Novel mutations in the antifolate drug resistance marker genes among Plasmodium vivax isolates exhibiting severe manifestations

Experimental Parasitology

Volumn 132, Issue 4, 2012, Pages 410-416

  Garg, Shilpi ^a   Saxena, Vishal ^a   Lumb, Vanshika ^b   Pakalapati, Deepak ^a   Boopathi, P A ^a   Subudhi, Amit Kumar ^a   Chowdhury, Shibasish ^a   Kochar, Sanjay K ^c   Kochar, Dhanpat K ^d   Sharma, Y D ^b   Das, Ashis ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^c S P MEDICAL COLLEGE   (India)

^d Kothari Medical College and Research Institute   (India)

Author keywords

Antifolate drug resistance; Novel mutations; Plasmodium vivax; Severe manifestations

Indexed keywords

CHLOROQUINE; DIHYDROFOLATE REDUCTASE; DIHYDROPTEROATE SYNTHASE; FOLIC ACID ANTAGONIST;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD; DRUG EFFECT; DRUG RESISTANCE; FEMALE; GENETIC MARKER; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HUMAN; INDIA; MALE; MIDDLE AGED; MUTATION; PARASITOLOGY; PLASMODIUM VIVAX; PLASMODIUM VIVAX MALARIA;

ADOLESCENT; ADULT; AGED; CHLOROQUINE; DIHYDROPTEROATE SYNTHASE; DRUG RESISTANCE; FEMALE; FOLIC ACID ANTAGONISTS; GENETIC MARKERS; GENOTYPE; HUMANS; INDIA; MALARIA, VIVAX; MALE; MIDDLE AGED; MUTATION; PLASMODIUM VIVAX; POLYMORPHISM, GENETIC; TETRAHYDROFOLATE DEHYDROGENASE; YOUNG ADULT;

MLCS; MLOWN;

EID: 84872807993     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2012.09.018     Document Type: Article

References (28)

1. Afsharpad, M., Zakeri, S., Pirahmadi, S., Djadid, N.D., Molecular assessment of dhfr/dhps mutations among Plasmodium vivax clinical isolates after introduction of sulfadoxine/pyrimethamine in combination with artesunate in Iran. Infect. Gen. Evol. 12 (2012), 38–44.
2. Alam, M.T., Bora, H., Bharti, P.K., Saifi, M.A., Das, M.K., Dev, V., Kumar, A., Singh, N., Dash, A.P., Das, B., Wajihullah, Sharma, Y.D., Similar trends of Pyrimethamine resistance-associated mutations in Plasmodium vivax and Plasmodium falciparum. Antimicrob. Agents Chemother. 51 (2007), 857–863.
3. Alexandra, M.A., Ferrerira, C.O., Siqueira, A.M., Magalhaes, B.L., Mourao, M.P.G., Lacerda, M.V., Alecrim, G.C., Severe Plasmodium vivax malaria, Brazilian Amazon. Emerg. Infect. Dis. 16:10 (2010), 1611–1614.
4. Auliff, A., Wilson, D.W., Russell, B., Gao, Q., Chen, N., Anh, L.N., Maguire, J., Bell, D., O'Neil, M.T., Cheng, Q., Amino acid mutations in Plasmodium vivax DHFR and DHPS from several geographical regions and susceptibility to antifolates drugs. Am. J. Trop. Med. Hyg. 75 (2006), 617–621.
5. Baird, J.K., Chloroquine resistance in Plasmodium vivax. Antimicrob. Agents Chemother. 48 (2004), 4075–4083.
6. Das, A., Holloway, B., Collins, W.E., Sharma, V.P., Ghosh, S.K., Sinha, S., Hasnain, S.E., Talwar, G.P., Lal, A.A., Species-specific 18S rRNA gene amplification for the detection of P. falciparum and P. vivax malaria parasites. Mol. Cell Probes. 9 (1995), 161–165.
7. Fidock, D.A., Nomura, T., Talley, A.T., Su, X.Z., Cooper, R., Dzekunov, S.M., Wellems, T.E., Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Mol. Cell 6 (2000), 861–871.
8. Garg, S., Saxena, V., Kanchan, S., Sharma, P., Mahajan, S., Kochar, D.K., Das, A., Novel point mutations in sulfadoxine resistance genes of Plasmodium falciparum from India. Acta Trop. 110 (2009), 75–79.
9. Genton, B., D'Acremont, V., Rare, L., Baea, K., Reeder, J.C., Alpers, M.P., Muller, I., Plasmodium vivax and mixed infections are associated with severe malaria in children: a prospective cohort study from Papua New Guinea. PLoS Med., 5(6), 2008, e127, 10.1371/journal.pmed.0050127.
10. Hall, T.A., BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucleic Acids Symp. Ser. 41 (1999), 95–98.
11. Hastings, M.D., Maguire, J.D., Bangs, M.J., Zimmerman, P.A., Reeder, J.C., Baird, J.K., Sibley, C.H., Novel Plasmodium vivax dhfr alleles from the Indonesian Archipelago and Papua New Guinea: association with pyrimethamine resistance determined by a Saccharomyces cerevisiae expression system. Antimicrob. Agents Chemother. 49 (2005), 733–740.
12. Imwong, M., Pukrittayakamee, S., Cheng, Q., Moore, C., Looareesuwan, S., Snounou, G., White, N.J., Day, N.P.J., Limited polymorphism in the dihydropteroate synthetase gene (dhps) of Plasmodium vivax isolates from Thailand. Antimicrob. Agents Chemother. 49 (2005), 4393–4395.
13. Kaur, S., Prajapati, S.K., Kalyanaraman, K., Mohammed, A., Joshi, H., Chauhan, V.S., Plasmodium vivax dihydrofolate reductase point mutations from the Indian subcontinent. Acta Trop. 97 (2006), 174–180.
14. Kochar, D., Saxena, V., Singh, N., Kochar, S.K., Kumar, V., Das, A., Plasmodium vivax Malaria. Emerg. Infect. Dis. 11 (2005), 132–134.
15. Kochar, D.K., Das, A., Kochar, S.K., Saxena, V., Sirohi, P., Garg, S., Kochar, A., Khatri, M.P., Gupta, V., Severe Vivax malaria – a report on serial cases from Bikaner (Northwest India). Am. J. Trop. Med. Hyg. 80 (2009), 194–198.
16. Kochar, D.K., Sirohi, P., Kochar, S.K., Budania, M.P., Lakhotia, J.P., Dynamics of malaria in Bikaner, Rajasthan, India (1975–2006). J. Vector Borne Dis. 44 (2007), 281–284.
17. Kongsaeree, P., Khongsuk, P., Leartsakulpanich, U., Chitnumsub, P., Tarnchompoo, B., Walkinshaw, M.D., Yuthavong, Y., Crystal structure of dihydrofolate reductase from Plasmodium vivax: pyrimethamine displacement linked with mutation-induced resistance. PNAS, USA 102 (2005), 13046–13051.
18. Korsinczky, M., Fischer, K., Chen, N., Baker, J., Rieckmann, K., Cheng, Q., Sulfadoxine resistance in Plasmodium vivax is associated with a specific amino acid in dihydropteroate synthase at the putative sulfadoxine-binding site. Antimicrob. Agents Chemother. 48 (2004), 2214–2222.
19. Leartsakulpanich, U., Imwong, M., Pukrittayakamee, S., White, N.J., Snounou, G., Sirawaraporn, W., Yuthavong, Y., Molecular characterization of dihydrofolate reductase in relation to antifolate resistance in Plasmodium vivax. Mol. Biochem. Parasitol. 119 (2002), 63–73.
20. Mendis, K., Sina, B.J., Marchesini, P., Carter, R., The neglected burden of Plasmodium vivax malaria. Am. J. Trop. Med. Hyg. 64 (2001), 97–106.
21. Na, B.K., Lee, H.W., Moon, S.U., In, T.S., Lin, K., Maung, M., Chung, G.T., Lee, J.K., Kim, T.S., Kong, Y., Genetic variations of the dihydrofolate reductase gene of Plasmodium vivax in Mandalay division Myanmar. Parasitol. Res. 96 (2005), 321–325.
22. Prajapati, S.K., Joshi, H., Dev, V., Dua, V.K., Molecular epidemiology of Plasmodium vivax antifolate resistance in India. Malar. J., 10, 2011, 102.
23. Sa, M.J., Yamamotoa, M.M., Fernandez-Becerra, C., de Azevedo, M.F., Papakrivos, J., Bronwen Naud´e, B., Wellems, T.E., Portillo, H.A., Expression and function of pvcrt-o, a Plasmodium vivax ortholog of pfcrt, in Plasmodium falciparum and Dictyostelium discoideum. Mol. Biochem. Parasitol. 150 (2006), 219–228.
24. Sambrook, J., Fritsch, E.F., Maniatis, T., Molecular Cloning: A Laboratory Manual. second ed., 1989, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, USA.
25. Sanchez, R., Sali, A., Evaluation of comparative protein structure modeling by MODELLER-3. Proteins Suppl. 1 (1997), 50–58.
26. Suwanarusk, R., Chavchich, M., Russell, B., Jaidee, A., Chalfein, F., Barends, M., Prasetyorini, B., Kenangalem, E., Piera, K.A., Lek-Uthal, U., Anstey, N.M., Tjitra, E., Nosten, F., Cheng, Q., Price, R.N., Amplification of pvmdr1 associated with multidrug resistant Plasmodium vivax. J. Invest. Dermatol. 198 (2008), 1558–1564.
27. Thompson, J.D., Higgins, D.G., Gibson, T.J., CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22 (1994), 4673–4680.
28. World Health Organisation, 2010. Guidelines for the Treatment of Malaria. second ed. < http://www.who.int/malaria/publications/atoz/9789241547925/en/>.