Asteropsin A: An unusual cystine-crosslinked peptide from porifera enhances neuronal Ca2 + influx

Biochimica et Biophysica Acta - General Subjects

Volumn 1830, Issue 3, 2013, Pages 2591-2599

  Li, Huayue ^a   Bowling, John J ^b,f   Fronczek, Frank R ^c   Hong, Jongki ^d   Jabba, Sairam V ^e   Murray, Thomas F ^e   Ha, Nam Chul ^a   Hamann, Mark T ^b,f   Jung, Jee H ^a  

^a Pusan National University   (South Korea)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c LOUISIANA STATE UNIVERSITY   (United States)

^d Kyung Hee University   (South Korea)

^e CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Bioactive peptide; Ion channelopathy; Natural product; NMR spectroscopy; Porifera; X ray crystallography

Indexed keywords

ASTEROPSIN A; CALCIUM ION; CYSTEINE; NEUROTOXIN; PEPTIDE; PROLINE; PYROGLUTAMIC ACID; SODIUM CHANNEL; UNCLASSIFIED DRUG; VERATRIDINE;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BRAIN CORTEX; CALCIUM CURRENT; CALCIUM SIGNALING; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG DETERMINATION; DRUG ISOLATION; DRUG MECHANISM; DRUG STRUCTURE; MOUSE; NERVE CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN CROSS LINKING; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SPONGE (PORIFERA); STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ACTION POTENTIALS; AMINO ACID SEQUENCE; ANIMALS; CALCIUM; CEREBRAL CORTEX; CRYSTALLOGRAPHY, X-RAY; CYSTINE; ION TRANSPORT; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEURONS; PEPTIDES; PORIFERA; PRIMARY CELL CULTURE; PROTEIN CONFORMATION; PROTEIN FOLDING; SODIUM CHANNELS; VERATRIDINE;

ASTEROPUS; MURINAE; PORIFERA;

EID: 84872818821     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2012.11.015     Document Type: Article

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