Development, characterization and clinical validation of new sensitive immunofluorometric assay for the measurement of serum thyroglobulin;Desenvolvimento, caracterização e validação clínica de um novo ensaio sensível para a dosagem da tiroglobulina sérica

Arquivos Brasileiros de Endocrinologia e Metabologia

Volumn 56, Issue 9, 2012, Pages 658-665

  Nakabashi, Cláudia C D ^a,b   Biscolla, Rosa Paula M ^a,b,c   Kasamatsu, Teresa S ^a   Tachibana, Teresinha T ^c   Barcelos, Rafaela N ^a   Malouf, Eduardo Z ^b   Andreoni, Danielle M ^a,b   Maciel, Rui M B ^a,b,c   Vieira, José Gilberto H ^a,c  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b HOSPITAL ISRAELITA ALBERT EINSTEIN   (Brazil)

^c Fleury   (Brazil)

Author keywords

Differentiated thyroid cancer; Highly sensitive assay; Thyroglobulin

Indexed keywords

DIAGNOSTIC AGENT; MONOCLONAL ANTIBODY; THYROGLOBULIN;

ADULT; AGED; ANIMAL; ARTICLE; BIOSYNTHESIS; BLOOD; FEMALE; FLUOROIMMUNOASSAY; HUMAN; MALE; METHODOLOGY; MIDDLE AGED; MOUSE; RABBIT; SENSITIVITY AND SPECIFICITY; STANDARD; THYROID TUMOR; VALIDATION STUDY;

ADULT; AGED; ANIMALS; ANTIBODIES, MONOCLONAL; FEMALE; FLUOROIMMUNOASSAY; HUMANS; MALE; MICE; MIDDLE AGED; RABBITS; SENSITIVITY AND SPECIFICITY; THYROGLOBULIN; THYROID NEOPLASMS; YOUNG ADULT;

EID: 84872770540     PISSN: 00042730     EISSN: 16779487     Source Type: Journal    
DOI: 10.1590/S0004-27302012000900010     Document Type: Article

References (35)

1. van de Graaf SAR, Ris-Stalpers C, Pauws E, Mendive FM, Targovnik HM, de Vijlder JJM. Up to date with human thyroglobulin. J Endocrinol. 2001;170:307-21.
2. Marinò M, McCluskey RT. Role of thyroid endocytic pathways in the control of thyroid hormone release. Am J Physiol Cell Physiol. 2000;279:C1295-306.
3. Lisi S, Pinchera A, McCluskey RT, Willnow TE, Refetoff S, Marcocci C, et al. Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: a control mechanism for thyroid hormone release. PNAS. 2003;100:14858-36.
4. Vejbjerg P, Knudsen N, Perrild H, Laurberg P, Carlé A, Pedersen IB, et al. Thyroglobulin as a marker of iodine nutrition status in the general population. Eur J Endocrinol. 2009;161:475-81.
5. Van Herle AJ, Uller RP, Matthews NL, Brown J. Radioimmunoassay for measurement of thyroglobulin in human serum. J Clin Invest. 1973;52:1320-7.
6. Lin J-D. Thyroglobulin and human thyroid cancer. Clin Chim Acta. 2008;388:15-21.
7. Brassard M, Borge I, Edet-Sanson A, Giraudet A-L, Mundler O, Toubeau M, et al. Long term follow-up of patients with papillary and follicular thyroid cancer: a prospective study on 715 patients. J Clin Endocrinol Metab. 2011;96:1352-9.
8. Spencer CA, Bergoglio LM, Kazarosyan M, Fatemi S, LoPresti JS. Clinical impact of thyroglobulin (Tg) and Tg autoantibody method differences on the management of patients with differentiated thyroid carcinomas. J Clin Endocrinol Metab. 2005;90:5566-75.
9. Schlumberger M, Hitzel A, Toubert ME, Corone C, Troalen F, Schlageter MH, et al. Comparison of seven serum thyroglobulin assays in the follow-up of papillary and follicular thyroid cancer patients. J Clin Endocrinol Metab. 2007;92:2487-95.
10. Maciel RMB. Ainda em busca do ensaio ideal para a tiroglobulina sérica no seguimento de pacientes com câncer diferenciado da tiróide. Arq Bras Endocrinol Metab. 2004;48:434-6.
11. Preissner CM, O'Kane DJ, Singh RJ, Morris JC, Grebe SK. Phantons in the assay tube: heterophile antibody interference in serum thyroglobulin assays. J Clin Endocrinol Metab. 2003;88:3069-74.
12. Giovanella L, Ghelfo A. Undetectable serum thyroglobulin due to negative interference of heterophile antibodies in relapsing thyroid carcinoma. Clin Chem. 2007;53:1873-4.
13. Ismail AA. Interference from endogenous antibodies in automated immunoassays: what laboratorians need to know. J Clin Pathol. 2009;62:673-8.
14. Spencer CA, Takeuchi M, Kasarosyan M, Wang CC, Guttler RB, Singer PA, et al. Serum thyroglobulin autoantibodies: prevalence, influence on serum thyroglobulin measurement, and prognostic significance in patients with differentiated thyroid carcinoma. J Clin Endocrinol Metab. 1998;83:1121-7.
15. Spencer C, Petrovic I, Fatemi S. Current thyroglobulin autoantibody (TgAb) assays fail to detect interfering TgAb that can result in the reporting of falsely low/undetectable serum Tg IMA values for patients with differentiated thyroid cancer. J Clin Endocrinol Metab. 2011;96:1283-91.
16. Vieira JGH, Kasamatsu TS, Hauache OM, Maciel RMB. Anticorpos anti-tiróide: aspectos metodológicos e importância diagnóstica. Arq Bras Endocrinol Metab. 2003;47:612-21.
17. Dufour DR. Thyroglobulin antibodies-Failing the test. J Clin Endocrinol Metab. 2011;96:1276-8.
18. Vaitukaitis J, Robbins JB, Nieschlag E, Ross GT. A method for producing specific antisera with small doses of immunogen. J Clin Endocrinol Metab. 1971;33:988-91.
19. Maciel RMB. Development of a radioimmunoassay for the measurement of serum thyroglobulin and its application in the follow-up of patients with differentiated thyroid cancer. Ph.D. Thesis, Federal University of Sao Paulo; 1983. p. 126.
20. Maciel RMB, Vieira JGH, Fonseca RMG, Russo EMK, Oliveira MAD, Rocca A. Desenvolvimento de um método radioimunológico para a dosagem de tiroglobulina sérica. Arq Bras Endocrinol Metab. 1986;30:31-9.
21. Goding JW. Antibody production by hybridomas. J Immunol Methods. 1980;39:285-308.
22. Pereira AB, Nishida SK, Vieira JGH, Lombardi MT, Silva MS, Ajzen H, et al. Monoclonal antibody-based immunoenzymometric assays of retinol-binding protein. Clin Chem. 1993;39:472-6.
23. Kendall C, Ionescu-Matiu I, Dressman GR. Utilization of the biotin-avidin system to amplify the sensitivity of the enzyme-linked immunosorbent assay (ELISA). J Immunol Methods. 1983;56:329-39.
24. Maciel RMB. O ensaio de tiroglobulina com melhor sensibilidade funcional enquanto os pacientes tomam L-T4 substituirá a tiroglobulina estimulada pelo TSH no seguimento dos pacientes com câncer diferenciado da tiróide? Arq Bras Endocrinol Metab. 2007;51:862-6.
25. Schulz R, Bethauser H, Stempka L, Heilig B, Moll A, Hufner M. Evidence for immunological differences between circulating and tissue-derived thyroglobulin in men. Eur J Clin Invest. 1989;19:459-63.
26. Prentice L, Kiso Y, Fukuma N, Horimoto M, Petersen V, Grennan F, et al. Monoclonal thyroglobulin autoantibodies: variable region analysis and epitope recognition. J Clin Endocrinol Metab. 1995;80:3877-86.
27. Cooper DS, Doherty GM, Haugen BR, Kloss RT, Lee SL, Mandel SJ, et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009;19:1-48.
28. Pacini F, Schlumberger M, Dralle H, Elisei R, Smit JW, Wiersinga W. European Thyroid Cancer Taskforce European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium. Eur J Endocrinol. 2006;154:787-803.
29. Maia AL, Ward LS, Carvalho GA, Graf H, Maciel RMB, Maciel LMZ, et al. Thyroid nodules and differentiated thyroid cancer: Brazilian Consensus. Arq Bras Endocrinol Metab. 2007;51:867-93.
30. Giovanella L, Ceriani L, Ghelfo A, Keller F, Sacchi A, Maffioli M, et al. Thyroglobulin assay during thyroxine treatment in low-risk differentiated thyroid cancer management: comparison with recombinant assay and imaging procedures. Clin Chem Lab Med. 200;44:648-52.
31. Smallridge RC, Meek SE, Morgan MA, Gates GS, Fox TP, Grebe S, et al. Monitoring thyroglobulin in a sensitive immunoassay has comparable sensitivity to recombinant human TSH-stimulated thyroglobulin in follow-up of thyroid cancer patients. J Clin Endocrinol Metab. 2007;92:82-7.
32. Iervasi A, Iervasi G, Ferdeghini M, Solimeo C, Bottoni A, Rossi L, et al. Clinical relevance of highly sensitive Tg assay in monitoring patients treated for differentiated thyroid cancer. Clin Endocrinol. 2007;67:434-41.
33. Levinson SS. The nature of heterophilic antibodies and their role in immunoassay interference. J Clin Immunoassay. 1992;15:108-15.
34. Boldarine VT, Maciel RMB, Guimaraes GS, Nakabashi CCD, Camacho CP, Andreoni DM, et al. Development of a sensitive and specific quantitative reverse transcription-polymerase chain reaction assay for blood thyroglobulin messenger ribonucleic acid in the follow-up of patients with differentiated thyroid carcinoma. J Clin Endocrinol Metab. 2010;95:1726-33.
35. Chinnappa P, Taguba L, Arciaga R, Faiman C, Siperstein A, Mehta AE, et al. Detection of thyrotropin-receptor messenger ribonucleic acid (mRNA) and thyroglobulin mRNA transcripts in peripheral blood of patients with thyroid disease: sensitive and specific markers for thyroid cancer. J Clin Endocrinol Metab. 2004;89:3705-9.