-
2
-
-
34547572902
-
Clinical activity of gemcitabine as a single agent and in combination
-
Peters GJ ed, Humana Press, New York, pp
-
Karp JR, Peters GJ and Nagourney RA: Clinical activity of gemcitabine as a single agent and in combination. In: Deoxynucleoside Analogs in Cancer Therapy. Peters GJ (ed.) Humana Press, New York, pp253-288, 2006.
-
(2006)
Deoxynucleoside Analogs in Cancer Therapy
, pp. 253-288
-
-
Karp, J.R.1
Peters, G.J.2
Nagourney, R.A.3
-
4
-
-
33749263031
-
Discovery and development of clofarabine: A nucleoside analogue for treating cancer
-
Bonate PL, Arthaud L, Cantrell WR Jr, Stephenson K, Secrist JA III and Weitman S: Discovery and development of clofarabine: a nucleoside analogue for treating cancer. Nat Rev Drug Discov 5: 855-863, 2006.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 855-863
-
-
Bonate, P.L.1
Arthaud, L.2
Cantrell Jr, W.R.3
Stephenson, K.4
Secrist III, J.A.5
Weitman, S.6
-
6
-
-
18044390106
-
The role of clofarabine in hematologic and solid malignancies - development of a next-generation nucleoside analog
-
Faderl S, Gandhi V, Keating M, Jeha S, Plunkett W and Kantarjian H: The role of clofarabine in hematologic and solid malignancies - development of a next-generation nucleoside analog. Cancer 103: 1985-1995, 2005.
-
(2005)
Cancer
, vol.103
, pp. 1985-1995
-
-
Faderl, S.1
Gandhi, V.2
Keating, M.3
Jeha, S.4
Plunkett, W.5
Kantarjian, H.6
-
7
-
-
0029053894
-
Metabolism and actions of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine in human lymphoblastoid cells
-
Xie C and Plunkett W: Metabolism and actions of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine in human lymphoblastoid cells. Cancer Res 55: 2847-2852, 1995.
-
(1995)
Cancer Res
, vol.55
, pp. 2847-2852
-
-
Xie, C.1
Plunkett, W.2
-
8
-
-
0037276433
-
Antitumor activity of 2-fluoro-2′-deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase
-
Parker WB, Allan PW, Hassan AE, Secrist JA III, Sorscher EJ and Waud WR: Antitumor activity of 2-fluoro-2′-deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase. Cancer Gene Ther 10: 23-29, 2003.
-
(2003)
Cancer Gene Ther
, vol.10
, pp. 23-29
-
-
Parker, W.B.1
Allan, P.W.2
Hassan, A.E.3
Secrist III, J.A.4
Sorscher, E.J.5
Waud, W.R.6
-
9
-
-
0029927229
-
Deoxynucleotide pool deletion and sustained inhibition of ribonucleotide reductase and DNA synthesis after treatment of human lymphoblastoid cells with 2-chloro-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine
-
Xie KC and Plunkett W: Deoxynucleotide pool deletion and sustained inhibition of ribonucleotide reductase and DNA synthesis after treatment of human lymphoblastoid cells with 2-chloro-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine. Cancer Res 565: 3030-3037, 1996.
-
(1996)
Cancer Res
, vol.565
, pp. 3030-3037
-
-
Xie, K.C.1
Plunkett, W.2
-
10
-
-
0034669944
-
Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria
-
Genini D, Adachi, S, Chao Q, et al: Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria. Blood 96: 3537-3543, 2000.
-
(2000)
Blood
, vol.96
, pp. 3537-3543
-
-
Genini, D.1
Adachi, S.2
Chao, Q.3
-
11
-
-
10744231168
-
Application of the CFU-GM assay to predict acute drug-induced neutropenia: An international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics
-
Pessina A: Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics. Toxicol Sci 75: 355-367, 2003.
-
(2003)
Toxicol Sci
, vol.75
, pp. 355-367
-
-
Pessina, A.1
-
12
-
-
33746879918
-
Drug development in oncology: Classical cytotoxics and molecularly targeted agents
-
Kummar S, Gutierrez M, Doroshow JH and Murgo AJ: Drug development in oncology: classical cytotoxics and molecularly targeted agents. Br J Clin Pharmacol 62: 15-26, 2006.
-
(2006)
Br J Clin Pharmacol
, vol.62
, pp. 15-26
-
-
Kummar, S.1
Gutierrez, M.2
Doroshow, J.H.3
Murgo, A.J.4
-
13
-
-
5144226837
-
A predictive model of human myelotoxicity using five camptothecin derivatives and the in vitro colony-forming unit granulocyte/macrophage assay
-
Masubuchi N, May RD and Atsumi R: A predictive model of human myelotoxicity using five camptothecin derivatives and the in vitro colony-forming unit granulocyte/macrophage assay. Clin Cancer Res 10: 6722-6731, 2004.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6722-6731
-
-
Masubuchi, N.1
May, R.D.2
Atsumi, R.3
-
14
-
-
0031054593
-
Differential toxicity of camptothecin, topotecan and 9-aminocamptothecin to human, canine, and murine myeloid progenitors (CFU-GM) in vitro
-
Erickson-Miller CL, May RD, Tomaszewski J, Osborn B, Murphy MJ, Page JG and Parchment RE: Differential toxicity of camptothecin, topotecan and 9-aminocamptothecin to human, canine, and murine myeloid progenitors (CFU-GM) in vitro. Cancer Chemother Pharmacol 39: 467-472, 1997.
-
(1997)
Cancer Chemother Pharmacol
, vol.39
, pp. 467-472
-
-
Erickson-Miller, C.L.1
May, R.D.2
Tomaszewski, J.3
Osborn, B.4
Murphy, M.J.5
Page, J.G.6
Parchment, R.E.7
-
15
-
-
55749097609
-
Bone marrow and tumor cell CFU and human tumor xenograft efficacy of non-camptothecin and camptothecin topoisomerase I inhibitors
-
Kurtzberg LS, Battle T, Rouleau C, et al: Bone marrow and tumor cell CFU and human tumor xenograft efficacy of non-camptothecin and camptothecin topoisomerase I inhibitors. Mol Cancer Ther 7: 3212-3222, 2008.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3212-3222
-
-
Kurtzberg, L.S.1
Battle, T.2
Rouleau, C.3
-
16
-
-
0025214710
-
Phorbol ester-induced cell cycle-specific growth inhibition of human B-lymphoma cell lines
-
Beckwith M, Longo DL, O'Connell CD, Moratz CM and Urba WJ: Phorbol ester-induced cell cycle-specific growth inhibition of human B-lymphoma cell lines. J Natl Cancer Inst 82: 501-509, 1990.
-
(1990)
J Natl Cancer Inst
, vol.82
, pp. 501-509
-
-
Beckwith, M.1
Longo, D.L.2
O'Connell, C.D.3
Moratz, C.M.4
Urba, W.J.5
-
17
-
-
0014115428
-
Production of free light chains of immunoglobulin by a haematopoietic cell line derived from a patient with multiple myeloma
-
Matsuoka Y, Moore GE, Yagi Y and Pressman D: Production of free light chains of immunoglobulin by a haematopoietic cell line derived from a patient with multiple myeloma. Proc Soc Exp Biol Med 125: 1246-1250, 1967.
-
(1967)
Proc Soc Exp Biol Med
, vol.125
, pp. 1246-1250
-
-
Matsuoka, Y.1
Moore, G.E.2
Yagi, Y.3
Pressman, D.4
-
18
-
-
0018779369
-
Establishment and characterization of a human prostatic carcinoma cell line (PC-3)
-
Kaighn ME, Narayan KS, Ohnuki Y, Lechner JF and Jones LW: Establishment and characterization of a human prostatic carcinoma cell line (PC-3). Invest Urol 17: 16-23, 1979.
-
(1979)
Invest Urol
, vol.17
, pp. 16-23
-
-
Kaighn, M.E.1
Narayan, K.S.2
Ohnuki, Y.3
Lechner, J.F.4
Jones, L.W.5
-
19
-
-
67649436399
-
-
Fogh J (ed.): In: Human Tumor Cells In Vitro 43. Plenum Press, New York, pp115-159, 1975.
-
Fogh J (ed.): In: Human Tumor Cells In Vitro 43. Plenum Press, New York, pp115-159, 1975.
-
-
-
-
21
-
-
33751090057
-
2-CdA in the treatment of hairy cell leukemia: A review of long-term follow-up
-
Gidron A and Tallman MS: 2-CdA in the treatment of hairy cell leukemia: a review of long-term follow-up. Leuk Lymphoma 47: 2301-2307, 2006.
-
(2006)
Leuk Lymphoma
, vol.47
, pp. 2301-2307
-
-
Gidron, A.1
Tallman, M.S.2
-
22
-
-
11844305611
-
The place of cladribine in the treatment of chronic lymphocytic leukemia: A 10-year experience in Poland
-
Robak T: The place of cladribine in the treatment of chronic lymphocytic leukemia: a 10-year experience in Poland. Ann Hematol 84: 63-70, 2005.
-
(2005)
Ann Hematol
, vol.84
, pp. 63-70
-
-
Robak, T.1
-
23
-
-
34249317776
-
Recent clinical trials of cladribine in hematological malignancies and autoimmune disorders
-
Robak T, Wierzbowska A and Robak E: Recent clinical trials of cladribine in hematological malignancies and autoimmune disorders. Rev Rec Clin Trials 1: 15-34, 2006.
-
(2006)
Rev Rec Clin Trials
, vol.1
, pp. 15-34
-
-
Robak, T.1
Wierzbowska, A.2
Robak, E.3
-
24
-
-
3042870116
-
Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignat human lymphoblasts in vitro and toward murine L1210 leukemia in vivo
-
Carson DA, Wasson DB, Kaye J, Ullman B, Martin DW Jr, Robins RK and Montgomery JA: Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignat human lymphoblasts in vitro and toward murine L1210 leukemia in vivo. Proc Natl Acad Sci USA 77: 6865-6969, 1980.
-
(1980)
Proc Natl Acad Sci USA
, vol.77
, pp. 6865-6969
-
-
Carson, D.A.1
Wasson, D.B.2
Kaye, J.3
Ullman, B.4
Martin Jr, D.W.5
Robins, R.K.6
Montgomery, J.A.7
-
25
-
-
0001514703
-
Antileukemic and immunosuppressive activity of 2-chloro-2′-deoxyadenosine
-
Carson DA, Wasson DB and Beutler E: Antileukemic and immunosuppressive activity of 2-chloro-2′-deoxyadenosine. Proc Natl Acad Sci USA 81: 2232-2236, 1984.
-
(1984)
Proc Natl Acad Sci USA
, vol.81
, pp. 2232-2236
-
-
Carson, D.A.1
Wasson, D.B.2
Beutler, E.3
-
26
-
-
0031882415
-
Pharmacokinetic and pharmacodynamic studies of fludarabine and cytosine arabinoside administered as loading boluses followed by continuous infusions after a Phase I/II study in pediatric patients with relapsed leukemias
-
Avramis VI, Wiersman S, Krailo MD, et al: Pharmacokinetic and pharmacodynamic studies of fludarabine and cytosine arabinoside administered as loading boluses followed by continuous infusions after a Phase I/II study in pediatric patients with relapsed leukemias. Clin Cancer Res 4: 45-52, 1998.
-
(1998)
Clin Cancer Res
, vol.4
, pp. 45-52
-
-
Avramis, V.I.1
Wiersman, S.2
Krailo, M.D.3
-
27
-
-
34147129045
-
Current treatment options in prolymphocytic leukemia
-
Robak T and Robak P: Current treatment options in prolymphocytic leukemia. Med Sci Monit 13: RA69-RA80, 2007.
-
(2007)
Med Sci Monit
, vol.13
-
-
Robak, T.1
Robak, P.2
-
28
-
-
54049158136
-
+-activation of human concentrative nucleoside transporter 3
-
+-activation of human concentrative nucleoside transporter 3. J Biol Chem 283: 24922-24934, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 24922-24934
-
-
Slugoski, M.D.1
Smith, K.M.2
Mulintas, R.3
-
29
-
-
33947430594
-
The role of nucleoside transporter in cancer chemotherapy with nucleoside drugs
-
Zhang J, Visser F, King KM, Baldwin SA, Young JD and Cass CE: The role of nucleoside transporter in cancer chemotherapy with nucleoside drugs. Cancer Metastasis Rev 26: 85-110, 2007.
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 85-110
-
-
Zhang, J.1
Visser, F.2
King, K.M.3
Baldwin, S.A.4
Young, J.D.5
Cass, C.E.6
-
30
-
-
57749116370
-
Immunohistochemistry for human concentrative nucleoside transporter 3 protein predicts fludarabine sensitivity in chronic lymphocytic leukemia
-
Tsang RY, Santos C, Ghosh S, et al: Immunohistochemistry for human concentrative nucleoside transporter 3 protein predicts fludarabine sensitivity in chronic lymphocytic leukemia. Mod Pathol 21: 1387-1393, 2008.
-
(2008)
Mod Pathol
, vol.21
, pp. 1387-1393
-
-
Tsang, R.Y.1
Santos, C.2
Ghosh, S.3
-
31
-
-
0025811415
-
Effects of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5′-triphosphate
-
Parker WB, Shaddix SC, Chang CH, et al: Effects of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5′-triphosphate. Cancer Res 51: 2386-2394, 1991.
-
(1991)
Cancer Res
, vol.51
, pp. 2386-2394
-
-
Parker, W.B.1
Shaddix, S.C.2
Chang, C.H.3
-
32
-
-
0026533461
-
Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2′-arabino-fluoro-2′-deoxyadenosine
-
Carson DA, Wasson DB, Esparza LM, Carrera CJ, Kipps TJ and Cottam HB: Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2′-arabino-fluoro-2′-deoxyadenosine. Proc Natl Acad Sci USA 89: 2970-2974, 1992.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 2970-2974
-
-
Carson, D.A.1
Wasson, D.B.2
Esparza, L.M.3
Carrera, C.J.4
Kipps, T.J.5
Cottam, H.B.6
-
33
-
-
30044450909
-
A comparison of the transportability, and its role in cytotoxicty, of clofarabine, cladribine, and fludarabine by recombinant human nucleoside transporters produced in three model expression systems
-
King KM, Damaraju VL, Vickers MF, et al: A comparison of the transportability, and its role in cytotoxicty, of clofarabine, cladribine, and fludarabine by recombinant human nucleoside transporters produced in three model expression systems. Mol Pharmacol 69: 346-353, 2006.
-
(2006)
Mol Pharmacol
, vol.69
, pp. 346-353
-
-
King, K.M.1
Damaraju, V.L.2
Vickers, M.F.3
-
34
-
-
44649134627
-
Pharmacogenomics of MRP transporters (ABCC1-5) and BCRP (ABCG2)
-
Gradhand U and Kim RB: Pharmacogenomics of MRP transporters (ABCC1-5) and BCRP (ABCG2). Drug Metab Rev 40: 317-354, 2008.
-
(2008)
Drug Metab Rev
, vol.40
, pp. 317-354
-
-
Gradhand, U.1
Kim, R.B.2
-
35
-
-
38549085409
-
Molecular model of the outward facing state of the human P-glycoprotein (ABCB1) and comparison to a model of the human MRP5 (ABCC5)
-
Ravna AW, Sylte I and Sager G: Molecular model of the outward facing state of the human P-glycoprotein (ABCB1) and comparison to a model of the human MRP5 (ABCC5). Theor Biol Med Mod 4: 33-46, 2007.
-
(2007)
Theor Biol Med Mod
, vol.4
, pp. 33-46
-
-
Ravna, A.W.1
Sylte, I.2
Sager, G.3
-
36
-
-
0036451578
-
Role of MRP4 and MRP5 in biology and chemotherapy
-
Sampath J, Adachi M, Hatse S, et al: Role of MRP4 and MRP5 in biology and chemotherapy. AAPS Pharm Sci 4: 1-9, 2002.
-
(2002)
AAPS Pharm Sci
, vol.4
, pp. 1-9
-
-
Sampath, J.1
Adachi, M.2
Hatse, S.3
-
37
-
-
0036893815
-
Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells
-
Wielinga PR, Reid G, Challa EE, et al: Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells. Mol Pharmacol 62: 1321-1331, 2002.
-
(2002)
Mol Pharmacol
, vol.62
, pp. 1321-1331
-
-
Wielinga, P.R.1
Reid, G.2
Challa, E.E.3
-
38
-
-
0345466497
-
Biochemical pharmacology and resistance to 2-chloro-2′-arabino-fluoro-2′-deoxyadenosine, a novel analog of cladribine in human leukemic cells
-
Lotfi K, Mansson E, Spasokoukotskaja T, et al: Biochemical pharmacology and resistance to 2-chloro-2′-arabino-fluoro-2′-deoxyadenosine, a novel analog of cladribine in human leukemic cells. Clin Cancer Res 5: 2438-2444, 1999.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 2438-2444
-
-
Lotfi, K.1
Mansson, E.2
Spasokoukotskaja, T.3
-
39
-
-
0027202081
-
Cellular pharmacology of fludarabine triphosphate in chronic lymphocytic leukemia cells during fludarabine therapy
-
Gandhi V. Kemena A, Keating MJ and Plunkett W: Cellular pharmacology of fludarabine triphosphate in chronic lymphocytic leukemia cells during fludarabine therapy. Leuk Lymphoma 10: 49-56, 1993.
-
(1993)
Leuk Lymphoma
, vol.10
, pp. 49-56
-
-
Gandhi, V.1
Kemena, A.2
Keating, M.J.3
Plunkett, W.4
-
40
-
-
54049152288
-
Clofarabine: Mechanisms of action, pharmacology and clinical investigations
-
Peters GJ ed, Humana Press, New York, pp
-
Gandhi V and Plunkett W: Clofarabine: mechanisms of action, pharmacology and clinical investigations. In: Deoxynucleoside Analogs in Cancer Therapy. Peters GJ (ed.) Humana Press, New York, pp153-171, 2006.
-
(2006)
Deoxynucleoside Analogs in Cancer Therapy
, pp. 153-171
-
-
Gandhi, V.1
Plunkett, W.2
-
41
-
-
0032917771
-
Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine, a novel deoxyadenosine analog, against human colon tumor xenografts by oral administration
-
Takahashi T, Kanazawa J, Akinaga S, Tamaoki T and Okabe M: Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine, a novel deoxyadenosine analog, against human colon tumor xenografts by oral administration. Cancer Chemother Pharmacol 43: 233-240, 1999.
-
(1999)
Cancer Chemother Pharmacol
, vol.43
, pp. 233-240
-
-
Takahashi, T.1
Kanazawa, J.2
Akinaga, S.3
Tamaoki, T.4
Okabe, M.5
-
42
-
-
0037445122
-
Phase I clinical and pharmacology study of clofarabine in patients with solid and hematologic cancers
-
Kantarjian H, Gandhi V, Kozuch P, et al: Phase I clinical and pharmacology study of clofarabine in patients with solid and hematologic cancers. J Clin Oncol 21: 1167-1173, 2003.
-
(2003)
J Clin Oncol
, vol.21
, pp. 1167-1173
-
-
Kantarjian, H.1
Gandhi, V.2
Kozuch, P.3
-
43
-
-
0038804087
-
Clofarabine-induced acral erythema during the treatment of patients with myelodysplasia and acute leukemia: Report of two cases
-
Chiao N, Bumgardner A and Duvic M: Clofarabine-induced acral erythema during the treatment of patients with myelodysplasia and acute leukemia: report of two cases. Leuk Lymphoma 44: 1405-1407, 2003.
-
(2003)
Leuk Lymphoma
, vol.44
, pp. 1405-1407
-
-
Chiao, N.1
Bumgardner, A.2
Duvic, M.3
-
44
-
-
1942422737
-
Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development
-
Peterson JK and Houghton PJ: Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development. Eur J Cancer 40: 837-844, 2004.
-
(2004)
Eur J Cancer
, vol.40
, pp. 837-844
-
-
Peterson, J.K.1
Houghton, P.J.2
-
45
-
-
34548851697
-
A phase I clinical-laboratory study of clofarabine followed by cyclophosphamide for adults with refractory acute leukemias
-
Karp JE, Ricklis RM, Balakrishnan K, et al: A phase I clinical-laboratory study of clofarabine followed by cyclophosphamide for adults with refractory acute leukemias. Blood 110: 1762-1769, 2007.
-
(2007)
Blood
, vol.110
, pp. 1762-1769
-
-
Karp, J.E.1
Ricklis, R.M.2
Balakrishnan, K.3
-
46
-
-
19944433802
-
Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemia
-
Faderl S, Gandhi V, O'Brien S, et al: Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemia. Blood 105: 940-947, 2005.
-
(2005)
Blood
, vol.105
, pp. 940-947
-
-
Faderl, S.1
Gandhi, V.2
O'Brien, S.3
-
47
-
-
52649154001
-
A randomized study of clofarabine versus clofarabine plus low dose cytarabine as frontline therapy for patients age ≥60 years with acute myeloid leukemia and high risk myelodysplastic syndrome
-
Faderl S, Ravandi F, Huang X, et al: A randomized study of clofarabine versus clofarabine plus low dose cytarabine as frontline therapy for patients age ≥60 years with acute myeloid leukemia and high risk myelodysplastic syndrome. Blood 112: 1638-1645, 2008.
-
(2008)
Blood
, vol.112
, pp. 1638-1645
-
-
Faderl, S.1
Ravandi, F.2
Huang, X.3
|