Technology of stable, prolonged-release eye-drops containing Cyclosporine A, distributed between lipid matrix and surface of the solid lipid microspheres (SLM)

International Journal of Pharmaceutics

Volumn 441, Issue 1-2, 2013, Pages 449-457

  Wolska, Eliza ^a   Sznitowska, Małgorzata ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

Cyclosporine; Phase distribution; Solid lipid microspheres; Solubility; Stability

Indexed keywords

CYCLOSPORIN A; EYE DROPS; GLYCEROL BEHENATE; GLYCEROL PALMITOSTEARATE; MICROSPHERE; MIGLYOL; NONIONIC SURFACTANT; POLYSORBATE 80; SOLID LIPID MICROSPHERE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION (PARAMETERS); DISPERSION; DRUG FORMULATION; DRUG RELEASE; EMULSION; GEL; LIPID SOLUBILITY; PARTICLE SIZE; PRIORITY JOURNAL; SHELF LIFE; SUSTAINED DRUG RELEASE;

CRYSTALLIZATION; CYCLOSPORINE; DELAYED-ACTION PREPARATIONS; DIGLYCERIDES; DRUG STABILITY; DRUG STORAGE; EXCIPIENTS; FATTY ACIDS; GELS; IMMUNOSUPPRESSIVE AGENTS; LIPIDS; MICROSPHERES; OPHTHALMIC SOLUTIONS; PARTICLE SIZE; POLYSORBATES; SURFACE-ACTIVE AGENTS; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS; TRIGLYCERIDES;

EID: 84872779309     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.11.009     Document Type: Article

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