. H. Oh. 2006. A nosocomial outbreak of Escherichia coli producing CTX-M-15 and OXA-30 β-lactamase. Infect. Control Hosp. Epidemiol. 27:312-314.
40. TEM-1G) encoding the parental TEM-1 β-lactamase. FEMS Microbiol. Lett. 220:177-180.
41. Pomba, C., J. D. da Fonseca, B. C. Baptista, J. D. Correia, and L. Martinez- Martinez. 2009. Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6′)-Ib-cr genes in a dog. Antimicrob. Agents Chemother. 53:327-328.
42. Sanchez, S., et al. 2002. Characterization of multidrug-resistant Escherichia coli isolates associated with nosocomial infections in dogs. J. Clin. Microbiol. 40:3586-3595.
43. Shaheen, B. W., D. M. Boothe, O. A. Oyarzabal, and T. Smaha. 2010. Antimicrobial resistance profiles and clonal relatedness of canine and feline Escherichia coli pathogens expressing multidrug resistance in the United States. J. Vet. Intern. Med. 24:323-330.
44. Shaheen, B. W., O. A. Oyarzabal, and D. M. Boothe. 2010. The role of class 1 and 2 integrons in mediating antimicrobial resistance among canine and feline clinical E. coli isolates from the US. Vet. Microbiol. 144:363-370.
45. Sideraki, V., W. Huang, T. Palzkill, and H. F. Gilbert. 2001. A secondary drug resistance mutation of TEM-1 β-lactamase that suppresses misfolding and aggregation. Proc. Natl. Acad. Sci. U. S. A. 98:283-288. (Pubitemid 32095901)
46. Sirichote, P., et al. 2010. Molecular characterization of extended-spectrum cephalosporinase-producing Salmonella enterica serovar Choleraesuis isolates from patients in Thailand and Denmark. J. Clin. Microbiol. 48:883-888.
47. Tracz, D. M., et al. 2007. ampC gene expression in promoter mutants of cefoxitin-resistant Escherichia coli clinical isolates. FEMS Microbiol. Lett. 270:265-271. (Pubitemid 46597360)
48. Whichard, J. M., et al. 2005. β-lactam resistance and Enterobacteriaceae, United States. Emerg. Infect. Dis. 11:1464-1466. (Pubitemid 41209149)
49. Winokur, P. L., D. L. Vonstein, L. J. Hoffman, E. K. Uhlenhopp, and G. V. Doern. 2001. Evidence for transfer of CMY-2 AmpC β-lactamase plasmids between Escherichia coli and Salmonella isolates from food animals and humans. Antimicrob. Agents Chemother. 45:2716-2722. (Pubitemid 32906662)
50. CMYgenes in Escherichia coli and Salmonella isolates from food animals and ground meat. Antimicrob. Agents Chemother. 45:3647-3650.