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Volumn 5, Issue 1, 2013, Pages 36-46

Cladribine and bendamustine exhibit inhibitory activity in dexamethasone-sensitive and -resistant multiple myeloma cells

Author keywords

Apoptosis; Bendamustine; Cladribine; Dexamethasone resistance; DNA damage response; Multiple myeloma

Indexed keywords

BENDAMUSTINE; C 4438; CASPASE 3; CASPASE 8; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CLADRIBINE; DEXAMETHASONE; HISTONE H2A; UNCLASSIFIED DRUG;

EID: 84872792551     PISSN: None     EISSN: 19438141     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (12)

References (37)
  • 2
    • 0031043125 scopus 로고    scopus 로고
    • The clinical pharmacokinetics of cladribine
    • Liliemark J. The clinical pharmacokinetics of cladribine. Clin Pharmacokinet 1997; 32: 120-131.
    • (1997) Clin Pharmacokinet , vol.32 , pp. 120-131
    • Liliemark, J.1
  • 3
    • 0022003367 scopus 로고
    • Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes
    • Seto S, Carrera CJ, Kubota M, Wasson DB and Carson DA. Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. J Clin Invest 1985; 75: 377-383.
    • (1985) J Clin Invest , vol.75 , pp. 377-383
    • Seto, S.1    Carrera, C.J.2    Kubota, M.3    Wasson, D.B.4    Carson, D.A.5
  • 4
    • 0343290261 scopus 로고    scopus 로고
    • Comparison of the effects of 2-chlorodeoxyadenosine and melphalan myeloma cell lines
    • Hjertner O, Borset M and Waage A. Comparison of the effects of 2-chlorodeoxyadenosine and melphalan myeloma cell lines. Leuk Res 1996; 20: 155-160.
    • (1996) Leuk Res , vol.20 , pp. 155-160
    • Hjertner, O.1    Borset, M.2    Waage, A.3
  • 5
    • 0037362951 scopus 로고    scopus 로고
    • Extended follow-up of patients with hairy cell leukemia after treatment with cladribine
    • Goodman GR, Burian C, Koziol JA and Saven A. Extended follow-up of patients with hairy cell leukemia after treatment with cladribine. J Clin Oncol 2003; 21: 891-896.
    • (2003) J Clin Oncol , vol.21 , pp. 891-896
    • Goodman, G.R.1    Burian, C.2    Koziol, J.A.3    Saven, A.4
  • 6
    • 72149085331 scopus 로고    scopus 로고
    • Cladribine (CdA) gives longer response duration than fudarabine (F) and high-dose intermittent chlorambucil (Chl) as frst-line treatment of symptomatic chronic lymphocytic leukemia (CLL). First results from the international randomized phase III trial
    • Karlsson KA, Stromberg M, Jonsson V, Mulligan SP, Liliemark J and Juliusson G. Cladribine (CdA) gives longer response duration than fudarabine (F) and high-dose intermittent chlorambucil (Chl) as frst-line treatment of symptomatic chronic lymphocytic leukemia (CLL). First results from the international randomized phase III trial. Blood 2007; 110: 194a-194a.
    • (2007) Blood , vol.110
    • Karlsson, K.A.1    Stromberg, M.2    Jonsson, V.3    Mulligan, S.P.4    Liliemark, J.5    Juliusson, G.6
  • 8
    • 58949092546 scopus 로고    scopus 로고
    • Activity of cladribine combined with cyclophosphamide in frontline therapy for chronic lymphocytic leukemia with 17p13.1/TP53 deletion: Report from the Polish Adult Leukemia Group
    • Robak T, Blonski JZ, Wawrzyniak E, Gora-Tybor J, Palacz A, Dmoszynska A, Konopka L, Warzocha K and Jamroziak K. Activity of cladribine combined with cyclophosphamide in frontline therapy for chronic lymphocytic leukemia with 17p13.1/TP53 deletion: report from the Polish Adult Leukemia Group. Cancer 2009; 115: 94100.
    • (2009) Cancer , vol.115 , pp. 94100
    • Robak, T.1    Blonski, J.Z.2    Wawrzyniak, E.3    Gora-Tybor, J.4    Palacz, A.5    Dmoszynska, A.6    Konopka, L.7    Warzocha, K.8    Jamroziak, K.9
  • 10
    • 77958155612 scopus 로고    scopus 로고
    • Beyond hairy cell: The activity of cladribine in other hematologic malignancies
    • Sigal DS, Miller HJ, Schram ED and Saven A. Beyond hairy cell: the activity of cladribine in other hematologic malignancies. Blood 2010; 116: 2884-2896.
    • (2010) Blood , vol.116 , pp. 2884-2896
    • Sigal, D.S.1    Miller, H.J.2    Schram, E.D.3    Saven, A.4
  • 13
    • 0027396904 scopus 로고
    • 2-Chlorodeoxyadenosine for multiple myeloma
    • Niesvizky R, Siegel D and Michaeli J. 2-Chlorodeoxyadenosine for multiple myeloma. Blood 1993; 81: 868-869.
    • (1993) Blood , vol.81 , pp. 868-869
    • Niesvizky, R.1    Siegel, D.2    Michaeli, J.3
  • 14
    • 0028127404 scopus 로고
    • Clinical and toxicological aspects of the antineoplastic drug cladribine: A review
    • Guchelaar HJ, Richel DJ and Schaafsma MR. Clinical and toxicological aspects of the antineoplastic drug cladribine: a review. Ann Hematol 1994; 69: 223-230.
    • (1994) Ann Hematol , vol.69 , pp. 223-230
    • Guchelaar, H.J.1    Richel, D.J.2    Schaafsma, M.R.3
  • 15
    • 0027455425 scopus 로고
    • 2 chlorodeoxyadenosine activity and cross resistance patterns in primary cultures of human hematologic neoplasms
    • Nagourney RA, Evans SS, Messenger JC, Su YZ and Weisenthal LM. 2 chlorodeoxyadenosine activity and cross resistance patterns in primary cultures of human hematologic neoplasms. Br J Cancer 1993; 67: 10-14.
    • (1993) Br J Cancer , vol.67 , pp. 10-14
    • Nagourney, R.A.1    Evans, S.S.2    Messenger, J.C.3    Su, Y.Z.4    Weisenthal, L.M.5
  • 17
    • 79959248152 scopus 로고    scopus 로고
    • Therapeutic potential of cladribine in combination with STAT3 inhibitor against multiple myeloma
    • Ma J, Wang S, Zhao M, Deng XS, Lee CK, Yu XD and Liu B. Therapeutic potential of cladribine in combination with STAT3 inhibitor against multiple myeloma. BMC Cancer 2011; 11: 255.
    • (2011) BMC Cancer , vol.11 , pp. 255
    • Ma, J.1    Wang, S.2    Zhao, M.3    Deng, X.S.4    Lee, C.K.5    Yu, X.D.6    Liu, B.7
  • 18
    • 40749085662 scopus 로고    scopus 로고
    • Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents
    • Leoni LM, Bailey B, Reifert J, Bendall HH, Zeller RW, Corbeil J, Elliott G and Niemeyer CC. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res 2008; 14: 309-317.
    • (2008) Clin Cancer Res , vol.14 , pp. 309-317
    • Leoni, L.M.1    Bailey, B.2    Reifert, J.3    Bendall, H.H.4    Zeller, R.W.5    Corbeil, J.6    Elliott, G.7    Niemeyer, C.C.8
  • 19
    • 60049088480 scopus 로고    scopus 로고
    • Bendamustine: A new look at an old drug
    • Kalaycio M. Bendamustine: a new look at an old drug. Cancer 2009; 115: 473-479.
    • (2009) Cancer , vol.115 , pp. 473-479
    • Kalaycio, M.1
  • 20
    • 0035351214 scopus 로고    scopus 로고
    • In vitro induction of apoptosis of neoplastic cells in low-grade non-Hodgkin's lymphomas using combinations of established cytotoxic drugs with bendamustine
    • Chow KU, Boehrer S, Geduldig K, Krapohl A, Hoelzer D, Mitrou PS and Weidmann E. In vitro induction of apoptosis of neoplastic cells in low-grade non-Hodgkin's lymphomas using combinations of established cytotoxic drugs with bendamustine. Haematologica 2001; 86: 485-493.
    • (2001) Haematologica , vol.86 , pp. 485-493
    • Chow, K.U.1    Boehrer, S.2    Geduldig, K.3    Krapohl, A.4    Hoelzer, D.5    Mitrou, P.S.6    Weidmann, E.7
  • 21
    • 64249163652 scopus 로고    scopus 로고
    • SDX-105 (Treanda (TM)) enhances the tumor growth inhibitory effect of rituximab in Daudi lymphoma xenografts
    • Kanekal S, Crain B, Elliott G and Multani PS. SDX-105 (Treanda (TM)) enhances the tumor growth inhibitory effect of rituximab in Daudi lymphoma xenografts. Blood 2004; 104: 229b-229b.
    • (2004) Blood , vol.104
    • Kanekal, S.1    Crain, B.2    Elliott, G.3    Multani, P.S.4
  • 23
    • 81155134123 scopus 로고    scopus 로고
    • Bendamustine in combination with thalidomide and dexamethasone is an effective therapy for myeloma patients with end stage renal disease
    • Ramasamy K, Hazel B, Mahmood S, Corderoy S and Schey S. Bendamustine in combination with thalidomide and dexamethasone is an effective therapy for myeloma patients with end stage renal disease. Br J Haematol 2011; 155: 632-634.
    • (2011) Br J Haematol , vol.155 , pp. 632-634
    • Ramasamy, K.1    Hazel, B.2    Mahmood, S.3    Corderoy, S.4    Schey, S.5
  • 25
    • 0037383192 scopus 로고    scopus 로고
    • Characterization of the MM.1 human multiple myeloma (MM) cell lines: A model system to elucidate the characteristics, behavior, and signaling of steroid-sensitive and -resistant MM cells
    • Greenstein S, Krett NL, Kurosawa Y, Ma C, Chauhan D, Hideshima T, Anderson KC and Rosen ST. Characterization of the MM.1 human multiple myeloma (MM) cell lines: a model system to elucidate the characteristics, behavior, and signaling of steroid-sensitive and -resistant MM cells. Exp Hematol 2003; 31: 271-282.
    • (2003) Exp Hematol , vol.31 , pp. 271-282
    • Greenstein, S.1    Krett, N.L.2    Kurosawa, Y.3    Ma, C.4    Chauhan, D.5    Hideshima, T.6    Anderson, K.C.7    Rosen, S.T.8
  • 26
    • 77955675650 scopus 로고    scopus 로고
    • HDAC inhibition synergistically enhances alkylator-induced DNA damage responses and apoptosis in multiple myeloma cells
    • Lee CK, Wang S, Huang X, Ryder J and Liu B. HDAC inhibition synergistically enhances alkylator-induced DNA damage responses and apoptosis in multiple myeloma cells. Cancer Lett 2010; 296: 233-240.
    • (2010) Cancer Lett , vol.296 , pp. 233-240
    • Lee, C.K.1    Wang, S.2    Huang, X.3    Ryder, J.4    Liu, B.5
  • 28
    • 23844481419 scopus 로고    scopus 로고
    • Purine nucleoside an-alogues for the treatment of hematological malignancies: Pharmacology and clinical applications
    • Robak T, Korycka A, Kasznicki M, WrzesienKus A and Smolewski P. Purine nucleoside an-alogues for the treatment of hematological malignancies: pharmacology and clinical applications. Curr Cancer Drug Targets 2005; 5: 421-444.
    • (2005) Curr Cancer Drug Targets , vol.5 , pp. 421-444
    • Robak, T.1    Korycka, A.2    Kasznicki, M.3    Wrzesienkus, A.4    Smolewski, P.5
  • 29
    • 84863101100 scopus 로고    scopus 로고
    • Bendamustine for treatment of chronic lymphocytic leukemia
    • Chang JE and Kahl BS. Bendamustine for treatment of chronic lymphocytic leukemia. Expert Opinion on Pharmacotherapy 2012; 13: 1495-1505.
    • (2012) Expert Opinion On Pharmacotherapy , vol.13 , pp. 1495-1505
    • Chang, J.E.1    Kahl, B.S.2
  • 32
    • 0035921689 scopus 로고    scopus 로고
    • Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma
    • Hideshima T, Nakamura N, Chauhan D and Anderson KC. Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma. Oncogene 2001; 20: 5991-6000.
    • (2001) Oncogene , vol.20 , pp. 5991-6000
    • Hideshima, T.1    Nakamura, N.2    Chauhan, D.3    Anderson, K.C.4
  • 34
    • 8344271002 scopus 로고    scopus 로고
    • Mechanisms of glucocorticoid-induced apoptosis in hematologic malignancies: Updates
    • Frankfurt O and Rosen ST. Mechanisms of glucocorticoid-induced apoptosis in hematologic malignancies: updates. Curr Opin Oncol 2004; 16: 553-563.
    • (2004) Curr Opin Oncol , vol.16 , pp. 553-563
    • Frankfurt, O.1    Rosen, S.T.2
  • 35
    • 83555174315 scopus 로고    scopus 로고
    • The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells
    • Monaghan KA, Khong T, Burns CJ and Spencer A. The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells. Leukemia 2011; 25: 1891-1899.
    • (2011) Leukemia , vol.25 , pp. 1891-1899
    • Monaghan, K.A.1    Khong, T.2    Burns, C.J.3    Spencer, A.4
  • 36
    • 77949429892 scopus 로고    scopus 로고
    • Novel therapeutic targets for multiple myeloma
    • Mahindra A, Cirstea D and Raje N. Novel therapeutic targets for multiple myeloma. Future Oncol 2010; 6: 407-418.
    • (2010) Future Oncol , vol.6 , pp. 407-418
    • Mahindra, A.1    Cirstea, D.2    Raje, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.