The Human Base Excision Repair Enzyme SMUG1 Directly Interacts with DKC1 and Contributes to RNA Quality Control

Molecular Cell

Volumn 49, Issue 2, 2013, Pages 339-345

  Jobert, Laure ^a   Skjeldam, Hanne K ^a   Dalhus, Bjørn ^a   Galashevskaya, Anastasia ^b   Vågbø, Cathrine Broberg ^b   Bjørås, Magnar ^a   Nilsen, Hilde ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYMETHYLDEOXYURIDINE; DYSKERIN; MEMBRANE PROTEIN; NUCLEOLIN; NUCLEOSIDE; RIBOSOME RNA; RNA; SINGLE STRAND SELECTIVE MONOFUNCTIONAL URACIL DNA GLYCOSYLASE 1; SINGLE STRANDED RNA; UNCLASSIFIED DRUG; URIDINE;

ARTICLE; CELLULAR DISTRIBUTION; COILED BODY; ISOMERIZATION; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; QUALITY CONTROL; RNA PROCESSING;

CELL CYCLE PROTEINS; CELL NUCLEOLUS; COILED BODIES; GENE LIBRARY; HELA CELLS; HUMANS; NUCLEAR PROTEINS; POLYADENYLATION; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN TRANSPORT; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, RIBOSOMAL, 18S; RNA, RIBOSOMAL, 28S; RNA, SMALL INTERFERING; URACIL-DNA GLYCOSIDASE; URIDINE;

EID: 84872812804     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2012.11.010     Document Type: Article

References (23)

1. Andersen K.R., Jensen T.H., Brodersen D.E. Take the "A" tail-quality control of ribosomal and transfer RNA. Biochim. Biophys. Acta 2008, 1779:532-537.
2. Boisvert F.M., van Koningsbruggen S., Navascués J., Lamond A.I. The multifunctional nucleolus. Nat. Rev. Mol. Cell Biol. 2007, 8:574-585.
3. Boorstein R.J., Cummings A., Marenstein D.R., Chan M.K., Ma Y., Neubert T.A., Brown S.M., Teebor G.W. Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1. J. Biol. Chem. 2001, 276:41991-41997.
4. Crain P.F. Preparation and enzymatic hydrolysis of DNA and RNA for mass spectrometry. Methods Enzymol. 1990, 193:782-790.
5. Darwanto A., Theruvathu J.A., Sowers J.L., Rogstad D.K., Pascal T., Goddard W., Sowers L.C. Mechanisms of base selection by human single-stranded selective monofunctional uracil-DNA glycosylase. J. Biol. Chem. 2009, 284:15835-15846.
6. Dokal I. Dyskeratosis congenita. Hematology (Am Soc Hematol Educ Program) 2011, 2011:480-486.
7. Fang F., Hoskins J., Butler J.S. 5-fluorouracil enhances exosome-dependent accumulation of polyadenylated rRNAs. Mol. Cell. Biol. 2004, 24:10766-10776.
8. Haushalter K.A., Todd Stukenberg M.W., Kirschner M.W., Verdine G.L. Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors. Curr. Biol. 1999, 9:174-185.
9. Hoskins J., Butler J.S. RNA-based 5-fluorouracil toxicity requires the pseudouridylation activity of Cbf5p. Genetics 2008, 179:323-330.
10. Jack K., Bellodi C., Landry D.M., Niederer R.O., Meskauskas A., Musalgaonkar S., Kopmar N., Krasnykh O., Dean A.M., Thompson S.R., et al. rRNA pseudouridylation defects affect ribosomal ligand binding and translational fidelity from yeast to human cells. Mol. Cell 2011, 44:660-666.
11. Kavli B., Sundheim O., Akbari M., Otterlei M., Nilsen H., Skorpen F., Aas P.A., Hagen L., Krokan H.E., Slupphaug G. hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup. J. Biol. Chem. 2002, 277:39926-39936.
12. Kemmerich K., Dingler F.A., Rada C., Neuberger M.S. Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice. Nucleic Acids Res. 2012, 40:6016-6025.
13. Li L., Ye K. Crystal structure of an H/ACA box ribonucleoprotein particle. Nature 2006, 443:302-307.
14. Marciniak R.A., Lombard D.B., Johnson F.B., Guarente L. Nucleolar localization of the Werner syndrome protein in human cells. Proc. Natl. Acad. Sci. USA 1998, 95:6887-6892.
15. Masaoka A., Matsubara M., Hasegawa R., Tanaka T., Kurisu S., Terato H., Ohyama Y., Karino N., Matsuda A., Ide H. Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions. Biochemistry 2003, 42:5003-5012.
16. Matsubara M., Tanaka T., Terato H., Ohmae E., Izumi S., Katayanagi K., Ide H. Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase. Nucleic Acids Res. 2004, 32:5291-5302.
17. Nilsen H., Rosewell I., Robins P., Skjelbred C.F., Andersen S., Slupphaug G., Daly G., Krokan H.E., Lindahl T., Barnes D.E. Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication. Mol. Cell 2000, 5:1059-1065.
18. Nilsen H., Haushalter K.A., Robins P., Barnes D.E., Verdine G.L., Lindahl T. Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylase. EMBO J. 2001, 20:4278-4286.
19. Pettersen H.S., Visnes T., Vågbø C.B., Svaasand E.K., Doseth B., Slupphaug G., Kavli B., Krokan H.E. UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation. Nucleic Acids Res. 2011, 39:8430-8444.
20. Rácz I., Király I., Lásztity D. Effect of light on the nucleotide composition of rRNA of wheat seedlings. Planta 1978, 142:263-267.
21. Tell G., Wilson D.M., Lee C.H. Intrusion of a DNA repair protein in the RNome world: is this the beginning of a new era?. Mol. Cell. Biol. 2010, 30:366-371.
22. Vascotto C., Fantini D., Romanello M., Cesaratto L., Deganuto M., Leonardi A., Radicella J.P., Kelley M.R., D'Ambrosio C., Scaloni A., et al. APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. Mol. Cell. Biol. 2009, 29:1834-1854.
23. Zhou J., Liang B., Li H. Structural and functional evidence of high specificity of Cbf5 for ACA trinucleotide. RNA 2011, 17:244-250.