Quantitative analyses of bone composition in acetylcholine receptor M3R and alpha7 knockout mice

Life Sciences

Volumn 91, Issue 21-22, 2012, Pages 997-1002

  Kliemann, Karin ^a   Kneffel, Mathias ^a   Bergen, Ivonne ^a   Kampschulte, Marian ^a   Langheinrich, Alexander C ^a   Dürselen, Lutz ^b   Ignatius, Anita ^b   Kilian, Olaf ^a,c   Schnettler, Reinhard ^a,d   Lips, Katrin S ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b UNIVERSITY OF ULM   (Germany)

^c University of Ulm ^*  (Germany)

^d UNIVERSITY HOSPITAL GIESSEN   (Germany)

Author keywords

Biomechanics; Bone composition; Knockout mice; Muscarinic receptor; Nicotinic receptor; Non neuronal cholinergic system; Quantitative Micro CT; Real time RT PCR

Indexed keywords

CHOLINERGIC RECEPTOR; CHOLINERGIC RECEPTOR ALPHA7; COLLAGEN TYPE 1; COLLAGEN TYPE 1 ALPHA1; COLLAGEN TYPE 1 ALPHA2; MUSCARINIC RECEPTOR; NICOTINIC RECEPTOR; PROTEIN M3R; UNCLASSIFIED DRUG; BUNGAROTOXIN RECEPTOR; COLLAGEN; MESSENGER RNA; MUSCARINIC M3 RECEPTOR;

ANIMAL EXPERIMENT; BIOMECHANICS; BONE CHARACTERISTICS AND FUNCTIONS; BONE COMPOSITION; BONE DENSITY; BONE MASS; COLLAGEN SYNTHESIS; CONFERENCE PAPER; DOWN REGULATION; FEMUR; HUMERUS; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; QUANTITATIVE ANALYSIS; TRABECULAR BONE; VERTEBRA; ANIMAL; ARTICLE; BONE; CHEMISTRY; GENE INACTIVATION; GENETICS; HISTOLOGY; MALE; METABOLISM; MOUSE MUTANT;

MUS;

ANIMALS; BIOMECHANICS; BONE AND BONES; BONE DENSITY; COLLAGEN; DOWN-REGULATION; GENE KNOCKOUT TECHNIQUES; MALE; MICE; MICE, KNOCKOUT; RECEPTOR, MUSCARINIC M3; RECEPTORS, NICOTINIC; RNA, MESSENGER;

EID: 84872818194     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.07.024     Document Type: Conference Paper

References (27)

1. J. Arredondo, V.T. Nguyen, A.I. Chernyavsky, D. Bercovich, A. Orr-Urtreger, D.E. Vetter, and S.A. Grando Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis Life Sci 28 2003 2063 2067
2. L.V. Borovikova, S. Ivanova, M. Zhang, H. Yang, G.I. Botchkina, L.R. Watkins, H. Wang, N. Abumrad, J.W. Eaton, and K.J. Tracey Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin Nature 405 2000 458 462
3. H. Chen, X. Zhou, Y. Washimi, and S. Shoumura Three-dimensional microstructure of the bone in a hamster model of senile osteoporosis Bone 43 2008 494 500
4. H. Chen, X. Zhou, S. Shoumura, S. Emura, and Y. Bunai Age- and gender-dependent changes in three-dimensional microstructure of cortical and trabecular bone at the human femoral neck Osteoporos Int 21 2010 627 636
5. H. Chen, Y. Washimi, K.Y. Kubo, and M. Onozuka Gender-related changes in three-dimensional microstructure of trabecular bone at the human proximal tibia with aging Histol Histopathol 26 2011 563 570
6. K. Engelke, M. Karolczak, A. Lutz, U. Seibert, S. Schaller, and W. Kalender Mikro-CT: Technologie und Applikationen zur Erfassung von Knochenarchitektur Radiologe 39 1999 203 212
7. M. En-Nosse, S. Hartmann, K. Trinkaus, V. Alt, B. Stigler, C. Heiss, O. Kilian, R. Schnettler, and K.S. Lips Expression of non-neuronal cholinergic system in osteoblast-like cells and its involvement in osteogenesis Cell Tissue Res 338 2009 203 215
8. S. Haag, S. Matthiesen, U.R. Juergens, and K. Racké Muscarinic receptors mediate stimulation of collagen synthesis in human lung fibroblasts Eur Respir J 32 2008 555 562
9. T. Hildebrand, and P. Rüegsegger Quantification of bone microarchitecture with the structure model index CMBBE 1 1997 15 23
10. B.S. Kim, S.J. Kim, H.J. Kim, S.J. Lee, Y.J. Park, J. Lee, and H.K. You Effects of nicotine on proliferation and osteoblast differentiation in human alveolar bone marrow-derived mesenchymal stem cells Life Sci 90 2012 109 115
11. P.S. Liu, Y.Y. Chen, C.K. Feng, Y.H. Lin, and T.C. Yu Muscarinic acetylcholine receptors present in human osteoblast and bone tissue Eur J Pharmacol 650 2011 34 40
12. S. Matthiesen, A. Bahulayan, S. Kempkens, S. Haag, M. Fuhrmann, C. Stichnote, U.R. Juergens, and K. Racké Muscarinic receptors mediate stimulation of human lung fibroblast proliferation Am J Respir Cell Mol Biol 35 2006 621 627
13. S. Matthiesen, A. Bahulayan, and K. Racké MAPK pathway mediates muscarinic receptor-induced human lung fibroblast proliferation Life Sci 80 2007 2259 2262
14. M. Murshed, and M.D. McKee Molecular determinants of extracellular matrix mineralization in bone and blood vessels Curr Opin Nephrol Hypertens 19 2010 359 365
15. A. Orr-Urtreger, F.M. Goldner, M. Saeki, I. Lorenz, I. Goldberg, M. De Biasi, J.A. Dani, J.W. Patrick, and A.L. Beaudet Mice deficient in the α7 neuronal nicotinic acetylcholine receptor lack α-bungarotoxin binding sites and hippocampal fast nicotinic currents J Neurosci 17 1997 9165 9171
16. A.M. Parfitt, C.H.E. Mathews, A.R. Villanueva, M. Kleerekoper, B. Frame, and D.S. Rao Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis J Clin Invest 72 1983 1396 1409
17. M.A. Parfitt, M.K. Drezner, F.H. Glorieux, J.A. Kanis, H. Malluche, P.J. Meunier, S.M. Ott, and R.R. Recker Bone histomorphometry: standardization of nomenclature, symbols, and units J Bone Miner Res 2 1987 595 610
18. V. Röntgen, R. Blakytny, R. Matthys, M. Landauer, T. Wehner, M. Göckelmann, P. Jermendy, M. Amling, T. Schinke, L. Claes, and A. Ignatius Fracture healing in mice under controlled rigid and flexible conditions using an adjustable external fixator J Orthop Res 28 2010 1456 1462
19. D.E. Rothem, L. Rothem, M. Soudry, A. Dahan, and R. Eliakim Nicotine modulates bone metabolism-associated gene expression in osteoblast cells J Bone Miner Metab 27 2009 555 561
20. P. Sarathchandra, and M.F. Pope Unexpected ultrastructural changes in bone osteoid collagens in osteogenesis imperfecta Micron 36 2005 696 702
21. T. Sato, T. Abe, D. Chida, N. Nakamoto, N. Hori, S. Kokabu, Y. Sakata, Y. Tomura, T. Iwata, M. Usui, K. Aiko, and T. Yoda Functional role of acetylcholine and the expression of cholinergic receptors and components in osteoblasts FEBS Lett 584 2010 817 824
22. H.S. Sekhon, J.A. Keller, B.J. Proskocil, E.L. Martin, and E.R. Spindel Maternal nicotine exposure upregulates collagen gene expression in fetal monkey lung. Association with alpha7 nicotinic acetylcholine receptors Am J Respir Cell Mol Biol 26 2002 31 41
23. H.S. Sekhon, B.J. Proskocil, J.A. Clark, and E.R. Spindel Prenatal nicotine exposure increases connective tissue expression in foetal monkey pulmonary vessels Eur Respir J 23 2004 906 915
24. 3 muscarinic receptor favors bone mass accrual by decreasing sympathetic activity Cell Metab 11 2010 231 238
25. M.M. Sran, S.K. Boyd, D.M. Cooper, K.M. Khan, R.F. Zernicke, and T.R. Oxland Regional trabecular morphology assessed by micro-CT is correlated with failure of aged thoracic vertebrae under a posteroanterior load and may determine the site of fracture Bone 40 2007 751 757
26. M. Yamada, T. Miyakawa, A. Duttaroy, A. Yamanaka, T. Moriguchi, R. Makita, M. Ogawa, C.J. Chou, B. Xia, J.N. Crawley, C.C. Felder, C.X. Deng, and J. Wess Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean Nature 410 2001 207 212
27. C.M. Yang, C.S. Chien, C.C. Yao, L.D. Hsio, Y.C. Huang, and C.B. Wu Mechanical strain induces collagenase-3 (MMP-13) expression in MC3T3-E1 osteoblastic cells J Biol Chem 279 2004 22158 22165