Expression of non-neuronal cholinergic system in osteoblast-like cells and its involvement in osteogenesis

Cell and Tissue Research

Volumn 338, Issue 2, 2009, Pages 203-215

  En Nosse, Maryam ^a   Hartmann, Sonja ^a   Trinkaus, Katja ^a   Alt, Volker ^a   Stigler, Brigitte ^a   Heiss, Christian ^a   Kilian, Olaf ^a   Schnettler, Reinhard ^a   Lips, Katrin Susanne ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Bone morphogenetic protein 2; Fracture; Nicotinic receptor; Non neuronal cholinergic system; Osteoblast; Rat (Wistar, adult male)

Indexed keywords

CARNITINE ACETYLTRANSFERASE; MUSCARINIC M2 RECEPTOR; MUSCARINIC M5 RECEPTOR; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA10; NICOTINIC RECEPTOR ALPHA3; NICOTINIC RECEPTOR ALPHA5; NICOTINIC RECEPTOR ALPHA9; NICOTINIC RECEPTOR BETA2; NICOTINIC RECEPTOR BETA3; OCTAMER TRANSCRIPTION FACTOR 1; RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DEVELOPMENT; CELL CULTURE; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; EMBRYO; FETUS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIBIA FRACTURE;

ACETYLCHOLINE; ANIMALS; BONE MORPHOGENETIC PROTEIN 2; BONE REMODELING; BUTYRYLCHOLINESTERASE; CARNITINE ACYLTRANSFERASES; CELL LINE; FRACTURE HEALING; HUMANS; MICE; ORGANIC CATION TRANSPORT PROTEINS; OSTEOBLASTS; OSTEOGENESIS; RATS; RECEPTORS, MUSCARINIC; RECEPTORS, NICOTINIC; UP-REGULATION;

MURINAE; RATTUS;

EID: 70350584818     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00441-009-0871-1     Document Type: Article

References (38)

1. AA Anderson J Helmering T Juan CM Li J McCormick M Graham DM Baker MA Damore MM Veniant DJ Lloyd 2009 Pancreatic islet expression profiling in diabetes-prone C57BLKS/J mice reveals transcriptional differences contributed by DBA loci, including Plagl1 and Nnt Pathogenetics 2 1 10.1186/1755-8417-2-1 19161594
2. J Arredondo LL Hall A Ndoye VT Nguyen AI Chernyavsky D Bercovich A Orr-Urtreger AL Beaudet SA Grando 2003 Central role of fibroblast alpha3 nicotinic acetylcholine receptor in mediating cutaneous effects of nicotine Lab Invest 83 207 225 12594236
3. B Berse W Szczecinska I Lopez-Coviella B Madziar V Zemelk R Kaminski K Kozar KS Lips U Pfeil JK Blusztajn 2005 Expression of high affinity choline transporter during mouse development in vivo and its upregulation by NGF and BMP-4 in vitro Brain Res Dev Brain Res 157 132 140 10.1016/j.devbrainres.2005. 03.013 15885806 (Pubitemid 40803510)
4. KP Brady H Dushkin D Förnzler T Koike F Magner H Her S Gullans GV Segre RM Green DR Beier 1999 A novel putative transporter maps to the osteosclerosis (oc) mutation and is not expressed in the oc mutant mouse Genomics 56 254 261 10.1006/geno.1998.5722 10087192 (Pubitemid 29159905)
5. Buisson P, Picard F, Bertrand D (2000) Neuronal nicotinic acetylcholine receptors: from biophysical properties to human diseases. In: Clementi F, Gotti C, Fornasari D (eds) Neuronal nicotinic acetylcholine receptors. Springer, Berlin Heidelberg New York, pp 272-299
6. MP Caulfield NJM Birdsall 1998 International Union of Pharmacology XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev 50 279 290
7. G Cho L Youngshin D Zand JA Golden 2008 Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling Mol Cell Biol 28 1565 1572 10.1128/MCB.01038-07 18160706
8. LE Eiden 1998 The cholinergic gene locus J Neurochem 70 2227 2240 9603187
9. JB Feitelson PP Rowell CS Roberts JT Fleming 2003 Two week nicotine treatment selectively increases bone vascular constriction in response to norepinephrine J Orthop Res 21 497 502 10.1016/S0736-0266(02)00235-8 12706023 (Pubitemid 36553041)
10. PG Genever MA Birch E Brown TM Skerry 1999 Osteoblast-derived acetylcholinesterase: a novel mediator of cell-matrix interactions in bone? Bone 24 297 303 10.1016/S8756-3282(98)00187-2 10221541 (Pubitemid 29134967)
11. D Grisaru E Lev-Lehman M Shapira E Chaikin JB Lessing A Eldor F Eckstain H Soreq 1999 Human osteogenesis involves differentiation-dependent increases in the morphogenetically active 3 alternative splicing variant of acetylcholinesterase Mol Cell Biol 19 788 795 9858601
12. DL Herber EG Severance J Cuevas D Morgan MN Gordon 2004 Biochemical and histochemical evidence of nonspecific binding of alpha7nAChR antibodies to mouse brain tissue J Histochem Cytochem 52 1367 1376 10.1369/jhc.4A6319.2004 15385583 (Pubitemid 39362460)
13. Hoogduijn MJ, Cheng A, Genever PG (2008) Functional nicotinic and muscarinic receptors on mesenchymal stem cells. Stem Cells Dev (in press)
14. CA Inkson AC Brabbs TS Grewal TM Skerry PG Genever 2004 Characterization of acetylcholinesterase expression and secretion during osteoblast differentiation Bone 35 819 827 10.1016/j.bone.2004.05.026 15454088 (Pubitemid 39349212)
15. G Jositsch T Papadakis RV Habergerger M Wolff J Wess W Kummer 2009 Suitability of muscarinic acetylcholine receptor antibodies for immunohistochemistry evaluated on tissue sections of receptor gene-deficient mice Naunyn Schmiedebergs Arch Pharmacol 379 389 395 10.1007/s00210-008-0365-9 18974978
16. W Kummer S Wiegand S Akinci I Wessler AH Schinkel J Wess H Koepsell RV Haberberger KS Lips 2006 Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse Respir Res 7 65 10.1186/1465-9921-7-65 16608531 (Pubitemid 43778774)
17. H Koepsell K Lips C Volk 2007 Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications Pharm Res 24 1227 1251 10.1007/s11095-007-9254-z 17473959 (Pubitemid 46876495)
18. JB Lian V Shalhoub F Aslam B Frenkel J Green M Hamrah GS Stein JL Stein 1997 Species-specific glucocorticoid and 1, 25-dihyroxyvitamin D responsiveness in mouse MC3T3-E1 osteoblasts: dexamethasone inhibits osteoblast differentiation and vitamin D down-regulates osteocalcin gene expression Endocrinology 138 2117 2127 10.1210/en.138.5.2117 9112412
19. KS Lips C Volk BM Schmitt U Pfeil P Arndt D Miska L Ermert W Kummer H Koepsell 2005 Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium Am J Respir Cell Mol Biol 33 79 88 10.1165/rcmb.2004-0363OC 15817714 (Pubitemid 40961017)
20. KS Lips J Wunsch S Zarghooni T Bschleipfer K Schukowski W Weidner I Wessler U Schwantes H Koepsell W Kummer 2007 Acetylcholine and molecular components of its synthesis and release machinery in the urothelium Eur Urol 51 1042 1053 10.1016/j.eururo.2006.10.028 17084519 (Pubitemid 46281424)
21. I Lopez-Coviella B Berse RS Thies JK Blusztajn 2002 Upregulation of acetylcholine synthesis by bone morphogenetic protein 9 in a murine septal cell line J Physiol (Paris) 96 53 59 10.1016/S0928-4257(01)00080-8 (Pubitemid 34087033)
22. J Massoulie 2002 The origin of the molecular diversity and functional anchoring of cholinesterases Neurosignals 11 130 143 10.1159/000065054 12138250 (Pubitemid 37490494)
23. ID McCarthy M Andhoga JJ Batten RT Mathie 1997 Endothelium-dependent vasodilatation produced by the L-arginine/nitric oxide pathway in normal and ischemic bone Acta Orthop Scand 68 361 368 9310041
24. NS Millar PC Harkness 2008 Assembly and trafficking of nicotinic acetylcholine receptors Mol Membr Biol 25 279 292 10.1080/09687680802035675 18446614 (Pubitemid 351620418)
25. N Moser N Mechawar I Jones A Gochberg-Sarver A Orr-Urtreger M Plomann R Salas B Molles L Marubio U Roth U Maskos U Winzer-Serhan JP Bourgeois AM Le Sourd M De Biasi H Schröder J Lindstrom A Maelicke JP Changeux A Wevers 2007 Evaluating the suitability of nicotinic acetylcholine receptor antibodies for standard immunodetection procedures J Neurochem 102 479 492 10.1111/j.1471-4159.2007.04498.x 17419810 (Pubitemid 47000591)
26. T Okuda T Haga 2003 High-affinity choline transporter Neurochem Res 28 483 488 10.1023/A:1022809003997 12675135 (Pubitemid 36314837)
27. A Pereira A McLaren WR Bell D Copolov B Dean 2003 Potential clozapine target sites on peripheral hematopoietic cells and stromal cells of the bone marrow Pharmacogenomics J 3 227 234 10.1038/sj.tpj.6500179 12931136 (Pubitemid 37160978)
28. SJ Romano RA Corriveau RI Schwarz DK Berg 1997 Expression of the nicotinic receptor alpha 7 gene in tendon and periosteum during early development J Neurochem 68 640 648 9003051
29. R Schoepfer WG Conroy P Whiting M Gore J Lindstrom 1990 Brain alpha-bungarotoxin binding protein cDNAs and MAbs reveal subtypes of this branch of the ligand-gated ion channel gene superfamily Neuron 5 35 48 10.1016/0896-6273(90)90031-A 2369519 (Pubitemid 20224498)
30. HS Sekhon JA Keller BJ Proskocil EL Martin ER Spindel 2002 Maternal nicotine exposure upregulates collagen gene expression in fetal monkey lung. Association with alpha7 nicotinic acetylcholine receptors Am J Respir Cell Mol Biol 26 31 41 11751201
31. H Sudo HA Kodama Y Amagai S Yamamoto S Kasai 1983 In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria J Cell Biol 96 191 198 10.1083/jcb.96.1.191 6826647 (Pubitemid 13155577)
32. MF Termaat FC Den Boer FC Bakker P Patka HJ Haarman 2005 Bone morphogenetic proteins Development and clinical efficacy in the treatment of fractures and bone defects. J Bone Joint Surg Am 87 1367 1378
33. JM Tournier K Maouche C Coraux JM Zahm I Cloez-Tayarani B Nawrocki-Raby A Bonnomet H Burlet F Lebargy M Polette P Birembaut 2006 Alpha3alpha5beta2- nicotinic acetylcholine receptor contributes to the wound repair of the respiratory epithelium by modulating intracellular calcium in migrating cells Am J Pathol 168 55 68 10.2353/ajpath.2006.050333 16400009 (Pubitemid 43062559)
34. S Tucek 1982 The synthesis and release of acetylcholine in normal and denervated rat diaphragms during incubations in vitro J Physiol (Lond) 322 54 69
35. LM Walker MR Preston JL Magnay PBM Thomas AJ El Haj 2001 Nicotinic regulation of c-fos and osteopontin expression in human-derived osteoblast-like cells and human trabecular bone organ culture Bone 28 603 608 10.1016/S8756-3282(01)00427-6 11425648 (Pubitemid 32586069)
36. S Wenisch K Trinkaus A Hild D Hose K Herde C Heiss O Kilian V Alt R Schnettler 2005 Human reaming debris: a source of multipotent stem cells Bone 36 74 83 10.1016/j.bone.2004.09.019 15664005 (Pubitemid 40128277)
37. I Wessler CJ Kirkpatrick 2008 Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans Br J Pharmacol 154 1558 1571 10.1038/bjp.2008.185 18500366
38. I Wessler E Roth C Deutsch P Brockerhoff F Bittinger CJ Kirkpatrick H Kolbinger 2001 Release of non-neuronal acetylcholine from the isolated human placenta is mediated by organic cation transporters Br J Pharmacol 134 951 956 10.1038/sj.bjp.0704335 11682442